KEGG   ENZYME: 1.3.1.73
Entry
EC 1.3.1.73                 Enzyme                                 
Name
1,2-dihydrovomilenine 19,20-reductase;
1,2-dihydrovomilenine reductase;
DHVR;
RR4 (gene name);
17-O-acetylnorajmaline:NADP+ oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
17-O-acetylnorajmaline:NADP+ 19,20-oxidoreductase
Reaction(IUBMB)
17-O-acetylnorajmaline + NADP+ = (2R)-1,2-dihydrovomilenine + NADPH + H+ [RN:R05879]
Reaction(KEGG)
R05879;
(other) R13383
Substrate
17-O-acetylnorajmaline [CPD:C11809];
NADP+ [CPD:C00006]
Product
(2R)-1,2-dihydrovomilenine [CPD:C11808];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the plant Rauvolfia serpentina, participates in the ajmaline biosynthesis pathway. It has a much lower activity on vomilenine.
History
EC 1.3.1.73 created 2002, modified 2024
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K27778  1,2-dihydrovomilenine 19,20-reductase
Reference
1  [PMID:12391554]
  Authors
Gao S, von Schumann G, Stockigt J.
  Title
A newly-detected reductase from Rauvolfia closes a gap in the biosynthesis of the antiarrhythmic alkaloid ajmaline.
  Journal
Planta Med 68:906-11 (2002)
DOI:10.1055/s-2002-34935
Reference
2  [PMID:38212296]
  Authors
Guo J, Gao D, Lian J, Qu Y
  Title
De novo biosynthesis of antiarrhythmic alkaloid ajmaline.
  Journal
Nat Commun 15:457 (2024)
DOI:10.1038/s41467-024-44797-z
  Sequence
[ag:WKU61918]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.73
IUBMB Enzyme Nomenclature: 1.3.1.73
ExPASy - ENZYME nomenclature database: 1.3.1.73
BRENDA, the Enzyme Database: 1.3.1.73

  All links  
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (2)   
All databases (4)   

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