| Entry |
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| Name |
arogenate dehydrogenase;
arogenic dehydrogenase (ambiguous);
cyclohexadienyl dehydrogenase;
pretyrosine dehydrogenase (ambiguous);
L-arogenate:NAD+ oxidoreductase;
arogenate dehydrogenase (NAD+)
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
L-arogenate:NAD+ oxidoreductase (decarboxylating)
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| Reaction(IUBMB) |
L-arogenate + NAD+ = L-tyrosine + NADH + CO2 [RN: R00732]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NAD+-specific enzymes have been reported from some bacteria [2] and plants [3]. Some enzymes also possess the activity of EC 1.3.1.12, prephenate dehydrogenase.
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| History |
EC 1.3.1.43 created 1989, modified 2003, modified 2005, modified 2015
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| Pathway |
| ec00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K00220 | cyclohexadieny/prephenate dehydrogenase |
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| Genes |
» show all
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| Reference |
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| Authors |
Stenmark SL, Pierson DL, Jensen RA, Glover GI. |
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| Title |
Blue-green bacteria synthesise L-tyrosine by the pretyrosine pathway. |
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| Journal |
Nature 247:290-2 (1974) |
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| Reference |
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| Authors |
Byng GS, Whitaker RJ, Gherna RL, Jensen RA |
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| Title |
Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae. |
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| Journal |
J Bacteriol 144:247-57 (1980) |
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| Reference |
3 |
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| Authors |
Byng, G., Whitaker, R., Flick, C. and Jensen, R.A. |
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| Title |
Enzymology of L-tyrosine biosynthesis in corn (Zea mays). |
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| Journal |
Phytochemistry 20:1289-1292 (1981) |
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| Reference |
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| Authors |
Mayer E, Waldner-Sander S, Keller B, Keller E, Lingens F. |
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| Title |
Purification of arogenate dehydrogenase from Phenylobacterium immobile. |
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| Journal |
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| Reference |
5 |
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| Authors |
Lingens, F., Keller, E. and Keller, B. |
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| Title |
Arogenate dehydrogenase from Phenylobacterium immobile. |
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| Journal |
Methods Enzymol 142:513-518 (1987) |
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| Reference |
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| Authors |
Zamir LO, Tiberio R, Devor KA, Sauriol F, Ahmad S, Jensen RA. |
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| Title |
Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa. |
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| Journal |
J Biol Chem 263:17284-90 (1988) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.3.1.43 |
| ExPASy - ENZYME nomenclature database: | 1.3.1.43 |
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