KEGG   ENZYME: 1.3.1.64
Entry
EC 1.3.1.64                 Enzyme                                 

Name
phthalate 4,5-cis-dihydrodiol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase
Reaction(IUBMB)
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + NADH + H+ [RN:R05275]
Reaction(KEGG)
R05275
Substrate
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate [CPD:C04783];
NAD+ [CPD:C00003]
Product
4,5-dihydroxyphthalate [CPD:C03233];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Involved in the phthalate degradation pathway in bacteria.
History
EC 1.3.1.64 created 2000
Pathway
ec00624  Polycyclic aromatic hydrocarbon degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18067  phthalate 4,5-cis-dihydrodiol dehydrogenase
Genes
PLUL: FOB45_02785
HAM: HALO0376
HSR: HSBAA_48110
HMD: CTT34_16675
CVI: CV_1407
CVC: BKX93_20060
CHRI: DK842_14610
CHRB: DK843_20170
RPF: Rpic12D_2780 Rpic12D_4959
CNC: CNE_2c21270(pht2)
BMJ: BMULJ_03711(ophB)
BMU: Bmul_4806
BMK: DM80_4021
BFN: OI25_3031
BPT: Bpet0249
BHZ: ACR54_04436(pht4)
POL: Bpro_1908
PNA: Pnap_4623
VEI: Veis_2924
CTES: O987_21845
LIM: L103DPR2_01699(pht4_1) L103DPR2_02575(pht4_2)
MMED: Mame_05094(pht4)
CID: P73_2965
LABT: FIU93_07210(pht2)
RID: RIdsm_00903(pht4)
ROT: FIV09_12215(pht3)
SPHR: BSY17_4183
MMC: Mmcs_5443
MGI: Mflv_0624
 » show all
Reference
1  [PMID:3805038]
  Authors
Batie CJ, LaHaie E, Ballou DP.
  Title
Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia.
  Journal
J Biol Chem 262:1510-8 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.64
IUBMB Enzyme Nomenclature: 1.3.1.64
ExPASy - ENZYME nomenclature database: 1.3.1.64
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.64
BRENDA, the Enzyme Database: 1.3.1.64

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