KEGG   ENZYME: 1.3.1.15
Entry
EC 1.3.1.15                 Enzyme                                 
Name
dihydroorotate dehydrogenase (NADP+);
orotate reductase;
dihydro-orotic dehydrogenase;
L-5,6-dihydro-orotate:NAD+ oxidoreductase;
orotate reductase (NADPH)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-dihydroorotate:NADP+ oxidoreductase
Reaction(IUBMB)
(S)-dihydroorotate + NADP+ = orotate + NADPH + H+ [RN:R01866]
Reaction(KEGG)
R01866
Substrate
(S)-dihydroorotate [CPD:C00337];
NADP+ [CPD:C00006]
Product
orotate [CPD:C00295];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Binds FMN and FAD [2]. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NAD+ (EC 1.3.1.14) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor .
History
EC 1.3.1.15 created 1972, modified 2011
Reference
1  [PMID:4380263]
  Authors
Taylor WH, Taylor ML, Eames DF.
  Title
Two functionally different dihydroorotic dehydrogenases in bacteria.
  Journal
J Bacteriol 91:2251-6 (1966)
DOI:10.1128/JB.91.6.2251-2256.1966
Reference
2  [PMID:13923427]
  Authors
UDAKA S, VENNESLAND B
  Title
Properties of triphosphopyridine nucleotide-linked dihydroorotic dehydrogenase.
  Journal
J Biol Chem 237:2018-24 (1962)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.15
IUBMB Enzyme Nomenclature: 1.3.1.15
ExPASy - ENZYME nomenclature database: 1.3.1.15
BRENDA, the Enzyme Database: 1.3.1.15
CAS: 37255-27-9

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Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (86)   
   RefSeq(nuc) (1)   
   GenBank (42)   
   EMBL (43)   
All databases (95)   

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