KEGG   ENZYME: 1.3.1.120Help
Entry
EC 1.3.1.120                Enzyme                                 

Name
cyclohexane-1-carbonyl-CoA reductase (NADP+);
1-cyclohexenylcarbonyl-CoA reductase (ambiguous);
chcA (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
cyclohexane-1-carbonyl-CoA:NADP+ 1-oxidoreductase
Reaction(IUBMB)
cyclohexane-1-carbonyl-CoA + NADP+ = cyclohex-1-ene-1-carbonyl-CoA + NADPH + H+ [RN:R12453]
Reaction(KEGG)
Substrate
cyclohexane-1-carbonyl-CoA [CPD:C09823];
NADP+ [CPD:C00006]
Product
cyclohex-1-ene-1-carbonyl-CoA [CPD:C09811];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Streptomyces collinus, is involved in a pathway that transforms shikimate to cyclohexane-1-carbonyl-CoA by a series of dehydration and double-bond reduction steps. Most of the steps in this process occur with the carboxylic acid activated as a coenzyme A thioester. The enzyme catalyses three steps in this pathway, also acting on (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA and (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA.
History
EC 1.3.1.120 created 2019
Orthology
K23738  cyclohexane-1-carbonyl-CoA reductase (NADP+)
Reference
1  [PMID:1597409]
  Authors
Reynolds KA, Wang P, Fox KM, Speedie MK, Lam Y, Floss HG
  Title
Purification and characterization of a novel enoyl coenzyme A reductase from Streptomyces collinus.
  Journal
J Bacteriol 174:3850-4 (1992)
Reference
2  [PMID:8955309]
  Authors
Wang P, Denoya CD, Morgenstern MR, Skinner DD, Wallace KK, Digate R, Patton S, Banavali N, Schuler G, Speedie MK, Reynolds KA
  Title
Cloning and characterization of the gene encoding 1-cyclohexenylcarbonyl coenzyme A reductase from Streptomyces collinus.
  Journal
J Bacteriol 178:6873-81 (1996)
DOI:10.1128/jb.178.23.6873-6881.1996
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.120
IUBMB Enzyme Nomenclature: 1.3.1.120
ExPASy - ENZYME nomenclature database: 1.3.1.120
BRENDA, the Enzyme Database: 1.3.1.120

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