KEGG   ENZYME: 1.3.1.21
Entry
EC 1.3.1.21                 Enzyme                                 
Name
7-dehydrocholesterol reductase;
DHCR7 (gene name);
7-DHC reductase;
7-dehydrocholesterol dehydrogenase/cholesterol oxidase;
Delta7-sterol reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cholesterol:NADP+ Delta7-oxidoreductase
Reaction(IUBMB)
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ [RN:R01456]
Reaction(KEGG)
R01456;
(other) R01451 R07487 R07492
Substrate
cholesterol [CPD:C00187];
NADP+ [CPD:C00006]
Product
cholesta-5,7-dien-3beta-ol [CPD:C01164];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is part of the cholesterol biosynthesis pathway.
History
EC 1.3.1.21 created 1972, modified 2013
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00213  7-dehydrocholesterol reductase
Genes
HSA1717(DHCR7)
PTR451393(DHCR7)
PPS100977099(DHCR7)
GGO101137517(DHCR7)
PON100172090(DHCR7)
NLE100580795(DHCR7)
HMH116469128(DHCR7)
MCC106993167(DHCR7)
MCF102120769(DHCR7)
MTHB126935956
MNI105469742(DHCR7)
CSAB103243806(DHCR7)
CATY105577293(DHCR7)
PANU101010909(DHCR7)
TGE112606050(DHCR7)
MLEU105545304(DHCR7)
RRO104677122(DHCR7)
RBB108538891(DHCR7)
TFN117080058(DHCR7)
PTEH111522348(DHCR7)
CANG105503255(DHCR7)
CJC100414321(DHCR7)
SBQ101045756(DHCR7)
CIMI108294121(DHCR7)
CSYR103276625(DHCR7)
MMUR105867499(DHCR7)
LCAT123642791(DHCR7)
PCOQ105827418(DHCR7)
OGA100958422(DHCR7)
MMU13360(Dhcr7)
MCAL110298721(Dhcr7)
MPAH110322282(Dhcr7)
RNO64191(Dhcr7)
MCOC116103276(Dhcr7)
ANU117718506(Dhcr7)
MUN110546825(Dhcr7)
CGE100771700(Dhcr7)
MAUA101841305(Dhcr7)
PROB127228589(Dhcr7)
PLEU114694270(Dhcr7)
MORG121458015(Dhcr7)
MFOT126498631
AAMP119803527(Dhcr7)
NGI103725600 103740337
HGL101703035(Dhcr7)
CPOC100732833(Dhcr7)
CCAN109689788(Dhcr7)
DORD105989128(Dhcr7)
DSP122102059(Dhcr7)
PLOP125362268(Dhcr7)
NCAR124960592
MMMA107157052(Dhcr7)
OPI101520708(DHCR7)
TUP102493586(DHCR7)
GVR103608311(DHCR7)
CFA483675(DHCR7)
CLUD112663199(DHCR7)
VVP112924153(DHCR7)
VLG121472135(DHCR7)
NPO129501273(DHCR7)
AML100467495(DHCR7)
UMR103671131(DHCR7)
UAH113243974(DHCR7)
UAR123778362(DHCR7)
ELK111150224
LLV125110315
MPUF101675119(DHCR7)
MNP132017182(DHCR7)
MLK131817385(DHCR7)
NVS122913260(DHCR7)
ORO101368291(DHCR7)
EJU114220354(DHCR7)
ZCA113914040(DHCR7)
MLX118016173(DHCR7)
NSU110576068(DHCR7)
LWW102738097(DHCR7)
FCA101089143(DHCR7)
PYU121023669(DHCR7)
PCOO112852126(DHCR7)
PBG122484108(DHCR7)
LRUF124506333
PTG102956988(DHCR7)
PPAD109246918(DHCR7)
PUC125929951
AJU106982857
HHV120233856(DHCR7)
BTA514745(DHCR7)
BOM102276304(DHCR7)
BIU109554435(DHCR7)
BBUB102394070(DHCR7)
BBIS104986925(DHCR7)
CHX102171848(DHCR7)
OAS101118320(DHCR7)
BTAX128068807(DHCR7)
ODA120874155(DHCR7)
CCAD122431047(DHCR7)
MBEZ129548654(DHCR7)
SSC100627707(DHCR7)
CFR102517817(DHCR7)
CBAI105070372(DHCR7)
CDK105104565(DHCR7)
VPC102531154(DHCR7)
BACU103016099(DHCR7)
LVE103089128(DHCR7)
OOR101275459(DHCR7)
DLE111183623(DHCR7)
PCAD102989395(DHCR7)
PSIU116757385(DHCR7)
NASI112402460(DHCR7)
ECB100061433(DHCR7)
EPZ103564418(DHCR7)
EAI106822732(DHCR7)
MYD102760533(DHCR7)
MMYO118649103(DHCR7)
MLF102430939(DHCR7)
MNA107540362(DHCR7)
PKL118721873(DHCR7)
EFUS103304069(DHCR7)
HAI109389313(DHCR7)
DRO112317115(DHCR7)
SHON118998403(DHCR7)
AJM119041928(DHCR7)
PDIC114489992(DHCR7)
PHAS123829345(DHCR7)
MMF118643176(DHCR7)
RFQ117030229(DHCR7)
PPAM129068508(DHCR7)
PALE102892007(DHCR7)
PGIG120584701(DHCR7)
PVP105299505(DHCR7)
RAY107503327(DHCR7)
MJV108394434(DHCR7)
TOD119249868(DHCR7)
SARA101538567(DHCR7)
LAV100670197(DHCR7)
TMU101359219
ETF101658512(DHCR7)
DNM101444654(DHCR7)
MDO100017714(DHCR7)
GAS123251008(DHCR7)
SHR111721517(DHCR7)
AFZ127541902
PCW110197175(DHCR7)
OAA100074666(DHCR7)
GGA422982(DHCR7)
PCOC116237941(DHCR7)
MGP100550588
CJO107314280(DHCR7)
TPAI128085617(DHCR7)
LMUT125694906(DHCR7)
NMEL110401504(DHCR7)
APLA101800178(DHCR7)
ACYG106044822(DHCR7)
CATA118250723(DHCR7)
AFUL116489828(DHCR7)
TGU100230558(DHCR7)
LSR110469627(DHCR7)
SCAN103822109(DHCR7)
PMOA120509922(DHCR7)
OTC121340217(DHCR7)
PRUF121349104(DHCR7)
GFR102043315(DHCR7)
FAB101808729(DHCR7)
OMA130253895(DHCR7)
PHI102100206(DHCR7)
PMAJ107206252(DHCR7)
CCAE111930662(DHCR7)
CCW104697600(DHCR7)
CBRC103614711(DHCR7)
ETL114070759(DHCR7)
ZAB102062905(DHCR7)
ACHL103811514(DHCR7)
SVG106854794(DHCR7)
MMEA130585863(DHCR7)
HRT120754615(DHCR7)
FPG101914766(DHCR7)
FCH102053203(DHCR7)
CLV102086618(DHCR7)
EGZ104124694(DHCR7)
NNI104009409(DHCR7)
PCRI104024253(DHCR7)
PLET104613994(DHCR7)
EHS104502473(DHCR7)
PCAO104039639(DHCR7)
ACUN113481362(DHCR7)
TALA104355711(DHCR7)
PADL103925768(DHCR7)
AFOR103904920(DHCR7)
ACHC115351755(DHCR7)
HALD104310554(DHCR7)
HLE104829449(DHCR7)
AGEN126047406
GCL127016862
CCRI104159911(DHCR7)
CSTI104549146(DHCR7)
CMAC104473695(DHCR7)
MUI104545398(DHCR7)
BREG104633339(DHCR7)
FGA104069096(DHCR7)
GSTE104258466(DHCR7)
LDI104339711(DHCR7)
MNB103782539(DHCR7)
OHA104330746(DHCR7)
NNT104413771(DHCR7)
SHAB115607411(DHCR7)
DPUB104297511(DHCR7)
PGUU104463834(DHCR7)
ACAR104517992(DHCR7)
CPEA104397462(DHCR7)
AVIT104278228(DHCR7)
CVF104287535(DHCR7)
RTD128909493(DHCR7)
CUCA104062237(DHCR7)
BRHI104491072(DHCR7)
AAM106498340(DHCR7)
AROW112977240(DHCR7)
NPD112948891(DHCR7)
TGT104578016(DHCR7)
DNE112979976(DHCR7)
SCAM104152849(DHCR7)
ASN102380697(DHCR7)
AMJ106737545(DHCR7)
CPOO109321385(DHCR7)
GGN109299003(DHCR7)
PSS102459270(DHCR7)
CMY102947477(DHCR7)
CCAY125638664(DHCR7)
DCC119857194(DHCR7)
CPIC101947621(DHCR7)
TST117877048(DHCR7)
CABI116818949(DHCR7)
MRV120405135(DHCR7)
ACS100565806(dhcr7)
ASAO132769003(DHCR7)
PVT110073543(DHCR7)
SUND121918254(DHCR7)
PBI103061207(DHCR7)
PMUR107294554 107294556 107294557
CTIG120316163 120316165
PGUT117665429(DHCR7)
APRI131187160(DHCR7)
PTEX113440284(DHCR7)
NSS113410263(DHCR7)
VKO123026946(DHCR7)
PMUA114596913 114596955
PRAF128414105(DHCR7)
ZVI118085975(DHCR7)
HCG128326625(DHCR7)
GJA107121513(DHCR7)
STOW125426602(DHCR7)
EMC129324208(DHCR7)
XLA379273(dhcr7.S) 380248(dhcr7.L)
XTR394844(dhcr7)
NPR108785887(DHCR7)
RTEM120916978(DHCR7)
BBUF120980536(DHCR7)
BGAR122920404(DHCR7)
MUO115468764(DHCR7)
GSH117351951(DHCR7)
DRE378446(dhcr7)
SRX107727115(dhcr7) 107730061
SANH107679738 107686818
SGH107584736 107594471
CCAR109103437 109103439
CAUA113052398 113106502(dhcr7)
CGIB127962617
PTET122349502(dhcr7)
LROH127168962(dhcr7)
OMC131544128(dhcr7)
PPRM120492710(dhcr7)
MAMB125265762(dhcr7)
CIDE127515957
MASI127414967 127440584
TROS130555939(dhcr7)
TDW130422017(dhcr7)
MANU129451254(dhcr7)
IPU108271323
IFU128614131(dhcr7)
PHYP113536460(dhcr7)
SMEO124391053(dhcr7)
TFD113646762(dhcr7)
TVC132856584(dhcr7)
AMEX103033332(dhcr7)
CMAO118818839(dhcr7)
EEE113578447(dhcr7)
CHAR105913319(dhcr7)
TRU101071896 115251974
TFS130521643(dhcr7)
TNGGSTEN00019198G001 GSTEN00019199G001
LCO104935369(dhcr7)
TBEN117471551(dhcr7)
CGOB115006464(dhcr7)
PGEO117441212(dhcr7)
GACU117556542(dhcr7)
ELY117260739(dhcr7)
EFO125904915(dhcr7)
PLEP121941592(dhcr7)
SLUC116043787(dhcr7)
ECRA117946960(dhcr7)
ESP116689111(dhcr7)
PFLV114556027(dhcr7)
GAT120810237(dhcr7)
PPUG119194275(dhcr7)
AFB129104369(dhcr7)
CLUM117728643(dhcr7)
MSAM119890143(dhcr7)
SCHU122870544(dhcr7)
CUD121512639(dhcr7)
ALAT119018480(dhcr7)
MZE101465690(dhcr7)
ONL100690153(dhcr7)
OAU116319954(dhcr7)
OLA101175471(dhcr7)
OML112161007(dhcr7)
XMA102220981(dhcr7)
XCO114143530(dhcr7)
XHE116718980(dhcr7)
PRET103462241(dhcr7)
PFOR103143972(dhcr7)
PLAI106965193(dhcr7)
PMEI106907307(dhcr7)
GAF122842170(dhcr7)
CVG107084879(dhcr7)
CTUL119773098(dhcr7)
GMU124867460(dhcr7)
NFU107395662(dhcr7)
KMR108237854(dhcr7)
ALIM106522244(dhcr7)
NWH119430190(dhcr7)
AOCE111567200(dhcr7)
MCEP125005602(dhcr7)
CSEM103378635(dhcr7)
POV109624743(dhcr7)
SSEN122762851(dhcr7)
HHIP117753157(dhcr7)
HSP118113349(dhcr7)
LCF108897736
SDU111222421(dhcr7)
SLAL111672324(dhcr7)
XGL120794018(dhcr7)
HCQ109524562(dhcr7)
SSCV125966987
SBIA133497562(dhcr7)
PEE133417728(dhcr7)
BPEC110162584(dhcr7)
MALB109963393(dhcr7)
BSPL114852650(dhcr7)
SJO128360594(dhcr7)
SASA106562054(dhcr7) 106587139
STRU115167486 115202959
OTW112249041 112263572
OMY110506398 110526232
OGO124033896 124035828
ONE115112100 115113560(dhcr7)
OKI109885858 109895470
OKE118358581 118393716
SALP111969284 111974247
SNH120024720 120046040
CCLU121573333 121582316
ELS105017269(dhcr7)
SFM108941239(dhcr7)
PKI111848083(dhcr7)
AANG118228367(dhcr7)
LOC102687604(dhcr7)
PSPA121294271 121330286
ARUT117432415 117435021
PSEX120525916(dhcr7)
LCM102362669(DHCR7)
CMK103175009(dhcr7)
RTP109935399(dhcr7)
CPLA122557616(dhcr7)
HOC132824513(dhcr7)
LERI129705587(dhcr7)
PMRN116956489(DHCR7)
LRJ133360441(DHCR7)
BFO118417666
BBEL109473755
CIN100176643
SCLV120341359
SPU100890065 576295
LPIC129269240
APLC110978603
AJC117115344 117115345
SKO100376362
BCOO119076860
BTAB109033727 109040108
CLEC106662750
HHAL106691588
NLU111049187
PHUPhum_PHUM060150
ZNE110832336
CSEC111867791
FCD110843314 110847206
DMK116931880
PVM113824348
PJA122260810
PCHN125026492
PMOO119579891
HAME121873193
PCLA123745382
CQD128685458
PTRU123509394
ESN126983770
HAZT108679563
EAF111702637
LSM121124146
TCF131881295
PPOI119093227 119093228 119093748
DSV119461006 119461010 119462124 119462125 119465009 119465134
RSAN119378567 119396498 119396499 119397514
RMP119174557 119174682 119174683
TUT107368480
DPTE113792916
DFR124495630
CSCU111636841 111636843
LPOL106460435
PMEO129584973
NAINECAME_04754
LOALOAG_02794
HROHELRODRAFT_79313
LGILOTGIDRAFT_103100
PVUL126817380
PCAN112574082 112574092
BGT106053689 106067257 106067259 106068985 106071865
GAE121374337
HRF124142180
HRJ124292304
CRG105325856
CVN111121358
CANU128167878
OED125671251
MYI110440867 110450587
PMAX117326295 117328004
MCAF127701228
MMER123525122 123533770
RPHI132725325 132737374 132737377 132752645
DPOL127853110 127861466 127862103 127862104 127862105 127862107
OBI106876505
OSN115218443 115230281
LAK106169024
NVE5509996
EPA110242772
ATEN116289898
AMIL114960291
PDAM113683113
SPIS111321947
DGT114531730
HSY130621501
AQU100636367
ATHAT1G50430(DWF5)
ALY9330313
CRB17900471
CSAT104742576 104758352 104777974
EUSEUTSA_v10011498mg
BRP103832876 103848761
BNA106418552 106439030
BOE106328352
RSZ108848514 108848528 108859250
THJ104809047
CPAP110808001
CIT102631279
CICCICLE_v100316312m
PVY116118627 116118637
MINC123218708
TCC18595600
GRA105777576
GHI107925075 107930432
GAB108489075
HSYR120183316
DZI111275360 111280710
EGR104450695
GMX102659420
GSJ114422541
PVUPHAVU_010G163700g
VRA106772893
VUN114167643
VUM124835918
CCAJ109807985
APRC113857075
MTR25491175 25493363
TPRA123906046
CAM101512763
PSAT127107144
VVO131601049
LJALj3g3v2039890.1(Lj3g3v2039890.1)
ADU107482511
AIP107638378
AHF112740793 112795520
LANG109357091
PCIN129287983
FVE101313328
RCN112187284
PPER18783828
PMUM103327428
PAVI110749995
PDUL117621069
MDM103405421 103443342
MSYL126612363 126634227
PXB103937156 103967673
ZJU112490083
MNT21386077
CSAV115716105
CSV101215997
CMO103500620
BHJ120086035
MCHA111016744
CMAX111494288
CMOS111464317
CPEP111778421
RCU8259961
JCU105646146
HBR110665944 110671373
MESC110631355
POP7455518 7490847
PEU105131675 105141128
PALZ118045106 118060206
JRE109004249
CILL122313108
CAVE132187667
QSU112034052
QLO115989537 115989826
TWL120010699
VVI100256426
SLY101248602 101256596
SPEN107008408 107023649
SOT102589505 102604909(StDWF5)
SSTN125872987 125873602
SDUL129887626 129898764
CANN107845860 107875679
LBB132603938 132626326
NTA107769866 107801501
NSY104249643
NTO104116435
NAU109241331
INI109190803
ITR116021708
SIND105157928
OEU111384711 111401765
EGT105975633
SSPL121797430 121801269
SMIL130989568
APAN127262826
HAN110886362 110894124
ECAD122595464
LSV111910394
CCAV112516735
DCR108205433
CSIN114274320
RVL131311662
AEW130762528
BVG104907279
SOE110785582
CQI110687958 110726750
ATRI130813920
MOF131158063
NNU104611738
MING122071172
TSS122661271
PSOM113298913 113298926 113358687
OSA4329318
DOSAOs02t0465400-01(Os02g0465400)
OBR102721516
OGL127763841
BDI100831660
ATS109780148
TDC119270461 119278614
TAES123063456 123072467 123080701
TUA125546047
LPER127317341
LRD124675285 124685348
SBI8084478
ZMA100282098
SITA101767487
SVS117850656
PVIR120655686 120700873
PHAI112903230
PDA103715514
EGU105049359 105050866
MUS103989528
ZOF122027064 122029360 122031900 122034394
DCT110113328
AOF109840367
MSIN131256646
NCOL116264959
ATR18440694
SMOSELMODRAFT_135440(DWF5-2) SELMODRAFT_185064(DWF5-1)
PPP112276736 112293214
CSLCOCSUDRAFT_40065
APROF751_0259
BPGBathy15g00040
MISMICPUN_108998
MPPMICPUCDRAFT_52902(JGI:MicpuC2_52902)
MGRMGG_03765
PPEIPpBr36_04241
PGRIPgNI_07152
FGRFGSG_03443
FPUFPSE_10292
FVNFVRRES_06430
FVRFVEG_13662
FOXFOXG_12967 FOXG_16578
NHENECHADRAFT_93940
FFCNCS54_00751200
FMUJ7337_012307
CMTCCM_08633
VALVDBG_05423
VDAVDAG_07075
CLUPCLUP02_17919
CHIGCH63R_14260
PFYPFICI_10198
SSLSS1G_02725
BFUBCIN_06g04020
PSCOLY89DRAFT_698617 LY89DRAFT_746866
GLZGLAREA_11782
ACTACLA_053300
AORAO090001000167 AO090003000792 AO090010000319 AO090010000690
AFVAFLA_000891 AFLA_008510 AFLA_013802 AFLA_014184
APUUAPUU_22197A APUU_40100A
PCSN7525_006324
PBLPAAG_04766
PBNPADG_02509
AJEHCAG_02739
BGHBDBG_04254
PFJMYCFIDRAFT_202295
FFUCLAFUR5_03217 CLAFUR5_09494
CBETCB0940_11579
NPAUCRNP2_6695
TMLGSTUM_00003588001
MBRMONBRDRAFT_26465
PTIPHATRDRAFT_30461
FCYFRACYDRAFT_223447
TPSTHAPSDRAFT_33794
AAFAURANDRAFT_20184
PIFPITG_13128
PSOJPHYSODRAFT_317102
SPARSPRG_01085
EHXEMIHUDRAFT_64273
GTTGUITHDRAFT_79561
NGRNAEGRDRAFT_44881
CBUCBU_1158
CBSCOXBURSA331_A1309
CBDCBUD_1256
CBCCbuK_1025
LLOLLO_1320(DWF)
LFALFA_1070(DWF)
LHALHA_0011(DWF)
LCDclem_14840
LSHCAB17_10890
LLG44548918_01594(DWF)
LJRNCTC11533_02823(DWF)
LCJNCTC11976_02540(DWF)
TMCLMI_2237(DWF)
MRMA7982_06883
SAMYDB32_007447
SRKFGW37_00250
PCUPC_RS05880
PNLPNK_0661(dhcr7)
PUVPUV_11120(DWF5)
WCHwcw_1842(dhcr7)
 » show all
Reference
1  [PMID:14189869]
  Authors
DEMPSEY ME, SEATON JD, SCHROEPFER GJ Jr, TROCKMAN RW.
  Title
THE INTERMEDIARY ROLE OF DELTA-5,7-CHOLESTADIEN-3-BETA-OL IN CHOLESTEROL BIOSYNTHESIS.
  Journal
J Biol Chem 239:1381-7 (1964)
Reference
2  [PMID:9465114]
  Authors
Moebius FF, Fitzky BU, Lee JN, Paik YK, Glossmann H
  Title
Molecular cloning and expression of the human delta7-sterol reductase.
  Journal
Proc Natl Acad Sci U S A 95:1899-902 (1998)
DOI:10.1073/pnas.95.4.1899
  Sequence
[hsa:1717]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.21
IUBMB Enzyme Nomenclature: 1.3.1.21
ExPASy - ENZYME nomenclature database: 1.3.1.21
BRENDA, the Enzyme Database: 1.3.1.21
CAS: 9080-21-1

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