KEGG   ENZYME: 1.3.1.104Help
Entry
EC 1.3.1.104                Enzyme                                 

Name
enoyl-[acyl-carrier-protein] reductase (NADPH);
acyl-ACP dehydrogenase (ambiguous);
enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase;
NADPH 2-enoyl Co A reductase;
enoyl-ACP reductase (ambiguous);
fabL (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
acyl-[acyl-carrier protein]:NADP+ oxidoreductase
Reaction(IUBMB)
an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ [RN:R01404]
Reaction(KEGG)
Substrate
acyl-[acyl-carrier protein] [CPD:C00173];
NADP+ [CPD:C00006]
Product
trans-2,3-dehydroacyl-[acyl-carrier protein] [CPD:C00693];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl-carrier protein, in an NADPH-dependent manner. This entry stands for enzymes whose stereo-specificity with respect to NADP+ is not known. [cf. EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific), EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.9, enoyl-[acyl-carrier-protein] reductase (NADH)].
History
EC 1.3.1.104 created 2013
Pathway
ec00061  Fatty acid biosynthesis
ec01100  Metabolic pathways
Orthology
K10780  enoyl-[acyl-carrier protein] reductase III
Genes
SMAF: D781_2232
SFW: WN53_21285
SFG: AV650_17030
SRZ: AXX16_2910
SERM: CLM71_11550
PALC: A0T30_17150
LPH: LPV_0452
LPO: LPO_0408
LPU: LPE509_02876
LPM: LP6_0350(fabL)
LPA: lpa_00572
LPE: lp12_0359
LLO: LLO_0519
LFA: LFA_2780(fabL)
LHA: LHA_0370(fabL)
LOK: Loa_00420
LCD: clem_13305(fabL)
LSH: CAB17_06780(fabL)
LLG: 44548918_00264(fabL)
LIB: E4T55_06160(fabL)
LGT: E4T54_04805(fabL)
TMC: LMI_0465(fabL)
GBI: PG2T_08100
BOZ: DBV39_18780(fabL)
DPR: Despr_0937
SUR: STAUR_7038
AGE: AA314_01964
MBD: MEBOL_004393
CFUS: CYFUS_001265
RBS: RHODOSMS8_02171(fabL)
RUE: DT065_17745(fabL)
RDI: CMV14_20020
BSU: BSU08650(fabL)
BSR: I33_0968
BSL: A7A1_0300
BSH: BSU6051_08650(fabL)
BSY: I653_04335
BSUT: BSUB_00939(fabL)
BSUL: BSUA_00939(fabL)
BSUS: Q433_04825
BSS: BSUW23_04355(fabL)
BST: GYO_1133
BSO: BSNT_07250(fabL)
BSN: BSn5_16190
BSQ: B657_08650(fabL)
BSX: C663_0887(fabL)
BSP: U712_04400
BLI: BL03039(fabL)
BLD: BLi00887(fabL)
BLH: BaLi_c09910(fabL)
BAY: RBAM_008740(fabL)
BAQ: BACAU_0849(fabL)
BYA: BANAU_0792(fabL)
BAMP: B938_04215
BAML: BAM5036_0783(fabL)
BAMA: RBAU_0847(fabL)
BAMN: BASU_0823(fabL)
BAMB: BAPNAU_0805(fabL)
BAMT: AJ82_04870
BAMY: V529_08190(fabL)
BMP: NG74_00869(fabL)
BAO: BAMF_0873(fabL)
BAZ: BAMTA208_03980(fabL)
BQL: LL3_00935(fabL)
BXH: BAXH7_00830(fabL)
BQY: MUS_0887(fabL)
BAMI: KSO_015445
BAMC: U471_08640
BAMF: U722_04360
BAE: BATR1942_01895
BVM: B9C48_04330
BHA: BH0938
BCL: ABC1313(fabL)
BPU: BPUM_0812
BPUM: BW16_04360
BPUS: UP12_04370
BPF: BpOF4_10865
BMQ: BMQ_0404
BMD: BMD_0405
BMH: BMWSH_4822(fabL)
BMEG: BG04_2695(fabL)
BCO: Bcell_0978
BCK: BCO26_2328
BAG: Bcoa_2111
BCOA: BF29_1474(fabL)
BJS: MY9_0954
BACI: B1NLA3E_03370
BIF: N288_05665
BLE: BleG1_1207
BMET: BMMGA3_03445(fabL)
GST: HW35_14250
BACW: QR42_04160
BACP: SB24_05545
BACB: OY17_07015
BACY: QF06_03160
BACL: BS34A_09630(fabL)
BALM: BsLM_0900
BEO: BEH_02810
BSM: BSM4216_0820
BSJ: UP17_03800
BON: A361_06105
BGY: BGLY_0909(fabL)
BFX: BC359_18390
BGI: BGM20_19495
BWH: A9C19_16770
BXI: BK049_03945
BHK: B4U37_05220
BKO: CKF48_03275
BALT: CFN77_04250(fabL)
BACS: AUL54_06290
BMUR: ABE28_003640
BSAF: BSL056_04215
BIT: BIS30_14905
BACQ: DOE78_05160(fabL)
GKA: GK0465
GTE: GTCCBUS3UF5_5810
GTK: GT3570_02290
GTM: GT3921_16915
GLI: GLN3_12750
GTN: GTNG_0470(fabI)
GWC: GWCH70_0470
GYC: GYMC61_1347
GYA: GYMC52_0468
GCT: GC56T3_3006
GMC: GY4MC1_3310
GGH: GHH_c04870(fabL)
GJF: M493_02735
GEA: GARCT_00511(fabL)
GEL: IB49_12935
GSE: GT50_12145
GSR: GS3922_13360
GEJ: A0V43_18130
GTH: Geoth_3364
PTL: AOT13_05915
ANM: GFC28_2058(fabL)
AAMY: GFC30_882(fabL)
ANL: GFC29_3376(fabL)
APAK: AP3564_02345
PSYH: D0S48_17065(fabL)
STEA: C0679_05560
LMO: lmo1688
LMN: LM5578_1835
LMY: LM5923_1787
LMT: LMRG_02762
LMOC: LMOSLCC5850_1751(fabL)
LMOE: BN418_2021
LMOB: BN419_2025
LMOD: LMON_1755
LMOW: AX10_02655
LMOQ: LM6179_2444(fabL)
LMR: LMR479A_1790(fabL)
LMOM: IJ09_01415
LMF: LMOf2365_1712
LMC: Lm4b_01702
LMOG: BN389_17160(fabL)
LMP: MUO_08685
LMOL: LMOL312_1695(fabL)
LMOJ: LM220_01906
LMOZ: LM1816_07017
LMOX: AX24_06135
LMH: LMHCC_0876
LMQ: LMM7_1777(fabL)
LML: lmo4a_1745(fabL)
LMG: LMKG_02669
LMS: LMLG_1553
LMJ: LMOG_02840
LMW: LMOSLCC2755_1700(fabL)
LMX: LMOSLCC2372_1754(fabL)
LMZ: LMOSLCC2482_1752(fabL)
LMON: LMOSLCC2376_1647(fabL)
LMOS: LMOSLCC7179_1662(fabL)
LMOO: LMOSLCC2378_1709(fabL)
LMOY: LMOSLCC2479_1752(fabL)
LMOT: LMOSLCC2540_1771(fabL)
LMOA: LMOATCC19117_1703(fabL)
LMOK: CQ02_08775
LMV: Y193_07125
LIN: lin1796
LWE: lwe1706
LSG: lse_1656
LIV: LIV_1663
LII: JL52_08810
LIW: AX25_08970
LIA: JL58_08955
LIO: JL53_09420
LWI: UE46_10530
BTHS: CNY62_10305
BBE: BBR47_10320(fabL)
BLR: BRLA_c007290(fabL)
BFM: BP422_00280
BAGR: BA6348_23750
PBJ: VN24_23250
ASOC: CB4_03899(fabL_1)
AAC: Aaci_2412
AAD: TC41_2687(fabG) TC41_2700(fabL)
BTS: Btus_2604
KYR: CVV65_13045
TUM: CBW65_01130
TAB: CIG75_05115
PLN: Plano_0800
PKU: AUO94_12280
PRT: AUC31_05130
PLL: I858_003125
PANA: BBH88_16255
PDG: BCM40_11645
PHC: BBI08_00375
PMAR: B0X71_04815
PPLA: BBI15_00615
PFAE: AJGP001_04920
PLX: CW734_06355
JEO: JMA_12600
SPSY: AZE41_03675
SPAE: E2C16_00445(fabL)
PAEK: D3873_10330(fabL)
PANC: E2636_04035(fabL)
PGQ: FK545_12995(fabL)
SAY: TPY_3240(fabL)
SAP: Sulac_1673
LPIL: LIP_1119
NBR: O3I_026240
NSL: BOX37_17080
NOZ: DMB37_02610
ROA: Pd630_LPD04497
DIZ: CT688_13190
SFA: Sfla_5328
STRP: F750_1295
SLE: sle_01250(sle_01250)
SGS: AVL59_46205
CUB: BJK06_01395
CPHY: B5808_12155
HUM: DVJ78_08790
HUW: FPZ11_10075
GRY: D7I44_00415
MIK: FOE78_00275
NDK: I601_1166(fabL)
PDX: Psed_2586
KAL: KALB_7822
MICH: FJK98_15115
SALE: EPH95_17465(fabL)
AFO: Afer_1057
NON: NOS3756_03710
ATM: ANT_17280
PSUB: Pelsub_P1998
CAP: CLDAP_22810
TTR: Tter_0966
RBA: RB10454(chcA)
PLM: Plim_1674
PEH: Spb1_25250(fabL)
CPH: Cpha266_1101
 » show all
Taxonomy
Reference
1  [PMID:11007778]
  Authors
Heath RJ, Su N, Murphy CK, Rock CO
  Title
The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis.
  Journal
J Biol Chem 275:40128-33 (2000)
DOI:10.1074/jbc.M005611200
  Sequence
[bsu:BSU08650]
Reference
2  [PMID:17329825]
  Authors
Kim KH, Park JK, Ha BH, Moon JH, Kim EE
  Title
Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 63:246-8 (2007)
DOI:10.1107/S1744309107008469
Reference
3  [PMID:21185310]
  Authors
Kim KH, Ha BH, Kim SJ, Hong SK, Hwang KY, Kim EE
  Title
Crystal structures of Enoyl-ACP reductases I (FabI) and III (FabL) from B. subtilis.
  Journal
J Mol Biol 406:403-15 (2011)
DOI:10.1016/j.jmb.2010.12.003
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.104
IUBMB Enzyme Nomenclature: 1.3.1.104
ExPASy - ENZYME nomenclature database: 1.3.1.104
BRENDA, the Enzyme Database: 1.3.1.104

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Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (19)   
   KEGG COMPOUND (19)   
Chemical reaction (11)   
   KEGG REACTION (8)   
   KEGG RCLASS (3)   
Gene (1428)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (250)   
   KEGG MGENES (967)   
   RefGene (210)   
Protein sequence (1395)   
   UniProt (511)   
   SWISS-PROT (22)   
   RefSeq(pep) (862)   
DNA sequence (7171)   
   RefSeq(nuc) (6633)   
   GenBank (250)   
   EMBL (288)   
All databases (10029)   

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