Entry
Name
precorrin-6A reductase;
precorrin-6X reductase;
precorrin-6Y:NADP+ oxidoreductase;
CobK
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
precorrin-6B:NADP+ oxidoreductase
Reaction(IUBMB)
precorrin-6B + NADP+ = precorrin-6A + NADPH + H+ [RN:
R05150 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, which participates in the aerobic (late cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses the reduction of the double bond between C-18 and C-19 of precorrin-6A. See EC
1.3.1.106 , cobalt-precorrin-6A reductase, for the corresponding enzyme that participates in the anaerobic cobalamin biosynthesis pathway.
History
EC 1.3.1.54 created 1999, modified 2004
Pathway
Orthology
K05895 precorrin-6A/cobalt-precorrin-6A reductase
Genes
KIE : NCTC12125_04869(cobK)
BSEL : RHD99_04890 RHD99_08260
METY : MRY16398_18720(cbiJ)
PAEB : NCGM1900_3402(cobK)
PPRC : PFLCHA0_c06610(cobK)
PMUD : NCTC8068_00604(cobK)
PFW : PF1751_v1c05640(cobK)
PPUU : PputUW4_00534(cobK)
PTAE : NCTC10697_03998(cobK)
TFRI : Thiofri_03991(cobK)
GAI : IMCC3135_08950(cobK)
HAAH : HALA3H3_800142(cobK)
BMV : BMASAVP1_A1599(cobK)
BML : BMA10229_A0260(cobK)
BPM : BURPS1710b_2116(cobK)
BPL : BURPS1106A_1971(cobK)
PDIO : PDMSB3_1858.1(cobK)
PLG : NCTC10937_00827(cobK)
SMEL : SM2011_c03189(cobK)
SFD : USDA257_c53930(cobK)
SAME : SAMCFNEI73_Ch3349(cobK)
AGR : AGROH133_09251(cobK)
AVV : RvVAT039_01100(cobK)
AVF : RvVAR031_22280(cobK)
REC : RHECIAT_PA0000374(cobK)
REL : REMIM1_PD00474(cobK)
REP : IE4803_PA00410(cobK)
REI : IE4771_PC00423(cobK)
RTR : RTCIAT899_PC07010(cobK)
RHL : LPU83_pLPU83d0183(cobK)
RGA : RGR602_PC01212(cobK)
RPHA : AMC79_PB00383(cobK)
NEN : NCHU2750_36490(cobK)
BIO : BR141012304_11398(cobK)
MAQU : Maq22A_c09450(cobK)
MTUN : MTUNDRAET4_2078(cobK)
FIL : BN1229_v1_3171(cobK)
RDE : RD1_3177(cobK) RD1_3822(cobK)
RLI : RLO149_c006220(cobK) RLO149_c024040
RPON : G3256_07160 G3256_12335
RFU : ROLI_011120(cobK_1) ROLI_018810(cobK_2)
PHP : PhaeoP97_00779(cobK)
PPIC : PhaeoP14_00734(cobK)
MALG : MALG_01205 MALG_01407
PABY : Ga0080574_TMP1470 Ga0080574_TMP4011
SUAM : BOO69_10290 BOO69_17195
SULZ : C1J03_01450 C1J03_09275
SULD : B5M07_08520 B5M07_16135
SPOT : G6548_10695 G6548_14670
SMED : JNX03_05630 JNX03_14265
SINL : DSM14862_01676(cobK_1) DSM14862_03168(cobK_2)
SFAV : PL335_08560 PL335_15190
SUAL : KDD17_07735 KDD17_15790
SDUB : R1T39_02440 R1T39_09995
SULB : IV89_000742 IV89_001588
SULY : ABM428_10400 ABM428_14300
SULP : AADW22_10805 AADW22_14730
SUSQ : K3756_07465 K3756_16965
SPSE : SULPSESMR1_01744(cobK) SULPSESMR1_02793(cobK)
TOM : BWR18_08175 BWR18_10970
RMM : ROSMUCSMR3_00813(cobK)
ROH : FIU89_08185(cobK1) FIU89_17360(cobK2)
AHT : ANTHELSMS3_02550 ANTHELSMS3_02943
MALU : KU6B_20520(cobK_1) KU6B_33060(cobK_2)
LALG : LentiSH36_01595(cobK)
MARU : FIU81_10990(cobK1) FIU81_13710(cobK2)
LVS : LOKVESSMR4R_01279(cobK)
GEH : HYN69_05170 HYN69_19250 HYN69_20060
PPRU : FDP22_00710 FDP22_12915
AALK : LGT41_0005745 LGT41_0012525
PROC : Ptc2401_01272(cobK)
LMOC : LMOSLCC5850_1189(cbiJ)
LMW : LMOSLCC2755_1192(cbiJ)
LMX : LMOSLCC2372_1196(cbiJ)
LMZ : LMOSLCC2482_1240(cbiJ)
LMON : LMOSLCC2376_1151(cbiJ)
LMOS : LMOSLCC7179_1167(cbiJ)
LMOO : LMOSLCC2378_1205(cbiJ)
LMOY : LMOSLCC2479_1197(cbiJ)
LMOT : LMOSLCC2540_1179(cbiJ)
LMOA : LMOATCC19117_1199(cbiJ)
BAYD : BSPP4475_15710(cobK)
PPQ : PPSQR21_047940(cobK)
PCHI : PC41400_25725(cobK)
SMEN : SAMEA4412692_0362(cobK)
LRU : HMPREF0538_20900(cobK)
AUR : HMPREF9243_1733(cobK)
AMIT : DBT49_0001560(cobK)
CCK : Ccar_11560 Ccar_15385
CTYK : CTK_C09520(cbiJ_cobK)
CDRK : B9W14_15735 B9W14_19430
CCOH : SAMEA4530647_0623(cbiJ)
CGEL : psyc5s11_37860(cbiJ)
BIE : RFF05_08610(cobK) RFF05_11320(cobK)
DMT : DESME_03910 DESME_05660
DOR : Desor_2790 Desor_4599
DAI : Desaci_0752 Desaci_2439
DMI : Desmer_0508 Desmer_2193 Desmer_3643
DRS : DEHRE_01400 DEHRE_14500
DKU : Desku_1461 Desku_1995
AACX : DEACI_1646 DEACI_2578
TJR : TherJR_1266 TherJR_1564
DGI : Desgi_2022 Desgi_2391
AWO : Awo_c10230(cbiJ1) Awo_c30220(cbiJ2)
AWI : CHL1_000465(cobK) CHL1_002753(cobK)
CBAR : PATL70BA_0223(cobK)
AMIC : Ami3637_03205(cobK)
ABUT : Ami103574_05920(cobK)
PDF : CD630DERM_34230(cbiJ)
PHX : KGNDJEFE_00487(cbiJ)
EAC : EAL2_808p01070(cbiJ)
MTHO : MOTHE_c10550(cobK) MOTHE_c12010
MTHZ : MOTHA_c11440(cobK) MOTHA_c12880
PIV : NCTC13079_00694(cobK)
VRM : 44547418_01210(cobK)
VDN : NCTC11831_00753(cobK)
SELM : TAMA11512_14890(cobK)
MANA : MAMMFC1_04001(cobK)
PFAC : PFJ30894_01756(cobK)
MBO : BQ2027_MB2096C(cobK)
MAVM : MAA44156_01804(cobK)
MMAE : MMARE11_29750(cobK)
MBAI : MB901379_02831(cobK)
MHEK : JMUB5695_02272(cobK)
MKY : IWGMT90018_27290(cobK)
MPHL : MPHLCCUG_02701(cobK)
MTHN : 4412656_01954(cobK)
MAUU : NCTC10437_00333(cobK)
MFLV : NCTC10271_02115(cobK)
MGO : AFA91_20080 AFA91_20680
MSAL : DSM43276_01910(cobK)
MTER : 4434518_03162(cobK)
CDIP : ERS451417_01234(cobK)
CUN : Cul210932_1137(cobK)
CUQ : Cul210931_1089(cobK)
CUJ : CUL131002_1121c(cobK)
CRL : NCTC7448_01902(cobK)
NFR : ERS450000_00919(cobK)
NAD : NCTC11293_04435(cobK)
RPY : Y013_10555 Y013_14675
RCR : NCTC10994_03349(cobK)
TPUL : TPB0596_24000(cobK)
DIT : C3V38_05690 C3V38_13650
DLU : A6035_07675 A6035_16460
DCD : VYL96_07735 VYL96_16105
SAMB : SAM23877_6458(cobK)
STRF : ASR50_30720 ASR50_31630
SLE : sle_07920(sle_07920)
SXT : KPP03845_105801(cobK)
DCO : SAMEA4475696_1937(cobK)
CGRN : 4412665_00798(cobK)
PAUS : NCTC13651_00957(cobK)
PPC : HMPREF9154_1259(cobK)
TEZ : BKM78_01605 BKM78_05685
TLA : TLA_TLA_00325(cobK_1) TLA_TLA_01150(cobK_2)
RAIN : Rai3103_04750 Rai3103_07515
NAQU : ENKNEFLB_00264(cobK_1) ENKNEFLB_01615(cobK_2)
PARQ : DSM112329_00634(cobK)
SYR : SynRCC307_0882(cobK)
SYX : SynWH7803_0618(cobK)
MVZ : myaer102_12070(cbiJ)
PAGH : NIES204_04420(cobK)
PRUN : PCC7821_03843(cobK)
NSPH : BDGGKGIB_00929(cobK)
FPOL : ERS445057_01283(cobK)
» show all
Taxonomy
Reference
Authors
Blanche F, Thibaut D, Famechon A, Debussche L, Cameron B, Crouzet J.
Title
Precorrin-6x reductase from Pseudomonas denitrificans: purification and characterization of the enzyme and identification of the structural gene.
Journal
Reference
Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
Title
The biosynthesis of adenosylcobalamin (vitamin B12).
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.54
ExPASy - ENZYME nomenclature database: 1.3.1.54