KEGG   ENZYME: 1.3.1.121
Entry
EC 1.3.1.121                Enzyme                                 
Name
4-amino-4-deoxyprephenate dehydrogenase;
cmlC (gene name);
papC (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
4-amino-4-deoxyprephenate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
4-amino-4-deoxyprephenate + NAD+ = 3-(4-aminophenyl)pyruvate + CO2 + NADH + H+ [RN:R12523]
Reaction(KEGG)
R12523
Substrate
4-amino-4-deoxyprephenate [CPD:C22210];
NAD+ [CPD:C00003]
Product
3-(4-aminophenyl)pyruvate [CPD:C21272];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacteria Streptomyces venezuelae and Streptomyces pristinaespiralis, participates in the biosynthesis of the antibiotics chloramphenicol and pristinamycin IA, respectively. cf. EC 1.3.1.12, prephenate dehydrogenase.
History
EC 1.3.1.121 created 2019
Orthology
K24002  4-amino-4-deoxyprephenate dehydrogenase
Genes
PLUplu3562
PLUMA4R40_17715
PAYPAU_01185(papC)
PTTVY86_14270
PAKHB0X70_18030
PLUICE143_18055
XDOXDD1_3340(papC)
PZAHU749_028615
PFSPFLU_1770
POIBOP93_20460
PRHLT40_00245
PUMHGP31_16685
PVWHU752_023340
PSAMHU731_009630 HU731_024775
PANHHU763_022805
PNBNK667_19975
BELBE61_78230
AGEAA314_04984
HOHHoch_1368
BLHBaLi_c05410
LGYT479_11110
MYEAB431_04565
MDXBTO20_27410
MCROMI149_04845
MIZBAB75_16515
CAUICAURIS_06030(tyrA)
CAPPCAPP_05535(tyrA)
RHARHA1_ro06105(tryA)
RERRER_18470
REYO5Y_08870
REBXU06_09105
RQIC1M55_09350
ROPROP_61620
ROAPd630_LPD02746
RPYY013_04230
RBYCEJ39_15065
RHBNY08_1915
RAVAAT18_13965
RFAA3L23_00261(tyrA_1)
RHSA3Q41_03153(tyrA_2)
RHWBFN03_03400
RRZCS378_03635
RHUA3Q40_00455(tyrA_1)
RHQIM25_18435
RHODAOT96_19710
RRT4535765_02685(tyrA_1)
RCRNCTC10994_00409(tyrA_2)
RTMG4H71_16465
RKOJWS14_33270
RGOKYT97_09330
ROZCBI38_20245
RPSKJWS13_10690
RGORNMQ04_11255
RHOPD8W71_12785
RHOORA302_09260
RHOUKZJ41_14990
REQREQ_23840
GORKTR9_2684
GTABCM27_14230
GRUGCWB2_10445(tyrA)
GAVC5O27_17100
GODGKZ92_10150
GHNMVF96_13970
GAMIIHQ52_13390
SVESVEN_0919
SPRISPRI_0305 SPRI_7048
SPLULK06_027065
SPUNBFF78_28825
SSPODDQ41_19520
SSEOD0Z67_01870
SHUNDWB77_07153(tyrA_3)
SPRACP972_04200
SXNIAG42_36280
RTEGSU10_09880
NGVCDO52_20860
MHAIOHB01_07945
SACGFDZ84_35425
PBROHOP40_07855
APRECNX65_18305
SSYIEKG83_30650
RUBGBA63_19860
CYCPCC7424_4586
 » show all
Reference
1  [PMID:9044253]
  Authors
Blanc V, Gil P, Bamas-Jacques N, Lorenzon S, Zagorec M, Schleuniger J, Bisch D, Blanche F, Debussche L, Crouzet J, Thibaut D
  Title
Identification and analysis of genes from Streptomyces pristinaespiralis encoding enzymes involved in the biosynthesis of the 4-dimethylamino-L-phenylalanine precursor of pristinamycin I.
  Journal
Mol Microbiol 23:191-202 (1997)
DOI:10.1046/j.1365-2958.1997.2031574.x
  Sequence
Reference
2  [PMID:11577160]
  Authors
He J, Magarvey N, Piraee M, Vining LC
  Title
The gene cluster for chloramphenicol biosynthesis in Streptomyces venezuelae ISP5230 includes novel shikimate pathway homologues and a monomodular non-ribosomal peptide synthetase gene.
  Journal
Microbiology 147:2817-29 (2001)
DOI:10.1099/00221287-147-10-2817
  Sequence
[sve:SVEN_0919]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.121
IUBMB Enzyme Nomenclature: 1.3.1.121
ExPASy - ENZYME nomenclature database: 1.3.1.121
BRENDA, the Enzyme Database: 1.3.1.121

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