KEGG   ENZYME: 1.3.1.113Help
Entry
EC 1.3.1.113                Enzyme                                 

Name
(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase;
bprA (gene name);
scbB (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
[(3S)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate:NADP+ oxidoreductase
Reaction(IUBMB)
a [(3S)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP+ = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + NADPH + H+ [RN:R11927]
Reaction(KEGG)
Substrate
[(3S)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate [CPD:C21773];
NADP+ [CPD:C00006]
Product
(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate [CPD:C21774];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacteria Streptomyces griseus and Streptomyces coelicolor, is involved in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.
History
EC 1.3.1.113 created 2017
Orthology
K22462  (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase
Genes
SCO: SCO6267(SCAH10.32)
SMA: SAVERM_3525
SGR: SGR_6890
SGB: WQO_00735
SHY: SHJG_4002
SHO: SHJGH_3767
SDV: BN159_2281
SFI: SFUL_270
SLV: SLIV_06810
SGU: SGLAU_25505
SRW: TUE45_pSRc_0611(azoB)
 » show all
Taxonomy
Reference
1  [PMID:17277085]
  Authors
Kato JY, Funa N, Watanabe H, Ohnishi Y, Horinouchi S
  Title
Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.
  Journal
Proc Natl Acad Sci U S A 104:2378-83 (2007)
DOI:10.1073/pnas.0607472104
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.113
IUBMB Enzyme Nomenclature: 1.3.1.113
ExPASy - ENZYME nomenclature database: 1.3.1.113
BRENDA, the Enzyme Database: 1.3.1.113

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