KEGG   ENZYME: 1.21.99.3
Entry
EC 1.21.99.3                Enzyme                                 

Name
thyroxine 5-deiodinase;
diiodothyronine 5'-deiodinase (ambiguous);
iodothyronine 5-deiodinase;
iodothyronine inner ring monodeiodinase;
type III iodothyronine deiodinase
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With unknown physiological acceptors
Sysname
3,3',5'-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
Reaction(IUBMB)
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor [RN:R07230]
Reaction(KEGG)
R07230
Substrate
3,3',5'-triiodo-L-thyronine [CPD:C07639];
iodide [CPD:C00708];
acceptor [CPD:C00028];
H+ [CPD:C00080]
Product
L-thyroxine [CPD:C01829];
reduced acceptor [CPD:C00030]
Comment
The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
History
EC 1.21.99.3 created 2003 as EC 1.97.1.11, transferred 2015 to EC 1.21.99.3
Orthology
K07754  thyroxine 5-deiodinase
Genes
HSA: 1735(DIO3)
PTR: 467559(DIO3)
PPS: 100992412(DIO3)
GGO: 101125055(DIO3)
PON: 100452020(DIO3)
NLE: 100592037(DIO3)
MCC: 708027(DIO3)
MCF: 102126318(DIO3)
CSAB: 103229715(DIO3)
RRO: 104654442(DIO3)
RBB: 108525896 108542292(DIO3)
CJC: 100411094(DIO3)
SBQ: 101051472(DIO3)
MMU: 107585(Dio3)
MCAL: 110307126(Dio3)
MPAH: 110324598(Dio3)
RNO: 29475(Dio3)
MUN: 110556113(Dio3)
CGE: 100753739(Dio3)
NGI: 103727635(Dio3)
HGL: 101697914(Dio3)
CCAN: 109703410(Dio3)
OCU: 100357267(DIO3)
TUP: 102489833(DIO3)
CFA: 612596(DIO3)
VVP: 112930337(DIO3)
AML: 100466435(DIO3)
UMR: 103656768(DIO3)
UAH: 113267255(DIO3)
ORO: 101370478(DIO3)
ELK: 111148790
FCA: 101094186(DIO3)
PTG: 102968143(DIO3)
PPAD: 109274568(DIO3)
AJU: 106987552(DIO3)
BTA: 494549(DIO3)
BOM: 102270867(DIO3)
BIU: 109575257(DIO3)
BBUB: 102415555(DIO3)
CHX: 102180706(DIO3)
OAS: 100142657(DIO3)
SSC: 414378(DIO3)
CFR: 102516992(DIO3)
CDK: 105105618(DIO3)
BACU: 103007374(DIO3)
LVE: 103088549(DIO3)
OOR: 101284116(DIO3)
DLE: 111175919(DIO3)
PCAD: 102983960(DIO3)
ECB: 100146344(DIO3)
EAI: 106839648(DIO3)
MYB: 102240362(DIO3)
MYD: 102764457(DIO3)
MNA: 107536490(DIO3)
HAI: 109381031(DIO3)
DRO: 112311125(DIO3)
PALE: 102884557(DIO3)
RAY: 107521364(DIO3)
MJV: 108391764(DIO3)
LAV: 100676785(DIO3)
TMU: 101350716
MDO: 100022264(DIO3)
SHR: 100930662(DIO3)
PCW: 110222383(DIO3)
OAA: 114815044(DIO3)
GGA: 395939(DIO3)
MGP: 104911266(DIO3)
CJO: 107315336(DIO3)
NMEL: 110401981(DIO3)
APLA: 101801522(DIO3)
ACYG: 106047811(DIO3)
TGU: 100232538(DIO3)
LSR: 110481158(DIO3)
SCAN: 103826423(DIO3)
GFR: 102031652(DIO3)
FAB: 101819627(DIO3)
PHI: 102113106(DIO3)
PMAJ: 107205941(DIO3)
CCAE: 111943428(DIO3)
CCW: 104688822(DIO3)
ETL: 114062325(DIO3)
FPG: 101916216(DIO3)
FCH: 102055253(DIO3)
CLV: 102085218(DIO3)
EGZ: 104124534(DIO3)
NNI: 104014506(DIO3)
PADL: 103920333(DIO3)
AAM: 106483159(DIO3)
ASN: 102379073(DIO3)
AMJ: 102557680(DIO3)
PSS: 102445065(DIO3)
CMY: 102944395(DIO3)
CPIC: 101941254(DIO3)
ACS: 103279636(dio3)
PVT: 110078939(DIO3)
PBI: 103067707(DIO3)
PMUR: 107295366(DIO3)
TSR: 106557133(DIO3)
PMUA: 114585828(DIO3)
GJA: 107121532(DIO3)
XLA: 397779(dio3.L) 447383(dio3.S)
XTR: 100038242(dio3)
NPR: 108788622(DIO3)
DRE: 100538339(dio3a) 798872(dio3b)
SRX: 107719697(dio3) 107728129
SANH: 107704370
SGH: 107557013 107568504(dio3)
CCAR: 109076128
IPU: 108257532
PHYP: 113532162
EEE: 113570552 113587266(dio3)
TRU: 100191069(dio3a) 100191070(dio3)
LCO: 104924692
MZE: 101473371 101482855(dio3)
ONL: 100534528(dio3) 102082306(dio3)
OLA: 101165608(dio3) 101170321
XMA: 102219896(dio3) 102224805
XCO: 114133777(dio3) 114159104
PRET: 103457920 103458832(dio3)
CVG: 107088052(dio3) 107100293
NFU: 107378073 107392233(dio3)
KMR: 108231770 108234184(dio3)
ALIM: 106518589 106522158(dio3)
AOCE: 111573799 111586185(dio3)
POV: 109627974(dio3) 109632292
LCF: 108874850(dio3) 108896892
SDU: 111225793(dio3) 111240420
SLAL: 111672563
HCQ: 109526721(dio3) 109530979
BPEC: 110155473(dio3) 110168270
MALB: 109955084(dio3) 109962216
SASA: 106608133
ELS: 105015993(dio3) 105030678
SFM: 108941519(dio3)
PKI: 111852458(dio3)
LCM: 102353393(DIO3)
CMK: 103175341(dio3)
RTP: 109921689(dio3)
CIN: 100187528
NVE: 5513824
 » show all
Reference
1  [PMID:7053997]
  Authors
Chopra IJ, Chua Teco GN.
  Title
Characteristics of inner ring (3 or 5) monodeiodination of 3,5-diiodothyronine in rat liver: evidence suggesting marked similarities of inner and outer ring deiodinases for iodothyronines.
  Journal
Endocrinology 110:89-97 (1982)
DOI:10.1210/endo-110-1-89
Reference
2  [PMID:11898402]
  Authors
Kohrle J.
  Title
Iodothyronine deiodinases.
  Journal
Methods Enzymol 347:125-67 (2002)
DOI:10.1016/s0076-6879(02)47014-0
Other DBs
ExplorEnz - The Enzyme Database: 1.21.99.3
IUBMB Enzyme Nomenclature: 1.21.99.3
ExPASy - ENZYME nomenclature database: 1.21.99.3
BRENDA, the Enzyme Database: 1.21.99.3
CAS: 74506-30-2

DBGET integrated database retrieval system