KEGG   ENZYME: 1.3.1.101
Entry
EC 1.3.1.101                Enzyme                                 
Name
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H];
digeranylgeranylglycerophospholipid reductase;
Ta0516m (gene name);
DGGGPL reductase;
2,3-digeranylgeranylglycerophospholipid reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2,3-bis-(O-phytany)l-sn-glycerol 1-phosphate:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NAD(P)+ = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 NAD(P)H + 8 H+ [RN:R10325 R10326]
Reaction(KEGG)
R10325 R10326
Substrate
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate [CPD:C20518];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate [CPD:C04638];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A flavoprotein (FAD). The enzyme from the archaeon Thermoplasma acidophilum is involved in the biosynthesis of membrane lipids. In vivo the reaction occurs in the reverse direction with the formation of 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate. cf. EC 1.3.7.11, 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase.
History
EC 1.3.1.101 created 2013
Pathway
ec00564  Glycerophospholipid metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K17830  digeranylgeranylglycerophospholipid reductase
Genes
STEMCLM74_07965
PMEXH4W19_05940
PDDMNQ95_14045
LABLA76x_2426
LAQGLA29479_2709
LGULG3211_2789
LEZGLE_2795
LEMLEN_2236
LMBC9I47_1426
LYTDWG18_07380
LYJFKV23_07190
LSXH8B22_00975
LHXLYSHEL_30720
LCASLYSCAS_30690
THESFHQ07_02060
TBVH9L17_15740
HHCM911_11185
EBSECTOBSL9_0276
TGRTgr7_2205
TKMTK90_0643
TVRTVD_10595
APRSBI364_13760
SVASVA_2992
ACIIC4901_12925
ATYA9R16_004045
CNCCNE_1c03080
CGDCR3_0650(fixC)
VPEVarpa_3679
VBOCKY39_19940
VAMC4F17_03155
SDRSCD_n00804
SULFCAP31_01895
SPLBSFPGR_29360
SNIVSFSGTM_27200
URUDSM104443_00527
BEBABWI17_02380
DOLDole_0399
MRMA7982_08128
DTIDesti_0238
DBRDeba_3038
HDNHden_0684
RVARvan_3542
FILBN1229_v1_0189
FIYBN1229_v1_0193
CMARIMCC12053_1371
RHCRGUI_1289
AFRAFE_2544
AFELferr_2172
ACUAtc_2341
ACZAcaty_c2184
AFIAcife_2465
AFJAFERRID_05040
AFPK1Y48_09080
CBKCLL_A1369 CLL_A1370
CLBClo1100_3094 Clo1100_3095
CLTCM240_1758 CM240_1759
HSCHVS_14075
CCECcel_1057 Ccel_1058
RHEREHE19_004620 EHE19_004625
SALQSYNTR_0780
CALKHUE98_00670
DORDesor_4339
PTHPTH_0378(FixC)
DKUDesku_2287
FWADCMF_14630
DGIDesgi_1545
TEXTeth514_0218 Teth514_0219
THXThet_0258 Thet_0259
TPDTeth39_1995
TITThit_0239 Thit_0240
TMTTmath_0322 Tmath_0323
TBOThebr_2044
TWIThewi_0279
TKITKV_c02330
TPZTph_c09910(bchP)
TXYThexy_2059
TSHTsac_0175
TEPTepRe1_0379
TAETepiRe1_0421
TOCToce_0251
NTHNther_1774
KMEH0A61_01699
STEDSPTER_30020(kmo)
PARNNBH00_13915
PMTPMT_0686
PMFP9303_15361
PMJP9211_08531
MARMAE_31260
MPKVL20_5387
MIQB5D77_03105
MVZmyaer102_06730
CSNCyast_1222
CYCPCC7424_4688
CYJCyan7822_4141
PAGHNIES204_25480
PPSUNO713_00666
OXYHCG48_06915
MVAGD0A34_03765
MICMic7113_1946
GEIGEI7407_1050
OACOscil6304_0659
ONIOsc7112_3504
PLPPle7327_4278
ABATCFX1CAM_1448
KBSEPA93_17655
PNLPNK_0017
PNDPla175_09780
FSUFisuc_0330 Fisuc_2122
FSCFSU_0745 FSU_2657
POMMED152_04120
POBLPB03_12595 LPB03_16045
PRNBW723_10930
POLABXQ17_11625
POACW731_11625
PLITK8354_10745
PBATJL193_08020
PCEAJ3359_02050
IALIALB_0329
HYAHY04AAS1_0807
HHOHydHO_0802
HYSHydSN_0819
TALThal_0865
TRDTHERU_04165
KPFIX53_05590
CPOCOPRO5265_1158
CABYCabys_957
DTHDICTH_0710
DTUDtur_0864
BANABARAN1_0630
BIHBIP78_0559
MJAMJ_0532
MFEMefer_0023 Mefer_0586
MVUMetvu_0248 Metvu_0470
MFSMFS40622_0302 MFS40622_0533
MIFMetin_0313
MJHJH146_0202
MESGMLAUSG7_0668
MESAMLASG1_0156
MIGMetig_0018
MMPMMP0388
MMQMmarC5_1250
MMXMmarC6_0522
MMZMmarC7_1386
MMDGYY_02010
MMAKMMKA1_04070
MMAOMMOS7_04030
MMADMMJJ_06490
MAEMaeo_1307
MVNMevan_1375
MVOMvol_1689
MOKMetok_0574
METFCFE53_00320
MTHMTH_1718 MTH_277
MMGMTBMA_c02950 MTBMA_c07260 MTBMA_c11210
MWOMWSIV6_0259 MWSIV6_0692 MWSIV6_1100
MTEEMTTB_09190 MTTB_14720
METCMTCT_0239 MTCT_1570
METEtca_00257(menJ_1) tca_01663(menJ_2)
METZMETMT2_0572 METMT2_0721 METMT2_1561
METKFVF72_00920 FVF72_03085
MTHMFZP57_01175 FZP57_03320 FZP57_05215
METJFZP68_06180 FZP68_08325
MSTMsp_0758 Msp_0874 Msp_1062 Msp_1307 Msp_1320
METBAW729_08940 AW729_09050 AW729_10575 AW729_10930
MRUmru_1341 mru_1441 mru_1471
MSIMsm_1701
MEBAbm4_0728 Abm4_1169
MMILsm9_1381
MEYETL18_04135
MOLYLM1_0823 YLM1_0971
MAROMarbSA_00110
METVK4897_00040
MELMetbo_0471 Metbo_2033 Metbo_2366
MEWMSWAN_0290 MSWAN_0605 MSWAN_1925
METHMBMB1_0335 MBMB1_0639 MBMB1_1556 MBMB1_1827
MFCBRM9_0792 BRM9_1599 BRM9_1933 BRM9_2158
MFIDSM1535_0120 DSM1535_0754 DSM1535_1097 DSM1535_2293
MCUBMCBB_0308 MCBB_0619 MCBB_1812
MSUBBK009_01280 BK009_06770 BK009_11855
METNBK008_02415 BK008_07495 BK008_09685
METTCIT01_01350 CIT01_04015 CIT01_04025 CIT01_07320 CIT01_10150
METOCIT02_03745 CIT02_05170 CIT02_08440 CIT02_10165
MEMEHYG87_07945 HYG87_10880
MFVMfer_0516 Mfer_1222
MKAMK1443 MK1645
AFUAF_0464
AFGAFULGI_00004710
APOArcpr_0713
AVEArcve_2050
ASTAsulf_00147 Asulf_01626
FPLFerp_0366 Ferp_1444
GACGACE_0072 GACE_0595
GAHGAH_00300 GAH_00353 GAH_01689
PFUPF0097
PFIPFC_07720
PHOPH0181(PH0181)
PABPAB0109(bchP)
PYNPNA2_0702
PYAPYCH_16330
PYSPy04_0252
PYCTQ32_00315
TKOTK1088
TONTON_0316
TGATGAM_1305
TSITSIB_0988
TBATERMP_00654
THEGQS_03690
THATAM4_1982
THMCL1_0388
TLTOCC_08470
THSTES1_0613
TNUBD01_0182
TEUTEU_06540
TGYX802_10265
THVADU37_CDS08620
TCHCHITON_0316
TPEPA0127_09785
TPIEA7C91_07555
TGGA3K92_03945
TCEA3L02_00260
TBSA3L01_02245
THHCDI07_02200
TSLA3L11_06065
TTDA3L14_03705
TPRFA3L09_05905
TRLA3L10_04285
TPAFA3L08_04750
THYA3L12_01970
TICFH039_04700
TCQTIRI35C_0673
THEMFPV09_04700
THEIK1720_08110
PPACPAP_07210
MBAMbar_A3422
MBYMSBRM_1245 MSBRM_2785
MBWMSBRW_1312
MBARMSBR2_1164 MSBR2_2742
MBAKMSBR3_1297 MSBR3_2679
MACMA_1484 MA_2893 MA_3894 MA_4421
MMAMM_0718 MM_2499 MM_3299
MMAZMmTuc01_0739 MmTuc01_2550 MmTuc01_3399
MMJMSMAS_0599 MSMAS_1387 MSMAS_2202
MMACMSMAC_0600 MSMAC_2252 MSMAC_2749
MVCMSVAZ_0959 MSVAZ_1325 MSVAZ_1805
MEKMSKOL_0928 MSKOL_1264 MSKOL_1782
MLSMSLAZ_1440 MSLAZ_1542 MSLAZ_2928
METMMSMTP_0646 MSMTP_0954 MSMTP_1509
MEFMSWH1_1330 MSWH1_1478 MSWH1_1898
MEQMSWHS_1414 MSWHS_1853 MSWHS_3173
MSJMSSAC_1463 MSSAC_2883 MSSAC_4107
MSZMSSIH_1494 MSSIH_2538 MSSIH_3643
MSWMSSIT_1552 MSSIT_2581 MSSIT_3698
MTHRMSTHT_0217 MSTHT_0358 MSTHT_1727 MSTHT_2311
MTHEMSTHC_0364 MSTHC_0514 MSTHC_0969 MSTHC_1561
MHORMSHOH_0251 MSHOH_1697 MSHOH_2811
MFZAOB57_000445 AOB57_001340 AOB57_003910 AOB57_007820
MBUMbur_0303 Mbur_0369 Mbur_0939 Mbur_1077 Mbur_1308
MMETMCMEM_0833 MCMEM_0997 MCMEM_1441 MCMEM_1598 MCMEM_1755
MELOJ7W08_02385 J7W08_03355 J7W08_05920 J7W08_06945 J7W08_07805
MMHMmah_0579 Mmah_0675 Mmah_1258 Mmah_1613
MHAZBHR79_00515 BHR79_05660 BHR79_07245 BHR79_10225
MEVMetev_0262 Metev_0801 Metev_1607 Metev_1731
MZHMzhil_0235 Mzhil_0513 Mzhil_0683 Mzhil_1608
MPYMpsy_0099 Mpsy_1026 Mpsy_1467 Mpsy_2554
MZIHWN40_01470 HWN40_03330 HWN40_05930 HWN40_09670
MHZMetho_0239 Metho_0947 Metho_1579 Metho_1933
MTPMthe_0044 Mthe_0513 Mthe_0671 Mthe_0714
MCJMCON_1147 MCON_3250 MCON_3296
MHIMhar_0556 Mhar_1078 Mhar_1156 Mhar_2172
MHUMhun_1123
MRTJKHC33_08510
MLAMlab_0431
MEMMemar_0506 Memar_1711
MBGBN140_1582
MEMAMMAB1_2023
MCHKMchiMG62_06300
MSUMOH143_09245
MPIMpet_1752
MENDL6E24_01525
MBNMboo_1945
MFOMetfor_1011
MPLMpal_0962
MPDMCP_0504 MCP_1168 MCP_1480
MEZMtc_0895(bchP) Mtc_1643 Mtc_1724
RCIRCIX2051(bchP) RCIX2708
HALVNG_0468C
HSLOE_1699R
HDLHALDL1_06480
HHBHhub_1531
HAGSJT689_03235
HABOJRZ79_01735
HNOLT974_03030
HLULT972_10470
HANRLJ422_01955
HJEHacjB3_14420
HALHHTSR_0966
HHSRHSR6_0997
HSUHLASF_0746
HSFHLASA_0743
SALRFQU85_11230
HALREFA46_006370 EFA46_006470
HALXM0R89_10965
HAXZM0R88_11400
SALIL593_01650
SAIMK0C01_10790
HARAAArcS_1790(fixC3)
HMArrnAC0726
HHIHAH_1373
HHNHISP_07025
HABSG26_14865
HTABVU17_06685
HALJG9465_08440 G9465_08805 G9465_20450
HSINKDQ40_06605
NPHNP_4564A
NMONmlp_2334 Nmlp_3608
NHOHWV23_05715
NSALHWV07_05475
HUTHuta_0881 Huta_1007 Huta_2954
HTIHTIA_0743 HTIA_2555
HALAHrd1104_04765 Hrd1104_09045
HMUHmuk_1955 Hmuk_2206 Hmuk_3091 Hmuk_3127
HALZE5139_02700 E5139_02875 E5139_12890 E5139_14170
HALLLC1Hm_1280 LC1Hm_1619(fixC) LC1Hm_2428(fixC3) LC1Hm_2469(fixC4)
HAZPGBQ70_02700 GBQ70_12905 GBQ70_14185
HALIBV210_03410
HSNDV733_10365
HDSHSR122_0270(fixC)
HRRHZS55_18830 HZS55_20705
HPELHZS54_21655 HZS54_22270 HZS54_24195
HLTI7X12_15485 I7X12_16545 I7X12_17600
HARCHARCEL1_04790
HDOMUK72_09380
SSAIN0B31_03370
HWAHQ_1534A
HWCHqrw_1635 Hqrw_3314
HVOHVO_1799
HMEHFX_1905(fixC)
HGIABY42_08860
HALEG3A49_12170
HLSKU306_03510
HBOHbor_11300
HAQDU484_09565 DU484_17775
HAJDU500_00815 DU500_09815
HAERDU502_06905 DU502_07185 DU502_16565
HRAEI982_07520 EI982_14380
HLMDV707_07230
HALMFCF25_11425
HLAHlac_0926
HALPDOS48_03545
HALBEKH57_07685
HEZZEO776_04760
HALQHrr1229_002660
HSSJ7656_12430
HSAIHPS36_02425
HAZZKI388_02310
SRUBC2R22_05450
HAEhalTADL_1048
HALNB4589_000260
HALGHUG10_08475
HALUHUG12_17860
HDFAArcSl_1381 AArcSl_1813
HAHHalar_0855
HTUHtur_1377 Htur_3081
HDABB347_05735 BB347_10350 BB347_10530
HSALJMJ58_01855 JMJ58_05545 JMJ58_12995 JMJ58_22355
HLOJ0X27_13130
HAKZJ0X25_02870 J0X25_13780
NMGNmag_0668 Nmag_1523 Nmag_2507 Nmag_2778
HXAHalxa_3925 Halxa_3960
NATNJ7G_0898 NJ7G_2427
NPENatpe_0646 Natpe_1962 Natpe_3244
NVRFEJ81_03545
NPLFGF80_01135 FGF80_07435
NAYHYG81_07440
HALYHYG82_09140 HYG82_16990
HJTDVR14_12450
NGENatgr_0786 Natgr_1266 Natgr_3103
HRUHalru_1246 Halru_2474
NOUNatoc_0699 Natoc_2139 Natoc_4277
HLRHALLA_08655 HALLA_13160 HALLA_17630
HLCCHINAEXTREME15935 CHINAEXTREME19570
NAJB1756_02305 B1756_04290 B1756_12495
NAGAArcMg_1023 AArcMg_2971 AArcMg_3119
NANAArc1_0731 AArc1_2601 AArc1_3025
NBGDV706_00945 DV706_09380 DV706_16325 DV706_19090
NASGCU68_02695 GCU68_12755
SAWLNGM29_01025
NACAQV86_03970
MELUMTLP_05820 MTLP_05840 MTLP_09940
MEAMMU439_04990
TACTa0516
TVOTVG1046096(TVG1046096) TVG1579590(TVG1579590)
PTOPTO0568 PTO0896
FACFACI_IFERC01G0166
FAIFAD_1079
CDIVCPM_0295 CPM_0485 CPM_0894
TARTALC_00223 TALC_00435 TALC_00774
MAXMMALV_02090 MMALV_03590 MMALV_08730
MERMMINT_02130 MMINT_12590 MMINT_13170 MMINT_17750
MEARMpt1_c01650 Mpt1_c12530
MEUZKRP56_01915
MARCAR505_0892 AR505_1433 AR505_1618
ABIAboo_0578
ACFAciM339_0374 AciM339_0468
SMRSmar_1462
DKADKAM_0159
DFDDesfe_0234
DMUDesmu_0290
TAGTagg_0378
THGTCELL_1246
HBUHbut_1257
STOSTK_04940
SOHD1869_02295
SOLSsol_0166
SSOASULA_0158
SSOLSULB_0159
SSOFSULC_0158
SSHIJ5U23_01149
SCASSACC_19360
SISLS215_0182
SIAM1425_0151
SIMM1627_0151
SIDM164_0170
SIYYG5714_0155
SINYN1551_2754
SIILD85_0155
SIHSiH_0155
SIRSiRe_0151
SICSiL_0142
SULABFU36_10465
SULEGFS03_02305
SULOGFS33_08920
MSEMsed_0681
MEMJMJ1HA_0791
MCNMcup_1399
MHKDFR87_03150
MPRUDFR88_03175
MTENGWK48_08960
MJNMjAS7_1447
AHOAhos_2154
AMANB6F84_03335
ABRIDFR85_06060
ASULDFR86_03340
AAMBD1866_05750
ACIHHS5_09650
SACDHS1genome_0804
SAZOD1868_10400
STEPIC006_2737
CMACmaq_0840
VDIVdis_1715
VMOVMUT_2242
TPETpen_0114 Tpen_0718
THBN186_01490 N186_04950
TCBTCARB_0050 TCARB_1382
THFMA03_00905 MA03_06135
THELIG193_04155 IG193_06980
ACIASE86_02030
FFOFFONT_1180
NMRNmar_0631
NIRNSED_03245
NKRNKOR_03230
NIDNPIRD3C_1636
NINNADRNF5_0722 NADRNF5_1519
NIWNisw_01750
NCLC5F47_05915
NOXC5F49_05755 C5F49_06640
NUEC5F50_04660
NIPNsoK4_05210
NCTNMSP_0453 NMSP_1055
NICDSQ20_03360
CSYCENSYa_0520 CENSYa_1317
NGANgar_c10460 Ngar_c11500 Ngar_c18750
NVNNVIE_003360 NVIE_011700
NEVNTE_01655 NTE_02579
TAANMY3_01977 NMY3_02141 NMY3_02989
NFNNFRAN_0449 NFRAN_2927
NCVNCAV_0324
CSUCSUB_C1349 CSUB_C1610
NBVT478_0510 T478_0975
TAHSU86_000125 SU86_003010
NIUDSQ19_03605
NDVNDEV_0107 NDEV_1206
KCRKcr_0058 Kcr_1359
BARCAOA65_1634
BARBAOA66_1225
FLTSv326_0975
LOKILokiarch_51240
PSYTDSAG12_02297
AGWQT03_C0001G0827
 » show all
Reference
1  [PMID:16788058]
  Authors
Nishimura Y, Eguchi T
  Title
Biosynthesis of archaeal membrane lipids: digeranylgeranylglycerophospholipid reductase of the thermoacidophilic archaeon Thermoplasma acidophilum.
  Journal
J Biochem 139:1073-81 (2006)
DOI:10.1093/jb/mvj118
  Sequence
[tac:Ta0516]
Reference
2  [PMID:17275067]
  Authors
Nishimura Y, Eguchi T
  Title
Stereochemistry of reduction in digeranylgeranylglycerophospholipid reductase involved in the biosynthesis of archaeal membrane lipids from Thermoplasma acidophilum.
  Journal
Bioorg Chem 35:276-83 (2007)
DOI:10.1016/j.bioorg.2006.12.001
  Sequence
[tac:Ta0516]
Reference
3  [PMID:20869368]
  Authors
Xu Q, Eguchi T, Mathews II, Rife CL, Chiu HJ, Farr CL, Feuerhelm J, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Weekes D, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA
  Title
Insights into substrate specificity of geranylgeranyl reductases revealed by the  structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids.
  Journal
J Mol Biol 404:403-17 (2010)
DOI:10.1016/j.jmb.2010.09.032
  Sequence
[tac:Ta0516]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.101
IUBMB Enzyme Nomenclature: 1.3.1.101
ExPASy - ENZYME nomenclature database: 1.3.1.101
BRENDA, the Enzyme Database: 1.3.1.101

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