Entry |
|
Name |
arogenate dehydrogenase;
arogenic dehydrogenase (ambiguous);
cyclohexadienyl dehydrogenase (ambiguous);
pretyrosine dehydrogenase (ambiguous);
L-arogenate:NAD+ oxidoreductase;
arogenate dehydrogenase (NAD+)
|
Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
L-arogenate:NAD+ oxidoreductase (decarboxylating)
|
Reaction(IUBMB) |
L-arogenate + NAD+ = L-tyrosine + NADH + CO2 [RN: R00732]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
|
Comment |
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NAD+-specific enzymes have been reported from some bacteria [2] and plants [3]. Some enzymes also possess the activity of EC 1.3.1.12, prephenate dehydrogenase.
|
History |
EC 1.3.1.43 created 1989, modified 2003, modified 2005, modified 2015
|
Pathway |
ec00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K00220 | cyclohexadieny/prephenate dehydrogenase |
K24018 | cyclohexadieny/prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase |
|
Genes |
» show all
|
Reference |
|
Authors |
Stenmark SL, Pierson DL, Jensen RA, Glover GI. |
Title |
Blue-green bacteria synthesise L-tyrosine by the pretyrosine pathway. |
Journal |
|
Reference |
|
Authors |
Byng GS, Whitaker RJ, Gherna RL, Jensen RA |
Title |
Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae. |
Journal |
|
Reference |
3 |
Authors |
Byng, G., Whitaker, R., Flick, C. and Jensen, R.A. |
Title |
Enzymology of L-tyrosine biosynthesis in corn (Zea mays). |
Journal |
Phytochemistry 20:1289-1292 (1981) |
Reference |
|
Authors |
Mayer E, Waldner-Sander S, Keller B, Keller E, Lingens F. |
Title |
Purification of arogenate dehydrogenase from Phenylobacterium immobile. |
Journal |
|
Reference |
5 |
Authors |
Lingens, F., Keller, E. and Keller, B. |
Title |
Arogenate dehydrogenase from Phenylobacterium immobile. |
Journal |
Methods Enzymol 142:513-518 (1987) |
Reference |
|
Authors |
Zamir LO, Tiberio R, Devor KA, Sauriol F, Ahmad S, Jensen RA. |
Title |
Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa. |
Journal |
J Biol Chem 263:17284-90 (1988) |
Other DBs |
ExplorEnz - The Enzyme Database: | 1.3.1.43 |
ExPASy - ENZYME nomenclature database: | 1.3.1.43 |
|