KEGG   ENZYME: 1.21.99.3
Entry
EC 1.21.99.3                Enzyme                                 
Name
thyroxine 5-deiodinase;
diiodothyronine 5'-deiodinase (ambiguous);
iodothyronine 5-deiodinase;
iodothyronine inner ring monodeiodinase;
type III iodothyronine deiodinase
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With unknown physiological acceptors
Sysname
3,3',5'-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
Reaction(IUBMB)
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor [RN:R07230]
Reaction(KEGG)
R07230
Substrate
3,3',5'-triiodo-L-thyronine [CPD:C07639];
iodide [CPD:C00708];
acceptor [CPD:C00028];
H+ [CPD:C00080]
Product
L-thyroxine [CPD:C01829];
reduced acceptor [CPD:C00030]
Comment
The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
History
EC 1.21.99.3 created 2003 as EC 1.97.1.11, transferred 2015 to EC 1.21.99.3
Orthology
K07754  thyroxine 5-deiodinase
Genes
HSA1735(DIO3)
PTR467559(DIO3)
PPS100992412(DIO3)
GGO101125055(DIO3)
PON100452020(DIO3)
NLE100592037(DIO3)
MCC708027(DIO3)
MCF102126318(DIO3)
CSAB103229715(DIO3)
CATY105596710(DIO3)
PANU101006429(DIO3)
TGE112628943(DIO3)
RRO104654442(DIO3)
RBB108525896 108542292(DIO3)
TFN117071362(DIO3)
PTEH111538146(DIO3)
CJC100411094(DIO3)
SBQ101051472(DIO3)
CSYR103250467
MMUR105861059(DIO3)
OGA100944498(DIO3)
MMU107585(Dio3)
MCAL110307126(Dio3)
MPAH110324598(Dio3)
RNO29475(Dio3)
MCOC116080664(Dio3)
MUN110556113(Dio3)
CGE100753739(Dio3)
PLEU114684512(Dio3)
NGI103727635(Dio3)
HGL101697914(Dio3)
CCAN109703410(Dio3)
DORD105984657(Dio3)
DSP122122626(Dio3)
NCAR124977702
OCU100357267(DIO3)
OPI101519762(DIO3)
TUP102489833(DIO3)
CFA612596(DIO3)
VVP112930337(DIO3)
VLG121493503(DIO3)
AML100466435(DIO3)
UMR103656768(DIO3)
UAH113267255(DIO3)
UAR123778168(DIO3)
ELK111148790
LLV125104740
MPUF101681341(DIO3)
ORO101370478(DIO3)
EJU114208578(DIO3)
ZCA113909741(DIO3)
MLX118002068(DIO3)
FCA101094186(DIO3)
PYU121032298(DIO3)
PBG122469553(DIO3)
PTG102968143(DIO3)
PPAD109274568(DIO3)
AJU106987552(DIO3)
HHV120244595(DIO3)
BTA494549(DIO3)
BOM102270867(DIO3)
BIU109575257(DIO3)
BBUB102415555(DIO3)
CHX102180706(DIO3)
OAS100142657(DIO3)
ODA120875177(DIO3)
CCAD122419698(DIO3)
SSC414378(DIO3)
CFR102516992(DIO3)
CBAI105079938(DIO3)
CDK105105618(DIO3)
VPC102527491(DIO3)
BACU103007374(DIO3)
LVE103088549(DIO3)
OOR101284116(DIO3)
DLE111175919(DIO3)
PCAD102983960(DIO3)
PSIU116746393(DIO3)
ECB100146344(DIO3)
EAI106839648(DIO3)
MYB102240362(DIO3)
MYD102764457(DIO3)
MMYO118659973(DIO3)
MLF102431009(DIO3)
MNA107536490(DIO3)
PKL118704255(DIO3)
HAI109381031(DIO3)
DRO112311125(DIO3)
SHON118976838(DIO3)
AJM119037980(DIO3) 119046939
PDIC114492635(DIO3)
PHAS123808430(DIO3)
MMF118615354(DIO3)
RFQ117022864(DIO3)
PALE102884557(DIO3)
PGIG120619708(DIO3)
PVP105299281(DIO3)
RAY107521364(DIO3)
MJV108391764(DIO3)
TOD119238335(DIO3)
SARA101549876(DIO3)
LAV100676785(DIO3)
TMU101350716
DNM101414989(DIO3)
MDO100022264(DIO3)
GAS123237598(DIO3)
SHR100930662(DIO3)
PCW110222383(DIO3)
OAA114815044(DIO3)
GGA395939(DIO3)
PCOC116228772(DIO3)
MGP104911266(DIO3)
CJO107315336(DIO3)
NMEL110401981(DIO3)
APLA101801522(DIO3)
ACYG106047811(DIO3)
AFUL116490224(DIO3)
TGU100232538(DIO3)
LSR110481158(DIO3)
SCAN103826423(DIO3)
PMOA120503823(DIO3)
OTC121332696(DIO3)
PRUF121358242(DIO3)
GFR102031652(DIO3)
FAB101819627(DIO3)
PHI102113106(DIO3)
PMAJ107205941(DIO3)
CCAE111943428(DIO3)
CCW104688822(DIO3)
ETL114062325(DIO3)
ZAB102074998(DIO3)
FPG101916216(DIO3)
FCH102055253(DIO3)
CLV102085218(DIO3)
EGZ104124534(DIO3)
NNI104014506(DIO3)
TALA104355805(DIO3)
PADL103920333(DIO3)
ACHC115335129(DIO3)
AAM106483159(DIO3)
AROW112972699(DIO3)
NPD112956957(DIO3)
DNE112989955(DIO3)
ASN102379073(DIO3)
AMJ102557680(DIO3)
CPOO109320872(DIO3)
GGN109299302(DIO3)
PSS102445065(DIO3)
CMY102944395(DIO3)
CPIC101941254(DIO3)
TST117876208(DIO3)
CABI116822685(DIO3)
MRV120405233(DIO3)
ACS103279636(dio3)
PVT110078939(DIO3)
SUND121927124
PBI103067707(DIO3)
PMUR107295366(DIO3)
TSR106557133(DIO3)
PGUT117665990(DIO3)
VKO123026698(DIO3)
PMUA114585828(DIO3)
ZVI118085949(DIO3)
GJA107121532(DIO3)
STOW125427502(DIO3)
XLA397779(dio3.L) 447383(dio3.S)
XTR100038242(dio3)
NPR108788622(DIO3)
RTEM120920433(DIO3)
BBUF120982236(DIO3)
BGAR122921751(DIO3)
DRE100538339(dio3a) 798872(dio3b)
SRX107719697(dio3) 107728129
SANH107704370
SGH107557013 107568504(dio3)
CCAR109076128
PPRM120492007(dio3b)
MAMB125269204(dio3a) 125278626(dio3b)
IPU108257532(dio3b)
PHYP113532162
SMEO124376555(dio3b)
TFD113655578(dio3b)
AMEX103026014 103042641
EEE113570552 113587266(dio3)
TRU100191069(dio3a) 100191070(dio3)
TNGGSTEN00020720G001
LCO104924692
NCC104944299 104955612
CGOB115004041 115027062(dio3)
ELY117266886(dio3a) 117270479
PLEP121953906(dio3a) 121955459
SLUC116037853(dio3a) 116066329
ECRA117935989(dio3a) 117961967
PFLV114547016(dio3) 114573444
GAT120808434 120833054(dio3a)
PPUG119194685 119227652(dio3a)
MSAM119909227 119909863(dio3a)
CUD121521555 121526310(dio3a)
MZE101473371 101482855(dio3)
ONL100534528(dio3) 102082306(dio3)
OAU116332304 116334813(dio3a)
OLA101165608(dio3) 101170321
OML112137075 112150353(dio3a)
XMA102219896(dio3) 102224805
XCO114133777(dio3) 114159104
XHE116708534(dio3) 116734614
PRET103457920 103458832(dio3)
PFOR103153273 103155528
PLAI106955540
PMEI106915673(dio3) 106916346
GAF122825480
CVG107088052(dio3) 107100293
CTUL119794784
GMU124855626(dio3a) 124881705
NFU107378073 107392233(dio3)
KMR108231770 108234184(dio3a)
ALIM106518589 106522158(dio3)
NWH119418103 119426984(dio3a)
AOCE111573799 111586185(dio3)
CSEM103378336 103380986
POV109627974(dio3) 109632292
SSEN122783656
HHIP117756061(dio3a) 117758453
LCF108874850(dio3) 108896892
SDU111225793(dio3) 111240420
SLAL111672563
XGL120788603 120795628(dio3a)
HCQ109526721(dio3) 109530979
BPEC110155473(dio3) 110168270
MALB109955084(dio3) 109962216
SASA106608133
OTW112218114 112262351(dio3a)
OMY110498181(dio3a) 110522491
OGO123995804 124001969(dio3a)
ONE115119862 115146687(dio3)
SALP111954170 111968939 112069449
SNH120019137
ELS105015993(dio3) 105030678
SFM108941519(dio3)
PKI111852458(dio3)
AANG118214155(dio3a) 118229335
LOC102698890(dio3)
PSPA121324276 121329498
ARUT117416609 117963846
LCM102353393(DIO3)
CMK103175341(dio3a)
RTP109921689(dio3)
BFO118423663 118427561
BBEL109464663 109465635 109467022 109476824
CIN100187528
SCLV120340714 120344040 120347387
SKO100367138 102809937
PJA122263866
PCHN125029022 125044312
HAME121861791 121864571
LGILOTGIDRAFT_227840
GAE121370721
HRF124149502 124149503
HRJ124254549 124254846 124255857
MMER123537981
LAK106152372 106170704 106170707
NVE5513824
EPA110232487 110236537 110243956 110252584 110252587
ATEN116288517 116288523 116288531 116307435
ADF107327167 107331111
AMIL114952603 114969593 114974176
PDAM113675602 113679277 113686682
SPIS111321009 111321076
XEN124437174 124454271 124454561 124454844 124454893 124454896 124454910
 » show all
Reference
1  [PMID:7053997]
  Authors
Chopra IJ, Chua Teco GN.
  Title
Characteristics of inner ring (3 or 5) monodeiodination of 3,5-diiodothyronine in rat liver: evidence suggesting marked similarities of inner and outer ring deiodinases for iodothyronines.
  Journal
Endocrinology 110:89-97 (1982)
DOI:10.1210/endo-110-1-89
Reference
2  [PMID:11898402]
  Authors
Kohrle J.
  Title
Iodothyronine deiodinases.
  Journal
Methods Enzymol 347:125-67 (2002)
DOI:10.1016/s0076-6879(02)47014-0
Other DBs
ExplorEnz - The Enzyme Database: 1.21.99.3
IUBMB Enzyme Nomenclature: 1.21.99.3
ExPASy - ENZYME nomenclature database: 1.21.99.3
BRENDA, the Enzyme Database: 1.21.99.3
CAS: 74506-30-2

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