Entry |
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Name |
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Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
(-)-menthone:NADP+ oxidoreductase
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Reaction(IUBMB) |
(1) (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+ [RN: R06419];
(2) (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+ [RN: R06420]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
NADH cannot replace NADPH as reductant. The Delta8,9-double bond of (+)-cis-isopulegone and the Delta1,2-double bond of (+/-)-piperitone are not substrates. The enzyme from peppermint (Mentha x piperita) converts (+)-pulegone into both (-)-menthone and (+)-isomenthone at a ratio of 70:30 for native enzyme but it does not catalyse the reverse reaction. This enzyme is a member of the medium-chain dehydrogenase/reductase superfamily.
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History |
EC 1.3.1.81 created 2008
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Pathway |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
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Reference |
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Authors |
Ringer KL, McConkey ME, Davis EM, Rushing GW, Croteau R. |
Title |
Monoterpene double-bond reductases of the (-)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (-)-isopiperitenone reductase and (+)-pulegone reductase of peppermint. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.3.1.81 |
ExPASy - ENZYME nomenclature database: | 1.3.1.81 |
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