KEGG   ENZYME: 1.3.1.101
Entry
EC 1.3.1.101                Enzyme                                 

Name
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H];
digeranylgeranylglycerophospholipid reductase;
Ta0516m (gene name);
DGGGPL reductase;
2,3-digeranylgeranylglycerophospholipid reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2,3-bis-(O-phytany)l-sn-glycerol 1-phosphate:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NAD(P)+ = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 NAD(P)H + 8 H+ [RN:R10325 R10326]
Reaction(KEGG)
R10325 R10326
Substrate
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate [CPD:C20518];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate;
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A flavoprotein (FAD). The enzyme from the archaeon Thermoplasma acidophilum is involved in the biosynthesis of membrane lipids. In vivo the reaction occurs in the reverse direction with the formation of 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate. cf. EC 1.3.7.11, 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase.
History
EC 1.3.1.101 created 2013
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K17830  digeranylgeranylglycerophospholipid reductase
Genes
STEM: CLM74_07965
LAB: LA76x_2426
LAQ: GLA29479_2709
LGU: LG3211_2789
LEZ: GLE_2795
LEM: LEN_2236
LMB: C9I47_1426
LYT: DWG18_07380
LYJ: FKV23_07190
THES: FHQ07_02060
TGR: Tgr7_2205
TKM: TK90_0643
TVR: TVD_10595
SVA: SVA_2992
CGD: CR3_0650(fixC)
DOL: Dole_0399
DBR: Deba_3038
HDN: Hden_0684
RVA: Rvan_3542
RHC: RGUI_1289
AFR: AFE_2544
ACU: Atc_2341
HSC: HVS_14075
SALQ: SYNTR_0780
PTH: PTH_0378(FixC)
TPZ: Tph_c09910(bchP)
TSH: Tsac_0175
TOC: Toce_0251
STED: SPTER_30020(kmo)
PMT: PMT_0686
MAR: MAE_31260
MPK: VL20_5387
PNL: PNK_0017
IAL: IALB_0329
TAL: Thal_0865
CABY: Cabys_957
DTU: Dtur_0864
MJA: MJ_0532
MMP: MMP0388
MMD: GYY_02010
MMAD: MMJJ_06490
MAE: Maeo_1307
MVO: Mvol_1689
METE: tca_00257(menJ_1) tca_01663(menJ_2)
MSI: Msm_1701
MMIL: sm9_1381
MEYE: TL18_04135
AFU: AF_0464
TAC: Ta0516
TVO: TVG1046096(TVG1046096) TVG1579590(TVG1579590)
FAI: FAD_1079
ABI: Aboo_0578
PFU: PF0097
PFI: PFC_07720
PHO: PH0181(PH0181)
PAB: PAB0109(bchP)
PYN: PNA2_0702
PYS: Py04_0252
TKO: TK1088
TON: TON_0316
TGA: TGAM_1305
TSI: TSIB_0988
THE: GQS_03690
THA: TAM4_1982
THM: CL1_0388
TLT: OCC_08470
THS: TES1_0613
TNU: BD01_0182
TEU: TEU_06540
PPAC: PAP_07210
MHU: Mhun_1123
MLA: Mlab_0431
MEMA: MMAB1_2023
MBN: Mboo_1945
MPL: Mpal_0962
RCI: RCIX2051(bchP) RCIX2708
HAL: VNG_0468C
HSL: OE_1699R
HHB: Hhub_1531
HALH: HTSR_0966
HHSR: HSR6_0997
HMA: rrnAC0726
HHI: HAH_1373
NPH: NP_4564A
HALL: LC1Hm_1280 LC1Hm_1619(fixC) LC1Hm_2428(fixC3) LC1Hm_2469(fixC4)
HWA: HQ_1534A
HVO: HVO_1799
HME: HFX_1905(fixC)
HLA: Hlac_0926
SMR: Smar_1462
DKA: DKAM_0159
TAG: Tagg_0378
HBU: Hbut_1257
STO: STK_04940
SOL: Ssol_0166
SSOA: SULA_0158
SSOL: SULB_0159
SSOF: SULC_0158
SID: M164_0170
SII: LD85_0155
SIH: SiH_0155
SIR: SiRe_0151
SIC: SiL_0142
MSE: Msed_0681
MCN: Mcup_1399
AHO: Ahos_2154
STEP: IC006_2737
CMA: Cmaq_0840
VDI: Vdis_1715
VMO: VMUT_2242
ACIA: SE86_02030
NMR: Nmar_0631
NCV: NCAV_0324
BARC: AOA65_1634
BARB: AOA66_1225
 » show all
Reference
1  [PMID:16788058]
  Authors
Nishimura Y, Eguchi T
  Title
Biosynthesis of archaeal membrane lipids: digeranylgeranylglycerophospholipid reductase of the thermoacidophilic archaeon Thermoplasma acidophilum.
  Journal
J Biochem 139:1073-81 (2006)
DOI:10.1093/jb/mvj118
  Sequence
[tac:Ta0516]
Reference
2  [PMID:17275067]
  Authors
Nishimura Y, Eguchi T
  Title
Stereochemistry of reduction in digeranylgeranylglycerophospholipid reductase involved in the biosynthesis of archaeal membrane lipids from Thermoplasma acidophilum.
  Journal
Bioorg Chem 35:276-83 (2007)
DOI:10.1016/j.bioorg.2006.12.001
  Sequence
[tac:Ta0516]
Reference
3  [PMID:20869368]
  Authors
Xu Q, Eguchi T, Mathews II, Rife CL, Chiu HJ, Farr CL, Feuerhelm J, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Weekes D, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA
  Title
Insights into substrate specificity of geranylgeranyl reductases revealed by the  structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids.
  Journal
J Mol Biol 404:403-17 (2010)
DOI:10.1016/j.jmb.2010.09.032
  Sequence
[tac:Ta0516]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.101
IUBMB Enzyme Nomenclature: 1.3.1.101
ExPASy - ENZYME nomenclature database: 1.3.1.101
BRENDA, the Enzyme Database: 1.3.1.101

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