KEGG   ENZYME: 1.3.1.104
Entry
EC 1.3.1.104                Enzyme                                 

Name
enoyl-[acyl-carrier-protein] reductase (NADPH);
acyl-ACP dehydrogenase (ambiguous);
enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase;
NADPH 2-enoyl Co A reductase;
enoyl-ACP reductase (ambiguous);
fabL (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
acyl-[acyl-carrier protein]:NADP+ oxidoreductase
Reaction(IUBMB)
an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ [RN:R01404]
Reaction(KEGG)
Substrate
acyl-[acyl-carrier protein] [CPD:C00173];
NADP+ [CPD:C00006]
Product
trans-2,3-dehydroacyl-[acyl-carrier protein] [CPD:C00693];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl-carrier protein, in an NADPH-dependent manner. This entry stands for enzymes whose stereo-specificity with respect to NADP+ is not known. [cf. EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific), EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.9, enoyl-[acyl-carrier-protein] reductase (NADH)].
History
EC 1.3.1.104 created 2013
Pathway
ec00061  Fatty acid biosynthesis
ec01100  Metabolic pathways
Orthology
K10780  enoyl-[acyl-carrier protein] reductase III
Genes
SMAF: D781_2232
SFW: WN53_21285
SFG: AV650_17030
SRZ: AXX16_2910
SERM: CLM71_11550
SRHZ: FO014_22215
PALC: A0T30_17150
PCAM: HNE05_12885
LPH: LPV_0452
LPO: LPO_0408
LPU: LPE509_02876
LPM: LP6_0350(fabL)
LPA: lpa_00572
LPE: lp12_0359
LLO: LLO_0519
LFA: LFA_2780(fabL)
LHA: LHA_0370(fabL)
LOK: Loa_00420
LCD: clem_13305(fabL)
LSH: CAB17_06780(fabL)
LLG: 44548918_00264(fabL)
LIB: E4T55_06160(fabL)
LGT: E4T54_04805(fabL)
LJR: NCTC11533_00288(fabL)
LCJ: NCTC11976_01126(fabL) NCTC11976_02509(phaB_4)
LWA: SAMEA4504053_0677(fabL)
LSS: NCTC12082_02402(fabL)
TMC: LMI_0465(fabL)
BMAR: HF888_13400
GBI: PG2T_08100
BOZ: DBV39_18780(fabL)
VEI: Veis_2543
DPR: Despr_0937
MSD: MYSTI_06026
CCX: COCOR_02185(fabG9)
MFU: LILAB_25050
SUR: STAUR_4694 STAUR_7038
AGE: AA314_01964 AA314_07156
AVM: JQX13_22655
MBD: MEBOL_004393
CFUS: CYFUS_001265
CCRO: CMC5_023740
SAMY: DB32_005294
LLU: AKJ09_02466
MRM: A7982_00886 A7982_02081
RBS: RHODOSMS8_02171(fabL)
RDI: CMV14_20020
BSU: BSU08650(fabL)
BSR: I33_0968
BSL: A7A1_0300
BSH: BSU6051_08650(fabL)
BSY: I653_04335
BSUT: BSUB_00939(fabL)
BSUL: BSUA_00939(fabL)
BSUS: Q433_04825
BSO: BSNT_07250(fabL)
BSN: BSn5_16190
BSQ: B657_08650(fabL)
BSX: C663_0887(fabL)
BSP: U712_04400
BSS: BSUW23_04355(fabL)
BST: GYO_1133
BLI: BL03039(fabL)
BLD: BLi00887(fabL)
BLH: BaLi_c09910(fabL)
BAY: RBAM_008740(fabL)
BAQ: BACAU_0849(fabL)
BYA: BANAU_0792(fabL)
BAMP: B938_04215
BAML: BAM5036_0783(fabL)
BAMA: RBAU_0847(fabL)
BAMN: BASU_0823(fabL)
BAMB: BAPNAU_0805(fabL)
BAMT: AJ82_04870
BAMY: V529_08190(fabL)
BMP: NG74_00869(fabL)
BAO: BAMF_0873(fabL)
BAZ: BAMTA208_03980(fabL)
BQL: LL3_00935(fabL)
BXH: BAXH7_00830(fabL)
BQY: MUS_0887(fabL)
BAMI: KSO_015445
BAMC: U471_08640
BAMF: U722_04360
BSIA: CWD84_17480
BAE: BATR1942_01895
BVM: B9C48_04330
BSON: S101395_01084(phbB)
BHT: DIC78_05445(fabL)
BMOJ: HC660_08980(fabL)
BTEQ: G4P54_04520(fabL)
BIQ: AN935_04495
BPU: BPUM_0812
BPUM: BW16_04360
BPUS: UP12_04370
BJS: MY9_0954
BACI: B1NLA3E_03370
BIF: N288_05665
BMET: BMMGA3_03445(fabL)
GST: HW35_14250
BACW: QR42_04160
BACP: SB24_05545
BACB: OY17_07015
BACY: QF06_03160
BACL: BS34A_09630(fabL)
BALM: BsLM_0900
BSM: BSM4216_0820
BGY: BGLY_0909(fabL)
BWH: A9C19_16770
BXI: BK049_03945
BALT: CFN77_04250(fabL)
BACS: AUL54_06290
BSAF: BSL056_04215
BIT: BIS30_14905
BACQ: DOE78_05160(fabL)
BFD: NCTC4823_02971(fabL)
BDA: FSZ17_06550(fabL)
BCO: Bcell_0978
BHK: B4U37_05220
BCIR: C2I06_23175
BMQ: BMQ_0404
BMD: BMD_0405
BMH: BMWSH_4822(fabL)
BMEG: BG04_2695(fabL)
BEO: BEH_02810
BFX: BC359_18390
BCK: BCO26_2328
BAG: Bcoa_2111
BCOA: BF29_1474(fabL)
BHA: BH0938
BCL: ABC1313(fabL)
BPF: BpOF4_10865
BLE: BleG1_1207
BGI: BGM20_19495
BON: A361_06105
BKO: CKF48_03275
CGOT: J1899_04845(fabL)
GKA: GK0465
GTE: GTCCBUS3UF5_5810
GTK: GT3570_02290
GTM: GT3921_16915
GLI: GLN3_12750
GTN: GTNG_0470(fabI)
GWC: GWCH70_0470
GYC: GYMC61_1347
GYA: GYMC52_0468
GCT: GC56T3_3006
GMC: GY4MC1_3310
GGH: GHH_c04870(fabL)
GJF: M493_02735
GEA: GARCT_00511(fabL)
GEL: IB49_12935
GSE: GT50_12145
GSR: GS3922_13360
GEJ: A0V43_18130
GZA: IC807_16070(fabL)
GTH: Geoth_3364
PTL: AOT13_05915
PTB: DER53_06955(fabL)
PCAL: BV455_01279(fabL)
ANM: GFC28_2058(fabL)
AAMY: GFC30_882(fabL)
ANL: GFC29_3376(fabL)
AND: GRQ40_02945(fabL)
ACAI: ISX45_18400(fabL)
APAK: AP3564_02345
BSJ: UP17_03800
BMUR: ABE28_003640
PBUT: DTO10_15160(fabL)
PASA: BAOM_0748(fabL)
PPSR: I6J18_10860(fabL)
BTHV: CQJ30_05400
PSYH: D0S48_17065(fabL)
PSYO: PB01_15925(fabL)
RUE: DT065_17745(fabL)
SALE: EPH95_17465(fabL)
SCIB: HUG20_05875(fabL)
SCIA: HUG15_08260(fabL)
NMK: CHR53_06670
MEKU: HUW50_12015(fabL)
AIA: AWH56_003345(fabL)
BLEN: NCTC4824_03129(fabL)
BVQ: FHE72_06720(fabL)
RMF: D5E69_07415(fabL)
BVJ: I5776_16130(fabL)
BOU: I5818_19755(fabL)
STEA: C0679_05560
LMO: lmo1688
LMN: LM5578_1835
LMY: LM5923_1787
LMT: LMRG_02762
LMOC: LMOSLCC5850_1751(fabL)
LMOE: BN418_2021
LMOB: BN419_2025
LMOD: LMON_1755
LMOW: AX10_02655
LMOQ: LM6179_2444(fabL)
LMR: LMR479A_1790(fabL)
LMOM: IJ09_01415
LMF: LMOf2365_1712
LMC: Lm4b_01702
LMOG: BN389_17160(fabL)
LMP: MUO_08685
LMOL: LMOL312_1695(fabL)
LMOJ: LM220_01906
LMOZ: LM1816_07017(fabL)
LMOX: AX24_06135
LMH: LMHCC_0876
LMQ: LMM7_1777(fabL)
LML: lmo4a_1745(fabL)
LMG: LMKG_02669
LMS: LMLG_1553
LMJ: LMOG_02840
LMW: LMOSLCC2755_1700(fabL)
LMX: LMOSLCC2372_1754(fabL)
LMZ: LMOSLCC2482_1752(fabL)
LMON: LMOSLCC2376_1647(fabL)
LMOS: LMOSLCC7179_1662(fabL)
LMOO: LMOSLCC2378_1709(fabL)
LMOY: LMOSLCC2479_1752(fabL)
LMOT: LMOSLCC2540_1771(fabL)
LMOA: LMOATCC19117_1703(fabL)
LMOK: CQ02_08775
LMV: Y193_07125(fabL)
LIN: lin1796
LWE: lwe1706
LSG: lse_1656
LIV: LIV_1663
LII: JL52_08810
LIW: AX25_08970
LIA: JL58_08955
LIO: JL53_09420
LWI: UE46_10530
LGZ: NCTC10812_01163(fabL)
BTHS: CNY62_10305
BBE: BBR47_10320(fabL)
BLR: BRLA_c007290(fabL)
BFM: BP422_00280
BAGR: BA6348_23750
BRW: GOP56_19540(fabL)
PBJ: VN24_23250
ASOC: CB4_03899(fabL_1)
AAC: Aaci_2398 Aaci_2412
AAD: TC41_2687(fabG) TC41_2700(fabL)
AFX: JZ786_19250(fabL) JZ786_19315
BTS: Btus_2604
KYR: CVV65_13045
TUM: CBW65_01130
TAB: CIG75_05115
EFF: skT53_19840(fabL)
PLN: Plano_0800
PKU: AUO94_12280
PRT: AUC31_05130
PLL: I858_003125
PANA: BBH88_16255
PDG: BCM40_11645
PHC: BBI08_00375
PMAR: B0X71_04815
PPLA: BBI15_00615
PFAE: AJGP001_04920
PLX: CW734_06355
PMAT: BBI11_05800
PDEC: H1Q58_04960(fabL)
PGQ: FK545_12995(fabL)
JEO: JMA_12600
SPSY: AZE41_03675
SPAE: E2C16_00445(fabL)
PAEK: D3873_10330(fabL)
PANC: E2636_04035(fabL)
PLAY: DNR44_015760(fabL)
SAY: TPY_3095 TPY_3240(fabL)
SAP: Sulac_0799 Sulac_1673
LPIL: LIP_1119
MMOR: MMOR_36050(fabL)
NBR: O3I_026240
NSL: BOX37_17080
NOZ: DMB37_02610
ROA: Pd630_LPD04497
DIZ: CT688_13190
SGB: WQO_30010
SVL: Strvi_8195
SHY: SHJG_1192
SHO: SHJGH_1027
SRC: M271_30645
SMAL: SMALA_2908
SSOI: I1A49_18470
SFA: Sfla_5328
SBH: SBI_06749 SBI_06855
STRP: F750_1295
SLE: sle_01250(sle_01250)
SGS: AVL59_46205
SAUO: BV401_18195
SVU: B1H20_30845
SALF: SMD44_08690
SKA: CP970_38055
SSPO: DDQ41_16075
SSEO: D0Z67_12220
SSPB: CP982_05330
SPLA: CP981_34470
LXL: KDY119_01212
MIO: AOA12_09960
MPAL: BO218_02695
MIH: BJP65_01770
MAUR: BOH66_10360
MOO: BWL13_01459(fabL)
MPRT: ET475_01045
CUB: BJK06_01395
CPHY: B5808_12155
HUM: DVJ78_08790
HUW: FPZ11_10075
GRY: D7I44_00415
HEA: HL652_11045
CELZ: E5225_00720
PSEI: GCE65_03975
MIK: FOE78_00275
MICG: GJV80_19840
NDK: I601_1166(fabL)
NOA: BKM31_45865
ACE: Acel_1197
AMYY: YIM_26855(fabL)
PDX: Psed_2586
KAL: KALB_7822
MICH: FJK98_15115
MCAB: HXZ27_30090
PLAB: C6361_09525
PLAT: C6W10_06020
ATL: Athai_27180
ASER: Asera_47540
CATI: CS0771_54770(fabL)
AFO: Afer_1057
AQZ: KSP35_11145
NON: NOS3756_03710
TRO: trd_0268
STI: Sthe_0993
ATM: ANT_17280
PSUB: Pelsub_P1998
CAP: CLDAP_22810
KBS: EPA93_26395
TTR: Tter_0966
RBA: RB10454(chcA)
LCRE: Pla8534_03000(fabL_1) Pla8534_16180(fabL_2)
AAGG: ETAA8_31190(fabL)
BVO: Pan97_33970(fabL_2)
PLM: Plim_1674
PEH: Spb1_25250(fabL)
MRI: Mal4_48560(fabL_2)
PLON: Pla110_25280(fabL)
SUS: Acid_2156
CPI: Cpin_5032
CHIH: GWR21_30980
SGN: SGRA_1403(fabI)
MUP: A0256_07540
MUC: MuYL_2694
MGOT: MgSA37_02494(fabL)
MGIN: FRZ54_06410
MGK: FSB76_12515
MMAB: HQ865_23795
MGIK: GO620_015025
SLI: Slin_3188
SRD: SD10_17175
SPIR: CWM47_06615
SPIK: EXU85_33670
GFO: GFO_1609(fabI)
GRL: LPB144_03625
GRS: C7S20_14460
RBI: RB2501_14724
CAT: CA2559_10903
MARM: YQ22_18190
MART: BTR34_17885
MARB: CJ263_18640
MARE: EJ994_04390
CAO: Celal_3842
CBAL: M667_15700
KDI: Krodi_2526
DOK: MED134_04719
DDO: I597_1946(fabL)
DOD: DCS32_14685
LACI: CW733_13200
ZGA: ZOBELLIA_4386
MUT: GVT53_13935
ASL: Aeqsu_2711
PTQ: P700755_000481
NDO: DDD_3154
NOM: AAT17_01000
NSD: BST91_04905
NOB: CW736_10875
NOJ: EJ995_09005
POM: MED152_08610
WIJ: BWZ20_08860
SYI: SB49_03770
TJE: TJEJU_0277
SALT: AO058_12230
OLL: CW732_02590
AUE: C5O00_12550
SPON: HME9304_03191(fabI)
KAN: IMCC3317_45070(fabL)
AQD: D1816_03765
EMAR: D1013_12460
MUR: EQY75_06045
AFLA: FHG64_01250
ANP: FK178_04090
OCI: FEZ18_06955
MGEL: G5B37_02090
GAA: HX109_13950
CAGG: HYG79_16880
ALTI: ALE3EI_2232
FBE: FF125_04625
CSAL: NBC122_00026(fabL)
CJG: NCTC13459_00416(fabL)
CCAS: EIB73_04505
CANT: NCTC13489_01022(fabL)
KDA: EIB71_08845
OHO: Oweho_0671
CPH: Cpha266_1101
CTS: Ctha_2098
IAL: IALB_0753
MRO: MROS_0289
CABY: Cabys_861
MOX: DAMO_2491
 » show all
Reference
1  [PMID:11007778]
  Authors
Heath RJ, Su N, Murphy CK, Rock CO
  Title
The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis.
  Journal
J Biol Chem 275:40128-33 (2000)
DOI:10.1074/jbc.M005611200
  Sequence
[bsu:BSU08650]
Reference
2  [PMID:17329825]
  Authors
Kim KH, Park JK, Ha BH, Moon JH, Kim EE
  Title
Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 63:246-8 (2007)
DOI:10.1107/S1744309107008469
Reference
3  [PMID:21185310]
  Authors
Kim KH, Ha BH, Kim SJ, Hong SK, Hwang KY, Kim EE
  Title
Crystal structures of Enoyl-ACP reductases I (FabI) and III (FabL) from B. subtilis.
  Journal
J Mol Biol 406:403-15 (2011)
DOI:10.1016/j.jmb.2010.12.003
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.104
IUBMB Enzyme Nomenclature: 1.3.1.104
ExPASy - ENZYME nomenclature database: 1.3.1.104
BRENDA, the Enzyme Database: 1.3.1.104

  All links  
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (19)   
   KEGG COMPOUND (19)   
Chemical reaction (11)   
   KEGG REACTION (8)   
   KEGG RCLASS (3)   
Gene (5496)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (430)   
   KEGG MGENES (4855)   
   RefGene (210)   
Protein sequence (1772)   
   UniProt (640)   
   SWISS-PROT (22)   
   RefSeq(pep) (1110)   
DNA sequence (10165)   
   RefSeq(nuc) (8979)   
   GenBank (600)   
   EMBL (586)   
Protein domain (7)   
   InterPro (7)   
All databases (17475)   

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