KEGG   ENZYME: 1.3.1.2
Entry
EC 1.3.1.2                  Enzyme                                 
Name
dihydropyrimidine dehydrogenase (NADP+);
dihydrothymine dehydrogenase;
dihydrouracil dehydrogenase (NADP+);
4,5-dihydrothymine: oxidoreductase;
DPD;
DHPDH;
dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate);
DHU dehydrogenase;
hydropyrimidine dehydrogenase;
dihydropyrimidine dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
5,6-dihydrouracil:NADP+ 5-oxidoreductase
Reaction(IUBMB)
5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ [RN:R00978]
Reaction(KEGG)
R00978;
(other) R01415 R08226
Substrate
5,6-dihydrouracil [CPD:C00429];
NADP+ [CPD:C00006]
Product
uracil [CPD:C00106];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on dihydrothymine.
History
EC 1.3.1.2 created 1961, modified 1986
Pathway
ec00240  Pyrimidine metabolism
ec00410  beta-Alanine metabolism
ec00770  Pantothenate and CoA biosynthesis
ec00983  Drug metabolism - other enzymes
ec01100  Metabolic pathways
Orthology
K00207  dihydropyrimidine dehydrogenase (NADP+)
Genes
HSA1806(DPYD)
PTR457047(DPYD)
PPS100967375(DPYD)
GGO101144752(DPYD)
PON100173131(DPYD)
NLE100604410(DPYD)
MCC715672(DPYD)
MCF102116182(DPYD)
MTHB126964310
CSAB103224388(DPYD)
CATY105590162(DPYD)
PANU100997971(DPYD)
TGE112636894(DPYD)
RRO104656399(DPYD)
RBB108514391(DPYD)
TFN117076084(DPYD)
PTEH111555134(DPYD)
CJC100399327(DPYD)
SBQ101050776(DPYD)
CSYR103263796
MMUR105885769(DPYD)
LCAT123635366(DPYD)
OGA100940469(DPYD)
MMU99586(Dpyd)
MCAL110291713(Dpyd)
MPAH110320876(Dpyd)
RNO81656(Dpyd)
MCOC116093698(Dpyd)
MUN110561789 110561851
CGE100765169(Dpyd)
MAUA101842442(Dpyd)
PLEU114700463(Dpyd)
MORG121445675(Dpyd)
MFOT126512098
AAMP119801309(Dpyd)
NGI103734644(Dpyd)
HGL101704452(Dpyd) 106007540
CPOC100727906(Dpyd)
CCAN109684940(Dpyd)
DORD106000801(Dpyd)
DSP122106473(Dpyd)
NCAR124983056
OCU100356889
OPI101517804(DPYD)
TUP102480430(DPYD)
CFA479935(DPYD)
CLUD112640799(DPYD)
VVP112918343(DPYD)
VLG121487181(DPYD)
AML100466550(DPYD)
UMR103669348(DPYD)
UAH113254371(DPYD)
UAR123795180(DPYD)
ELK111142998
LLV125098417
MPUF101693928(DPYD)
ORO101365435(DPYD)
EJU114207889(DPYD)
ZCA113935827(DPYD)
MLX118019104(DPYD)
NSU110580563(DPYD)
LWW102728785(DPYD)
FCA101084380(DPYD)
PYU121027529(DPYD)
PBG122480812(DPYD)
LRUF124515401
PPAD109271896(DPYD)
AJU106968124(DPYD)
HHV120229445(DPYD)
BTA281124(DPYD)
BOM102267734(DPYD)
BIU109556033(DPYD)
BBUB102407735(DPYD)
CHX102181553(DPYD)
OAS101109311(DPYD)
ODA120856824(DPYD)
CCAD122436655(DPYD)
SSC397109(DPYD)
CFR102504040(DPYD)
CBAI105065339(DPYD)
CDK105085122(DPYD)
VPC102524977(DPYD)
BACU103009948(DPYD)
LVE103085271(DPYD)
OOR101279013(DPYD)
DLE111164012(DPYD)
PCAD102986090(DPYD)
PSIU116753023(DPYD)
ECB100057177(DPYD)
EPZ103540156(DPYD)
EAI106828119(DPYD)
MYB102257347
MYD102754526(DPYD)
MMYO118673617(DPYD)
MLF102434586
MNA107530660(DPYD)
PKL118727125(DPYD)
HAI109386016(DPYD)
DRO112313689(DPYD)
SHON118990649(DPYD)
AJM119054992(DPYD)
PDIC114489423(DPYD)
PHAS123804405(DPYD)
MMF118637328(DPYD)
RFQ117014653(DPYD)
PALE102878429(DPYD)
PGIG120607821(DPYD)
PVP105305987(DPYD)
RAY107517295
MJV108392517
TOD119235158(DPYD)
SARA101541274(DPYD)
LAV100676827(DPYD)
TMU101360586
ETF101648630(DPYD)
DNM101444218(DPYD)
MDO100032923(DPYD)
GAS123243930(DPYD)
SHR100930277(DPYD)
PCW110217286(DPYD)
OAA100077139(DPYD)
GGA429083(DPYD)
PCOC116243498(DPYD)
MGP100538897
CJO107317539(DPYD)
NMEL110402541(DPYD)
APLA101793833(DPYD)
ACYG106039427(DPYD)
AFUL116491841(DPYD)
TGU100222559(DPYD)
LSR110467965(DPYD)
SCAN103815131(DPYD)
PMOA120506502(DPYD)
OTC121345174(DPYD)
PRUF121362166(DPYD)
GFR102041285(DPYD)
FAB101814169(DPYD)
PHI102101448(DPYD)
PMAJ107208013(DPYD)
CCAE111932636(DPYD)
CCW104695364(DPYD)
CBRC103612770(DPYD)
ETL114055644(DPYD)
ZAB102066238(DPYD)
ACHL103810492(DPYD)
FPG101911279(DPYD)
FCH102050877(DPYD)
CLV102092031(DPYD)
EGZ104134025(DPYD)
NNI104015600(DPYD)
ACUN113482868(DPYD)
TALA104359316(DPYD)
PADL103925182(DPYD)
AFOR103908151(DPYD)
ACHC115349370(DPYD)
HALD104324167(DPYD)
HLE104841242(DPYD)
AGEN126041986
GCL127019091
CCRI104159053(DPYD)
CSTI104560643(DPYD)
LDI104345914(DPYD)
MNB103772264(DPYD)
OHA104332593(DPYD)
NNT104408106(DPYD)
DPUB104309713
ACAR104520410(DPYD)
CPEA104396872(DPYD)
AVIT104270603(DPYD)
CVF104286331(DPYD)
CUCA104061582(DPYD)
AAM106499764(DPYD)
AROW112961947(DPYD)
NPD112946230(DPYD)
TGT104573512 104577998(DPYD)
DNE112979780(DPYD)
SCAM104151256(DPYD)
ASN102371859(DPYD)
AMJ102574438(DPYD)
CPOO109307260(DPYD)
GGN109286864(DPYD)
PSS102451891(DPYD)
CMY102931992(DPYD)
CPIC101944618
TST117881664(DPYD)
CABI116826931
MRV120370087(DPYD)
ACS100566998(dpyd)
PVT110083089(DPYD)
PBI103065336
PMUR107284500(DPYD)
CTIG120306487(DPYD)
TSR106550261(DPYD)
PGUT117677212(DPYD)
VKO123024534(DPYD)
PMUA114598746(DPYD)
ZVI118089265(DPYD)
GJA107121000
STOW125433140(DPYD)
XLA447312(dpyd.L)
XTR734021(dpyd)
NPR108795821(DPYD)
RTEM120945656(DPYD)
BBUF120978613(DPYD)
BGAR122944045(DPYD)
DRE405829(dpydb)
SRX107710600(dpyd) 107712781 107718148 107739013
SANH107677268 107677757 107700576(dpyd)
SGH107570487 107589900 107590279 107594652(dpyd)
CCAR109078535
CAUA113045497 113045498 113093832 113115806
PPRM120478773(dpyda.1) 120483195(dpydb)
MAMB125250007(dpydb) 125258450(dpyda.1)
IPU108268608(dpyda.1)
PHYP113533990(dpyd)
SMEO124383889(dpyda.1)
TFD113644504(dpyda.1)
AMEX103045749(dpyd)
EEE113581184(dpyd)
TRU101067586(dpyd)
TNGGSTEN00010070G001
LCO104933920(dpyd)
NCC104943349
CGOB115022154
ELY117272060(dpydb)
EFO125902709(dpydb)
PLEP121951329(dpydb)
SLUC116057757(dpydb)
ECRA117954432(dpydb)
ESP116699029(dpyd)
PFLV114565059(dpyd)
GAT120816280(dpydb)
PPUG119209265(dpydb)
MSAM119902592(dpydb)
ALAT119010710(dpydb)
MZE101482026(dpyd)
ONL100689784(dpyd)
OAU116316784(dpydb)
OLA101175598(dpyd)
OML112147590(dpydb)
XMA102231146(dpyd)
XCO114146947(dpyd)
XHE116722177(dpyd)
PRET103479304(dpyd)
PFOR103146989(dpyd)
PLAI106951348(dpyd)
PMEI106917803(dpyd)
GAF122841104(dpydb)
CVG107088605(dpyd)
CTUL119774143(dpydb)
GMU124869881(dpydb)
NFU107384175(dpyd)
KMR108239550(dpydb)
ALIM106524919(dpyd)
NWH119414399(dpydb)
AOCE111582266(dpyd)
MCEP125010506(dpydb)
CSEM103396555(dpyd)
POV109645501(dpyd)
SSEN122777477(dpydb)
HHIP117777907(dpydb)
HSP118117321(dpydb)
LCF108884496(dpydb)
SDU111239137(dpyd)
SLAL111650603(dpyd)
XGL120799301(dpydb)
HCQ109515477(dpyd)
BPEC110170438(dpyd)
MALB109974739(dpyd)
BSPL114844095(dpydb)
SASA106568897 106578501 106598776(dpyd)
STRU115153181 115156802
OTW112215544 112260360(dpydb)
OMY110530943 110535495
OGO123991186 124009398
ONE115105060 115114290
SALP111956525 111973028
SNH120028105 120055832(dpydb)
CCLU121535103 121549908
ELS105022585(dpyd)
SFM108935471(dpyd)
PKI111840098(dpyd)
AANG118225829(dpyda.1)
LOC102688311(dpyd)
PSPA121330800
ARUT117411703
PSEX120514913
LCM102354352
CMK103174634
RTP109913919
BFO118431860
BBEL109476104
CIN100175681
SCLV120345830
SPU575768
APLC110980146
AJC117125056
SKO100374659
DMEDmel_CG2194(su(r))
DER6549848
DSE6619786
DSIDsimw501_GD16077(Dsim_GD16077)
DYADyak_GE17405
DAN6501864
DSR110184122
DPO4815980
DPE6599960
DMN108153085
DWI6644270 6648584
DGR6569257
DMODmoj_GI15089
DAZ108619914
DNV108656597
DHE111603165
DVI6632051
CCAT101450268
BOD106615762 106615819
RZE108375880 108378517
MDE101887760
SCAC106087485
LCQ111674770
LSQ119599940
HIS119657313
AGAAgaP_AGAP001021
ACOZ120948807
AARA120905824
ASTE118503252
AAG5573038
AALB109402631
CQUCpipJ_CPIJ005573
CPII120414164
CNS116339648
BCOO119067419
AME410207
ACER107999506
ALAB122711986
BIM100744411
BBIF117209555
BVK117234475
BVAN117158485
BTER100643616
BPYO122571955
CCAL108622367
OBB114871645 114871653
MGEN117220129
NMEA116433702
CGIG122401837
SOC105204110
MPHA105836825
AEC105155075
ACEP105622942
PBAR105429684
VEM105560073
HST105186354
DQU106743935
CFO105255244
FEX115241278
LHU105669833
PGC109853586
OBO105276392
PCF106791840
PFUC122515924
VPS122635062
NVI100121034
CSOL105368293
TPRE106651903
MDL103573726
CGLO123267743
FAS105269602
DAM107043147
AGIF122852998
CINS118071515
LHT122499775
CCIN107267822
TCA658821
DPA109544561
SOY115884525
ATD109603754
CSET123309767
AGB108909620
LDC111508839
NVL108558313
APLN108737067
PPYR116174196 116178541
OTU111423597
BMOR101737414
BMAN114240581
MSEX115442784
DPLKGM_210796
BANY112053762
NIQ126770493
PMAC106717531
PPOT106107272
PXU106119011
PRAP111001391
PBX123708047
PNAP125049803
ZCE119832193
CCRC123695861
HAW110372024
HZE124633524
TNL113494686
SLIU111359355
OFU114365800
PXY105384082 105396948
CFEL113372142
API100163680
DNX107161427
AGS114132804
RMD113556253
BTAB109030148
DCI103509433
CLEC106664100
HHAL106680075
NLU111062651
PHUPhum_PHUM424200
FOC113207093
TPAL117645229
ZNE110834090
CSEC111869516
SGRE126297821
FCD110856813
DPXDAPPUDRAFT_202177
DMK116924817
DPZ124344567
PVM113812764
PJA122260966
PCHN125047532
HAME121868183
PCLA123771880
PTRU123498405
HAZT108672582
EAF111704528 111704529
LSM121122479
PPOI119091423
ISCIscW_ISCW022746
DSV119433732
RSAN119404573
RMP119181419
VDE111243771
VJA111262198
TUT107361163
DPTE113799579
DFR124494592
CSCU111641327
SDM118196045
CELCELE_C25F6.3(dpyd-1)
CBRCBG_14689(Cbr-dpyd-1)
NAINECAME_11849
HROHELRODRAFT_69873
LGILOTGIDRAFT_233044
PCAN112573163
BGT106050444
GAE121375609
HRF124138758
HRJ124285860
CRG105346767
MYI110451490
PMAX117325208
MMER123524345
OBI106882744
OSN115223777
LAK106175633 106175638 106178467
OVIT265_12739
EGLEGR_09764
NVE5507598
EPA110236321
ATEN116293513
ADF107328165 107354002
AMIL114961385
PDAM113664131
SPIS111320636
DGT114527864
XEN124434293
AQU100641502
ATHAT3G17810(PYD1)
ALY9321297
CRB17893581
CSAT104746129 104765626 104782634
EUSEUTSA_v10020777mg
BRP103839011 103869649
BNA106347415 106427199 106429281 106435966 106452022
BOE106293455 106343135
RSZ108812448 108835351 108856752 108858907
THJ104820334
CPAP110823211
CIT102610369
CICCICLE_v10020301mg
PVY116137926
MINC123195509 123204472
TCC18604415
GRA105800046
GHI107890863 121206239
GAB108457198
DZI111282270 111311393
EGR104425851
GMX100804632 100818990
GSJ114368747 114418704
PVUPHAVU_004G148000g
VRA106775408
VAR108346000
VUN114182264
CCAJ109787752
APRC113867276
MTR11414639
CAM101500819
PSAT127102535
LJALj2g3v0658080.1(Lj2g3v0658080.1) Lj2g3v0658080.2(Lj2g3v0658080.2)
ADU107490600
AIP107644107
AHF112750889 112802382
LANG109343061
FVE101301107
RCN112179054
PPER18777397
PMUM103338666
PAVI110746662
PDUL117627838
MDM103438108 114820973
PXB103946911 103950551
ZJU107408650
MNT21402274
CSV101202899
CMO103504066
BHJ120083488
MCHA111009064
CMAX111489957 111495821
CMOS111431318 111457127
CPEP111783149 111802736
RCU8284766
JCU105646380
HBR110647320
MESC110617610
POP18105605 7486698
PEU105110421 105142036
PALZ118057291
JRE108983065 108993229
QSU112004318
QLO115965329
TWL119987056
VVI100249021
VRI117904210
SLY543719(PYD1A)
SPEN107015267
SOT102599024
SSTN125858091
CANN107862856
NTA107809767 107809801
NSY104250053
NTO104118980
NAU109231263
INI109147604 109157123
ITR116027467
SIND105158186 105166912
OEU111405330
EGT105972396
SSPL121760203 121763093 121763637 121787038
APAN127243615
HAN110912634 110918786
ECAD122586935
LSV111903026
CCAV112510145
DCR108204559
CSIN114283006
BVG104906088
SOE110779297
CQI110699514 110706070
NNU104607306
MING122060236
TSS122656241
PSOM113310494 113322337
OSA4330657
DOSAOs02t0736400-01(Os02g0736400)
OBR102714808
BDI100844077
ATS109755593
TDC119317803 119322547
TAES123128329 123138178 123145434
TUA125514550
LPER127306200
SBI8068612
ZMA100274265
SITA101776256
SVS117837261
PVIR120641111 120657171
PHAI112878734
PDA103706801 103723740 120106106
EGU105042108 105053171
MUS103995258
ZOF122052057 122056573
DCT110098369
PEQ110029968
AOF109823934
NCOL116262078
ATR18439578
SMOSELMODRAFT_80950 SELMODRAFT_88846
PPP112272917 112275905
CRECHLRE_13g578750v5
VCNVOLCADRAFT_80405
MNGMNEG_4561
CSLCOCSUDRAFT_18241
CVRCHLNCDRAFT_31559 CHLNCDRAFT_55724
APROF751_5402
MISMICPUN_109450
DDIDDB_G0267966(pyd1)
DPPDICPUDRAFT_94040
DFADFA_11424(pyd1)
EHIEHI_012980(14.t00017)
EDIEDI_044620
EIVEIN_151150
ACANACA1_192070
TETTTHERM_01250100
PTMGSPATT00007208001
NGRNAEGRDRAFT_78714
TVATVAG_2v0073560
MBDMEBOL_006458
CFUSCYFUS_005391
AAGGETAA8_48610(preA)
LPAVPLANPX_2064
AMUCPan181_21750(preA)
PNDPla175_14190(preA)
CACICLOAM1631
 » show all
Reference
1  [PMID:13825299]
  Authors
FRITZSON P.
  Title
Properties and assay of dihydrouracil dehydrogenase of rat liver.
  Journal
J Biol Chem 235:719-25 (1960)
Reference
2  [PMID:7451435]
  Authors
Shiotani T, Weber G.
  Title
Purification and properties of dihydrothymine dehydrogenase from rat liver.
  Journal
J Biol Chem 256:219-24 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.2
IUBMB Enzyme Nomenclature: 1.3.1.2
ExPASy - ENZYME nomenclature database: 1.3.1.2
BRENDA, the Enzyme Database: 1.3.1.2
CAS: 9029-01-0

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