Entry Name arogenate dehydrogenase;
Class Oxidoreductases;BRITE hierarchy
Sysname L-arogenate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB) L-arogenate + NAD+ = L-tyrosine + NADH + CO2 [RN:
R00732 ]
Reaction(KEGG) Substrate Product Comment Arogenate dehydrogenases may utilize NAD+ (EC
1.3.1.43 ), NADP+ (EC
1.3.1.78 ), or both (EC
1.3.1.79 ). NAD+-specific enzymes have been reported from some bacteria [2] and plants [3]. Some enzymes also possess the activity of EC
1.3.1.12 , prephenate dehydrogenase.
History EC 1.3.1.43 created 1989, modified 2003, modified 2005, modified 2015
Pathway ec00400 Phenylalanine, tyrosine and tryptophan biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology K00220 cyclohexadieny/prephenate dehydrogenase
K24018 cyclohexadieny/prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase
Genes » show all Taxonomy Reference Authors Stenmark SL, Pierson DL, Jensen RA, Glover GI.
Title Blue-green bacteria synthesise L-tyrosine by the pretyrosine pathway.
Journal Reference Authors Byng GS, Whitaker RJ, Gherna RL, Jensen RA
Title Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae.
Journal Reference 3
Authors Byng, G., Whitaker, R., Flick, C. and Jensen, R.A.
Title Enzymology of L-tyrosine biosynthesis in corn (Zea mays).
Journal Phytochemistry 20:1289-1292 (1981)
Reference Authors Mayer E, Waldner-Sander S, Keller B, Keller E, Lingens F.
Title Purification of arogenate dehydrogenase from Phenylobacterium immobile.
Journal Reference 5
Authors Lingens, F., Keller, E. and Keller, B.
Title Arogenate dehydrogenase from Phenylobacterium immobile.
Journal Methods Enzymol 142:513-518 (1987)
Reference Authors Zamir LO, Tiberio R, Devor KA, Sauriol F, Ahmad S, Jensen RA.
Title Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa.
Journal J Biol Chem 263:17284-90 (1988)
Other DBs ExplorEnz - The Enzyme Database: 1.3.1.43
ExPASy - ENZYME nomenclature database: 1.3.1.43
