Entry |
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Name |
8-oxogeranial reductase;
AmISY
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Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
(R)-8-oxocitronellyl enol:NADP+ oxidoreductase
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Reaction(IUBMB) |
(R)-8-oxocitronellyl enol + NADP+ = (6E)-8-oxogeranial + NADPH + H+
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Substrate |
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Product |
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Comment |
The enzyme, characterized from the plant Antirrhinum majus (snapdragon), is involved in biosynthesis of 7-epi-iridoids such as antirrhinoside. The enzyme catalyses the stereospecific reduction of 8-oxogeranial, forming an unstable product that in the absence of additional cylases undergoes spontaneous cyclization to (-)-cis,trans-nepetalactol. cf. EC 1.3.1.122, (S)-8-oxocitronellyl enol synthase.
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History |
EC 1.3.1.123 created 2019
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Orthology |
K23968 | 8-oxogeranial reductase |
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Reference |
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Authors |
Kries H, Kellner F, Kamileen MO, O'Connor SE |
Title |
Inverted stereocontrol of iridoid synthase in snapdragon. |
Journal |
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Sequence |
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Reference |
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Authors |
Lichman BR, O'Connor SE, Kries H |
Title |
Biocatalytic Strategies towards [4+2] Cycloadditions. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.3.1.123 |
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