KEGG ENZYME: 1.3.1.86

ENZYME: 1.3.1.86

Entry

EC 1.3.1.86                 Enzyme

Name

crotonyl-CoA reductase;
butyryl-CoA dehydrogenase;
butyryl dehydrogenase;
unsaturated acyl-CoA reductase;
ethylene reductase;
enoyl-coenzyme A reductase;
unsaturated acyl coenzyme A reductase;
butyryl coenzyme A dehydrogenase;
short-chain acyl CoA dehydrogenase;
short-chain acyl-coenzyme A dehydrogenase;
3-hydroxyacyl CoA reductase;
butanoyl-CoA:(acceptor) 2,3-oxidoreductase;
CCR

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

butanoyl-CoA:NADP+ 2,3-oxidoreductase

Reaction(IUBMB)

butanoyl-CoA + NADP+ = (E)-but-2-enoyl-CoA + NADPH + H+ [RN:R09738]

Reaction(KEGG)

R09738

Substrate

butanoyl-CoA [CPD:C00136];
NADP+ [CPD:C00006]

Product

(E)-but-2-enoyl-CoA [CPD:C00877];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Catalyses the reaction in the reverse direction. This enzyme from Streptomyces collinus is specific for (E)-but-2-enoyl-CoA, and is proposed to provide butanoyl-CoA as a starter unit for straight-chain fatty acid biosynthesis.

History

EC 1.3.1.86 created 2011

Pathway

ec00650

Butanoate metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

ec01120

Microbial metabolism in diverse environments

Orthology

K17829

crotonyl-CoA reductase

Genes

RSU:	NHU_00907(ttmP)

ANT:	Arnit_2215

DDS:

Ddes_1332

DEF:	CNY67_08750(ccrA)

DOA:	AXF15_01755

EUZ:	DVS28_a1285

NAH:	F5544_31360(ccrA)

RANT:

RHODO2019_03955(ccrA)

TPR:

Tpau_3474

SCO:	SCO6473(SC9C7.09c)

SALB:

XNR_0456

SMA:	SAVERM_1911(ccrA2)

SGR:

SGR_1170

SGB:

WQO_29560

SFI:

SFUL_6327

SANL:

KZO11_31645(ccrA)

SGRF:

SGFS_030170 SGFS_032050

SCYE:

R2B67_04490(ccrA)

SCB:	SCAB_17621 SCAB_79701

SSX:	SACTE_5660

SVL:	Strvi_2501 Strvi_3810

SHY:

SHJG_7434

SHO:	SHJGH_7194

SRC:	M271_06415 M271_13255 M271_39450

SMAL:

SMALA_1368 SMALA_6101 SMALA_7129

SAUO:

BV401_10670 BV401_34300 BV401_39275

SSOI:

I1A49_10355(ccrA) I1A49_34355(ccrA) I1A49_39425(ccrA)

SANT:

QR300_05435(ccrA) QR300_11055(ccrA)

SFA:

Sfla_0905

SBH:	SBI_01394 SBI_02836

SVE:

SVEN_6307

SDV:	BN159_0687 BN159_1952

SALS:

SLNWT_0464 SLNWT_7289

STRP:

F750_5949

SCI:	B446_01590(kirN) B446_29770 B446_33700(kirN)

SLV:	SLIV_06060(ccrA2)

SGU:	SGLAU_27255(ccrA2)

SVT:	SVTN_30770

STRE:

GZL_00064 GZL_02323 GZL_09198 GZL_09349

SCW:	TU94_27475

SLD:

T261_1717

SLC:	SL103_24360

STRM:

M444_27580

STRC:

AA958_28645 AA958_29285

SAMB:

SAM23877_5633(srm4) SAM23877_6067(ccr)

SPRI:

SPRI_1330

SCZ:	ABE83_04720

SCX:	AS200_10820

SRW:	TUE45_01107(ccr_1) TUE45_07075(ccr_2)

STRF:

ASR50_29040

SLE:	sle_13020(sle_13020)

SRN:	A4G23_04917(ccr)

SPAV:

Spa2297_26930 Spa2297_32695

STRT:

A8713_26360

SCLF:

BB341_03675

SGS:	AVL59_13890

STSI:

A4E84_33270

SKY:	D0C37_03820(ccrA)

SALW:

CP975_29945(ccrA)

SGM:	GCM10017557_10790(qor) GCM10017557_14280

SCAD:

DN051_09610(ccrA)

SPHW:

NFX46_11075(ccrA)

SGRS:

V9K83_05690(ccrA)

SLS:	SLINC_6872 SLINC_8376

SNR:	SNOUR_10725(ccrA2) SNOUR_41350(ccr)

SALU:

DC74_1416 DC74_6487

SALL:

SAZ_07600 SAZ_33460

SPLU:

LK06_027860

STRD:

NI25_06035

SNW:	BBN63_05335

SSIA:

A7J05_00360 A7J05_06520 A7J05_36375

SVU:	B1H20_30390

SPUN:

BFF78_09060

SGV:	B1H19_32470

SLAU:

SLA_6261 SLA_7255

SALF:

SMD44_07018(ccrA)

SALJ:

SMD11_0917(ccrA) SMD11_1338(ccrA)

SLX:	SLAV_08020(ccrA1)

SFK:	KY5_6787c KY5_7834

SNZ:	DC008_28375(ccrA)

SGE:	DWG14_00548(ccr_2) DWG14_01738(ccrA2)

SRJ:

SRO_1425

SVQ:	N6Q81_28290(ccrA)

SLK:	SLUN_32575(ccrA)

SDX:	C4B68_06490(ccrA)

SGD:	ELQ87_06715(ccrA)

SQZ:	FQU76_28255(ccrA) FQU76_32240(ccrA)

SCYA:

EJ357_38675(ccrA)

SAST:

CD934_04580(ccrA)

SNQ:	CP978_27100(ccrA)

STIR:

DDW44_26350(ccrA)

SKA:	CP970_06740(ccrA)

SGZ:	C0216_10225(ccrA) C0216_31390(ccrA)

SVN:	CP980_06480(ccrA)

SNK:	CP967_03935(ccrA)

SHAW:

CEB94_34120(ccrA) CEB94_37125(ccrA)

SRK:	FGW37_26435(ccrA)

SFIC:

EIZ62_05455(ccrA)

SGAL:

CP966_29715(ccrA)

SSPO:

DDQ41_27620(ccrA)

SVR:	CP971_08930(ccrA)

SPAD:

DVK44_29750(ccrA)

SFY:	GFH48_09625(ccrA)

SAQU:

EJC51_37845(ccrA)

SGF:	HEP81_01391(ccrA_1)

SCAV:

CVT27_29040(ccrA)

SSEO:

D0Z67_24055(ccrA)

SBY:	H7H31_05440(ccrA)

SRIM:

CP984_01705(ccrA) CP984_07145(ccrA)

SSUB:

CP968_06975(ccrA)

SPHV:

F9278_39485(ccrA)

SCIN:

CP977_28235(ccrA)

SFUG:

CNQ36_27180(ccrA)

SPAC:

B1H29_06755

STSU:

B7R87_01675 B7R87_28645

SCHA:

CP983_08255(ccrA)

SGX:	H4W23_31955(ccrA)

SCOE:

CP976_35275(ccrA)

SBAT:

G4Z16_04710(ccrA)

SSPB:

CP982_33020(ccrA)

SNF:	JYK04_06750(ccrA2_1)

SPLA:

CP981_31660(ccrA)

SBRO:

GQF42_34505(ccrA)

STUI:

GCM10017668_58330

SATA:

C5746_34340(ccrA)

SCHF:

IPT68_30325(ccrA)

SHUN:

DWB77_01615(ccrA2)

SCYG:

S1361_04920(ccrA2) S1361_32255(ccr2)

SFEU:

IM697_30275(ccrA)

SLIA:

HA039_05415(ccrA)

SDW:	K7C20_30100(ccrA)

SVD:	CP969_31025(ccrA)

SCAL:

I6J39_30195(ccrA)

SAUH:

SU9_028725(ccrA) SU9_031630(ccrA)

SFB:	CP974_26300(ccrA)

SMOB:

J7W19_26405(ccrA)

SPRA:

CP972_29695(ccrA)

SPEU:

CGZ69_30580(ccrA)

SROI:

IAG44_07405(ccrA)

SXN:	IAG42_06400(ccrA)

SGJ:	IAG43_27270(ccrA)

SHK:	J2N69_31310(ccrA)

SANU:

K7396_06910(ccrA)

STRY:

EQG64_00020(ccrA) EQG64_30325(ccrA)

SDD:	D9753_06035(ccrA)

SACT:

DMT42_31230(ccrA)

SGOB:

test1122_23255(ccrA)

SINE:

KI385_35830(ccrA)

SLF:	JEQ17_10570(ccrA)

SDEC:

L3078_37530(ccrA)

SAOV:

G3H79_06000(ccrA)

SDUR:

M4V62_09165(ccrA) M4V62_38690(ccrA)

SYAN:

NRK68_28085(ccrA)

SRUG:

F0345_25095(ccrA)

SAKB:

K1J60_07745(ccrA)

STAA:

LDH80_08490(ccrA)

SNIG:

HEK616_47020 HEK616_51550

SVIO:

HWN34_03175(ccrA)

SCAE:

IHE65_07980(ccrA) IHE65_08820(ccrA)

STUB:

MMF93_27335(ccrA)

SSPN:

LXH13_31700(ccrA)

SCIR:

STRCI_006606(ccrA) STRCI_007728(ccrA)

SXT:	KPP03845_105978(ccrA2)

SLON:

LGI35_34450(ccrA)

SDRZ:

NEH16_04235(ccrA)

STUD:

STRTU_001167(ccrA)

STEE:

F3L20_13735(ccrA)

SENG:

OJ254_28090(ccrA) OJ254_30590(ccrA)

SGK:	PET44_26105(ccrA)

SYUN:

MOV08_00140(ccrA) MOV08_10525(ccrA) MOV08_42715(ccrA)

SARG:

HKX69_05550(ccrA)

SJN:	RI060_07355(ccrA)

SCYN:

N8I84_32180(ccrA)

SOV:	QZH56_05540(ccrA)

SFIY:

F0344_03860(ccrA)

SHAU:

K9S39_10765(ccrA)

SKG:	KJK29_05555(ccrA)

SCOA:

QU709_07140(ccrA)

SLAI:

P8A22_05560(ccrA)

SFP:	QUY26_06970(ccrA)

SCHG:

NRO40_24750(ccrA)

STTN:

BSL84_27875

SINN:

ABB07_06445 ABB07_06645

STRZ:

OYE22_05250(ccrA)

SCAY:

PYS65_05380(ccrA)

KBU:	Q4V64_44555(ccrA) Q4V64_45340(ccrA)

SARM:

DVA86_00485(ccrA)

SLUO:

PS467_31670(ccrA) PS467_39410(ccrA)

STPB:

QR97_28980 QR97_30510

SRPA:

HEP86_32940(ccrA)

SMIB:

SMIR_03615(ccrA)

SCAJ:

O1G22_08155(ccrA)

STRW:

QHG49_06945(ccrA)

STRL:

HEP84_40880(ccrA)

STSD:

HEP87_42420(ccrA)

SRPZ:

HEP85_31815(ccrA)

SCHE:

QRN89_28735(ccrA)

SGLY:

P8A20_04845(ccrA)

SCAT:

P8A18_29505(ccrA)

STII:

DRB96_25090(ccrA)

STIC:

DRB89_24685(ccrA)

SABD:

N8I86_30335(ccrA)

STRV:

EZV63_30880(ccrA) EZV63_32615(ccrA) EZV63_36190(ccrA)

SPAZ:

ABXI76_04520(ccrA)

SPIH:

ABXR15_03205(ccrA)

SMOD:

POD33_25575(ccrA)

SPOF:

P8A21_33900(ccrA)

STBR:

ABDE16_06590(ccrA)

SGRO:

UBV09_28355(ccrA)

STAC:

ABII15_31575(ccrA)

STVB:

OH133_04960(ccrA) OH133_33500(ccrA)

SSOC:

ABZO31_27315(ccrA)

SSLI:

R2D22_06990(ccrA)

STYI:

C9F11_32145(ccrA1)

SCIT:

V2W30_32460(ccrA)

SSIR:

WAB15_32925(ccrA)

SEXP:

SLV14_001414(ccrA)

SFLU:

ACKTSN_08540(ccrA)

SOKE:

ACE1N8_30040(ccrA)

SSTO:

ACE1OC_08385(ccrA)

SLUA:

AB8735_29750(ccrA)

STGO:

KBP30_01650(ccrA) KBP30_08555(ccrA)

STCM:

SCMC78_08890(ccrA)

STID:

G7Z12_06470(ccrA)

STCZ:

JHY03_60140(ccrA)

STSG:

B6R96_07145

STHU:

M1P56_21960(ccrA) M1P56_23300(ccrA)

STRQ:

CGL27_09580(ccrA) CGL27_35730(ccrA) CGL27_42230(ccrA)

SSEC:

ABZO29_10630(ccrA)

SHUG:

ABVG11_04165(ccrA) ABVG11_09025(ccrA) ABVG11_36690(ccrA)

STRK:

R2B38_34670(ccrA)

STJL:

ACE1OA_06975(ccrA)

STHP:

MQE23_09185(ccrA) MQE23_16035(ccrA)

STRX:

A6E92_04035

STFR:

SFR_0765

STFD:

B1K54_29685

STSM:

B9S66_27360(ccrA)

STFI:

WID27_05990(ccrA)

SCT:	SCAT_0122 SCAT_3263(ccr) SCAT_4859(ccr)

SCY:	SCATT_01300 SCATT_32610 SCATT_48530

KSK:	KSE_56510(ccr1) KSE_70410(ccr2)

KAB:	B7C62_31670

KAU:	B6264_03990

KIT:	CFP65_5574

KIS:	HUT16_26335(ccrA)

KCH:	O1G21_06700(ccrA) O1G21_11810(ccrA)

KCM:	ABWK59_24665(ccrA)

KNB:	ACF9IK_10110(ccrA)

KIC:	KCMC57_up18170(ccrA)

KPUR:

ACFCLZ_04835(ccrA) ACFCLZ_27570(ccrA)

STRI:

C7M71_024015(ccrA)

PPOD:

AB0761_11175(ccrA)

YIA:	LO772_11890(ccrA)

STRH:

GXP74_30635(ccrA)

ABRY:

NYE86_04265(ccrA) NYE86_24195(ccrA)

AGLA:

OIE69_10745(ccrA)

AREV:

RVR_8200 RVR_8766

ICA:	Intca_2418

ARS:	ADJ73_15655

JTE:	ASJ30_04335

JLI:	EXU32_10460(ccrA)

JME:	EEW87_010490(ccrA)

JAY:	H7A72_04305(ccrA)

JCR:	O9K63_00790(ccrA)

JAI:	V1351_04375(ccrA)

JTR:	V3C34_07325(ccrA)

TEH:	GKE56_08395(ccrA)

TED:	U5C87_19820(ccrA)

KNO:	V6K52_06580(ccrA)

NCA:

Noca_1795

NDK:	I601_3892(ccr_1)

NOY:	EXE57_04975(ccrA)

NOI:	FCL41_11260(ccrA)

NOO:	FE634_09285(ccrA)

NSN:	EXE58_14365(ccrA)

NBE:	Back2_04340

NANO:

G5V58_14345(ccrA)

NMES:

H9L09_15910(ccrA)

NARO:

CFH99_10030(ccrA)

NPI:	G7071_11245(ccrA)

NAQU:

ENKNEFLB_01882(ccr_1)

NRO:	K8W59_11035(ccrA)

NOQ:	LN652_20215(ccrA)

NCQ:	K6T13_05955(ccrA)

NPC:	KUV85_07785(ccrA)

NPS:	KRR39_03695(ccrA)

NMAR:

HPC71_14835(ccrA)

NFC:	KG111_11410(ccrA)

NRN:	SHK17_06895(ccrA)

NBI:	SHK19_14415(ccrA)

NOF:	MF408_18715

NOCR:

OSR43_14825(ccrA)

NOCW:

ABFU82_03745(ccrA)

NOCA:

ncot_12935(ccrA)

NOCL:

KM427_09225(ccrA)

NOCD:

QJ852_16850(ccrA)

NOCQ:

QI633_16160(ccrA)

NLB:	P5P86_14750(ccrA)

PSIM:

KR76_10630

AER:	AERYTH_06800

AEZ:	C3E78_12365(ccrA)

AEB:	C6I20_10340(ccrA)

AEF:	GEV26_12405(ccrA)

ASEZ:

H9L21_10350(ccrA)

ADB:	NP095_10540(ccrA)

AWN:	NQV15_13025(ccrA)

MUZ:	H4N58_06095(ccrA)

MQR:	AB3M34_07410(ccrA)

SGRG:

L0C25_02355(ccrA)

NBT:	KLP28_14805(ccrA)

KFL:

Kfla_4989

KQI:	F1D05_07275(ccrA)

KSL:	OG809_40925(ccrA)

KRI:	OX958_11845(ccrA)

NAL:

B005_2057

ACTW:

F7P10_02800(ccrA)

AGRA:

AGRA3207_004337(ccrA)

AWS:	ACN3XK_62045(ccrA)

NCX:	Nocox_19935(ccr1)

FRA:	Francci3_0999 Francci3_3690

FAL:

FRAAL5913

FRE:	Franean1_1041 Franean1_3014 Franean1_4051

FSY:	FsymDg_3826

FRI:	FraEuI1c_0956

GOB:

Gobs_4114

BSD:	BLASA_3898

BLAP:

MVA48_21160

BBRG:

U6N30_22480(ccrA)

BMON:

ABDB74_16110(ccrA)

AMD:	AMED_1574(qor)

AMN:

RAM_07995

AMM:	AMES_1564(qor)

AMZ:	B737_1565(qor)

AOI:	AORI_6359(ccr)

AJA:	AJAP_07605(ccr)

AMQ:	AMETH_5552(qor)

AMYC:

CU254_06330(ccrA)

AMYB:

BKN51_25265

AAB:	A4R43_20575

AMYY:

YIM_09020(ccr1)

AORI:

SD37_08570

AACD:

LWP59_32235(ccrA)

APRT:

MUY14_28655(ccrA)

AROO:

NQK81_33960(ccrA)

ATHM:

L1857_30645(ccrA)

AMOG:

QRX60_02950(ccrA)

ACYN:

ORV05_03775(ccrA)

ACOR:

LCL61_34370(ccrA)

AMYZ:

HUW46_05277(ccr_3) HUW46_06157(ccr_4)

ANW:	QP939_03030(ccrA)

AMYD:

K1T34_33875(ccrA)

AMYE:

MJQ72_17725(ccrA)

AMYS:

CVV72_37485(ccrA)

ARHI:

AB5I40_18465(ccrA)

PDX:

Psed_1713

PSEA:

WY02_10715

PSEE:

FRP1_03485

PSEH:

XF36_19290

PSEQ:

AD006_11095

PECQ:

AD017_18925

PHH:	AFB00_04595

PAUT:

Pdca_54450(qor_4)

PBRO:

HOP40_14625(ccrA)

PPEL:

H6H00_14120(ccrA)

PSDS:

K1T35_40630(ccrA)

PALQ:

PaSha_16695(ccrA)

SESP:

BN6_73120

SSYI:

EKG83_40835(ccrA)

SACX:

IOD16_30460(ccrA)

KAL:

KALB_7555

KUT:	JJ691_101410(ccrA) JJ691_31710(qor_3) JJ691_90400(qor_11)

KBR:	Q4V65_32140(ccrA)

KPHY:

AOZ06_46110

LED:	BBK82_20900

LXR:	ACRSBM_03070(ccrA)

LENT:

JNUCC0626_19525(ccrA) JNUCC0626_40725(ccrA)

AHM:	TL08_14615

ACTI:

UA75_17830

ACAD:

UA74_17295

AHG:	AHOG_15470(ccr)

ALO:

CRK58980

PMAD:

BAY61_24435

ACTU:

Actkin_05087(ccr)

AAUR:

V5P93_001611(ccrA)

CROS:

N8J89_34970(ccrA)

ACTY:

OG774_11685(ccrA)

UME:	RM788_17980(ccrA)

STP:	Strop_3612

SAQ:

Sare_3994

MAU:	Micau_5101

MIL:

ML5_3210

MICB:

MicB006_4119

MTUA:

CSH63_32170(ccrA)

MTEM:

GCE86_20130(ccrA)

MCAB:

HXZ27_06160(rosM)

MCHL:

PVK74_15775(ccrA)

MFEU:

H1D33_01025(ccrA)

MPRN:

Q3V37_12415(ccrA)

MHAW:

RMN56_17345(ccrA)

ACTN:

L083_2886

ACTR:

Asp14428_74420(qor_4)

PFLA:

Pflav_056950

PSUU:

Psuf_016530 Psuf_046990(qor_4)

CATI:

CS0771_21970(qor_1)

DVC:	Dvina_07605(ccrA)

DMAT:

Dmats_07125(ccrA)

DFU:	Dfulv_07030(ccrA)

DROS:

Drose_07385(ccrA)

DAUR:

Daura_06955(ccrA)

DACT:

KZZ52_06830(ccrA)

CAI:

Caci_1252

SNA:

Snas_4138

EKE:	EK0264_16515(ccrA)

JTL:	M6D93_07735(ccrA)

JCY:	M6B22_19790(ccrA)

JAT:	SAMN05892883_2622

ABAI:

IMCC26256_11169

AFO:

Afer_0105

AYM:	YM304_37120

ATQ:	GH723_16625(ccrA)

AQZ:	KSP35_14110(ccrA)

IAM:	HC251_22975(ccrA)

IMA:	PO878_01325(ccrA)

DHI:	LH044_12590(ccrA)

» show all

Reference

1 [PMID:8521864]

Authors

Wallace KK, Bao ZY, Dai H, Digate R, Schuler G, Speedie MK, Reynolds KA

Title

Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli.

Journal

Eur J Biochem 233:954-62 (1995)
DOI:10.1111/j.1432-1033.1995.954_3.x

Sequence

[ag:AAA92890]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.1.86

IUBMB Enzyme Nomenclature:

1.3.1.86

ExPASy - ENZYME nomenclature database:

1.3.1.86

BRENDA, the Enzyme Database:

1.3.1.86

All links

Gene (704)   
   MGENES (567)   
   RefGene (137)   
Protein sequence (543)   
   UniProt (540)   
   SWISS-PROT (3)   
DNA sequence (305)   
   GenBank (156)   
   EMBL (149)   
All databases (1552)   

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