KEGG ENZYME: 1.21.99.3

ENZYME: 1.21.99.3

Entry

EC 1.21.99.3                Enzyme

Name

thyroxine 5-deiodinase;
diiodothyronine 5'-deiodinase (ambiguous);
iodothyronine 5-deiodinase;
iodothyronine inner ring monodeiodinase;
type III iodothyronine deiodinase

Class

Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With unknown physiological acceptors

Sysname

3,3',5'-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

Reaction(IUBMB)

3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor [RN:R07230]

Reaction(KEGG)

R07230

Substrate

3,3',5'-triiodo-L-thyronine [CPD:C07639];
iodide [CPD:C00708];
acceptor [CPD:C00028];
H+ [CPD:C00080]

Product

L-thyroxine [CPD:C01829];
reduced acceptor [CPD:C00030]

Comment

The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.

History

EC 1.21.99.3 created 2003 as EC 1.97.1.11, transferred 2015 to EC 1.21.99.3

Orthology

K07754

thyroxine 5-deiodinase

Genes

HSA:	1735(DIO3)

PPYG:

129013086(DIO3)

NLE:	100592037(DIO3)

HMH:	116484818(DIO3)

SSYN:

129487435(DIO3)

MCC:	708027(DIO3)

MCF:	102126318(DIO3)

MTHB:

126958441

MNI:	105467397(DIO3)

CSAB:

103229715(DIO3)

CATY:

105596710(DIO3)

PANU:

101006429(DIO3)

TGE:	112628943(DIO3)

MLEU:

105547869(DIO3)

RRO:	104654442(DIO3)

RBB:	108525896 108542292(DIO3)

TFN:	117071362(DIO3)

PTEH:

111538146(DIO3)

CANG:

105518452(DIO3)

CJC:	100411094(DIO3)

SBQ:	101051472(DIO3)

CIMI:

108304053(DIO3)

ANAN:

105730183(DIO3)

CSYR:

103250467

MMUR:

105861059(DIO3)

LCAT:

123622899(DIO3)

PCOQ:

105812592(DIO3)

OGA:	100944498(DIO3)

MMU:	107585(Dio3)

MCAL:

110307126(Dio3)

MPAH:

110324598(Dio3)

RNO:	29475(Dio3)

MCOC:

116080664(Dio3)

ANU:	117697357(Dio3)

ASYL:

127687836(Dio3)

MUN:	110556113(Dio3)

CGE:	100753739(Dio3)

MAUA:

101833489(Dio3)

PROB:

127231144(Dio3)

PLEU:

114684512(Dio3)

MORG:

121434456(Dio3)

MFOT:

126509131

AAMP:

119819687(Dio3)

NGI:	103727635(Dio3)

HGL:	101697914(Dio3)

CCAN:

109703410(Dio3)

DORD:

105984657(Dio3)

DSP:	122122626(Dio3)

PLOP:

125363605(Dio3)

NCAR:

124977702

MMMA:

107134905(Dio3)

ITI:	101965858(Dio3)

OCU:	100357267(DIO3)

OPI:	101519762(DIO3)

TUP:	102489833(DIO3)

GVR:	103597912(DIO3)

CFA:	612596(DIO3)

CLUD:

112657662(DIO3)

VVP:	112930337(DIO3)

VLG:	121493503(DIO3)

NPO:	129496148(DIO3)

AML:	100466435(DIO3)

UMR:	103656768(DIO3)

UAH:	113267255(DIO3)

UAR:	123778168(DIO3)

ELK:

111148790

LLV:

125104740

MPUF:

101681341(DIO3)

MNP:	132008349(DIO3)

MLK:	131836996(DIO3)

NVS:	122893121(DIO3)

ORO:	101370478(DIO3)

EJU:	114208578(DIO3)

ZCA:	113909741(DIO3)

MLX:	118002068(DIO3)

NSU:	110571571(DIO3)

LWW:	102733003(DIO3)

FCA:	101094186(DIO3)

PYU:	121032298(DIO3)

PBG:	122469553(DIO3)

PVIV:

125168881(DIO3)

LRUF:

124512286

LGF:	123584333(DIO3)

AJU:

106987552

PTG:	102968143(DIO3)

PPAD:

109274568(DIO3)

PUC:

125909156

PLEZ:

122223136(DIO3)

HHV:	120244595(DIO3)

BTA:	494549(DIO3)

BOM:	102270867(DIO3)

BIU:	109575257(DIO3)

BBUB:

102415555(DIO3)

BBIS:

104996948(DIO3)

CHX:	102180706(DIO3)

OAS:	100142657(DIO3)

BTAX:

128066933(DIO3)

CSUM:

138095547(DIO3)

ODA:	120875177(DIO3)

CCAD:

122419698(DIO3)

MREE:

136147367(DIO3)

OVR:	110150517(DIO3)

MBEZ:

129550178(DIO3)

SSC:	414378(DIO3)

CFR:	102516992(DIO3)

CBAI:

105079938(DIO3)

CDK:	105105618(DIO3)

VPC:	102527491(DIO3)

BACU:

103007374(DIO3)

BMUS:

118890735(DIO3)

LVE:	103088549(DIO3)

OOR:	101284116(DIO3)

LALB:

132529045(DIO3)

DLE:	111175919(DIO3)

PCAD:

102983960(DIO3)

PSIU:

116746393(DIO3)

NASI:

112409638(DIO3)

ECB:	100146344(DIO3)

EAI:	106839648(DIO3)

MYB:	102240362(DIO3)

MYD:	102764457(DIO3)

MMYO:

118659973(DIO3)

MLF:	102431009(DIO3)

MDT:	132229941(DIO3)

MYUM:

139001551 139001792

PKL:	118704255(DIO3)

EFUS:

103298057(DIO3)

MNA:	107536490(DIO3)

DRO:	112311125(DIO3)

SHON:

118976838(DIO3)

AJM:	119037980(DIO3)

PDIC:

114492635(DIO3)

PHAS:

123808430(DIO3)

MMF:	118615354(DIO3)

PPAM:

129066164(DIO3)

HAI:	109381031(DIO3)

RFQ:	117022864(DIO3)

PALE:

102884557(DIO3)

PGIG:

120619708(DIO3)

PVP:	105299281(DIO3)

RAY:	107521364(DIO3)

MJV:	108391764(DIO3)

TOD:	119238335(DIO3)

SARA:

101549876(DIO3)

SFUM:

130023200(DIO3)

SETR:

126003597(DIO3)

LAV:	100676785(DIO3)

TMU:

101350716

ETF:	101640547(DIO3)

DNM:	101414989(DIO3)

MDO:	100022264(DIO3)

GAS:	123237598(DIO3)

SHR:	100930662(DIO3)

AFZ:

127549901

PCW:	110222383(DIO3)

TVP:	118841074(DIO3)

PBRV:

138173647 138173836(DIO3)

OAA:	114815044(DIO3)

TACU:

119928525(DIO3)

GGA:	395939(DIO3)

PCOC:

116228772(DIO3)

MGP:	104911266(DIO3)

CJO:	107315336(DIO3)

TPAI:

128085350(DIO3)

LMUT:

125694740(DIO3)

NMEL:

110401981(DIO3)

APLA:

101801522(DIO3)

ACYG:

106047811(DIO3)

CATA:

118250356(DIO3)

AFUL:

116490224(DIO3)

TGU:	100232538(DIO3)

LSR:	110481158(DIO3)

SCAN:

103826423(DIO3)

PMOA:

120503823(DIO3)

OTC:	121332696(DIO3)

PRUF:

121358242(DIO3)

ATRC:

139589766(DIO3)

GFR:	102031652(DIO3)

FAB:	101819627(DIO3)

OMA:	130254446(DIO3)

PHI:	102113106(DIO3)

PMAJ:

107205941(DIO3)

CCAE:

111943428(DIO3)

CCW:	104688822(DIO3)

CBRC:

103612159(DIO3)

ACOE:

138110875(DIO3)

ETL:	114062325(DIO3)

ZAB:	102074998(DIO3)

ZLE:	135448398(DIO3)

ACHL:

103801775(DIO3)

SVG:	106850549(DIO3)

MMEA:

130573371(DIO3)

HRT:	120754281(DIO3)

SATI:

136362864(DIO3)

CCIC:

134045363(DIO3)

FPG:	101916216(DIO3)

FCH:	102055253(DIO3)

CCRI:

104157090(DIO3)

NNT:	104406289(DIO3)

SHAB:

115606652(DIO3)

TALA:

104355805(DIO3)

ACHC:

115335129(DIO3)

HLE:	104841920(DIO3)

AGEN:

126050751

HHAR:

128139969(DIO3)

GCL:

127016918

LDI:	104345019(DIO3)

MNB:	103778224(DIO3)

DPUB:

104304360(DIO3)

PPUS:

135190479(DIO3)

BRHI:

104497234(DIO3)

EGZ:	104124534(DIO3)

NNI:	104014506(DIO3)

PCRI:

104037309(DIO3)

PADL:

103920333(DIO3)

AFOR:

103900211(DIO3)

CLV:	102085218(DIO3)

MUI:

104538035

PGUU:

104464568(DIO3)

PLET:

104616038(DIO3)

EHS:	104510326(DIO3)

CUCA:

104057738(DIO3)

TEO:	104371337(DIO3)

OHA:	104331578(DIO3)

ACAR:

104530433(DIO3)

CPEA:

104389059(DIO3)

CVF:	104291795(DIO3)

RTD:	128909004(DIO3)

AAM:	106483159(DIO3)

AROW:

112972699(DIO3)

NPD:	112956957(DIO3)

TGT:	104564842(DIO3)

DNE:	112989955(DIO3)

SCAM:

104144521(DIO3)

ASN:	102379073(DIO3)

AMJ:	102557680(DIO3)

CPOO:

109320872(DIO3)

GGN:	109299302(DIO3)

PSS:	102445065(DIO3)

CMY:	102944395(DIO3)

CCAY:

125638347(DIO3)

DCC:	119857456(DIO3)

CPIC:

101941254(DIO3)

TST:	117876208(DIO3)

CABI:

116822685(DIO3)

MRV:	120405233(DIO3)

ACS:	103279636(dio3)

ASAO:

132762357(DIO3)

PVT:	110078939(DIO3)

SUND:

121927124

PBI:	103067707(DIO3)

PMUR:

107295366(DIO3)

CTIG:

120318011(DIO3)

TSR:	106557133(DIO3)

PGUT:

117665990(DIO3)

APRI:

131187922(DIO3)

PTEX:

113435007(DIO3)

NSS:	113420346(DIO3)

VKO:	123026698(DIO3)

PMUA:

114585828(DIO3)

PRAF:

128406059(DIO3)

ZVI:	118085949(DIO3)

HCG:	128341255(DIO3)

GJA:	107121532(DIO3)

STOW:

125427502(DIO3)

EMC:	129324631(DIO3)

XLA:	397779(dio3.L) 447383(dio3.S)

XTR:	100038242(dio3)

NPR:	108788622(DIO3)

RTEM:

120920433(DIO3)

BBUF:

120982236(DIO3)

BGAR:

122921751(DIO3)

PWL:	138260143(DIO3)

MUO:	115477904(DIO3)

GSH:	117364203(DIO3)

DRE:	100538339(dio3a) 798872(dio3b)

SRX:	107719697(dio3) 107728129

SANH:

107704370

SGH:	107557013 107568504(dio3)

CCAR:

109058856 109076067(dio3b) 109076128

CGIB:

127984480

PTET:

122325311(dio3b) 122334428(dio3a)

LROH:

127180075(dio3a) 127182627(dio3b)

OMC:	131523709(dio3a) 131526931(dio3b)

PPRM:

120492007(dio3b)

RKG:	130082332(dio3b)

MAMB:

125269204(dio3a) 125278626(dio3b)

CIDE:

127499026 127501967

CERY:

137006621(dio3a) 137019269(dio3b)

MASI:

127416346 127455246

TROS:

130560443(dio3a) 130566079(dio3b)

TDW:	130434392(dio3b) 130436847(dio3a)

MANU:

129417706(dio3a) 129428918(dio3b)

PDAB:

135738404(dio3b) 135761045(dio3a)

IPU:	108257532(dio3b)

IFU:	128601427(dio3b)

PHYP:

113532162

SMEO:

124376555(dio3b)

TFD:	113655578(dio3b)

TVC:	132843194(dio3b)

CGAR:

128514719(dio3b)

NGRA:

132883025(dio3b)

TRN:	134320091(dio3b) 134325208(dio3a)

AMEX:

103026014(dio3b) 103042641(dio3a)

CMAO:

118815599(dio3b) 118823611(dio3a)

EEE:	113570552 113587266(dio3)

CHAR:

105908262(dio3a) 105909575(dio3b)

SPIL:

134067539(dio3a) 134097807

TRU:	100191069(dio3a) 100191070(dio3)

TFS:	130513225(dio3a) 130515971

TNG:	GSTEN00020720G001

LCO:

104924692

NCC:	104944299 104955612

TBEN:

117478338(dio3a) 117498516

CGOB:

115004041 115027062(dio3)

PGEO:

117440106 117467991(dio3a)

GACU:

117554269 117556439(dio3a)

EMAC:

134877209 134881726(dio3a)

ELY:	117266886(dio3a) 117270479

EFO:	125897305 125900444(dio3a)

PLEP:

121953906(dio3a) 121955459

SLUC:

116037853(dio3a) 116066329

ECRA:

117935989(dio3a) 117961967

ESP:	116670285(dio3) 116706592

PFLV:

114547016(dio3) 114573444

GAT:	120808434 120833054(dio3a)

PPUG:

119194685 119227652(dio3a)

AFB:	129103750(dio3a) 129107230

CLUM:

117725142(dio3a) 117727005

PSWI:

130191216(dio3a) 130202697

CANA:

137785684 137787749(dio3a)

CVE:	137871225 137884563(dio3a)

MSAM:

119909227 119909863(dio3a)

SCHU:

122862208(dio3a) 122863646

CUD:	121521555 121526310(dio3a)

SPUL:

138584973 138591313(dio3a)

LMIX:

132985146 132993528(dio3a)

ALAT:

119004643(dio3a)

ASTR:

137611090(dio3a) 137613444

MZE:	101473371 101482855(dio3)

ONL:	100534528(dio3) 102082306(dio3)

OAU:	116332304 116334813(dio3a)

OLA:	101165608(dio3) 101170321

OML:	112137075 112150353(dio3a)

CSAI:

133462334(dio3a) 133464651

XMA:	102219896(dio3) 102224805

XCO:	114133777(dio3) 114159104

XHE:	116708534(dio3) 116734614

PRET:

103457920 103458832(dio3)

PFOR:

103153273 103155528

PLAI:

106955540

PMEI:

106915673(dio3) 106916346

GAF:

122825480

PPRL:

129369265 129374796(dio3a)

CVG:	107088052(dio3) 107100293

CTUL:

119794784

GMU:	124855626(dio3a) 124881705

NFU:	107378073 107392233(dio3)

KMR:	108231770 108234184(dio3a)

ALIM:

106518589 106522158(dio3)

NWH:	119418103 119426984(dio3a)

AOCE:

111573799 111586185(dio3a)

EJA:	138199676(dio3a) 138203547

BFRE:

138631332 138633900(dio3a)

MCEP:

124999560 125023746(dio3a)

CSEM:

103378336 103380986

POV:	109627974(dio3) 109632292

SSEN:

122783656

SSOE:

131443996

HHIP:

117756061(dio3a) 117758453

HSP:	118099034 118116579(dio3a)

PPLT:

128451147(dio3a) 128460546

SMAU:

118286458(dio3a) 118290077

LCF:	108874850(dio3a) 108896892

SDU:	111225793(dio3) 111240420

SLAL:

111672563

XGL:	120788603 120795628(dio3a)

HCQ:	109526721(dio3) 109530979

SSCV:

125980447(dio3a) 125990375

SBIA:

133496460 133513247(dio3a)

PEE:	133412758(dio3a) 133417309

PTAO:

133467998 133487788(dio3a)

BPEC:

110155473(dio3) 110168270

ENY:	140354683 140370950(dio3a)

MALB:

109955084(dio3) 109962216

BSPL:

114848855(dio3a) 114849421(dio3b)

SJO:	128375385(dio3a) 128377121

SSCO:

133997605 134000983(dio3a)

GMH:	115534774 115543441(dio3)

SASA:

106608133

STRU:

115168294

OTW:	112218114 112262351(dio3a)

OMY:	110498181(dio3a) 110522491

OGO:	123995804 124001969(dio3a)

ONE:	115119862 115146687(dio3)

OKI:	109866554 109893994(dio3)

OKE:	118362249(dio3a) 118387208

OMM:	135507434(dio3a)

OCLA:

139407852

SALP:

111954170 111968939 112069449

SNH:

120019137

CCLU:

121544432(dio3a) 121548631

ELS:	105015993(dio3) 105030678

OEP:	134024665(dio3b) 134026177(dio3a)

SFM:	108941519(dio3)

PKI:	111852458(dio3)

AANG:

118214155(dio3a) 118229335

AROT:

135251776(dio3a) 135257054

CCOG:

133129077 133137100(dio3a)

LOC:	102698890(dio3)

PSPA:

121324276 121329498

ARUT:

117416609 117963846

PSEX:

120518460(dio3a)

LCM:	102353393(DIO3)

CMK:	103175341(dio3a)

RTP:	109921689(dio3a)

CPLA:

122553516(dio3a)

HOC:	132817949(dio3a)

LERI:

129700547(dio3a)

PMRN:

116948378(DIO3)

LRJ:

133352604

BFO:	118423663 118427561

BBEL:

109464663 109465635 109467022 109476824

CIN:

100187528

SCLV:

120340714 120344040 120347387

SKO:	100367138 102809937

PJA:

122263866

PCHN:

125029022 125044312

PMOO:

119579197

HAME:

121861791

CQD:

128703182

TCF:

131888124

LPOL:

106476113

LGI:	LOTGIDRAFT_227840

LSAX:

138973617

GAE:

121370721

HRF:	124149502 124149503

HRJ:	124254549 124254846 124255857

HASI:

137279206

HCRA:

139455132

OED:

125651854

AIRR:

138333409

MCAF:

127711812 127711813

MMER:

123537981

RPHI:

132716569

LJP:	135471097 135480502

LAK:	106152372 106170704 106170707

LLON:

135484600 135486676 135487451

NVE:

5513824

EPA:	110232487 110236537 110243956 110252584 110252587

ATEN:

116288517 116288523 116288531 116307435

ADF:	107327167 107331111

AMIL:

114952603 114974176 122953672

MCAZ:

138016439 138017840 138017841 138019243 138027172

MFOO:

137993115 137999153 138000547 138000548 138000550

PDAM:

113675602 113679277 113686682

SPIS:

111321009 111321076

XEN:	124437174 124454271 124454561 124454844 124454893 124454896 124454910

HSY:	130640654 130642204

RES:	135683310 135690842

» show all

Reference

1 [PMID:7053997]

Authors

Chopra IJ, Chua Teco GN.

Title

Characteristics of inner ring (3 or 5) monodeiodination of 3,5-diiodothyronine in rat liver: evidence suggesting marked similarities of inner and outer ring deiodinases for iodothyronines.

Journal

Endocrinology 110:89-97 (1982)
DOI:10.1210/endo-110-1-89

Reference

2 [PMID:11898402]

Authors

Kohrle J.

Title

Iodothyronine deiodinases.

Journal

Methods Enzymol 347:125-67 (2002)
DOI:10.1016/s0076-6879(02)47014-0

Other DBs

ExplorEnz - The Enzyme Database:

1.21.99.3

IUBMB Enzyme Nomenclature:

1.21.99.3

ExPASy - ENZYME nomenclature database:

1.21.99.3

BRENDA, the Enzyme Database:

1.21.99.3

CAS:	74506-30-2

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Gene (1156)   
   MGENES (78)   
   RefGene (1078)   
Protein sequence (37)   
   UniProt (10)   
   SWISS-PROT (10)   
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DNA sequence (20)   
   RefSeq(nuc) (18)   
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Protein domain (4)   
   InterPro (4)   
All databases (1217)   

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