KEGG ENZYME: 1.3.1.40

ENZYME: 1.3.1.40

Entry

EC 1.3.1.40                 Enzyme

Name

2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase;
2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

2,6-dioxo-6-phenylhexanoate:NADP+ Delta2-oxidoreductase

Reaction(IUBMB)

2,6-dioxo-6-phenylhexanoate + NADP+ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + NADPH + H+ [RN:R03463]

Reaction(KEGG)

R03463

Substrate

2,6-dioxo-6-phenylhexanoate [CPD:C03750];
NADP+ [CPD:C00006]

Product

2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate [CPD:C01273];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Broad specificity; reduces a number of compounds produced by Pseudomonas from aromatic hydrocarbons by ring fission.

History

EC 1.3.1.40 created 1989

Reference

Authors

Omori T, Ishigooka H, Minoda Y.

Title

Purification and some properties of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid(HOPDA) reducing enzyme from Pseudomonas cruciviae S93B1 involved in the degradation of biphenyl.

Journal

Agric Biol Chem 50:1513-1518 (1986)

Other DBs

ExplorEnz - The Enzyme Database:

1.3.1.40

IUBMB Enzyme Nomenclature:

1.3.1.40

ExPASy - ENZYME nomenclature database:

1.3.1.40

BRENDA, the Enzyme Database:

1.3.1.40

CAS:	104645-83-2

All links

Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
All databases (7)   

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