KEGG   ENZYME: 1.3.1.102
Entry
EC 1.3.1.102                Enzyme                                 
Name
2-alkenal reductase (NADP+);
NADPH-dependent alkenal/one oxidoreductase;
NADPH:2-alkenal alpha,beta-hydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
n-alkanal:NADP+ 2-oxidoreductase
Reaction(IUBMB)
an n-alkanal + NADP+ = an alk-2-enal + NADPH + H+ [RN:R07350]
Reaction(KEGG)
R07350
Substrate
n-alkanal [CPD:C15596];
NADP+ [CPD:C00006]
Product
alk-2-enal [CPD:C15597];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Shows highest activity with 1-nitrocyclohexene but also has significant activity with 2-methylpentenal and trans-cinnamaldehyde [3]. Involved in the detoxication of alpha,beta-unsaturated aldehydes and ketones. Has very low activity with NAD as reductant (cf. EC 1.3.1.74, 2-alkenal reductase [NAD(P)+]).
History
EC 1.3.1.102 created 2013
Orthology
K19825  2-alkenal reductase (NADP+)
Genes
AJM119059002
CPAP110826271 110826278
CIT102615811 102616685 102617488 102617769 102618046 102621181
PVY116115923 116116564 116116566 116116577 116116589 116116680
MINC123195993 123196659 123196660 123196864 123220993 123221686 123221688 123221690 123221691 123221696 123221698
TCC18602284 18602291
GRA105796310 105796313 128031870
GHI107903483 107903502 107903511 107927492 107935948
GAB108474473 108475430
HSYR120113802 120113829 120190221 120218133
DZI111287632 111287633 111306279 111307648
EGR104428043 104435513 104453341 104456168 104456174 104456326 104457194 104457199 104457207 120295526
GMX100809668 100811802 100812337 100812880 100813407
GSJ114406411 114406418 114406420 114406422 114406423
PVUPHAVU_010G038200g PHAVU_010G038800g PHAVU_010G039100g PHAVU_010G039300g
VRA106774048 106774051 106774283
VAR108346928 108347504 108347505 108347718 108347738
VUN114165985 114166230 114166385 114166550 114167137 114167413 114167481
VUM124824736 124824737 124826191 124826193
CCAJ109788148 109791880 109794540 109797694 109800713 109819174
APRC113848978 113849004 113849029 113849085 113849154 113859794 113872369
MTR11444659 25500180 25500182 25500194 25500196 25500199
TPRA123883282 123883283 123883284 123883294 123883296 123883297 123883871 123883872 123883911 123883912 123885649 123923185
CAM101491786 101491922 101492713 101495283 101495606 101499884
PSAT127076614 127076615 127076616 127076619 127076634 127117596
VVO131615717 131616158 131616163 131616164 131616166 131618027 131618028
LJALj3g3v0642510.1(Lj3g3v0642510.1) Lj3g3v0642510.2(Lj3g3v0642510.2) Lj3g3v0642510.3(Lj3g3v0642510.3) Lj3g3v0642610.1(Lj3g3v0642610.1) Lj3g3v0642610.2(Lj3g3v0642610.2)
ADU107467531 107472674 107472675 107472677 107472678 107472703
AIP107615010 107615011 107617219 107617220 107618512 107619028 107619065 107631838 107631839
AHF112712267 112731236 112731252 112731268 112731284 112731300 112731316 112731928 112734142 112734143 112775483 112776572 112776720 112777292 112777293 112777294 112777364 112779354 112791980 112791981
LANG109331521 109343422 109346524 109352137 109352142 109352148
PCIN129289966 129291408 129295066 129318505 129318558 129318755
FVE101294504 101300754 101301231 101301518 101302097 101302385
RCN112184401 112184402 112184403 112186522 112187240 112189298 112189479 112190053 112190521 112190633
PPER18769053 18769346 18769406 18771345 18771701 18775322 18791196
PMUM103319393 103335605 103341330 103341331 103341333
PAVI110744686 110756840 110756892 110756905 110756906 110756907 110772057
PDUL117634647 117634777 117635762 117635910 117635911 117637867
MDM103406679 103406680 103417941 103431365 103431366 103446588 103446595 114820074 114826964
MSYL126590796 126590805 126590818 126590829 126590831 126590850 126590877 126591496 126602655 126605800
PXB103935601 103956033 103956035 103956036 103956039
ZJU107408089 107409479 125421152 125421153 125421359 125423354
MNT21401474 21403262 21403263
CSAV115696848 115697048 115697049 115697314 115698188 115708061 115717591
CSV101204788 101215655 101222067 105436085
CMO103488484 103495451 103495452 103495453 103503360
BHJ120075641 120077478 120077791 120078101 120078388
MCHA111021664 111021674
CMAX111472465 111486066 111486067 111492170
CMOS111434569 111434570 111439571 111462851
CPEP111776490 111793146 111793147 111805593
RCU8279670 8279671 8279676
JCU105636653 105636654 105636655 105636656 105636659 105641608
HBR110638895 110638903 110638904 110638905 110640378 110640379 110640380 110645473 110649251 110651916 110665637
MESC110614417 110615096 110616244 110620755 110626053 110626410 110630518
POP18106419 18106420 18109598 7459928 7459930 7469546
PEU105111031 105111570 105111572 105111573 105117707 105141926 105141927
PALZ118029122 118029124 118029648 118029656 118029660 118029663 118029664 118056094 118056095 118056096 118056098 118059613
JRE108981303 108981304 109003565 109005046 109005049 109005050 109013642 109013644 109018074
CILL122278592 122278612 122278617 122278628 122278669 122295158 122300793 122300794 122300797 122306043
CAVE132175536 132177078 132177079 132177081 132177177 132177178 132177509 132177819 132178693 132178792 132178800 132178940 132179534
QSU111991015 111991016 111991017 111991037 111991039 111991040 112007345 112007352 112007361 112007372 112007406 112007435 112007530 112007535 112007804 112007841 112007852 112007863 112009690 112009691 112025926 112030806 112030807
QLO115962564 115962769 115962911 115962919 115962920 115962921 115962922 115962923 115962925 115962926 115962927 115963047 115963048 115963049 115963050 115964167 115965115 115965149 115965162 115965172 115965361 115965456 115965882 115965883 115965884 115965885 115966066
TWL119988442
VVI100256090 100259258 100262970 100268122
VRI117914025 117914760 117914762 117915350
SLY101246540 101248372 101260017
SPEN107005751 107007681 107011489 107014797 107021842
SOT102578654 102581079 102596003 102597808 102599848
SSTN125849944 125858953 125860408 125868051 125869911 125872496
SDUL129882719 129882726 129894109 129899328
CANN107842343 107850744 107868137 107876055 124885430
LBB132604313 132611379 132613686 132637500 132644993
NTA107804017 107825579 107826139 107830910(DBR)
NSY104219384 104231555
NTO104093506 104114456
NAU109226814 109235640
INI109156910 109156911 109156912 109156916 109156917 109170275 109170276 109170278 109170279
ITR115996410 116024102 116025813 116026040 116026285
SIND105167155 105167157
OEU111406377 111406378
EGT105950544 105950589 105959482 105959483 105961456
SSPL121767085 121767949 121773215 121773216 121774684 121775500 121776271 121777025 121777031 121777033 121777442 121777485 121777486 121805530 121809558
SMIL130991870 130996539 130996555 130996570 130999688 130999729 130999732 130999733 130999734 131000171 131000175 131000177
APAN127252905
HAN110878529 110878536 110878544 110895457 110895459 118480164
ECAD122578073 122581308 122581328 122582551 122582552 122582553 122582577 122582651 122609986
LSV111892375 111899364 111899368 111899466
CCAV112504871 112505065 112512368 112512618 112513151 112518955 112518956 112519236 112519282
DCR108196875 108197590
CSIN114272699 114272700 114290878 114293126
RVL131301827 131301828 131301829 131301830 131301831 131301832 131321400 131326347
AEW130758094 130765475 130765503 130796314 130796321 130796498
BVG104889047 104889049
SOE110788922 110788925
CQI110717475 110738676 110738677
ATRI130806623 130806651 130806661 130825555
MOF131150377
NNU104586797 104586807 104586835 104593340
MING122076999 122085006 122085099 122086941 122091482 122091483 122091484 122091485 122091488
TSS122640394 122644221 122644222 122644223 122644225 122644226 122654976 122657072 122657074 122661208
PSOM113329925
OSA4336283
DOSAOs04t0497000-01(Os04g0497000)
OBR102716958
OGL127769282
BDI100827217 100827727 100828038 100828644
ATS109740477 109743195 109743200 109746860 109746864
TDC119300236 119302483 119307848 119311160 119311162 119353041 119358805 119367091 119367094
TAES123040357 123048487 123048489 123107425 123107426 123110792 123112723 123112724 123119786 123122202 123122203 123172217 123184505 123187253
TUA125508165 125510030 125510032 125535393 125540814
LPER127299687 127300548 127313101
LRD124654005 124654148 124654379 124654491 124654685 124683891
SBI8058160
ZMA100285730
SITA101763211 101763616
SVS117850761 117850762
PVIR120663783 120679765 120696981
PHAI112887242
PDA103708595 103708608 103715217 103724332 103724333 103724335 120103886 120108404 120112158 120112159
EGU105038598 105038600 105051506
MUS103985225 103985226 103987166
ZOF121971645 121976007 121976008 122002357 122002358 122006613 122006614 122008538 122017041 122022429 122027009 122029991 122053368
DCT110095562 110095566
PEQ110027397 110027493 110031241
AOF109824078 109830159 109830229 109830230 109830231
MSIN131246085 131246086 131250901 131250904 131250905 131250906 131250907 131250909 131250910 131251258
NCOL116252119 116252121
ATR18438048 18440022 18448629 18448631 18448633
 » show all
Reference
1  [PMID:11117876]
  Authors
Hirata T, Tamura Y, Yokobatake N, Shimoda K, Ashida Y
  Title
A 38 kDa allylic alcohol dehydrogenase from the cultured cells of Nicotiana tabacum.
  Journal
Phytochemistry 55:297-303 (2000)
DOI:10.1016/S0031-9422(00)00326-5
  Sequence
Reference
2  [PMID:17945329]
  Authors
Matsushima A, Sato Y, Otsuka M, Watanabe T, Yamamoto H, Hirata T
  Title
An enone reductase from Nicotiana tabacum: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant proteins.
  Journal
Bioorg Chem 36:23-8 (2008)
DOI:10.1016/j.bioorg.2007.08.005
  Sequence
Reference
3  [PMID:27547488]
  Authors
Mansell DJ, Toogood HS, Waller J, Hughes JM, Levy CW, Gardiner JM, Scrutton NS
  Title
Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization  of a Double Bond Reductase from Nicotiana tabacum.
  Journal
ACS Catal 3:370-379 (2013)
DOI:10.1021/cs300709m
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.102
IUBMB Enzyme Nomenclature: 1.3.1.102
ExPASy - ENZYME nomenclature database: 1.3.1.102
BRENDA, the Enzyme Database: 1.3.1.102

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