Entry |
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Name |
(-)-pinoresinol reductase;
pinoresinol/lariciresinol reductase;
pinoresinol-lariciresinol reductases;
(-)-pinoresinol-(-)-lariciresinol reductase;
PLR
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Class |
Oxidoreductases;
Reducing C-O-C group as acceptor;
With NADH or NADPH as donor
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Sysname |
(-)-lariciresinol:NADP+ oxidoreductase
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Reaction(IUBMB) |
(-)-lariciresinol + NADP+ = (-)-pinoresinol + NADPH + H+ [RN: R10227]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that usually further reduces the product to (+)-secoisolariciresinol [EC 1.23.1.4, (-)-lariciresinol reductase]. Isolated from the plants Thuja plicata (western red cedar) [1], Linum perenne (perennial flax) [2] and Arabidopsis thaliana (thale cress) [3].
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History |
EC 1.23.1.3 created 2013
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Pathway |
ec00999 | Biosynthesis of secondary metabolites - unclassified |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K21568 | pinoresinol/lariciresinol reductase |
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Genes |
» show all
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Reference |
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Authors |
Fujita M, Gang DR, Davin LB, Lewis NG |
Title |
Recombinant pinoresinol-lariciresinol reductases from western red cedar (Thuja plicata) catalyze opposite enantiospecific conversions. |
Journal |
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Sequence |
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Reference |
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Authors |
Hemmati S, Schmidt TJ, Fuss E |
Title |
(+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B. |
Journal |
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Reference |
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Authors |
Nakatsubo T, Mizutani M, Suzuki S, Hattori T, Umezawa T |
Title |
Characterization of Arabidopsis thaliana pinoresinol reductase, a new type of enzyme involved in lignan biosynthesis. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.23.1.3 |
ExPASy - ENZYME nomenclature database: | 1.23.1.3 |
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