KEGG   ENZYME: 1.3.1.108Help
Entry
EC 1.3.1.108                Enzyme                                 

Name
caffeoyl-CoA reductase;
electron-bifurcating caffeoyl-CoA reductase;
caffeoyl-CoA reductase-Etf complex;
hydrocaffeoyl-CoA:NAD+,ferredoxin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3-(3,4-dihydroxyphenyl)propanoyl-CoA:NAD+,ferredoxin oxidoreductase
Reaction(IUBMB)
3-(3,4-dihydroxyphenyl)propanoyl-CoA + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster [RN:R11674]
Reaction(KEGG)
Substrate
3-(3,4-dihydroxyphenyl)propanoyl-CoA [CPD:C21175];
NAD+ [CPD:C00003];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138]
Product
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA [CPD:C00323];
NADH [CPD:C00004];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Comment
The enzyme, characterized from the bacterium Acetobacterium woodii, contains two [4Fe-4S] clusters and FAD. The enzyme couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant. It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction. It also reduces 4-coumaroyl-CoA and feruloyl-CoA.
History
EC 1.3.1.108 created 2015
Orthology
K22430  caffeyl-CoA reductase-Etf complex subunit CarC
K22431  caffeyl-CoA reductase-Etf complex subunit CarD
K22432  caffeyl-CoA reductase-Etf complex subunit CarE
Genes
DTI: Desti_1829
PDU: PDUR_16105
LACA: LAC1533_0102
CTET: BN906_02283
CBO: CBO2194(etfA1) CBO2195(etfB1) CBO2196(acdB) CBO3286(etfA2) CBO3287(etfB2) CBO3288(acdA)
CBA: CLB_2132 CLB_2133 CLB_2134 CLB_3342 CLB_3343 CLB_3344
CBH: CLC_2137 CLC_2138 CLC_2139 CLC_3228 CLC_3229 CLC_3230
CBY: CLM_2395 CLM_2396 CLM_2397 CLM_3719 CLM_3720 CLM_3721
CBL: CLK_1632 CLK_1633 CLK_1634 CLK_2702 CLK_2703 CLK_2704
CBB: CLD_1235 CLD_1236 CLD_1237 CLD_2384 CLD_2385 CLD_2386
CLS: CXIVA_25230(CaiA)
CLD: CLSPO_c22260(etfA1) CLSPO_c22270(etfB1) CLSPO_c22280(bcd1) CLSPO_c34060(etfA3) CLSPO_c34070(etfB3) CLSPO_c34080(mmgC)
FPR: FP2_20560
FPA: FPR_29620
CPRO: CPRO_21620(acrB_2)
CDF: CD630_03990(acdB) CD630_04000(etfB1) CD630_04010(etfA1)
PDC: CDIF630_00527(acdB) CDIF630_00528(etfB1) CDIF630_00529(etfA1)
CDC: CD196_0384(acdB) CD196_0385(etfB1) CD196_0386(etfA1)
CDL: CDR20291_0370(acdB) CDR20291_0371(etfB1) CDR20291_0372(etfA1)
AWO: Awo_c15720(carC) Awo_c15730(carD) Awo_c15740(carE)
PHAR: NCTC13077_01414(etfB_2)
GLJ: GKIL_0714(fixB)
ABAT: CFX1CAM_0767(etfA) CFX1CAM_0768(etfB)
VBL: L21SP4_02442(etfA)
ETI: RSTT_558(etfA)
CACI: CLOAM1482
CDIV: CPM_1624
MARC: AR505_0763
HTI: HTIA_2047
 » show all
Taxonomy
Reference
1  [PMID:23479729]
  Authors
Bertsch J, Parthasarathy A, Buckel W, Muller V
  Title
An electron-bifurcating caffeyl-CoA reductase.
  Journal
J Biol Chem 288:11304-11 (2013)
DOI:10.1074/jbc.M112.444919
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.108
IUBMB Enzyme Nomenclature: 1.3.1.108
ExPASy - ENZYME nomenclature database: 1.3.1.108
BRENDA, the Enzyme Database: 1.3.1.108

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