KEGG   ENZYME: 1.3.1.45
Entry
EC 1.3.1.45                 Enzyme                                 

Name
2'-hydroxyisoflavone reductase;
NADPH:2'-hydroxyisoflavone oxidoreductase;
isoflavone reductase;
2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
vestitone:NADP+ oxidoreductase
Reaction(IUBMB)
vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+ [RN:R06562]
Reaction(KEGG)
R06562;
(other) R06563 R07747 R07751
Substrate
vestitone [CPD:C00786];
NADP+ [CPD:C00006]
Product
2'-hydroxyformononetin [CPD:C02920];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
In the reverse reaction, a 2'-hydroxyisoflavone is reduced to an isoflavanone; 2'-hydroxypseudobaptigenin also acts. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.
History
EC 1.3.1.45 created 1990
Pathway
ec00943  Isoflavonoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05281  2'-hydroxyisoflavone reductase
Genes
PSU: Psesu_1429
PSUW: WQ53_15890
PMEX: H4W19_06650
LAB: LA76x_1468
LAQ: GLA29479_4369
LCP: LC55x_1203
LGU: LG3211_1114
LEZ: GLE_1089
LEM: LEN_3828
LMB: C9I47_2587
AHA: AHA_3033
ASA: ASA_3054
AVR: B565_2847
AMED: B224_3781
ACAV: VI35_14675
EBA: c2A203
DALK: DSCA_19400
JAN: Jann_2459
PSF: PSE_p0196
BAN: BA_3051
BAR: GBAA_3051
BAT: BAS2836
BAI: BAA_3101
BANT: A16_58865
BANR: A16R_31210
BANS: BAPAT_2926
BANV: DJ46_1808
BCE: BC3031
BCQ: BCQ_2858
BCX: BCA_3114
BNC: BCN_2885
BCF: bcf_14865
BTL: BALH_2726
BTT: HD73_2926
BTHI: BTK_14500
BTM: MC28_2230
BTI: BTG_04145
BTW: BF38_4219
BWW: bwei_1984
BMYO: BG05_2985
BMYC: DJ92_97
HLI: HLI_03715
PMW: B2K_28795
JEO: JMA_07960
RER: RER_40990
REY: O5Y_19135
RHB: NY08_3458
SALB: XNR_4656
SGR: SGR_2256
SGB: WQO_24185
SFA: Sfla_2031
SBH: SBI_03183
SHY: SHJG_3705
SVE: SVEN_1879
SALS: SLNWT_5660
STRP: F750_4790
SFI: SFUL_5073
SALU: DC74_4616
SALL: SAZ_24655
STRE: GZL_04227
SLD: T261_3648
STRM: M444_29395
SPRI: SPRI_5287
SLE: sle_49380(sle_49380)
STRD: NI25_28105
SFK: KY5_2208
SRJ: SRO_5250
LXL: KDY119_00756(rfbB)
CMS: CMS1442
CMC: CMN_01091
ART: Arth_2412
ARM: ART_2342
AAU: AAur_2389
ACH: Achl_2166
LMOI: VV02_15895
IDO: I598_0180(tal_1)
CFL: Cfla_3358
SERJ: SGUI_2052
MPH: MLP_40500
NCA: Noca_4501
PSIM: KR76_26675
NDA: Ndas_5466
NAL: B005_1631
GOB: Gobs_1271
MMAR: MODMU_1275
SEN: SACE_7146
AORI: SD37_26555
PSEA: WY02_18510
PSEE: FRP1_24285
PSEH: XF36_22895
PAUT: Pdca_04960
AMI: Amir_6880
SESP: BN6_82550
ALO: CRK60448
SAQ: Sare_1526
MIL: ML5_1949
ASE: ACPL_4350
ACTN: L083_3993
ACTS: ACWT_4221
TBI: Tbis_2308
WIN: WPG_2484
SALI: L593_01295
 » show all
Reference
1
  Authors
Tiemann, K., Hinderer, W. and Barz, W.
  Title
Isolation of NADPH:isoflavone oxidoreductase, a new enzyme of pterocarpan biosynthesis in cell suspensions of Cicer arietinum.
  Journal
FEBS Lett 213:324-328 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.45
IUBMB Enzyme Nomenclature: 1.3.1.45
ExPASy - ENZYME nomenclature database: 1.3.1.45
BRENDA, the Enzyme Database: 1.3.1.45
CAS: 128449-69-4

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