KEGG   ENZYME: 1.3.1.24
Entry
EC 1.3.1.24                 Enzyme                                 
Name
biliverdin reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
bilirubin:NAD(P)+ oxidoreductase
Reaction(IUBMB)
bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+ [RN:R02391 R02393]
Reaction(KEGG)
R02391 R02393
Substrate
bilirubin [CPD:C00486];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
biliverdin [CPD:C00500];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.3.1.24 created 1972
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00214  biliverdin reductase
K05901  biliverdin reductase / flavin reductase
Genes
HSA644(BLVRA) 645(BLVRB)
PTR456039(BLVRB) 463366(BLVRA)
PPS100976517(BLVRA) 100989093(BLVRB)
GGO101142015(BLVRB) 101145695(BLVRA)
PON100434664(BLVRA) 100446184(BLVRB)
NLE100581836(BLVRA) 100587172(BLVRB)
MCC700980(BLVRA) 703020(BLVRB)
MCF102136439(BLVRA) 102142962(BLVRB)
MTHB126942092 126950173
CSAB103226154(BLVRA) 103234707(BLVRB)
CATY105596923(BLVRA) 105597983(BLVRB)
PANU101016751(BLVRA) 101021963(BLVRB)
TGE112613110(BLVRB) 112621432(BLVRA)
RRO104676113(BLVRB) 104676702(BLVRA)
RBB108539085(BLVRB) 108544019(BLVRA)
TFN117073278(BLVRA) 117073745 117091948(BLVRB) 117092438
PTEH111552284(BLVRA) 111553962(BLVRB)
CJC100391206(BLVRB) 100404177(BLVRA)
SBQ101043206(BLVRB) 101051509(BLVRA)
CSYR103259601(BLVRA) 103272286(BLVRB)
MMUR105858418(BLVRA) 105876763(BLVRB)
LCAT123624314(BLVRB) 123646929(BLVRA)
OGA100950640(BLVRA) 100956880(BLVRB)
MMU109778(Blvra) 233016(Blvrb)
MCAL110289426(Blvra) 110297893(Blvrb)
MPAH110318000(Blvra) 110331802(Blvrb)
RNO116599(Blvra) 292737(Blvrb)
MCOC116090867(Blvra) 116101881(Blvrb)
MUN110556744(Blvrb)
CGE100751522(Blvra) 100768929(Blvrb)
MAUA101830950(Blvra) 101844617(Blvrb)
PLEU114681553(Blvrb) 114709079(Blvra)
MORG121449703(Blvrb) 121453592 121460306 121465757
MFOT126492547 126494384
AAMP119814714(Blvra) 119821315 119821342(Blvrb)
NGI103733050(Blvra) 103750766(Blvrb)
HGL101697384(Blvrb) 101722954(Blvra)
CPOC100720346(Blvra) 100723970(Blvrb)
CCAN109682461(Blvra) 109688540(Blvrb)
DORD105998024(Blvrb) 105998315 105998325(Blvra)
DSP122097439(Blvrb) 122120733 122120751
NCAR124966872 124990712
OCU100340115(BLVRB) 100346798(BLVRA)
OPI101521301(BLVRA) 101535891(BLVRB)
TUP102476728(BLVRA) 102490802(BLVRB)
CFA475867(BLVRA) 476456(BLVRB)
CLUD112645456(BLVRB) 112661285(BLVRA)
VVP112925818(BLVRA) 112928368(BLVRB)
VLG121471481 121478308 121485710(BLVRB)
AML100467254(BLVRB) 100474311(BLVRA)
UMR103661047(BLVRB) 103674578(BLVRA)
UAH113243564(BLVRB) 113257951(BLVRA)
UAR123784022(BLVRB) 123789449(BLVRA)
ELK111157033 111161593
LLV125081067 125088933 125098045
MPUF101682683(BLVRB) 101684368(BLVRA)
ORO101371765(BLVRB) 101385773(BLVRA)
EJU114202467(BLVRB) 114213694(BLVRA)
ZCA113911751(BLVRA) 113936395(BLVRB)
MLX118022653(BLVRB) 118024538(BLVRA)
NSU110590243(BLVRB) 110592624(BLVRA)
FCA101088735(BLVRA) 101092315(BLVRB)
PYU121011436(BLVRB) 121022250(BLVRA)
PBG122487694(BLVRA) 122494035(BLVRB)
LRUF124511113 124524619
PTG102957548(BLVRA) 102957700(BLVRB)
PPAD109256587(BLVRB) 109267994(BLVRA)
AJU106977737(BLVRA) 106979604(BLVRB)
HHV120234066(BLVRA) 120240932(BLVRB)
BTA281650(BLVRB) 504596(BLVRA)
BOM102277747(BLVRB) 102279089(BLVRA)
BIU109557549(BLVRA) 109572681(BLVRB)
BBUB102400165(BLVRA) 102402107(BLVRB)
CHX102186555(BLVRA) 102187796(BLVRB)
OAS101118353(BLVRA) 101119750(BLVRB)
ODA120872449(BLVRB) 120877506(BLVRA)
CCAD122420884(BLVRB) 122437815(BLVRA) 122443458 122445143
SSC100515289(BLVRA) 100625219(BLVRB)
CFR102503539(BLVRA) 102522968(BLVRB)
CBAI105062862(BLVRB) 105080543(BLVRA)
CDK105092327(BLVRA) 105093394(BLVRB)
VPC102531101(BLVRA) 102543677(BLVRB)
BACU103006819(BLVRA) 103014515(BLVRB)
LVE103073162(BLVRA) 103082225(BLVRB)
OOR101269881(BLVRB) 101285825(BLVRA)
DLE111180848(BLVRB) 111184507(BLVRA)
PCAD102976583(BLVRA) 102992855(BLVRB)
PSIU116743687(BLVRB) 116759469(BLVRA)
ECB100064761(BLVRA) 100068145(BLVRB)
EPZ103555616(BLVRA) 103560493(BLVRB)
EAI106839159(BLVRA) 106843297(BLVRB)
MYB102243524(BLVRA) 102251416(BLVRB)
MYD102759928(BLVRB) 102775325(BLVRA)
MMYO118666497(BLVRA) 118666507 118674559(BLVRB)
MLF102420568(BLVRA) 102432652(BLVRB)
MNA107534172(BLVRB) 107536706(BLVRA)
PKL118702235(BLVRB) 118711468(BLVRA)
HAI109374869(BLVRB) 109375451(BLVRA)
DRO112302634(BLVRA) 112320111(BLVRB)
SHON118979366(BLVRA) 118988083(BLVRB)
AJM119040590(BLVRB) 119045632(BLVRA)
PDIC114507877(BLVRA) 114511105(BLVRB)
PHAS123811438(BLVRA) 123823786(BLVRB)
MMF118619652(BLVRA) 118639318(BLVRB)
RFQ117012367(BLVRA) 117035103(BLVRB)
PALE102879551(BLVRB) 102892087(BLVRA)
PGIG120595620(BLVRB) 120612211(BLVRA)
PVP105300209(BLVRB) 105310146(BLVRA)
RAY107507069(BLVRA) 107521823(BLVRB)
MJV108395290(BLVRA) 108404844(BLVRB)
TOD119241601(BLVRA) 119249327(BLVRB)
SARA101557111(BLVRB)
LAV100660266(BLVRA) 100665167(BLVRB)
TMU101354315 101359133
DNM101437673(BLVRB) 101438042(BLVRA)
MDO100017892(BLVRB) 100029544(BLVRA)
GAS123247440(BLVRA) 123255652(BLVRB)
SHR100915926(BLVRA) 100930351(BLVRB)
PCW110202810(BLVRB) 110204985(BLVRA)
OAA100073853(BLVRB) 100076047(BLVRA)
GGA420776(BLVRA)
PCOC116232777(BLVRA)
MGP100303679(BLVRB) 100542635(BLVRA)
CJO107309812(BLVRA)
NMEL110393199(BLVRA)
APLA101793149(BLVRA) 113841036(BLVRB)
ACYG106042895(BLVRA)
AFUL116486003(BLVRA)
TGU100231163(BLVRA)
LSR110471167(BLVRA)
SCAN103819361(BLVRA)
PMOA120504986(BLVRA)
OTC121346985(BLVRA)
PRUF121352902(BLVRA)
GFR102043974(BLVRA)
FAB101818701(BLVRA)
PHI102102005(BLVRA) 102113532(BLVRB)
PMAJ107200264(BLVRA)
CCAE111923662(BLVRA) 111943368(BLVRB)
CCW104688918(BLVRA)
CBRC103615756(BLVRA)
ETL114066665(BLVRA)
ZAB102067314(BLVRA)
ACHL103809049(BLVRA)
FPG101924606(BLVRA)
FCH102055391(BLVRA)
CLV102097224(BLVRA)
EGZ104125204(BLVRA)
NNI104012409(BLVRA)
PLET104621190(BLVRA)
PCRI104038641(BLVRA)
ACUN113477524(BLVRA)
TALA104358092(BLVRA)
PADL103914851(BLVRA)
AFOR103895345(BLVRA)
ACHC115337712 115338915(BLVRA)
HALD104321959(BLVRB) 104324748(BLVRA)
CCRI104162133(BLVRA)
CSTI104561932(BLVRA)
EHS104507709(BLVRA)
CMAC104482223(BLVRA)
MUI104540328(BLVRA)
FGA104077789(BLVRA)
GSTE104261203(BLVRA)
LDI104348874(BLVRA)
MNB103773233(BLVRA)
OHA104337145(BLVRA)
NNT104410210(BLVRA)
DPUB104298257(BLVRA)
PGUU104464311(BLVRA)
ACAR104532175(BLVRA)
AVIT104272407(BLVRA)
CVF104290330(BLVRA)
AAM106493723(BLVRB) 106495280(BLVRA)
AROW112960997(BLVRB) 112970681(BLVRA)
NPD112953621(BLVRA) 112955489(BLVRB)
TGT104572768(BLVRB) 104576394(BLVRA)
DNE112996103(BLVRA) 112996331(BLVRB)
SCAM104147046(BLVRA)
ASN102371445(BLVRA) 102387963(BLVRB)
AMJ102567480(BLVRA) 102574563(BLVRB)
CPOO109310473(BLVRA)
GGN109291883(BLVRA)
PSS102463244(BLVRA)
CMY102933712(BLVRA) 114022374(BLVRB)
CPIC101948417(BLVRB) 101950655(BLVRA)
TST117872616(BLVRA) 117888630(BLVRB)
CABI116832633(BLVRA) 116833857(BLVRB)
MRV120388171(BLVRB) 120397944(BLVRA)
ACS100564394(blvra) 100564796(blvrb)
PVT110075662(BLVRB) 110081583(BLVRA)
SUND121916153(BLVRB) 121935151(BLVRA)
PBI103049956(BLVRA) 103053858(BLVRB)
PMUR107285666(BLVRB) 107285970(BLVRA)
CTIG120305224(BLVRA) 120316372(BLVRB)
TSR106541075(BLVRB) 106554646(BLVRA)
PGUT117664992(BLVRA) 117677851(BLVRB)
VKO123021032(BLVRB) 123035600(BLVRA)
PMUA114603071(BLVRB) 114607647(BLVRA)
ZVI118077685(BLVRA) 118078075 118086651(BLVRB)
GJA107107369(BLVRB) 107109993(BLVRA)
STOW125430722(BLVRB) 125441181(BLVRA)
XLA100137674(blvra.L) 443881(blvrb.L)
XTR100124834(blvrb) 116406791 448743(blvra)
NPR108791950(BLVRB) 108797466(BLVRA)
RTEM120913299(BLVRB) 120940417(BLVRA)
BBUF120977966(BLVRB) 121001623(BLVRA)
BGAR122923946(BLVRB) 122939192(BLVRA)
DRE436959(blvrb) 767661(blvra)
SRX107713657(blvra) 107717620(blvrb) 107757787
SANH107656146(blvra) 107670601 107692505
SGH107599292 107600218(blvra) 107602119(blvrb)
CCAR109049161 109103811 109109302 109109306
CAUA113045342 113061728 113082608 113113305 113118645
PPRM120460021 120460038
MAMB125251391(blvra) 125254500(blvrb)
IPU100528810(blvra) 108264654 124626957
PHYP113526426(blvrb) 113540050(blvra)
SMEO124387103(blvra) 124396010(blvrb)
TFD113638812(blvrb) 113644061(blvra)
AMEX103037727(blvra) 103040962(blvrb)
EEE113580124(blvrb) 113584243(blvra)
TRU101061122(blvrb) 101070243(blvra)
TNGGSTEN00005221G001 GSTEN00035152G001
LCO104927805(blvrb) 104930153(blvra)
NCC104965039(blvrb)
CGOB115018241(blvrb)
ELY117259444(blvrb) 117271967(blvra)
EFO125888677(blvrb) 125902825(blvra)
PLEP121943190(blvrb) 121951682(blvra)
SLUC116043927(blvra) 116053283(blvrb)
ECRA117942519(blvrb) 117954643(blvra)
ESP116687001(blvrb) 116699657(blvra)
PFLV114552606(blvrb) 114565488(blvra)
GAT120816012(blvra) 120829425(blvrb)
PPUG119209594(blvra) 119222042(blvrb)
MSAM119882831(blvrb) 119898414 119902545
CUD121520165(blvra) 121526977(blvrb)
ALAT119010937(blvra) 119033096(blvrb)
MZE101473603(blvra) 101484658(blvrb)
ONL100702669(blvrb) 100707226(blvra)
OAU116320348(blvrb) 116334117(blvra)
OLA101163919(blvrb) 101175193(blvra)
OML112149783(blvrb) 112151831(blvra)
XMA102228591(blvrb) 102229366(blvra)
XCO114133538(blvrb) 114147006(blvra)
XHE116707592 116707593 116721392(blvra)
PRET103475161(blvrb) 103479218(blvra)
PFOR103132196 103132198 103138303(blvrb)
PLAI106947919(blvrb)
PMEI106912489 106921476(blvrb)
GAF122832913(blvrb) 122840784(blvra)
CVG107094869(blvrb) 107099251(blvra)
CTUL119781479(blvra) 119796633(blvrb)
GMU124869467(blvra) 124883659(blvrb)
NFU107379787(blvrb) 107384337(blvra)
KMR108247879(blvrb)
ALIM106522783(blvrb)
NWH119411413(blvrb)
AOCE111570374(blvra) 111586211(blvrb)
MCEP125010503(blvra) 125012958(blvrb)
CSEM103377891(blvrb)
POV109630121(blvrb) 109637664(blvra)
SSEN122773296(blvrb) 122781407(blvra)
HHIP117773323(blvrb) 117777785(blvra)
HSP118105862(blvrb) 118117736(blvra)
LCF108873329 108876241 108896723(blvra)
SDU111216890(blvrb) 111233913(blvra)
SLAL111648412(blvra) 111662215(blvrb)
XGL120792571(blvrb) 120799498(blvra)
HCQ109515486(blvra) 109529422(blvrb)
BPEC110168032(blvra) 110172712(blvrb)
MALB109963258(blvrb) 109971399(blvra)
BSPL114845037(blvra) 114867627(blvrb)
SASA106569211(blvra) 106580739(blvrb) 106599287 106612705(BLVRB)
STRU115157081(blvra) 115163034(blvrb) 115169698 115205994
OTW112226884 112260526 112265119 112266772
OMY110503591 110507468 110508670 110530384(blvra)
OGO123993025 124005618 124009326(blvra) 124041810
ONE115103034 115114471(blvra) 115137042 115141548
SALP111956520(blvra) 111979178 111982788 111982809
SNH120018812 120020327 120028367 120055899
CCLU121535274(blvra) 121562566 121568255
ELS105023068(blvrb) 105024256(blvra)
SFM108928749(blvrb) 108934031(blvra)
PKI111844029(blvrb) 111851401(blvra)
AANG118209415(blvrb) 118234043(blvra)
LOC102697502(blvra) 102698532(blvrb)
PSPA121303818 121304996(blvrb) 121314565(blvra)
ARUT117397815 117415212 117435450(blvra)
LCM102358034(BLVRB)
CMK103173572(blvrb) 103181265(blvra)
RTP109926910(blvrb) 109932707(blvra)
BFO118410084 118414353 118424422
CIN100185152
SCLV120347803 120347819 120347831 120347846 120347854 120347866
SPU100889296 576533 578603
APLC110978883 110978939
SKO100374763
DER6552273
DSIDsimw501_GD20759(Dsim_GD20759)
DYADyak_GE24730
DSR110188190
DPO4801507
DPE6588134
DMN108156553
DWI6647397
DMODmoj_GI24882
DAZ108618551
DNV108659243
DHE111602756
DVI6630042
MDE101892800
LCQ111676095
AGAAgaP_AGAP001321
ACOZ120949584
AAG5565330
AALB109405306 109406365 115258289
CQUCpipJ_CPIJ011826
CPII120431012
AME412445
ACER107994237
ALAB122714807
BIM100749252
BBIF117205099
BVK117231092
BVAN117157637
BTER100646178
BPYO122567783
CCAL108630984
OBB114877540
MGEN117219339
NMEA116423944
SOC105203387 105203429 105203443 105203453 105204185 113003480
MPHA105830426
AEC105144797
ACEP105624072
PBAR105426660
VEM105557622
HST105187135
DQU106744067
CFO105252649
FEX115234327
LHU105674651
PGC109861802
OBO105281931
PCF106793889
PFUC122526549
VPS122634421
NVI100113525
CSOL105360908
MDL103574018 103575546
TCA664311
DPA109534878
ATD109595167
NVL108556546
BMOR101736226
BMAN114248437
DPLKGM_212873
BANY112054677
NIQ126775902
PMAC106708927
PPOT106101151
PXU106120319
PRAP111001233
ZCE119828598
HAW110382146
HZE124640134
TNL113504959
SLIU111350206
OFU114353154
PXY105393340
API100168586(Blvrb) 100574136
DNX107162985
AGS114130365
RMD113557849
BTAB109043576
NLU111052374
PHUPhum_PHUM514080
ZNE110828593
CSEC111868350
DPXDAPPUDRAFT_230602
DMK116929398
PVM113830326
HAZT108664641
ISCIscW_ISCW003581
DSV119458384
RSAN119373566
RMP119167602
TUT107359695 107367634
CSCU111640897
PTEP107444427
SDM118193070
LGILOTGIDRAFT_113739 LOTGIDRAFT_145414
PCAN112555334 112555727
BGT106056578
GAE121372113
HRF124150678
HRJ124269493 124291888
CRG105324708
MYI110441547 110447723 110448057 110462494
PMAX117327562
MMER123552301
OBI106880542
OSN115231904
LAK106151286 106161246 106163455 106163456 106163458
NVE5501074 5503663
EPA110232712 110232713
ATEN116290024
ADF107351009
AMIL114954138 114954195 114961956
PDAM113668012 113669019 113669042 113678890 113678891
SPIS111322492 111322494 111325275 111325299 111340822
GTTGUITHDRAFT_77488
NGRNAEGRDRAFT_69441 NAEGRDRAFT_71868(FM182)
SYNslr1784(bvdR)
SYZMYO_12210(bvdR)
SYYSYNGTS_0221(bvdR)
SYTSYNGTI_0221(bvdR)
SYSSYNPCCN_0221(bvdR)
SYQSYNPCCP_0221(bvdR)
SYJD082_05120(bvdR)
SYOC7I86_01140
SYPSYNPCC7002_A2324(bvdR)
CYACYA_2461
CYBCYB_1431
SYNPSyn7502_02676
SYVAWQ23_11570
SYLAWQ21_12925
DSLDacsa_2266
CMPCha6605_2462
WNAKA717_27555
LEPLepto7376_2097
LENLEP3755_11850
LETO77CONTIG1_00600(ydgJ)
LBOLBWT_24670
KOVK9N68_27525
LSCKIK02_22810
LSKJ5X98_17000
HHGXM38_017200(ydgJ)
PSEUPse7367_2209
PSERABRG53_1076
THEUHPC62_14710
GLPGlo7428_0283
GENGM3709_2746
GEEGM3708_551
CHONNIES4102_33910
MARMAE_61890(bvdR)
MPKVL20_2197
MIQB5D77_11890
MVZmyaer102_33990(bvdR)
CANCyan10605_2173
CSNCyast_1886
CYLAA637_13445(bvdR)
HAOPCC7418_3675
ENNFRE64_16160
CYTcce_1608(bvdR)
CWACwatDRAFT_1271
CYPPCC8801_1204
CYHCyan8802_1233
CYCPCC7424_1770
CYJCyan7822_0090
TERTery_0913
ARPNIES39_B00110(bvdR)
PAGHNIES204_35780
PPSUNO713_02938(Blvra)
OXYHCG48_06440
MVAGD0A34_04130
LFSHFV01_01140
MICMic7113_3639
GEIGEI7407_2687
OACOscil6304_4400
ONIOsc7112_4818
MPROBJP34_19335
PHORJWS08_18805
PYHNEA10_14015
CEPCri9333_0116
GVIglr0850(bvdR)
GLJGKIL_1362(bvdR)
GMLISF26_10610
ANAalr4149(bvdR)
NPUNpun_R3726
NOSNos7107_2542
NOPNos7524_0955
NONNOS3756_15210
NFLCOO91_03826
NOECLI64_06725
NSHGXM_05714
NEDHUN01_21975
AVAAva_0755
NAZAazo_0182
ANBANA_C11517
ACYAnacy_0624
AWAAA650_24650
ANNEH233_04545
CSGCylst_4447
RSINB6N60_00447
CALOCal7507_5868
CALTCal6303_0865
CALHIJ00_21030
CALNNIES2098_43910
RIVRiv7116_4314
FISFIS3754_15940
NSPHBDGGKGIB_01111(ydgJ)
DOUBMF77_04781(ligC)
DFSHGD76_20120
DHTNG743_11180
CCURIAR63_09680
CRKL3I90_14075
AFLOHEQ12_14655
TOQHCG51_33235
NCNBZZ01_06600
CTHEChro_2639
PLPPle7327_4594
SCSSta7437_2854
STANSTA3757_01550
CEOETSB_0923(bvdR)
CERRGRSB_0875(bvdR)
CTMCabther_A1380
CVLJ8C06_02540
CHLOJ8C02_06680
 » show all
Reference
1  [PMID:4378982]
  Authors
Singleton JW, Laster L.
  Title
Biliverdin reductase of guinea pig liver.
  Journal
J Biol Chem 240:4780-9 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.24
IUBMB Enzyme Nomenclature: 1.3.1.24
ExPASy - ENZYME nomenclature database: 1.3.1.24
BRENDA, the Enzyme Database: 1.3.1.24
CAS: 9074-10-6

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