Entry
Name
cobalt-precorrin-6A reductase;
cbiJ (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
cobalt-precorrin-6B:NAD+ oxidoreductase
Reaction(IUBMB)
cobalt-precorrin-6B + NAD+ = cobalt-precorrin-6A + NADH + H+ [RN:
R05812 ]
Reaction(KEGG)
Substrate
cobalt-precorrin-6B;
NAD+ [CPD:
C00003 ]
Product
Comment
The enzyme, which participates in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses the reduction of the double bond between C-18 and C-19 of cobalt-precorrin-6A. The enzyme from the bacterium Bacillus megaterium has no activity with NADPH. See EC
1.3.1.54 , precorrin-6A reductase, for the corresponding enzyme that participates in the aerobic cobalamin biosynthesis pathway.
History
EC 1.3.1.106 created 2014
Pathway
Orthology
K05895 precorrin-6A/cobalt-precorrin-6A reductase
Genes
KIE : NCTC12125_04869(cobK)
BSEL : RHD99_04890 RHD99_08260
METY : MRY16398_18720(cbiJ)
PAEB : NCGM1900_3402(cobK)
PPRC : PFLCHA0_c06610(cobK)
PMUD : NCTC8068_00604(cobK)
PFW : PF1751_v1c05640(cobK)
PPUU : PputUW4_00534(cobK)
PTAE : NCTC10697_03998(cobK)
TFRI : Thiofri_03991(cobK)
GAI : IMCC3135_08950(cobK)
HAAH : HALA3H3_800142(cobK)
BMV : BMASAVP1_A1599(cobK)
BML : BMA10229_A0260(cobK)
BPM : BURPS1710b_2116(cobK)
BPL : BURPS1106A_1971(cobK)
PDIO : PDMSB3_1858.1(cobK)
PLG : NCTC10937_00827(cobK)
SMEL : SM2011_c03189(cobK)
SFD : USDA257_c53930(cobK)
SAME : SAMCFNEI73_Ch3349(cobK)
AGR : AGROH133_09251(cobK)
AVV : RvVAT039_01100(cobK)
AVF : RvVAR031_22280(cobK)
REC : RHECIAT_PA0000374(cobK)
REL : REMIM1_PD00474(cobK)
REP : IE4803_PA00410(cobK)
REI : IE4771_PC00423(cobK)
RTR : RTCIAT899_PC07010(cobK)
RHL : LPU83_pLPU83d0183(cobK)
RGA : RGR602_PC01212(cobK)
RPHA : AMC79_PB00383(cobK)
NEN : NCHU2750_36490(cobK)
BIO : BR141012304_11398(cobK)
MAQU : Maq22A_c09450(cobK)
MTUN : MTUNDRAET4_2078(cobK)
FIL : BN1229_v1_3171(cobK)
RDE : RD1_3177(cobK) RD1_3822(cobK)
RLI : RLO149_c006220(cobK) RLO149_c024040
RPON : G3256_07160 G3256_12335
RFU : ROLI_011120(cobK_1) ROLI_018810(cobK_2)
PHP : PhaeoP97_00779(cobK)
PPIC : PhaeoP14_00734(cobK)
MALG : MALG_01205 MALG_01407
PABY : Ga0080574_TMP1470 Ga0080574_TMP4011
SUAM : BOO69_10290 BOO69_17195
SULZ : C1J03_01450 C1J03_09275
SULD : B5M07_08520 B5M07_16135
SPOT : G6548_10695 G6548_14670
SMED : JNX03_05630 JNX03_14265
SINL : DSM14862_01676(cobK_1) DSM14862_03168(cobK_2)
SFAV : PL335_08560 PL335_15190
SUAL : KDD17_07735 KDD17_15790
SDUB : R1T39_02440 R1T39_09995
SULB : IV89_000742 IV89_001588
SULY : ABM428_10400 ABM428_14300
SPSE : SULPSESMR1_01744(cobK) SULPSESMR1_02793(cobK)
TOM : BWR18_08175 BWR18_10970
RMM : ROSMUCSMR3_00813(cobK)
ROH : FIU89_08185(cobK1) FIU89_17360(cobK2)
AHT : ANTHELSMS3_02550 ANTHELSMS3_02943
MALU : KU6B_20520(cobK_1) KU6B_33060(cobK_2)
LALG : LentiSH36_01595(cobK)
MARU : FIU81_10990(cobK1) FIU81_13710(cobK2)
LVS : LOKVESSMR4R_01279(cobK)
GEH : HYN69_05170 HYN69_19250 HYN69_20060
PPRU : FDP22_00710 FDP22_12915
AALK : LGT41_0005745 LGT41_0012525
PROC : Ptc2401_01272(cobK)
LMOC : LMOSLCC5850_1189(cbiJ)
LMW : LMOSLCC2755_1192(cbiJ)
LMX : LMOSLCC2372_1196(cbiJ)
LMZ : LMOSLCC2482_1240(cbiJ)
LMON : LMOSLCC2376_1151(cbiJ)
LMOS : LMOSLCC7179_1167(cbiJ)
LMOO : LMOSLCC2378_1205(cbiJ)
LMOY : LMOSLCC2479_1197(cbiJ)
LMOT : LMOSLCC2540_1179(cbiJ)
LMOA : LMOATCC19117_1199(cbiJ)
BAYD : BSPP4475_15710(cobK)
PPQ : PPSQR21_047940(cobK)
PCHI : PC41400_25725(cobK)
SMEN : SAMEA4412692_0362(cobK)
LRU : HMPREF0538_20900(cobK)
AUR : HMPREF9243_1733(cobK)
AMIT : DBT49_0001560(cobK)
CCK : Ccar_11560 Ccar_15385
CTYK : CTK_C09520(cbiJ_cobK)
CDRK : B9W14_15735 B9W14_19430
CCOH : SAMEA4530647_0623(cbiJ)
CGEL : psyc5s11_37860(cbiJ)
DMT : DESME_03910 DESME_05660
DOR : Desor_2790 Desor_4599
DAI : Desaci_0752 Desaci_2439
DMI : Desmer_0508 Desmer_2193 Desmer_3643
DRS : DEHRE_01400 DEHRE_14500
DKU : Desku_1461 Desku_1995
AACX : DEACI_1646 DEACI_2578
TJR : TherJR_1266 TherJR_1564
DGI : Desgi_2022 Desgi_2391
AWO : Awo_c10230(cbiJ1) Awo_c30220(cbiJ2)
AWI : CHL1_000465(cobK) CHL1_002753(cobK)
CBAR : PATL70BA_0223(cobK)
AMIC : Ami3637_03205(cobK)
ABUT : Ami103574_05920(cobK)
PDF : CD630DERM_34230(cbiJ)
PHX : KGNDJEFE_00487(cbiJ)
EAC : EAL2_808p01070(cbiJ)
MTHO : MOTHE_c10550(cobK) MOTHE_c12010
MTHZ : MOTHA_c11440(cobK) MOTHA_c12880
PIV : NCTC13079_00694(cobK)
VRM : 44547418_01210(cobK)
VDN : NCTC11831_00753(cobK)
SELM : TAMA11512_14890(cobK)
MANA : MAMMFC1_04001(cobK)
PFAC : PFJ30894_01756(cobK)
MBO : BQ2027_MB2096C(cobK)
MMAE : MMARE11_29750(cobK)
MBAI : MB901379_02831(cobK)
MHEK : JMUB5695_02272(cobK)
MKY : IWGMT90018_27290(cobK)
MPHL : MPHLCCUG_02701(cobK)
MTHN : 4412656_01954(cobK)
MAUU : NCTC10437_00333(cobK)
MFLV : NCTC10271_02115(cobK)
MGO : AFA91_20080 AFA91_20680
MSAL : DSM43276_01910(cobK)
MTER : 4434518_03162(cobK)
CDIP : ERS451417_01234(cobK)
CUN : Cul210932_1137(cobK)
CUQ : Cul210931_1089(cobK)
CUJ : CUL131002_1121c(cobK)
CRL : NCTC7448_01902(cobK)
NFR : ERS450000_00919(cobK)
NAD : NCTC11293_04435(cobK)
RPY : Y013_10555 Y013_14675
RCR : NCTC10994_03349(cobK)
TPUL : TPB0596_24000(cobK)
DIT : C3V38_05690 C3V38_13650
DLU : A6035_07675 A6035_16460
DCD : VYL96_07735 VYL96_16105
SAMB : SAM23877_6458(cobK)
STRF : ASR50_30720 ASR50_31630
SLE : sle_07920(sle_07920)
SXT : KPP03845_105801(cobK)
DCO : SAMEA4475696_1937(cobK)
CGRN : 4412665_00798(cobK)
PAUS : NCTC13651_00957(cobK)
PPC : HMPREF9154_1259(cobK)
TEZ : BKM78_01605 BKM78_05685
TLA : TLA_TLA_00325(cobK_1) TLA_TLA_01150(cobK_2)
RAIN : Rai3103_04750 Rai3103_07515
NAQU : ENKNEFLB_00264(cobK_1) ENKNEFLB_01615(cobK_2)
PARQ : DSM112329_00634(cobK)
SYR : SynRCC307_0882(cobK)
SYX : SynWH7803_0618(cobK)
MVZ : myaer102_12070(cbiJ)
PAGH : NIES204_04420(cobK)
PRUN : PCC7821_03843(cobK)
NSPH : BDGGKGIB_00929(cobK)
FPOL : ERS445057_01283(cobK)
» show all
Taxonomy
Reference
Authors
Kim W, Major TA, Whitman WB
Title
Role of the precorrin 6-X reductase gene in cobamide biosynthesis in Methanococcus maripaludis.
Journal
Sequence
Reference
Authors
Moore SJ, Lawrence AD, Biedendieck R, Deery E, Frank S, Howard MJ, Rigby SE, Warren MJ
Title
Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12).
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.3.1.106