KEGG   ENZYME: 1.3.1.102
Entry
EC 1.3.1.102                Enzyme                                 
Name
2-alkenal reductase (NADP+);
NADPH-dependent alkenal/one oxidoreductase;
NADPH:2-alkenal alpha,beta-hydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
n-alkanal:NADP+ 2-oxidoreductase
Reaction(IUBMB)
an n-alkanal + NADP+ = an alk-2-enal + NADPH + H+ [RN:R07350]
Reaction(KEGG)
R07350
Substrate
n-alkanal [CPD:C15596];
NADP+ [CPD:C00006]
Product
alk-2-enal [CPD:C15597];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Shows highest activity with 1-nitrocyclohexene but also has significant activity with 2-methylpentenal and trans-cinnamaldehyde [3]. Involved in the detoxication of alpha,beta-unsaturated aldehydes and ketones. Has very low activity with NAD as reductant (cf. EC 1.3.1.74, 2-alkenal reductase [NAD(P)+]).
History
EC 1.3.1.102 created 2013
Orthology
K19825  2-alkenal reductase (NADP+)
Genes
AJM119059002
ATHAT5G16990
ALY9309870
CRB111830114
CSAT104769987 104782816
EUSEUTSA_v10013973mg
BRP103856227
BNA106371937 106385673
BOE106332953
RSZ108817048
THJ104802919
CPAP110826271 110826278
CIT102615811 102616107 102616685 102617769 102618046 102620626 102621181
PVY116115923 116116564 116116566 116116680
MINC123220993 123221688 123221690 123221691 123221696
TCC18602284 18602291
GRA105796313
GHI107903483 107927492
GAB108474473
DZI111287632 111287633 111307648
EGR104457199
GMX100811802
GSJ114406418
PVUPHAVU_010G038800g
VRA106774048
VAR108347504 108347505
VUN114166230
CCAJ109794540 109800713
APRC113849004 113849029 113849085 113849154
MTRMTR_8g009820
CAM101492713 101495283
LJALj3g3v0642510.1(Lj3g3v0642510.1) Lj3g3v0642510.2(Lj3g3v0642510.2)
ADU107472676
AIP107615010 107615011
AHF112731236
LANG109343422 109352137
FVE101300754
RCN112186522 112189298
PPER18769406 18775322
PMUM103335605 103341331
PAVI110744686 110756907
PDUL117634647 117635910 117635911
MDM103406680 103431366 103446595 114820074 114826964
PXB103956035
ZJU107408089
MNT21401474 21403262
CSV105436085
CMO103495452 103495453 103503360
BHJ120075641 120078101 120078388
MCHA111021674
CMAX111472465
CMOS111439571
CPEP111776490
RCU8279676
JCU105636656 105636659
HBR110638905 110649251 110651916 110665637
MESC110615096 110626053 110626410
POP18106396 18106413 18106420 18106711
PEU105111031
PALZ118029122 118029648 118056094 118056095 118056096
JRE108981303 108981304 109005050 109013644
QSU111991015 111991017 111991037 111991039 111991040 112007352 112007361 112007372 112007406 112007435 112007530 112025926 112030806 112030807
QLO115962564 115962769 115962911 115962919 115962920 115962921 115962922 115962923 115962925 115962926 115963047 115963048 115963049 115963050 115965115 115965172 115965883 115965884 115966066
TWL119988442
VVI100256090 100259258 100262970
VRI117914025 117914760 117915350
SLY101246540
SPEN107011489 107014797 107021842
SOT102581079 102599848
SSTN125858953 125860408 125869911 125872496
CANN107842343 107868137 107876055 124885430
NTA107825579 107830910(DBR)
NSY104231555
NTO104093506
NAU109226814
INI109156910 109156911 109156912 109156916 109156917 109170275 109170276 109170278 109170279
ITR115996410 116024102 116025813 116026040 116026285
SIND105167157
OEU111406378
EGT105950544 105950589 105959483 105961456
SSPL121767949 121774684 121776271 121777025 121777031 121777033 121777485 121805530 121809558
HAN110878529 110878536 110878544
ECAD122578073 122581308 122581328 122582551 122582552 122582553 122582577 122582651 122609986
LSV111899364 111899368 111899466
CCAV112504871 112505065 112518955 112518956 112519236 112519282
DCR108196875
CSIN114272699 114272700 114290878 114293126
BVG104889047
SOE110788925
CQI110738676 110738677
NNU104586797 104586835 104593340
MING122076999 122085006 122086941 122091483 122091484 122091485 122091488
TSS122640394 122644221 122644222 122644223 122644225 122644226 122654976 122657072 122661208
PSOM113329925
NCOL116252119 116252121
OSA4336283
DOSAOs04t0497000-01(Os04g0497000)
OBR102716958
BDI100827217 100828038 100828644
ATS109740477 109743195 109743200 109746860 109746864
TDC119300236 119302483 119307848 119311160 119311162 119353041 119358805 119367091 119367094
TAES123040357 123048487 123048489 123107425 123107426 123110792 123112723 123112724 123119786 123122202 123122203 123172217 123184505 123187253
TUA125508165 125510030 125510032 125535393 125540814
SBI8058160
ZMA100285730
SITA101763211 101763616
SVS117850761 117850762
PVIR120663783 120679765 120696981
PHAI112887242
PDA103724335
EGU105038599
MUS103985225
DCT110095562
PEQ110027397 110031241
AOF109824078 109830159
ATR18448631
PPP112284446
 » show all
Reference
1  [PMID:11117876]
  Authors
Hirata T, Tamura Y, Yokobatake N, Shimoda K, Ashida Y
  Title
A 38 kDa allylic alcohol dehydrogenase from the cultured cells of Nicotiana tabacum.
  Journal
Phytochemistry 55:297-303 (2000)
DOI:10.1016/S0031-9422(00)00326-5
  Sequence
Reference
2  [PMID:17945329]
  Authors
Matsushima A, Sato Y, Otsuka M, Watanabe T, Yamamoto H, Hirata T
  Title
An enone reductase from Nicotiana tabacum: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant proteins.
  Journal
Bioorg Chem 36:23-8 (2008)
DOI:10.1016/j.bioorg.2007.08.005
  Sequence
Reference
3  [PMID:27547488]
  Authors
Mansell DJ, Toogood HS, Waller J, Hughes JM, Levy CW, Gardiner JM, Scrutton NS
  Title
Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization  of a Double Bond Reductase from Nicotiana tabacum.
  Journal
ACS Catal 3:370-379 (2013)
DOI:10.1021/cs300709m
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.102
IUBMB Enzyme Nomenclature: 1.3.1.102
ExPASy - ENZYME nomenclature database: 1.3.1.102
BRENDA, the Enzyme Database: 1.3.1.102

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