| Entry |
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| Name |
enoyl-[acyl-carrier-protein] reductase (NADPH);
acyl-ACP dehydrogenase (ambiguous);
enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase;
NADPH 2-enoyl Co A reductase;
enoyl-ACP reductase (ambiguous);
fabL (gene name)
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
acyl-[acyl-carrier protein]:NADP+ oxidoreductase
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| Reaction(IUBMB) |
an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ [RN: R01404]
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| Reaction(KEGG) |
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| Substrate |
acyl-[acyl-carrier protein] [CPD: C00173];
NADP+ [CPD: C00006]
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| Product |
trans-2,3-dehydroacyl-[acyl-carrier protein] [CPD: C00693];
NADPH [CPD: C00005];
H+ [CPD: C00080]
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| Comment |
The enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl-carrier protein, in an NADPH-dependent manner. This entry stands for enzymes whose stereo-specificity with respect to NADP+ is not known. [cf. EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific), EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.9, enoyl-[acyl-carrier-protein] reductase (NADH)].
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| History |
EC 1.3.1.104 created 2013
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| Pathway |
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| Orthology |
| K10780 | enoyl-[acyl-carrier protein] reductase III |
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| Genes |
» show all
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| Reference |
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| Authors |
Heath RJ, Su N, Murphy CK, Rock CO |
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| Title |
The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Kim KH, Park JK, Ha BH, Moon JH, Kim EE |
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| Title |
Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis. |
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| Journal |
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| Reference |
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| Authors |
Kim KH, Ha BH, Kim SJ, Hong SK, Hwang KY, Kim EE |
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| Title |
Crystal structures of Enoyl-ACP reductases I (FabI) and III (FabL) from B. subtilis. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.3.1.104 |
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