KEGG   ENZYME: 1.3.1.25
Entry
EC 1.3.1.25                 Enzyme                                 
Name
1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase;
3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase;
3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase;
dihydrodihydroxybenzoate dehydrogenase;
DHBDH;
cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase;
2-hydro-1,2-dihydroxybenzoate dehydrogenase;
cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase;
dihydrodihydroxybenzoate dehydrogenase;
(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+ [RN:R00813]
Reaction(KEGG)
R00813;
(other) R08111 R08112 R08113
Substrate
(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate [CPD:C06321];
NAD+ [CPD:C00003]
Product
catechol [CPD:C00090];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.3.1.25 created 1976, modified 2004 (EC 1.3.1.55 created 1999, incorporated 2004)
Pathway
ec00362  Benzoate degradation
ec00364  Fluorobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05783  dihydroxycyclohexadiene carboxylate dehydrogenase
Genes
EFEEFER_1485(benD)
KPNKPN_01869
KPUKP1_2934
KPMKPHS_28390
KPPA79E_2376
KPHKPNIH24_14210(benD)
KPZKPNIH27_13570(benD)
KPVKPNIH29_14240(benD)
KPWKPNIH30_14505(benD)
KPYKPNIH31_13520(benD)
KPGKPNIH32_14400(benD)
KPCKPNIH10_14040(benD)
KPQKPR0928_14020(benD)
KPTVK055_0615
KPOKPN2242_12265(benD)
KPRKPR_2933(benD)
KPJN559_2421
KPID364_09585(benD)
KPAKPNJ1_02608
KPSKPNJ2_02563
KPXPMK1_04210(lvr)
KPBFH42_05420(benD)
KPNEKU54_012115(benD)
KPNULI86_12050(benD)
KPNKBN49_2969(benD)
KVAKvar_2435
KPEKPK_2488(cbeD)
KPKA593_24210(benD)
KVDKR75_22145(benD)
KVQSP68_02890(benD)
KOCAB185_22235(benD)
KQUAVR78_18380(benD)
EAEEAE_19880(benD)
EARCCG29904
KQVB8P98_13160(benD)
KARLGL98_11655
KGRJJJ10_14635
KLMBWI76_13720(benD)
RORRORB6_06755(benD)
RONTE10_13830(benD)
RPLNB1209_13860(benD)
RAODSD31_13375
RTGNCTC13098_03815(lvr_2)
CSEDJY391_11115
CAFAL524_15085
CFARCI104_13175(benD)
CIRC2U53_22220(benD)
CTELGBC03_17315
EBTEBL_c18160
PGELG71_16210(benD)
BUFD8682_03275
IZHFEM41_18110
PSGCG163CM_11650(lvr)
EBFD782_2133
EBUCUC76_01775(benD)
SMWSMWW4_v1c30600
SMAFD781_2850
SRZAXX16_2219
SERMCLM71_14595(benD)
SFJSAMEA4384070_3090(xecD)
SSURATE40_011850(benD)
SRHZFO014_19065
SENPKHA73_15020
SNEMNLX84_15360(benD)
RBADH2866_19745
XSASB85_10140(benD)
PSDDSC_14910(benD)
PWIMWN52_14980
VNAPN96_18365(benD)
VEJVEJY3_17926(benD)
VJPNP165_16980(benD)
PAEPA2515(xylL)
PAEVN297_2586
PAEIN296_2586
PAUPA14_32130(xylL)
PAPPSPA7_2722(xylL)
PAGPLES_27801(xylL)
PAFPAM18_2524(benD)
PNCNCGM2_3520(benD)
PAEBNCGM1900_4012(benD)
PDKPADK2_12670(benD)
PSGG655_12450(benD)
PRPM062_13075(benD)
PAEPPA1S_13070(benD)
PAERPA1R_gp0309
PAEMU769_12650(benD)
PAELT223_14270(benD)
PAESSCV20265_2794
PAEUBN889_02739(benD)
PAEGAI22_20850(benD)
PAECM802_2583
PAEOM801_2451
PMKMDS_4167
PREPCA10_30910(benD)
PPSEBN5_3608(benD)
PFUWKF707C_15520(bzaB) KF707C_28440
PCQPcP3B5_23360(lvr)
PNTG5B91_12950 G5B91_33240
PPAAB7D75_12600
PPUPP_3164(benD)
PPFPput_2551
PPGPputGB1_2685
PPWPputW619_2707
PPTPPS_2762
PPBPPUBIRD1_2569(benD)
PPIYSA_10652
PPXT1E_1059(benD)
PPUHB479_13460(benD)
PPUTL483_17645(benD)
PPUNPP4_25400(benD) PP4_48180(benD)
PPUDDW66_3021
PFVPsefu_2026
PMONX969_13160(benD)
PMOTX970_12805(benD)
PPJRK21_01914
PALDLU682_014705
PFLPFL_3855(xylL)
PPRCPFLCHA0_c39130(xylL)
PPROPPC_3951(benD)
PFEPSF113_2894(benD)
PFNHZ99_02920(benD)
PFOPfl01_2324 Pfl01_2965(benD)
PMANOU5_6167(xylL)
PAZOAYR47_21845(benD)
PMUDNCTC8068_02088(xylL)
PFXA7318_13915(benD)
PENPSEEN3140(benD)
PLULFOB45_00445
PBAPSEBR_a2882
PPUUPputUW4_03254(xylL)
PDRH681_11365(benD)
PSVPVLB_12230(benD)
PKCPKB_2103(xylL)
PCHEY04_20395(benD)
PCZPCL1606_21670
PCPJM49_10825(benD)
PCHPC4K32_4170
PFZAV641_09800(benD)
PLQAA042_19050(benD)
PALKPSAKL28_52390
PSESPSCI_4806(benD)
PSEMTO66_21090(benD)
PPSYAOC04_06645(benD)
PSOSPOS17_3976(benD)
PFKPFAS1_22860(benD)
PPSLBJP27_02335(benD)
PSETTHL1_2895
PSILPMA3_10990(benD)
PYMAK972_2990
PALLUYA_06695(benD) UYA_20405(benD)
PUMHGP31_18590
PPSHG5J76_17155
PGYAWU82_15480(benD)
PLALFXN65_12620
PEZHWQ56_13965
PDWBV82_2263
PZEHU754_016970
PSEPC4K39_5809
PPIIQL104_20245
PTZHU718_017520
PSHHHU773_013520
PANHHU763_012295
PAZEKSS91_10650
PORYEJA05_13820
PWZJ7655_17885
PTKEXN22_01370
PTWTUM18999_29750(xylL)
PTAENCTC10697_02700(benD)
PGFJ0G10_14060
PCAVD3880_08570
PJUL1P09_13265
PPHNHU825_11445
PIZLAB08_R37340
PSIHLOY51_13760
PFITKJY40_13375
PASILG197_19385
PKMPZ739_13785
PNBNK667_09060
PSOAPSm6_53110(xylL)
PTAIICN73_19815
PKKQQ992_13220
PKJQ1W70_24410
PHYGJTY93_12530
PHOMKJF94_14040
PCHEQYM18_03975
PCUCPSH97_17065
PTRLOU419_12615 OU419_14760
PSAPST_1670(benD)
PSRPSTAA_1698(benD)
PSCA458_09170(benD)
PSJPSJM300_08880(benD)
PSHPsest_2696
PSTUUIB01_13630(benD)
PSEDDM292_11225
PCHLLLJ08_12930
PBMCL52_07430(benD)
PKGLW136_09530
SDEGGOM96_16690
AVNAvin_08620(benD)
AVLAvCA_08620(benD)
AVDAvCA6_08620(benD)
ACXAchr_32810(benD)
HPEGEAO82_00580
PDENF1C79_04600
PBAUOS670_01855
MHCMARHY0281(benD)
MADHP15_1108
MPQABA45_01255(benD)
MARIACP86_12000(benD)
MANPEHN06_02095
PCRPcryo_1264
PSOPSYCG_06665(benD)
PALIA3K91_1588
PSPGAK823_04985
PSYGAK825_05000
PSYPE5677_05445
ACBA1S_1212
ABYABAYE2558(benD)
ABCACICU_01189
ABNAB57_1347
ABBABBFA_02336(lvr)
ABXABK1_1644
ABZABZJ_01348
ABRABTJ_02517
ABDABTW07_1376
ABHM3Q_1568
ABADABD1_12210(benD)
ABJBJAB07104_01359
ABABBJAB0715_01371
ABAJBJAB0868_01307
ABAZP795_11430
ABKLX00_05835
ABAUIX87_04590
ABAAIX88_08130
ABWBL01_13775
ABALABLAC_20300
ACCBDGL_000463(benD)
ANORR32_12270
ALCOTEC02_13000
ACALBUM88_05780
ASEII8T81_13015
ACDAOLE_13350(benD)
ACIACIAD1439(benD)
ATTAMQ28_00600
AEIAOY20_11285
AJORZ95_08915
ACWA0J50_11650
ACVAMD27_07845
AJNBVL33_09975
ASOLBEN76_06765
ASJAsACE_CH01477(benD)
AIDCTZ23_07100
ADVDJ533_10820
ARJDOM24_07535
AWUBEN71_06045
ACUMC9E88_012210
AGUAS4_23700(benD)
ALWFOB21_01940
ADSFPL17_10305
ABERBSR55_11570
ATNFM020_08965
ALJG8D99_08475
ATGJ4G44_08925
AVBRYU24_15340(benD)
ABOUACBO_16050(benD)
AGYLFPL18_02705
AVZHWI77_08295
ATZM5E07_08995(benD)
APRLPY247_10070(benD)
AVIVLF296_04285(benD)
MOIMOVS_09455
MNJLU290_09610
AMGAMEC673_15500(benD)
ALRDS731_05535
CYQQ91_2245
CZACYCME_2563(benD)
CYYCPC19_01575
CCAGSR908_06600(benD)
HAKKO116_00235
HHUAR456_17680(benD)
HSIBOX17_05810(benD)
HHHCLM76_07040(benD)
HBEBEI_1519
HCAMI4484_18800
HPIZGYM47_16275
HPROLMS44_22930
HQDK1Y77_14475
HASOB2G49_18140(benD)
HNPSR894_21530(benD)
APACS7S_13320
MMEMarme_1558
MARSA8C75_10510(benD)
MGEOCFI10_04840(benD)
MSECLN244_11355
MRZKDW95_03785
ASIMFE240_08800
OCEGU3_01775
OPEPU634_15430(benD)
ZDFAN401_00165(benD)
GBIPG2T_09665
VMSLVJ82_06055
USULVJ78_07365
UTELVJ83_07960
PSENH8B_1753(benD)
RSCRCFBP_11859(benD)
RSLRPSI07_1884(benD)
RSNRSPO_c01859
RSYRSUY_19290
RSGJK151_11745
RPIRpic_1367
RPFRpic12D_1431
RPJN234_27840 N234_37270(benD)
RMNTK49_11665(benD)
RINACS15_1754
RWEKOL96_15110
REHH16_A1960(benD)
CNCCNE_1c19300(benD)
CUHBJN34_08575(benD)
REUReut_B4406
RMERmet_4885(benD)
CBWRR42_s0554
CCUPBKK81_23220(benD)
CUPBKK80_33070(benD)
CUUBKK79_23955(benD)
CPAUEHF44_23095
COXE0W60_20505 E0W60_32235
CUKKB879_22055
BMABMAA0184
BMVBMASAVP1_1357(benD)
BMLBMA10229_1552(benD)
BMNBMA10247_A0212(benD)
BMALDM55_3534
BMAEDM78_4623
BMAQDM76_4231
BMAIDM57_14455(benD)
BMAFDM51_3935
BMAZBM44_3496
BMABBM45_4332
BPSBPSS1906(benD)
BPMBURPS1710b_A1002(benD)
BPLBURPS1106A_A2584(benD)
BPDBURPS668_A2728(benD)
BPSEBDL_5312
BPSMBBQ_4224
BPSUBBN_5371
BPSDBBX_4477
BPZBP1026B_II2045(benD)
BPQBPC006_II2547
BPKBBK_4645
BPSHDR55_5828
BPSABBU_4103
BPSOX996_5626
BUTX994_5189
BTEBTH_II0470
BTQBTQ_3763
BTJBTJ_4794
BTZBTL_5580
BTDBTI_5084
BTVBTHA_4621
BTHEBTN_5251
BTHMBTRA_5521
BTHADR62_5380(benD)
BTHLBG87_5596
BOKDM82_6196
BOCBG90_4468
BUUWS70_27015(benD)
BSAVWS86_28725(benD)
BHGI6G56_27550
BUDAQ610_29995(benD)
BVIBcep1808_5828
BVEAK36_5311
BURBcep18194_C7049
BCMBcenmc03_6134
BCHBcen2424_6527
BCENDM39_5094
BCEWDM40_5132
BCEOI35_7537
BAMBamb_6581
BACBamMC406_6296
BMJBMULJ_05284(benD)
BMUBmul_3241
BMKDM80_4620
BMULNP80_3313
BCEDDM42_7057
BCEPAPZ15_36345(benD)
BDLAK34_5715
BPYRABD05_32070(benD)
BCONNL30_37450(benD)
BUBBW23_4425
BDFWI26_27680(benD)
BLATWK25_16340(benD)
BTEIWS51_27265(benD)
BSEMWJ12_16745(benD)
BPSLWS57_00510(benD)
BMECWJ16_18210(benD)
BSTGWT74_22610(benD)
BSTLBBJ41_36465(benD)
BARINLX30_38100(benD)
BAENL3V59_35265
BUGBC1001_1344
BGOBM43_5498
BYIBYI23_D002180
BUKMYA_5341
BUEBRPE67_DCDS03930
BULBW21_4619
BUQAC233_11160
BUMAXG89_16415(benD)
BUIAX768_26125(benD)
BURKDM992_37910
BXEBxe_B0912(benD)
BXBDR64_6233
BPHBphy_5349
BGEBC1002_6177
BPXBUPH_01851
BPYBphyt_1594
BUZAYM40_26005(benD)
BCAIK788_0005752
PSPWBJG93_32100
PARBCJU94_35245(benD) CJU94_37920(benD)
PHSC2L64_29825(benD) C2L64_48515(benD)
PTERC2L65_18575(benD)
PCJCUJ87_08370(benD)
PTSCUJ90_10080(benD)
PCAFDSC91_002403
PTROG5S35_36180
PGISI6I06_20450 I6I06_20465
PACPFAZ97_31360
PACSFAZ98_17695
PDIOPDMSB3_2246.1(benD)
PSAAQEN71_10475
PKFRW095_28370(benD)
CABASBC2_79750
BUOBRPE64_DCDS08510
CABKNK8_62330(benD)
TVLFAZ95_35085
TCARU0034_22855
BPTBpet1396(benD)
BHOD560_1121
BHMD558_1108
BTRMSAMEA390648701944(benD)
AXYAXYL_01800
AISBUW96_17365
ACHRC2U31_10450(benD)
ACHBDVB37_15210
ACHOH4P35_21825
AMUIPE062_18435
APESFOC84_03560
AAEGRA224_23820
AFAUZ73_17880(benD)
AFQAFA_08575(benD)
AAQUD3M96_09795
AAMMFE795_07790
OURCEQ07_11095
OUEI6G29_07010
PNAPnap_2109
ACRABSY15_1216
CSERCCO03_07070(benD)
CODOLAD35_11955
ADNAlide_2649
HPSEHPF_01835(lvr)
DIHG7047_12820
SIMPC6571_19145
JAJEKL02_16455
JASFJQ89_23180
HSEHsero_1311(cbeD)
HSZACP92_06560(benD)
HRBHrubri_1137(cbeD)
HHFE2K99_06475
HFRG5S34_06740
MASWAM586_16570(benD)
MVARMasN3_08590(benD)
MLIRLPB04_18845
MALIEYF70_17200
MUMFCL38_01220
TMJP0M04_19620(benD)
GLCJQN73_16180
AONDEH84_15075
RBUPG1C_04535
DARDaro_2781
DDENKI615_11390
TMZTmz1t_3099
THKCCZ27_03210(benD) CCZ27_16240(benD)
AMIHCO731_00666(ydaD)
ANJAMD1_0688(benD)
PHTBLM14_21520(benD)
SFHSFHH103_03581
SFDUSDA257_c54420(benD)
SINOSS05631_c27060
ESJSJ05684_b58660
EAKEKH55_4347
EGIPZN02_004568(benD)
STEGQA637_26185(benD)
EADOV14_a1474(fabG2)
EAHFA04_27030(benD)
ENPJVX98_05245
AVFRvVAR031_pl03340(benD)
RHKKim5_CH01085(benD)
RSULN2599_31260(benD)
ARAArad_12206
BBETF8237_17750
BOSBSY19_2041
XAUXaut_4355
XDIEZH22_09305
LNEFZC33_07195
METM446_1327
MNOMnod_2371
MEEDA075_16970
MTEADK419_08715
MINDmvi_57260(benD)
RHZRHPLAN_59320
RUTFIU92_22560(novJ)
CMARIMCC12053_2583
CEHCEW89_02920(benD)
CONTQ29_16490(benD)
SULDB5M07_19090(benD)
RMMROSMUCSMR3_03736(lvr)
ROKRAK1035_2575
ROTFIV09_19530(ycdF3)
RMAIMACH21_04310(benD)
PDEPden_1180
PCONB0A89_14340(benD)
PZHCX676_12390(benD)
PPANESD82_01805
PSANHGN31_00295
PALPJHW40_08100
PFEOE3U26_15400
TECAKL02_003795
LVRT8T21_16925(benD)
NARSaro_0540 Saro_3837
NPPPP1Y_AT15839 PP1Y_AT31260
NPNJI59_24685
NREBES08_19580(benD)
NOGGKE62_05255
NDRHT578_08795
NHUMPQ457_18340(benD)
SWISwit_2636 Swit_5024
SPHDHY78_12335(benD)
SPHMG432_15085(benD)
SECHB18_24650
SNAPPQ455_02565(benD)
SSAGKV697_00100
SPHRBSY17_105
SPHTK426_21224(benD)
SYAA6768_16780(benD)
SBARH5V43_22415
SPHYCHN51_07050
BLASBSY18_3981
BFWB5J99_00990(benD)
ALBAEB_P2434
CNAAB433_18075
ERYCP97_14260
RGIRGI145_20865(benD)
RMUCFOB66_02980
AZLAZL_a07370(benD)
AZMDM194_25860
AZSE6C72_15470
SMUCJL100_027665
SROEJL101_026020
PARHI5S86_15030
PPABKET34_26490
MMATMMAGJ_52720(benD)
CGLCgl2407(Cgl2407)
CGBcg2640(benD)
CGUWA5_2323(BenD)
CGTcgR_2288
CGSC624_11685(benD)
CGGC629_11695(benD)
CGMcgp_2640(benD)
CGJAR0_11525(benD)
CGQCGLAR1_11375(benD)
CGXSB89_11180(benD)
CEFCE2308
CHNA605_11140(benD)
CCNH924_10135(benD)
CMDB841_10265(benD)
CIICIMIT_11045(benD)
CMQB840_09755(xylL)
CDXCDES_10945(benD)
CSTACSTAT_12750(benD)
CCJZccrud_10715(benD)
CAMGCAMM_12485(benD)
CSURN24_2477(benD)
CCYSSAMEA4530656_0415(benD)
CYZC3B44_09185
CCOECETAM_10400(lvr)
COKCOCCU_10780(lvr2)
CCYCSCMU_25440(benD)
CPOYGP475_09410
CHINJ5O04_00825
CFACCFAEC_10595(ycdF)
CATRCATRI_09855(ycdF)
CGFCGUA_10475(fabG9)
CSUEQP029_00475
CBREQP027_08665
BFVC628_11665(benD)
RHARHA1_ro02387(benD)
RQIC1M55_27410(benD)
ROPROP_21010(benD)
ROAPd630_LPD06583
RPYY013_13600(benD)
RBYCEJ39_00980(benD)
RAVAAT18_24450(benD)
RRZCS378_14030(benD)
RHQIM25_04945(benD)
RHODAOT96_07380(benD)
RRT4535765_04644(benD)
RCRNCTC10994_02858(benD)
RKOJWS14_12420
ROZCBI38_27130(benD)
RPSKJWS13_33420
RGORNMQ04_19740(benD)
DTMBJL86_1202
DPCA6048_05505(benD)
DLUA6035_05570(benD)
DKNNHB83_05170
SQZFQU76_02750
STSUB7R87_02845(benD)
ARUASPU41_14625(benD)
ARNCGK93_10510(benD)
ACRYAC20117_04985(benD)
ARTPE5206_02265
AODQ8Z05_21375
APNAsphe3_35130
PSULAU252_22710(benD)
PSNINIBR502771_06640
PSEYGU243_07215
PDELJCQ34_18045
POKSMD14_09435
GLUF0M17_16120
KPLKPaMU14_10935(benD)
KFVAS188_00025(benD)
KRSEQG70_04345
SATKSA2016_0099
CIGE7744_08330
PAEYKUF55_15625
SVISvir_19240
ACTYOG774_03995
SHTKO02_15975(benD)
FSEDI487_06970
FAGK5I29_09300
CSALNBC122_01822(ycdF)
CHRCQGN23_05710
 » show all
Reference
1  [PMID:4341530]
  Authors
Reiner AM.
  Title
Metabolism of aromatic compounds in bacteria. Purification and properties of the catechol-forming enzyme, 3,5-cyclohexadiene-1,2-diol-1-carboxylic acid (NAD + ) oxidoreductase (decarboxylating).
  Journal
J Biol Chem 247:4960-5 (1972)
Reference
2  [PMID:1740120]
  Authors
Neidle E, Hartnett C, Ornston LN, Bairoch A, Rekik M, Harayama S
  Title
cis-diol dehydrogenases encoded by the TOL pWW0 plasmid xylL gene and the Acinetobacter calcoaceticus chromosomal benD gene are members of the short-chain alcohol dehydrogenase superfamily.
  Journal
Eur J Biochem 204:113-20 (1992)
DOI:10.1111/j.1432-1033.1992.tb16612.x
  Sequence
[aci:ACIAD1439]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.25
IUBMB Enzyme Nomenclature: 1.3.1.25
ExPASy - ENZYME nomenclature database: 1.3.1.25
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.25
BRENDA, the Enzyme Database: 1.3.1.25
CAS: 60496-16-4

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