KEGG ENZYME: 1.3.1.64

ENZYME: 1.3.1.64

Entry

EC 1.3.1.64                 Enzyme

Name

phthalate 4,5-cis-dihydrodiol dehydrogenase

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase

Reaction(IUBMB)

cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + NADH + H+ [RN:R05275]

Reaction(KEGG)

R05275

Substrate

cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate [CPD:C04783];
NAD+ [CPD:C00003]

Product

4,5-dihydroxyphthalate [CPD:C03233];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Involved in the phthalate degradation pathway in bacteria.

History

EC 1.3.1.64 created 2000

Pathway

ec00624

Polycyclic aromatic hydrocarbon degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K18067

phthalate 4,5-cis-dihydrodiol dehydrogenase

Genes

PLUL:

FOB45_02785

HARO:

R50071_44710

HAM:

HALO0376

HSR:	HSBAA_48110

HMD:	CTT34_16675

HSX:	HNO51_14910

MPRF:

J8N69_04560

MGEO:

CFI10_14940

CVI:

CV_1407

CVC:	BKX93_20060

CHRI:

DK842_14610

CHRB:

DK843_20170

RPF:	Rpic12D_2780 Rpic12D_4959

CNC:	CNE_2c21270(pht2)

CUK:	KB879_16025

BVI:	Bcep1808_4272

BMJ:	BMULJ_03711(ophB)

BMU:

Bmul_4806

BMK:

DM80_4021

BYI:	BYI23_B001660 BYI23_D008170

BURT:

BTHE68_67900

BFN:

OI25_3031

BCAI:

K788_0000442

PHS:	C2L64_49420

PANN:

PanNE5_13510

PANX:

OYT13_00090

BUO:	BRPE64_DCDS03570 BRPE64_DCDS07100

CABK:

NK8_60750

BUE:	BRPE67_BCDS04050 BRPE67_DCDS10090

BPT:

Bpet0249

BHZ:	ACR54_04436(pht4)

BBRO:

BAU06_03765

BFZ:	BAU07_15850

BPDZ:

BBN53_00970

BOH:	AKI39_21315

AAEG:

RA224_28115

AVH:	WHX56_15255

POLL:

OEG81_03520

PIG:	EGT29_25715

RHY:	RD110_25730

POL:

Bpro_1908

PNA:

Pnap_4623

POS:	DT070_20435

POO:	F7R28_10140

ACID:

CBP33_05515

ACIP:

CBP36_05965 CBP36_20390

ACIN:

CBP34_05350

ACIS:

CBP35_12980

VEI:

Veis_2924

DEL:	DelCs14_1659

CTT:	CtCNB1_1487

CTES:

O987_21845

OTK:	C6570_10600

LIM:	L103DPR2_01699(pht4_1) L103DPR2_02575(pht4_2)

LIMI:

LINBF2_03490

HYR:	BSY239_3462

HYN:	F9K07_27565

HTN:	KI616_03500 KI616_03540

HYDA:

ABSY19_16380

DIM:	K2L43_12475

MASW:

AM586_27435 AM586_27600 AM586_27665

ABAW:

D5400_03690 D5400_20245

BVV:	BHK69_01750

BVES:

QO058_19450

BOI:	BLM15_16150

LNE:	FZC33_27460

MOC:	BB934_42765

MIV:	C4E04_17825

RHZ:	RHPLAN_09750 RHPLAN_11140

DSAL:

K1X15_01470

MMED:

Mame_05094(pht4)

PSIN:

CAK95_02255 CAK95_05905

LABT:

FIU93_07210(pht2)

PHAE:

N1037_23070

CID:

P73_2965

CEH:	CEW89_13895

TPRO:

Ga0080559_TMP5106

PABY:

Ga0080574_TMP2100

RID:	RIdsm_00903(pht4)

ROT:	FIV09_12215(pht3)

RMH:	LVO79_19205

HDH:	G5B40_16615

LVR:	T8T21_20000

MANH:

LA6_006113(pht4)

NOR:	FA702_15520

NDR:	HT578_08885

SPHR:

BSY17_4183

SHYD:

CJD35_19415 CJD35_19640

SPAG:

sphantq_04491(pht4)

SPCA:

GL174_20790 GL174_21635

SPHJ:

BSL82_13975

CNA:	AB433_10230

POT:	E2E27_18195

RMT:	IAI58_16240

TLU:	R1T41_00610

THGO:

M9H61_18400

PERI:

RE409_28285

ANEU:

PP175_12740

MMC:

Mmcs_5443

MKM:	Mkms_5612 Mkms_5840

MYE:	AB431_15435

MGAU:

MGALJ_00490

MGI:

Mflv_0624

MGAD:

MGAD_31770

MPAE:

K0O64_27355

MFRE:

EXE63_06710 EXE63_21950

RKO:	JWS14_17115

PSNI:

NIBR502771_04435

ARHD:

VSH64_08850

RMAR:

GBA65_17505

VAB:

WPS_30500

» show all

Reference

1 [PMID:3805038]

Authors

Batie CJ, LaHaie E, Ballou DP.

Title

Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia.

Journal

J Biol Chem 262:1510-8 (1987)

Other DBs

ExplorEnz - The Enzyme Database:

1.3.1.64

IUBMB Enzyme Nomenclature:

1.3.1.64

ExPASy - ENZYME nomenclature database:

1.3.1.64

UM-BBD (Biocatalysis/Biodegradation Database):

1.3.1.64

BRENDA, the Enzyme Database:

1.3.1.64

DBGET integrated database retrieval system