KEGG   ENZYME: 1.3.1.121Help
Entry
EC 1.3.1.121                Enzyme                                 

Name
4-amino-4-deoxyprephenate dehydrogenase;
cmlC (gene name);
papC (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-amino-4-deoxyprephenate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
4-amino-4-deoxyprephenate + NAD+ = 3-(4-aminophenyl)pyruvate + CO2 + NADH + H+ [RN:R12523]
Reaction(KEGG)
Substrate
4-amino-4-deoxyprephenate [CPD:C22210];
NAD+ [CPD:C00003]
Product
3-(4-aminophenyl)pyruvate [CPD:C21272];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacteria Streptomyces venezuelae and Streptomyces pristinaespiralis, participates in the biosynthesis of the antibiotics chloramphenicol and pristinamycin IA, respectively. cf. EC 1.3.1.12, prephenate dehydrogenase.
History
EC 1.3.1.121 created 2019
Orthology
K24002  4-amino-4-deoxyprephenate dehydrogenase
Genes
PLU: plu3562
PLUM: A4R40_17715
PAY: PAU_01185(papC)
PTT: VY86_14270
XDO: XDD1_3340(papC)
RBD: ALSL_2131
PFS: PFLU_1770
POI: BOP93_20460
PRH: LT40_00245
AGE: AA314_04984
HOH: Hoch_1368
RHA: RHA1_ro06105(tryA)
RER: RER_18470
REY: O5Y_08870
ROP: ROP_61620
REQ: REQ_23840
RHB: NY08_1915
RFA: A3L23_00261(tyrA_1)
RHS: A3Q41_03153(tyrA_2)
RHU: A3Q40_00455(tyrA_1)
RRT: 4535765_02685(tyrA_1)
GOR: KTR9_2684
GRU: GCWB2_10445(tyrA)
SVE: SVEN_0919
 » show all
Taxonomy
Reference
1  [PMID:9044253]
  Authors
Blanc V, Gil P, Bamas-Jacques N, Lorenzon S, Zagorec M, Schleuniger J, Bisch D, Blanche F, Debussche L, Crouzet J, Thibaut D.
  Title
Identification and analysis of genes from Streptomyces pristinaespiralis encoding enzymes involved in the biosynthesis of the 4-dimethylamino-L-phenylalanine precursor of pristinamycin I.
  Journal
Mol Microbiol 23:191-202 (1997)
DOI:10.1046/j.1365-2958.1997.2031574.x
  Sequence
Reference
2  [PMID:11577160]
  Authors
He J, Magarvey N, Piraee M, Vining LC
  Title
The gene cluster for chloramphenicol biosynthesis in Streptomyces venezuelae ISP5230 includes novel shikimate pathway homologues and a monomodular non-ribosomal peptide synthetase gene.
  Journal
Microbiology 147:2817-29 (2001)
DOI:10.1099/00221287-147-10-2817
  Sequence
[sve:SVEN_0919]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.121
IUBMB Enzyme Nomenclature: 1.3.1.121
ExPASy - ENZYME nomenclature database: 1.3.1.121
BRENDA, the Enzyme Database: 1.3.1.121

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