KEGG   ENZYME: 1.3.1.124
Entry
EC 1.3.1.124                Enzyme                                 

Name
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing];
SPS19 (gene name);
DECR1 (gene name);
DECR2 (gene name);
Delta2,Delta4-dienoyl-CoA reductase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(3E)-3-enoyl-CoA:NADP+ 4-oxidoreductase
Reaction(IUBMB)
(1) a (3E)-3-enoyl-CoA + NADP+ = a (2E,4E)-2,4-dienoyl-CoA + NADPH + H+ [RN:R12629];
(2) a (3E)-3-enoyl-CoA + NADP+ = a (2E,4Z)-2,4-dienoyl-CoA + NADPH + H+ [RN:R12630]
Reaction(KEGG)
R12629 R12630
Substrate
(3E)-3-enoyl-CoA [CPD:C05067];
NADP+ [CPD:C00006]
Product
(2E,4E)-2,4-dienoyl-CoA [CPD:C04512];
NADPH [CPD:C00005];
H+ [CPD:C00080];
(2E,4Z)-2,4-dienoyl-CoA [CPD:C22258]
Comment
This enzyme, characterized from eukaryotic organisms, catalyses the reduction of either (2E,4E)-2,4-dienoyl-CoA or (2E,4Z)-2,4-dienoyl-CoA to (3E)-3-enoyl-CoA. The best substrates for the enzyme from bovine liver have a chain-length of 8 or 10 carbons. Mammals possess both mitochondrial and peroxisomal variants of this enzyme. cf. EC 1.3.1.34, 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing].
History
EC 1.3.1.124 created 2020
Orthology
K13236  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
K13237  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], peroxisomal
Genes
HSA: 1666(DECR1) 26063(DECR2)
PTR: 100608945 112204143 736777(DECR1)
PPS: 100985245(DECR1) 100989760(DECR2)
GGO: 101126321(DECR1) 101152371(DECR2)
PON: 100172330(DECR2) 100448925(DECR1)
NLE: 100585734(DECR1) 100585845(DECR2)
MCC: 695540(DECR2) 696035(DECR1)
MCF: 102144225(DECR1) 102145768(DECR2)
CSAB: 103225407(DECR2) 103237099(DECR1)
CATY: 105572964(DECR1) 105574485(DECR2)
PANU: 100137284(DECR2) 101007820(DECR1)
RRO: 104654648(DECR1) 104676958(DECR2)
RBB: 108521129(DECR2) 108526907(DECR1)
TFN: 117079485(DECR1) 117097911(DECR2)
CJC: 100393816(DECR2) 100400830(DECR1)
SBQ: 101032159(DECR1) 101050434(DECR2)
MMUR: 105856269(DECR2) 105870550(DECR1)
MMU: 26378(Decr2) 67460(Decr1)
MCAL: 110284239(Decr2) 110293087(Decr1)
MPAH: 110338200(Decr2) 110338860(Decr1)
RNO: 117543(Decr1) 64461(Decr2)
MCOC: 116078584(Decr2) 116088046(Decr1)
MUN: 110545064(Decr1) 110548715(Decr2)
CGE: 100753128(Decr1) 100759323(Decr2)
PLEU: 114681238(Decr2) 114694598(Decr1)
NGI: 103729535(Decr1) 103752377(Decr2)
HGL: 101720323(Decr2) 101721782(Decr1)
CCAN: 109681383 109690121(Decr1) 109694652(Decr2)
OCU: 100352241(DECR1) 103347237(DECR2)
TUP: 102471220(DECR2) 102475445(DECR1) 102492775
CFA: 100688128(DECR2) 477938(DECR1)
VVP: 112909058(DECR2) 112914054 112930908(DECR1)
VLG: 121486921(DECR2) 121498775(DECR1)
AML: 100473271(DECR2) 100481266(DECR1)
UMR: 103661415(DECR1) 103668732(DECR2)
UAH: 113245374(DECR2) 113252959(DECR1)
ORO: 101375736(DECR1) 101376230(DECR2)
MPUF: 101687475(DECR1) 101694106(DECR2)
EJU: 114213514(DECR1) 114215739(DECR2)
MLX: 118014999(DECR1) 118021655(DECR2)
FCA: 101087299(DECR1) 101088540(DECR2)
PTG: 102950586(DECR1) 102970768(DECR2)
PPAD: 109259629(DECR2) 109269462(DECR1)
AJU: 106977360(DECR2) 106984789(DECR1)
HHV: 120225181(DECR2) 120237333(DECR1)
BTA: 509952(DECR1) 768256(DECR2)
BOM: 102267072(DECR2) 102276962(DECR1)
BIU: 109568554(DECR1) 109578698(DECR2)
BBUB: 102392805(DECR2) 102404940(DECR1)
CHX: 102186732(DECR2) 102191818(DECR1)
OAS: 101110109(DECR2) 101115040(DECR1)
ODA: 120854962(DECR2) 120878512(DECR1)
SSC: 100524368(DECR2) 503544(DECR1)
CFR: 102506320(DECR1) 102522579(DECR2)
CDK: 105087539(DECR1) 105098427(DECR2)
BACU: 103003311(DECR2) 103018125(DECR1)
LVE: 103083575(DECR2) 103090523(DECR1)
OOR: 101271181(DECR2) 101276216(DECR1)
DLE: 111180437(DECR1) 111185099(DECR2)
PCAD: 102982907(DECR1) 102984684(DECR2) 112063138
ECB: 100053423(DECR1) 100065146(DECR2)
EPZ: 103543686 103564116(DECR2)
EAI: 106836165(DECR2) 106838975(DECR1)
MYB: 102239975(DECR1) 102249531(DECR2)
MYD: 102760553(DECR2) 102770411(DECR1)
MMYO: 118652899(DECR2) 118670476(DECR1)
MNA: 107526478(DECR1) 107545463(DECR2)
HAI: 109385940(DECR2) 109387599(DECR1)
DRO: 112298258(DECR2) 112310308(DECR1)
SHON: 118978854(DECR2) 118989287(DECR1)
AJM: 119058255(DECR2) 119060054(DECR1)
MMF: 118631588(DECR1) 118642269(DECR2)
PALE: 102877745(DECR2) 102882014(DECR1)
RAY: 107506135(DECR2) 107507471(DECR1)
MJV: 108384590(DECR2) 108394802(DECR1)
LAV: 100664822(DECR1) 100676256(DECR2)
MDO: 100020025(DECR2) 100029422(DECR1)
SHR: 100915519(DECR1) 100924629(DECR2)
PCW: 110203269(DECR1) 110221885(DECR2)
OAA: 100076917(DECR1) 100078257(DECR2)
GGA: 100858408(DECR2) 420218(DECR1)
PCOC: 116227594(DECR1) 116230281(DECR2)
MGP: 100542270(DECR1) 100544413(DECR2)
CJO: 107310389(DECR1) 107320900(DECR2)
NMEL: 110394082(DECR1) 110405763(DECR2)
APLA: 101794432(DECR2) 101800525(DECR1)
ACYG: 106030535(DECR1) 106033348(DECR2)
TGU: 100190086(DECR1) 100223602(DECR2)
LSR: 110477426(DECR1) 110482682(DECR2)
SCAN: 103813424(DECR1) 103817937(DECR2)
PMOA: 120495776(DECR1) 120512925(DECR2)
GFR: 102031386(DECR1) 102041641(DECR2)
FAB: 101810228(DECR1) 101811791(DECR2)
PHI: 102099571(DECR2) 102100338(DECR1)
PMAJ: 107199912(DECR1) 107211421(DECR2)
CCAE: 111924567(DECR1) 111936243(DECR2)
CCW: 104684942(DECR2) 104692760(DECR1)
ETL: 114061737(DECR1) 114067200(DECR2)
FPG: 101919053(DECR2) 101923272(DECR1)
FCH: 102049751(DECR2) 102056124(DECR1)
CLV: 102091063(DECR1) 102098896(DECR2)
EGZ: 104125807(DECR1) 104127269(DECR2)
NNI: 104016406(DECR1) 104023473(DECR2)
ACUN: 113476727(DECR1) 113485712(DECR2)
PADL: 103912560(DECR2) 103917311(DECR1)
AAM: 106496198(DECR1) 106500017(DECR2)
ASN: 102367904(DECR2) 102380885(DECR1)
AMJ: 102565758(DECR2) 102571942(DECR1)
CPOO: 109313424(DECR2) 109320262(DECR1)
GGN: 109287156(DECR2) 109305025(DECR1)
PSS: 102453305(DECR2)
CMY: 102929590(DECR1) 102939334(DECR2)
CPIC: 101933439(DECR1) 101947023(DECR2)
TST: 117873644(DECR1) 117884008(DECR2)
CABI: 116833650(DECR1) 116836023(DECR2)
ACS: 100561525(decr2) 100568104(decr1)
PVT: 110089491(DECR2) 110090231(DECR1)
PBI: 103053170(DECR1) 103053628(DECR2)
PMUR: 107285746(DECR1) 107290316(DECR2)
TSR: 106540583(DECR2)
PGUT: 117668489(DECR1) 117673137(DECR2)
PMUA: 114584421(DECR2) 114600444(DECR1)
ZVI: 118090362(DECR1) 118092971(DECR2)
GJA: 107105991(DECR1) 107126196(DECR2)
XLA: 100137679(decr1.L) 443792(decr2.L)
XTR: 394884(decr2) 447965(decr1)
NPR: 108790945(DECR2) 108804496(DECR1)
DRE: 406623(decr2) 436717(decr1)
IPU: 108264653(decr2) 108270672(decr1)
PHYP: 113526897(decr1) 113533695(decr2)
EEE: 113572222(decr1) 113586569(decr2)
TRU: 101075792(decr2) 101076267(decr1)
LCO: 104919685(decr2) 104937307(decr1)
NCC: 104946354(decr2)
ELY: 117246739(decr2) 117265949(decr1)
PLEP: 121937690(decr1) 121958915(decr2)
SLUC: 116044255(decr2) 116058490(decr1)
GAT: 120811158(decr1) 120819325(decr2)
CUD: 121514327(decr1) 121527972(decr2)
MZE: 101470346(decr2) 101484990(decr1)
ONL: 100699352(decr2) 100709209(decr1)
OAU: 116319921(decr2) 116334898(decr1)
OLA: 101162249(decr2) 101168931(decr1)
OML: 112139359(decr1) 112154585(decr2)
XMA: 102231692(decr2) 102237059(decr1)
XCO: 114140124(decr1) 114149662(decr2)
XHE: 116717891(decr1) 116726581(decr2)
PRET: 103477451(decr1) 103481087(decr2)
CVG: 107084994(decr2) 107095266(decr1)
NFU: 107379237(decr1) 107388057(decr2)
KMR: 108228469(decr1) 108237227(decr2)
ALIM: 106517386(decr2) 106536744(decr1)
AOCE: 111569477(decr1) 111579698(decr2)
CSEM: 103381689(decr2) 103388041(decr1)
LCF: 108884700(decr1) 108886783(decr2)
SDU: 111220127(decr2) 111234085(decr1)
SLAL: 111649954(decr1) 111658619(decr2)
XGL: 120784411(decr1) 120794747(decr2)
HCQ: 109512151(decr1) 109526513(decr2)
BPEC: 110159721(decr2) 110172361(decr1)
MALB: 109963511(decr2) 109970890(decr1)
SASA: 106580438 106605467(decr1)
OTW: 112222869(decr1) 112223710(decr2)
OMY: 110486585(decr1) 110491617(decr2)
SALP: 111950544 111965036(decr1) 111978551(decr2)
ELS: 105019171(decr1) 105021269(decr2)
SFM: 108923861(decr2) 108940513(decr1)
PKI: 111841908(decr2) 111860660(decr1)
LOC: 102687852(decr2) 102691826(decr1)
PSPA: 121301046(decr2) 121314994(decr1)
ARUT: 117431304(decr2) 117435439(decr1)
LCM: 102356436(DECR1) 102366665(DECR2)
CMK: 103178764(decr2) 103184930(decr1)
RTP: 109913573(decr1) 109932331(decr2)
PVM: 113816958
HAME: 121863235
EAF: 111706449
VDE: 111247167
VJA: 111273806
CSCU: 111633074
CEL: CELE_F53C11.3(F53C11.3) CELE_T05C12.3(decr-1.3) CELE_W01C9.4(decr-1.2)
SPIS: 111336265
DGT: 114517200
HMG: 100208057
ATH: AT2G07640 AT3G12800(SDRB)
ALY: 9320993
CRB: 17890996
THJ: 104826329
PVY: 116137055
VRA: 106755217
VAR: 108319077
VUN: 114170705
CCAJ: 109791092
APRC: 113864488
LJA: Lj0g3v0286659.1(Lj0g3v0286659.1) Lj0g3v0286659.2(Lj0g3v0286659.2)
ADU: 107478393
AIP: 107630070
LANG: 109339361
PXB: 103933731
MNT: 112091285
CSV: 101215029
CMO: 103489636
BHJ: 120078067
MCHA: 111016706
CMAX: 111468426
CMOS: 111455238
CPEP: 111776381
HBR: 110665963
QLO: 115987299
TWL: 119987620
SLY: 101254404
SPEN: 107025337
SOT: 102605057
CANN: 107878931
NSY: 104219422
NAU: 109234111
INI: 109178098
ITR: 116019133
BVG: 104887053
SOE: 110804428
NNU: 104599664
MING: 122090015
OSA: 4336980
DOSA: Os04t0614000-01(Os04g0614000)
OBR: 102701258
BDI: 100838861
ATS: 109766461
PDA: 103713168
ATR: 18421380
MNG: MNEG_7336
APRO: F751_1204
SCE: YNL202W(SPS19)
ERC: Ecym_6446
KMX: KLMA_50587(SPS19)
NCS: NCAS_0G01600(NCAS0G01600)
NDI: NDAI_0F03580(NDAI0F03580)
TPF: TPHA_0O01750(TPHA0O01750)
TBL: TBLA_0B00350(TBLA0B00350)
TDL: TDEL_0A00890(TDEL0A00890)
KAF: KAFR_0A07740(KAFR0A07740)
CAL: CAALFM_C102270CA(CaO19.3684) CAALFM_C400830WA(SPS20)
SLB: AWJ20_246(SPS19) AWJ20_4294(SPS19)
NCR: NCU07958
NTE: NEUTE1DRAFT120724(NEUTE1DRAFT_120724)
MGR: MGG_05138
SSCK: SPSK_02618
MAW: MAC_03197
MAJ: MAA_04291
CMT: CCM_02294
MBE: MBM_09949
ANI: AN7770.2
ANG: ANI_1_444134(An15g02860)
ABE: ARB_04033
TVE: TRV_05037
PNO: SNOG_16378(SNOG_16377)
PTE: PTT_16264
CNE: CNI03790
CNB: CNBH3620
TASA: A1Q1_00949
ABP: AGABI1DRAFT115110(AGABI1DRAFT_115110)
ABV: AGABI2DRAFT196138(AGABI2DRAFT_196138)
MGL: MGL_1622
MRT: MRET_0717
PTI: PHATRDRAFT_11319(DER1)
SPAR: SPRG_02815
MSTO: MSTO_20200
 » show all
Reference
1  [PMID:729581]
  Authors
Kunau WH, Dommes P.
  Title
Degradation of unsaturated fatty acids. Identification of intermediates in the degradation of cis-4-decenoly-CoA by extracts of beef-liver mitochondria.
  Journal
Eur J Biochem 91:533-44 (1978)
DOI:10.1111/j.1432-1033.1978.tb12707.x
Reference
2  [PMID:6749495]
  Authors
Dommes V, Luster W, Cvetanovic M, Kunau WH.
  Title
Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli.
  Journal
Eur J Biochem 125:335-41 (1982)
DOI:10.1111/j.1432-1033.1982.tb06688.x
Reference
3  [PMID:9268358]
  Authors
Gurvitz A, Rottensteiner H, Kilpelainen SH, Hartig A, Hiltunen JK, Binder M, Dawes IW, Hamilton B
  Title
The Saccharomyces cerevisiae peroxisomal 2,4-dienoyl-CoA reductase is encoded by the oleate-inducible gene SPS19.
  Journal
J Biol Chem 272:22140-7 (1997)
DOI:10.1074/jbc.272.35.22140
  Sequence
[hsa:1666] [rno:117543] [sce:YNL202W]
Reference
4  [PMID:10464321]
  Authors
Geisbrecht BV, Liang X, Morrell JC, Schulz H, Gould SJ
  Title
The mouse gene PDCR encodes a peroxisomal delta(2), delta(4)-dienoyl-CoA reductase.
  Journal
J Biol Chem 274:25814-20 (1999)
DOI:10.1074/jbc.274.36.25814
  Sequence
[mmu:26378]
Reference
5  [PMID:11514237]
  Authors
De Nys K, Meyhi E, Mannaerts GP, Fransen M, Van Veldhoven PP
  Title
Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase.
  Journal
Biochim Biophys Acta 1533:66-72 (2001)
DOI:10.1016/s1388-1981(01)00141-x
  Sequence
[hsa:26063]
Reference
6  [PMID:15531764]
  Authors
Alphey MS, Yu W, Byres E, Li D, Hunter WN
  Title
Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site.
  Journal
J Biol Chem 280:3068-77 (2005)
DOI:10.1074/jbc.M411069200
  Sequence
[hsa:1666]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.124
IUBMB Enzyme Nomenclature: 1.3.1.124
ExPASy - ENZYME nomenclature database: 1.3.1.124
BRENDA, the Enzyme Database: 1.3.1.124

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