KEGG   ENZYME: 1.3.1.117Help
Entry
EC 1.3.1.117                Enzyme                                 

Name
hydroxycinnamoyl-CoA reductase;
MdHCDBR;
hydroxycinnamoyl-CoA double bond reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
dihydro-4-coumaroyl-CoA:NADP+ 2,3-oxidoreductase
Reaction(IUBMB)
(1) dihydro-4-coumaroyl-CoA + NADP+ = trans-4-coumaroyl-CoA + NADPH + H+ [RN:R12112];
(2) dihydroferuloyl-CoA + NADP+ = trans-feruloyl-CoA + NADPH + H+ [RN:R12113]
Reaction(KEGG)
Substrate
dihydro-4-coumaroyl-CoA [CPD:C21913];
NADP+ [CPD:C00006];
dihydroferuloyl-CoA [CPD:C21914]
Product
trans-4-coumaroyl-CoA [CPD:C00223];
NADPH [CPD:C00005];
H+ [CPD:C00080];
trans-feruloyl-CoA [CPD:C00406]
Comment
Isolated from Malus X domestica (apple). Involved in dihydrochalcone biosynthesis.
History
EC 1.3.1.117 created 2018
Pathway
ec00941  Flavonoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:25152451]
  Authors
Ibdah M, Berim A, Martens S, Valderrama AL, Palmieri L, Lewinsohn E, Gang DR
  Title
Identification and cloning of an NADPH-dependent hydroxycinnamoyl-CoA double bond reductase involved in dihydrochalcone formation in Malusxdomestica Borkh.
  Journal
Phytochemistry 107:24-31 (2014)
DOI:10.1016/j.phytochem.2014.07.027
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.117
IUBMB Enzyme Nomenclature: 1.3.1.117
ExPASy - ENZYME nomenclature database: 1.3.1.117
BRENDA, the Enzyme Database: 1.3.1.117

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