KEGG   ENZYME: 1.23.1.3
Entry
EC 1.23.1.3                 Enzyme                                 

Name
(-)-pinoresinol reductase;
pinoresinol/lariciresinol reductase;
pinoresinol-lariciresinol reductases;
(-)-pinoresinol-(-)-lariciresinol reductase;
PLR
Class
Oxidoreductases;
Reducing C-O-C group as acceptor;
With NADH or NADPH as donor
Sysname
(-)-lariciresinol:NADP+ oxidoreductase
Reaction(IUBMB)
(-)-lariciresinol + NADP+ = (-)-pinoresinol + NADPH + H+ [RN:R10227]
Reaction(KEGG)
R10227
Substrate
(-)-lariciresinol [CPD:C20454];
NADP+ [CPD:C00006]
Product
(-)-pinoresinol [CPD:C20455];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that usually further reduces the product to (+)-secoisolariciresinol [EC 1.23.1.4, (-)-lariciresinol reductase]. Isolated from the plants Thuja plicata (western red cedar) [1], Linum perenne (perennial flax) [2] and Arabidopsis thaliana (thale cress) [3].
History
EC 1.23.1.3 created 2013
Pathway
ec00998  Biosynthesis of various secondary metabolites - part 2
ec01110  Biosynthesis of secondary metabolites
Orthology
K21568  pinoresinol/lariciresinol reductase
Genes
ATH: AT1G32100(PRR1) AT4G13660(PRR2)
ALY: 9306436 9329761
CRB: 17878264 17898640 17899710
CSAT: 104719089 104723827 104723828 104732343 104741806 104757581 104757582 104777243
EUS: EUTSA_v10008239mg EUTSA_v10009995mg EUTSA_v10026944mg
BRP: 103840191 103868905
BNA: 106362498 106441553 106443341 106451749 106451753 106453825 111203922
BOE: 106292815 106294294
RSZ: 108856438 108856439 108856515
THJ: 104798498 104814402 104814409
CPAP: 110826366
CIT: 102608004 102608287
CIC: CICLE_v10001909mg CICLE_v10001913mg
TCC: 18606866 18606867
GRA: 105791865 105791869
GHI: 107900659 107900663 107929415 107929420
GAB: 108468897 108468899
DZI: 111286131 111289303 111304310
EGR: 104444249 104444250 104444251 104444254
GMX: 100775382 100780465 100786578
GSJ: 114367117 114369002 114390881
PVU: PHAVU_002G132300g PHAVU_002G132400g PHAVU_003G272900g
VRA: 106765640 106776909 106777876
VAR: 108331686 108335043 108335182
VUN: 114173139 114173523 114175607
CCAJ: 109791501 109801295 109806363
MTR: MTR_5g027240 MTR_5g027290 MTR_8g071130
CAM: 101492057 101501430
LJA: Lj0g3v0024519.1(Lj0g3v0024519.1) Lj0g3v0067389.1(Lj0g3v0067389.1) Lj0g3v0151959.1(Lj0g3v0151959.1) Lj2g3v1536370.1(Lj2g3v1536370.1)
ADU: 107475254 107479134 107487050 107487131 107487132
AIP: 107622394 107624243 107641612 107642385 107642387
LANG: 109332970 109349050
FVE: 101307211 101307794 105351891
RCN: 112177128 112177129 112177130
PPER: 18775767 18775835 18776245 18777823 18778052
PMUM: 103336794 103336795 103336796 103336797
PAVI: 110761041 110772979 110772980
MDM: 103453140 103453142
PXB: 103928035
ZJU: 107410011 107430985 107434370 107434379
CSV: 101212644 101218862
CMO: 103499245 103499247
MCHA: 111022994 111025718
CMAX: 111466859 111466861 111466862
CMOS: 111464117 111464118 111464122
CPEP: 111776321 111776322 111811889
RCU: 8284632 8284633
JCU: 105632658
HBR: 110640204 110649727
MESC: 110602482 110604749 110605546
POP: 18094088 18094089 7465466
PEU: 105121482 105121485 105128209
JRE: 108980191 109014289
QSU: 112001516 112001517 112001518 112015239 112023934 112023936
VVI: 100243193 100248319 100253437(IFRL1) 100259918 100260187 100854593
SLY: 101258966 101259550
SPEN: 107021294 107021639
SOT: 102590543 102597564
CANN: 107869653 107872854 107872855
NTA: 107767259 107806386 107825620
NSY: 104220290 104234527
NTO: 104085289 104092562 104092564
NAU: 109227228
INI: 109177381 109177391 109177392
SIND: 105172735 105172736
OEU: 111387338 111387358 111387367 111408132 111408280
HAN: 110865009 110920952 110930107 110930108 110930109
LSV: 111887528 111898507 111902652
CCAV: 112529291 112529297 112529363 112529620
DCR: 108192976 108193011 108206746
BVG: 104893088
SOE: 110801329
CQI: 110692822 110732670
NNU: 104596321 104596322 104596323
PSOM: 113322331
OSA: 4351925 4351926 4351932
DOSA: Os12t0263200-01(Os12g0263200) Os12t0265100-01(Os12g0265100)
OBR: 102717852 102718130
BDI: 100842184
ATS: 109737033 109785841 109785845 109785846
SBI: 110429729 110429730
ZMA: 103650598
SITA: 101764846 101781583
PDA: 103697428 103698420
EGU: 105040244 105041891 105060630
MUS: 103981518
DCT: 110113106 110116470
PEQ: 110020110
AOF: 109827161 109840604
ATR: 18423509 18443892 18443893 18443896
SMO: SELMODRAFT_122655 SELMODRAFT_172293 SELMODRAFT_230858 SELMODRAFT_233106 SELMODRAFT_414671 SELMODRAFT_414678 SELMODRAFT_438560 SELMODRAFT_74219 SELMODRAFT_74385 SELMODRAFT_74402
SSE: Ssed_3603
 » show all
Reference
1  [PMID:9872995]
  Authors
Fujita M, Gang DR, Davin LB, Lewis NG
  Title
Recombinant pinoresinol-lariciresinol reductases from western red cedar (Thuja plicata) catalyze opposite enantiospecific conversions.
  Journal
J Biol Chem 274:618-27 (1999)
DOI:10.1074/jbc.274.2.618
  Sequence
Reference
2  [PMID:17257599]
  Authors
Hemmati S, Schmidt TJ, Fuss E
  Title
(+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B.
  Journal
FEBS Lett 581:603-10 (2007)
DOI:10.1016/j.febslet.2007.01.018
Reference
3  [PMID:18347017]
  Authors
Nakatsubo T, Mizutani M, Suzuki S, Hattori T, Umezawa T
  Title
Characterization of Arabidopsis thaliana pinoresinol reductase, a new type of enzyme involved in lignan biosynthesis.
  Journal
J Biol Chem 283:15550-7 (2008)
DOI:10.1074/jbc.M801131200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.23.1.3
IUBMB Enzyme Nomenclature: 1.23.1.3
ExPASy - ENZYME nomenclature database: 1.23.1.3
BRENDA, the Enzyme Database: 1.23.1.3

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Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (278)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (267)   
   KEGG MGENES (5)   
   RefGene (5)   
Protein sequence (12)   
   UniProt (6)   
   SWISS-PROT (6)   
Protein domain (2)   
   InterPro (2)   
All databases (304)   

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