KEGG   ENZYME: 1.3.1.8
Entry
EC 1.3.1.8                  Enzyme                                 
Name
acyl-CoA dehydrogenase (NADP+);
2-enoyl-CoA reductase;
dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate);
enoyl coenzyme A reductase;
crotonyl coenzyme A reductase;
crotonyl-CoA reductase;
acyl-CoA dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
acyl-CoA:NADP+ 2-oxidoreductase
Reaction(IUBMB)
acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+ [RN:R00385]
Reaction(KEGG)
R00385 > R01278 R03776 R03856 R03989 R04753 R06985
Substrate
acyl-CoA [CPD:C00040];
NADP+ [CPD:C00006]
Product
2,3-dehydroacyl-CoA [CPD:C00605];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The liver enzyme acts on enoyl-CoA derivatives of carbon chain length 4 to 16, with optimum activity on 2-hexenoyl-CoA. In Escherichia coli, cis-specific and trans-specific enzymes exist [EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) and EC 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)].
History
EC 1.3.1.8 created 1972, modified 1986
Pathway
ec00062  Fatty acid elongation
ec01100  Metabolic pathways
Reference
1  [PMID:6749495]
  Authors
Dommes V, Luster W, Cvetanovic M, Kunau WH.
  Title
Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli.
  Journal
Eur J Biochem 125:335-41 (1982)
DOI:10.1111/j.1432-1033.1982.tb06688.x
Reference
2  [PMID:4387390]
  Authors
Seubert W, Lamberts I, Kramer R, Ohly B
  Title
On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA.
  Journal
Biochim Biophys Acta 164:498-517 (1968)
DOI:10.1016/0005-2760(68)90180-X
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.8
IUBMB Enzyme Nomenclature: 1.3.1.8
ExPASy - ENZYME nomenclature database: 1.3.1.8
BRENDA, the Enzyme Database: 1.3.1.8
CAS: 37251-07-3

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (17)   
   KEGG COMPOUND (17)   
Chemical reaction (8)   
   KEGG REACTION (7)   
   KEGG RCLASS (1)   
Protein sequence (13)   
   UniProt (7)   
   RefSeq(pep) (2)   
   PDBSTR (4)   
DNA sequence (34)   
   RefSeq(nuc) (4)   
   GenBank (17)   
   EMBL (13)   
3D Structure (1)   
   PDB (1)   
All databases (77)   

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