KEGG   ENZYME: 1.3.2.4
Entry
EC 1.3.2.4                  Enzyme                                 
Name
fumarate reductase (cytochrome);
fccA (gene name);
fcc3 (gene name);
flavocytochrome c3
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a cytochrome as acceptor
Sysname
succinate:ferricytochrome-c oxidoreductase
Reaction(IUBMB)
succinate + 2 ferricytochrome c = fumarate + 2 ferrocytochrome c [RN:R13137]
Reaction(KEGG)
R13137
Substrate
succinate [CPD:C00042];
ferricytochrome c [CPD:C00125]
Product
fumarate [CPD:C00122];
ferrocytochrome c [CPD:C00126]
Comment
Contains a non-covalently bound FAD cofactor and four heme c groups. The enzyme, characterized from the bacterium Shewanella frigidimarina, is a soluble periplasmic protein that functions as a terminal electron acceptor during anaerobic growth. The direct electron donor is the membrane-bound tetraheme c-type cytochrome CymA (EC 7.1.1.8, quinol---cytochrome-c reductase), which receives the electrons from the membrane quinol pool.
History
EC 1.3.2.4 created 2022
Pathway
ec00020  Citrate cycle (TCA cycle)
ec00620  Pyruvate metabolism
ec00650  Butanoate metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K26318  fumarate reductase (cytochrome)
Genes
SONSO_0970(fccA)
SFRSfri_3690
SAZSama_0611
SBLSbal_0859
SBMShew185_3505
SBNSbal195_3628
SBPSbal223_3433
SBTSbal678_3651
SBSSbal117_0955
SBBSbal175_3411
SLOShew_3112
SPCSputcn32_0905
SHPSput200_0902
SSESsed_3877
SPLSpea_0722
SHEShewmr4_0808
SHMShewmr7_3215
SHNShewana3_3318
SHWSputw3181_3267
SHLShal_0776
SWDSwoo_3776
SWPswp_4352
SHFCEQ32_11620
SJASJ2017_0503
SPSWSps_04949
SBJCF168_04200
SMAVCFF01_15645
SHEWCKQ84_03180
SALGBS332_03245
SLJEGC82_20545
SMAIEXU30_11795
SPOLFH971_18500
SBKSHEWBE_1282(fccA)
SKHSTH12_00145
SLITJQC75_02835
SCAATUM17387_07670
SPSHFM037_23565
SEURFM038_004020
SYKKDN34_13800
SAVIJYB87_03940
SGLAFJ709_02680
SINVK8B83_04405
SXMMKD32_16500(fccA)
SVMKDH10_003463
SHEJMZ182_04200(fccA)
SSEHN7V09_06640(fccA)
SCHKGII14_18165
SACHK0H61_13985(fccA)
SAEGK0H80_15945
SDEOD0436_17960(fccA)
SMESK0I73_03760
SHAOK0H81_16235
SZHK0H63_03445(fccA)
SSPAK0I31_16180
SHNSK0J45_15960
SRHSK0I63_16090
SPSJK0I62_03605
SMAYK0H60_16630(fccA)
SOGRA178_17680(fccA)
FBLFbal_1806
FESHER31_12130
GEMGM21_4127
GEBGM18_3822
GEFFO488_03675
GLOGlov_3541 Glov_3625
GBMGbem_3597 Gbem_4036
GBNGEOBRER4_39050
GERKP004_01890 KP004_19445
GSUBKP001_13600 KP001_16875
GNTKP003_01525 KP003_19430
GPLM1B72_00310 M1B72_19080
GEPQ9293_09155
MSILMETEAL_10940
MSEAMETESE_16190
MSCHN508_000493
 » show all
Reference
1  [PMID:1333793]
  Authors
Pealing SL, Black AC, Manson FD, Ward FB, Chapman SK, Reid GA.
  Title
Sequence of the gene encoding flavocytochrome c from Shewanella putrefaciens: a tetraheme flavoenzyme that is a soluble fumarate reductase related to the membrane-bound enzymes from other bacteria.
  Journal
Biochemistry 31:12132-40 (1992)
DOI:10.1021/bi00163a023
  Sequence
[sfr:Sfri_3690]
Reference
2  [PMID:7742319]
  Authors
Pealing SL, Cheesman MR, Reid GA, Thomson AJ, Ward FB, Chapman SK.
  Title
Spectroscopic and kinetic studies of the tetraheme flavocytochrome c from Shewanella putrefaciens NCIMB400.
  Journal
Biochemistry 34:6153-8 (1995)
DOI:10.1021/bi00018a018
Reference
3  [PMID:9579067]
  Authors
Gordon EHJ, Pealing SL, Chapman SK, Ward FB, Reid GA.
  Title
Physiological function and regulation of flavocytochrome c3, the soluble fumarate reductase from Shewanella putrefaciens NCIMB 400.
  Journal
Microbiology (Reading) 144 ( Pt 4):937-945 (1998)
DOI:10.1099/00221287-144-4-937
Reference
4  [PMID:10978153]
  Authors
Doherty MK, Pealing SL, Miles CS, Moysey R, Taylor P, Walkinshaw MD, Reid GA, Chapman SK.
  Title
Identification of the active site acid/base catalyst in a bacterial fumarate reductase: a kinetic and crystallographic study.
  Journal
Biochemistry 39:10695-701 (2000)
DOI:10.1021/bi000871l
Reference
5  [PMID:11004445]
  Authors
Reid GA, Miles CS, Moysey RK, Pankhurst KL, Chapman SK.
  Title
Catalysis in fumarate reductase.
  Journal
Biochim Biophys Acta 1459:310-5 (2000)
DOI:10.1016/s0005-2728(00)00166-3
  Sequence
[son:SO_0970] [sfr:Sfri_3690]
Reference
6  [PMID:12196158]
  Authors
Schwalb C, Chapman SK, Reid GA.
  Title
The membrane-bound tetrahaem c-type cytochrome CymA interacts directly with the soluble fumarate reductase in Shewanella.
  Journal
Biochem Soc Trans 30:658-62 (2002)
DOI:10.1042/bst0300658
Other DBs
ExplorEnz - The Enzyme Database: 1.3.2.4
IUBMB Enzyme Nomenclature: 1.3.2.4
ExPASy - ENZYME nomenclature database: 1.3.2.4
BRENDA, the Enzyme Database: 1.3.2.4

DBGET integrated database retrieval system