KEGG   ENZYME: 1.3.1.84
Entry
EC 1.3.1.84                 Enzyme                                 

Name
acrylyl-CoA reductase (NADPH)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
propanoyl-CoA:NADP+ oxidoreductase
Reaction(IUBMB)
propanoyl-CoA + NADP+ = acryloyl-CoA + NADPH + H+ [RN:R00919]
Reaction(KEGG)
R00919
Substrate
propanoyl-CoA [CPD:C00100];
NADP+ [CPD:C00006]
Product
acryloyl-CoA [CPD:C00894];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA [2]. Different from EC 1.3.1.8, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16. Contains Zn2+.
History
EC 1.3.1.84 created 2009, modified 2014
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14469  acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
K15020  acryloyl-coenzyme A reductase
Genes
BNG: EH206_02650
TCI: A7K98_04000
PCI: PCH70_27690
PFS: PFLU_2204
PSES: PSCI_5565
PVW: HU752_019175
PIG: EGT29_20960
DOE: DENOEST_2465
MXA: MXAN_4266
MSD: MYSTI_03692
CCX: COCOR_03605(adhP)
GOY: GLS_c14560(adhT)
PDX: Psed_3739
RCA: Rcas_2930
CAU: Caur_0613
CAG: Cagg_3394
CTS: Ctha_1050
TAC: Ta0841
TVO: TVG0995648(TVG0995648)
PTO: PTO1151
FAI: FAD_0007
CDIV: CPM_0774
STO: STK_04800
SSO: SSO0764(adh-2)
SAI: Saci_0911(adh)
MSE: Msed_1426
MCN: Mcup_0809
AHO: Ahos_2283
CSTY: KN1_18030
STEP: IC006_1239
PAI: PAE1921
PIS: Pisl_1770
PCL: Pcal_0882
PAS: Pars_2114
PYR: P186_0181
POG: Pogu_2773
TNE: Tneu_0785
CMA: Cmaq_1615
TTN: TTX_1731(adhP)
TUZ: TUZN_1795
VDI: Vdis_0393
VMO: VMUT_1233
 » show all
Reference
1  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
Reference
2  [PMID:19429610]
  Authors
Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G
  Title
3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.
  Journal
J Bacteriol 191:4572-81 (2009)
DOI:10.1128/JB.00068-09
  Sequence
[sto:STK_04800]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.84
IUBMB Enzyme Nomenclature: 1.3.1.84
ExPASy - ENZYME nomenclature database: 1.3.1.84
BRENDA, the Enzyme Database: 1.3.1.84

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