KEGG   ENZYME: 1.3.1.110Help
Entry
EC 1.3.1.110                Enzyme                                 

Name
lactate dehydrogenase (NAD+,ferredoxin);
electron bifurcating LDH/Etf complex
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
lactate:NAD+,ferredoxin oxidoreductase
Reaction(IUBMB)
lactate + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = pyruvate + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster [RN:R11676]
Reaction(KEGG)
Substrate
lactate [CPD:C01432];
NAD+ [CPD:C00003];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138]
Product
pyruvate [CPD:C00022];
NADH [CPD:C00004];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Comment
The enzyme, isolated from the bacterium Acetobacterium woodii, uses flavin-based electron confurcation to drive endergonic lactate oxidation with NAD+ as oxidant at the expense of simultaneous exergonic electron flow from reduced ferredoxin to NAD+.
History
EC 1.3.1.110 created 2015
Reference
1  [PMID:24762045]
  Authors
Weghoff MC, Bertsch J, Muller V
  Title
A novel mode of lactate metabolism in strictly anaerobic bacteria.
  Journal
Environ Microbiol 17:670-7 (2015)
DOI:10.1111/1462-2920.12493
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.110
IUBMB Enzyme Nomenclature: 1.3.1.110
ExPASy - ENZYME nomenclature database: 1.3.1.110
BRENDA, the Enzyme Database: 1.3.1.110

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