Entry |
|
Name |
dihydropyrimidine dehydrogenase (NADP+);
dihydrothymine dehydrogenase;
dihydrouracil dehydrogenase (NADP+);
4,5-dihydrothymine: oxidoreductase;
DPD;
DHPDH;
dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate);
DHU dehydrogenase;
hydropyrimidine dehydrogenase;
dihydropyrimidine dehydrogenase (NADP)
|
Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
5,6-dihydrouracil:NADP+ 5-oxidoreductase
|
Reaction(IUBMB) |
5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ [RN: R00978]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
|
Comment |
Also acts on dihydrothymine.
|
History |
EC 1.3.1.2 created 1961, modified 1986
|
Pathway |
ec00770 | Pantothenate and CoA biosynthesis |
ec00983 | Drug metabolism - other enzymes |
|
Orthology |
K00207 | dihydropyrimidine dehydrogenase (NADP+) |
|
Genes |
HGL: | 101704452(Dpyd) 106007540 |
TGT: | 104573512 104577998(DPYD) |
DRE: | 405829(dpydb) 768165(dpyda.1) |
SRX: | 107710600(dpyd) 107712781 107718148 107739013 |
SANH: | 107677268 107677757 107700576(dpyd) |
SGH: | 107570487 107589900 107590279 107594652(dpyd) |
CAUA: | 113045497 113045498 113093832 113115806 |
CGIB: | 127946544 127951434 128027277 |
PTET: | 122330059(dpyda.1) 122360317(dpydb) |
LROH: | 127156007(dpyda.1) 127175303(dpydb) |
OMC: | 131532634(dpydb) 131533613(dpyda.1) |
PPRM: | 120478773(dpyda.1) 120483195(dpydb) |
RKG: | 130084063(dpyda.1) 130089583(dpydb) |
MAMB: | 125250007(dpydb) 125258450(dpyda.1) |
CIDE: | 127495656 127505764 127524791 |
CERY: | 137003017(dpydb) 137014448(dpyda.1) |
MASI: | 127440388 127442398 |
TROS: | 130546673(dpyda.1) 130554329(dpydb) |
TDW: | 130412839(dpyda.1) 130417895(dpydb) |
CHAR: | 105889391(dpyda.1) 105910742(dpydb) |
SASA: | 106568897 106578501 106598776(dpyd) |
STRU: | 115153181 115156802 |
OTW: | 112215544 112260360(dpydb) |
OKI: | 109875091 109909978(dpyd) |
OKE: | 118361160 118402232(dpydb) |
SALP: | 111956525 111973028 |
SNH: | 120028105 120055832(dpydb) |
CCLU: | 121535103 121549908 |
DSI: | Dsimw501_GD16077(Dsim_GD16077) |
PPYR: | 116174196 116178541 |
LPOL: | 106459229 106463815 |
CEL: | CELE_C25F6.3(dpyd-1) |
CBR: | CBG_14689(Cbr-dpyd-1) |
LAK: | 106175633 106175638 106178467 |
CSAT: | 104746129 104765626 104782634 |
BNA: | 106347415 106427199 106429281 106435966 106452022 |
RSZ: | 108812448 108835351 108856752 108858907 130494369 |
MINC: | 123195509 123204472 |
HSYR: | 120192070 120209384 |
QSA: | O6P43_005228 O6P43_008460 |
MSYL: | 126599834 126626756 |
CMAX: | 111489957 111495821 |
CMOS: | 111431318 111457127 |
CPEP: | 111783149 111802736 |
CILL: | 122296362 122299761 |
SIND: | 105158186 105166912 |
SSPL: | 121760203 121763093 121763637 121787038 |
SHIS: | 125200982 125214107 |
PSOM: | 113310494 113322337 |
TAES: | 123128329 123138178 123145434 |
MFLO: | 136464399 136478039 |
PVIR: | 120641111 120657171 |
PAUA: | 133921291 133931441 |
PDA: | 103706801 103723740 120106106 |
ACAK: | 137935281 137955034 137955812 137959166 |
SMO: | SELMODRAFT_80950 SELMODRAFT_88846 |
CVR: | CHLNCDRAFT_31559 CHLNCDRAFT_55724 |
EHI: | EHI_012980(14.t00017) |
» show all
|
Reference |
|
Authors |
FRITZSON P. |
Title |
Properties and assay of dihydrouracil dehydrogenase of rat liver. |
Journal |
J Biol Chem 235:719-25 (1960) |
Reference |
|
Authors |
Shiotani T, Weber G. |
Title |
Purification and properties of dihydrothymine dehydrogenase from rat liver. |
Journal |
J Biol Chem 256:219-24 (1981) |
Other DBs |
ExplorEnz - The Enzyme Database: | 1.3.1.2 |
ExPASy - ENZYME nomenclature database: | 1.3.1.2 |
BRENDA, the Enzyme Database: | 1.3.1.2 |
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