KEGG ENZYME: 1.3.1.126

ENZYME: 1.3.1.126

Entry

EC 1.3.1.126                Enzyme

Name

2-epi-5-epi-valiolone dehydrogenase;
gadusol synthase

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

2-epi-5-epi-valiolone:NAD+ 2,3-oxidoreductase

Reaction(IUBMB)

2-epi-5-epi-valiolone + NAD+ = demethylgadusol + NADH + H+ [RN:R13233]

Reaction(KEGG)

R13233

Substrate

2-epi-5-epi-valiolone [CPD:C17691];
NAD+ [CPD:C00003]

Product

demethylgadusol [CPD:C22843];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC 2.1.1.391, demethylgadusol O-methyltransferase.

History

EC 1.3.1.126 created 2023

Orthology

K27180

2-epi-5-epi-valiolone dehydrogenase / demethylgadusol O-methyltransferase

Genes

GGA:

427595

PCOC:

116239517

MGP:

100539521

LMUT:

125698928

NMEL:

110404901

APLA:

101799721

AACU:

137862361

ACYG:

106035461

CATA:

118248298

AFUL:

116493133

TGU:

100220728

SCAN:

103817204

PMOA:

120514102

OTC:

121347313

PRUF:

121350570

ATRC:

139595677

GFR:

102035220

FAB:

101811274

OMA:

130258466

PHI:

102106494

PMAJ:

107210123

CCAE:

111935282

CCW:

104683367

CBRC:

103624387

ACOE:

138117796

ETL:

114070866

ZAB:

102064640

ZLE:

135453401

ACHL:

103801836

SVG:

106850326

MMEA:

130573735

HRT:

120758375

CCIC:

134048696

FPG:

101919857

FCH:

102050380

CCRI:

104164037

NNT:

104409958

SHAB:

115614836

ACUN:

113484874

TALA:

104367530

ACHC:

115333431

HALD:

104316123

HLE:

104835325

AGEN:

126049929

HHAR:

128136610

BBUT:

142042895

GCL:

127021668

CSTI:

104552977

LDI:

104347206

MNB:

103776755

DPUB:

104308149

PPUS:

135182197

AVIT:

104267135

BRHI:

104498892

EGZ:

104132680

NNI:

104017002

PCRI:

104035598

PCAO:

104053892

PARX:

142058240

PADL:

103921829

AFOR:

103903316

CBOR:

142086021

CBOY:

140658249

MAME:

142415399

CLV:

102090989

CNIC:

135992878

MUI:

104544299

PGUU:

104465706

PLET:

104623815

EHS:

104510750

CMAC:

104477206

CUCA:

104061235

TEO:

104376371

BREG:

104642376

OHA:

104331382

CPEA:

104388117

CVF:

104285190

RTD:

128915711

CRID:

134521567

LMIC:

141749511

AAM:

106483813

AROW:

112970541

NPD:

112958683

TGT:

104568936

SCAM:

104140966

PSS:

102457357

CIZ:

142019291

CMY:

102930500

CCAY:

125640551

LKP:

140915157

NDS:

141991379

DCC:

119858417

CPIC:

101935589

TST:

117879970

CABI:

116820413

MRV:

120369035

EMQ:

137147956

ACS:

100554218

ASAO:

132766704

PVT:

110077700

SUND:

121920321

PMUA:

114590905

PRAF:

128408717

ZVI:

118080056

HCG:

128345691

XLA:	100158280(MGC147226.S)

XTR:	780086(MGC147226)

NPR:

108786178

RTEM:

120945167

ACAT:

141103000

PADS:

140336248

BBUF:

120978448

BGAR:

122943624

DTC:

141084790

DRE:	541322(zgc:113054)

SRX:	107713510 107750276

SANH:

107666963 107680730

SGH:	107584471 107599438

CCAR:

109087613 109101349

CAUA:

113050481 113096077

CGIB:

127960178 128015849

PTET:

122347014(zgc:113054)

LROH:

127167199

GRF:

141347149

OMC:

131542645

PPRM:

120491652

RKG:

130087420

MAMB:

125273456

CIDE:

127514920

CERY:

137010744

MASI:

127445878 127449111

TROS:

130557343

TDW:

130425142

MANU:

129451276

PDAB:

135769894

AMEX:

103021811

CMAO:

118808675

CHAR:

105909985

SPIL:

134092719

ASAD:

121707714

LCO:

104922195

NCC:

104967325

TBEN:

117475566

CGOB:

115008435

GACU:

117543689

EMAC:

134883513

ELY:

117256495

EFO:

125895529

PLEP:

121957745

SLUC:

116036489

ECRA:

117943945

ESP:

116687340

PFLV:

114554302

GAT:

120835675

PPUG:

119229406

AFB:

129105645

CLUM:

117731046

PSWI:

130208772(zgc:113054)

CANA:

137796798

CVE:

137870638

MSAM:

119885941

SCHU:

122865549

EARM:

139283476

CUD:

121507503

SPUL:

138606383

LMIX:

132977723

HTC:

141798457

ALAT:

119021886

ASTR:

137595607

PKLU:

139219794

MZE:	101474366(zgc:113054)

ONL:

100697673

OAU:

116312425

OLA:

101163242

OML:

112145089

CSAI:

133448921

XMA:

102222561

XCO:

114147841

XHE:

116710902

PRET:

103465591

PFOR:

103129385

GAF:

122834118

PPRL:

129353592

CVG:

107082361

CTUL:

119783617

GMU:

124857128

NFU:

107385807

KMR:

108247579

ALIM:

106518257

LTU:

140303880

AOCE:

111566138

EJA:

138206942

BFRE:

138630297

MCEP:

125007378

CSEM:

103386309

POV:

109629028

SSEN:

122768789

SSOE:

131461100(zgc:113054)

HHIP:

117762039

HSP:

118105524

PPLT:

128456920

SMAU:

118309765

LCF:

108898864

SDU:

111221906

SLAL:

111668680

XGL:

120783458

BPEC:

110170265

ENY:

140365462

BSPL:

114856131

SJO:

128355230

SSCO:

134003038

TTY:

137182038

GMH:

115557687

SASA:

106565741

STRU:

115207553

OTW:

112220213

OMY:

110494595

OGO:

124003812

ONE:

115143400

OKI:

109898094

OKE:

118388340

OMM:

135540223

OCLA:

139371284

SALP:

111969388

SNH:

120060128

SFON:

129851126

CCLU:

121575039

ELS:

105017436

OEP:

134022152

SFM:

108923381

LOC:

102695979

ARUT:

117963408

AFRA:

136030892

LLON:

135502120 135502121 135502122

CSL:	COCSUDRAFT_55647

AAF:	AURANDRAFT_30097

» show all

Reference

1 [PMID:25965179]

Authors

Osborn AR, Almabruk KH, Holzwarth G, Asamizu S, LaDu J, Kean KM, Karplus PA, Tanguay RL, Bakalinsky AT, Mahmud T.

Title

De novo synthesis of a sunscreen compound in vertebrates.

Journal

Elife 4:05919 (2015)
DOI:10.7554/eLife.05919

Sequence

[dre:541322]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.1.126

IUBMB Enzyme Nomenclature:

1.3.1.126

ExPASy - ENZYME nomenclature database:

1.3.1.126

BRENDA, the Enzyme Database:

1.3.1.126

All links

Gene (152)   
   MGENES (152)   
All databases (152)   

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