ENZYME: 1.3.3.11 Help
Entry
Name
pyrroloquinoline-quinone synthase;
PqqC;
6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) [incorrect]
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing)
Reaction(IUBMB)
6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O [RN:
R07353 ]
Reaction(KEGG)
Substrate
6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate [CPD:
C15599 ];
O2 [CPD:
C00007 ]
Product
4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate [CPD:
C00113 ];
H2O2 [CPD:
C00027 ];
H2O [CPD:
C00001 ]
Comment
So far only a single turnover of the enzyme has been observed, and the pyrroloquinoline quinone remains bound to it. It is not yet known what releases the product in the bacterium.
History
EC 1.3.3.11 created 2005
Orthology
K06137 pyrroloquinoline-quinone synthase
Genes
CLAP : NCTC11466_01759(pqqC)
SMW : SMWW4_v1c09260(pqqC1) SMWW4_v1c24130(pqqC2)
SFJ : SAMEA4384070_2480(pqqC)
SOF : NCTC11214_04413(pqqC)
SNEM : NLX84_04525(pqqC) NLX84_12240(pqqC)
TPTY : NCTC11468_01819(pqqC)
XFU : XFF4834R_chr15170(pqqC)
XPH : XppCFBP6546_03180(pqqC)
XHD : LMG31886_12330(pqqCD)
LAB : LA76x_0598 LA76x_3896(pqqC)
LAQ : GLA29479_2672 GLA29479_3370(pqqC)
PAEB : NCGM1900_4500(pqqC)
PPUH : B479_02365 B479_18535
PPUD : DW66_0387 DW66_4170
PMON : X969_00190 X969_17945
PMOT : X970_00190 X970_17580
PPJ : RK21_00767 RK21_04641
PAMG : BKM19_024795 BKM19_027135
PPRC : PFLCHA0_c56270(pqqC)
PFE : PSF113_2911 PSF113_5385(pqqC)
PMAN : OU5_4016(pqqC) OU5_6122
PMUD : NCTC8068_04900(pqqC)
PFW : PF1751_v1c50270(pqqC)
PBA : PSEBR_a2041 PSEBR_a2864 PSEBR_a5167
PPUU : PputUW4_02940(pqqC1) PputUW4_04967(pqqC2)
PFK : PFAS1_13855 PFAS1_27355
PSIL : PMA3_15645 PMA3_27705
PUM : HGP31_10680(pqqC) HGP31_20490(pqqC) HGP31_28625(pqqC)
PBZ : GN234_03315 GN234_20950(pqqC)
PTRT : HU722_0027020(pqqC)
PXN : HU772_002015(pqqC) HU772_009530
PAZE : KSS91_16400(pqqC) KSS91_26400(pqqC)
PTW : TUM18999_41810(pqqC)
PZA : HU749_011885(pqqC) HU749_027340(pqqC)
PTAE : NCTC10697_00436(pqqC)
PJU : L1P09_01765(pqqC) L1P09_08885
PHF : NLY38_13820(pqqC) NLY38_14660(pqqC)
PIZ : LAB08_R21610(pqqC) LAB08_R32440(pqqC) LAB08_R55620(pqqC)
PASI : LG197_07020(pqqC) LG197_25360
PKM : PZ739_01950(pqqC) PZ739_11960(pqqC)
PNB : NK667_14200(pqqC) NK667_30295(pqqC)
PKJ : Q1W70_12690(pqqC) Q1W70_24565(pqqC)
PHOM : KJF94_12740(pqqC) KJF94_23985(pqqC)
PCUC : PSH97_12365(pqqC) PSH97_25570(pqqC)
MSHE : MAALD49_33540(pqqC)
MISZ : MishRS11D_21320(pqqC)
THIS : HZT40_10650 HZT40_22055(pqqC)
TWN : L2Y54_05500(pqqC) L2Y54_16150
TLC : RCF98_03730 RCF98_08175(pqqC)
TDU : QJT80_06715 QJT80_12955(pqqC)
GAI : IMCC3135_24215(pqqC)
HCAM : I4484_16135(pqqC) I4484_18735(pqqC)
HSX : HNO51_16060(pqqC) HNO51_18690(pqqC)
HSV : HNO53_16630(pqqC) HNO53_19010(pqqC)
HTX : EKK97_03435 EKK97_18150(pqqC)
GBI : PG2T_13335 PG2T_14460
RPJ : N234_11915 N234_31070
REH : H16_B1051(pqqC1) H16_B1880(pqqC2)
CNC : CNE_2c10130(pqqC1) CNE_2c18360(pqqC2) CNE_BB1p04370(pqqC)
CUH : BJN34_11445 BJN34_25305
REU : Reut_A1780 Reut_B3762
CTI : RALTA_A1791 RALTA_B0440(pqqC2) RALTA_B0670(pqqC1) RALTA_B1579
CBW : RR42_m2315 RR42_s1355 RR42_s1360
CGD : CR3_1422(pqqC) CR3_3394(pqqC)
CCUP : BKK81_28240 BKK81_32025
CUP : BKK80_24325 BKK80_28135
CUU : BKK79_29600 BKK79_34050
COX : E0W60_02935 E0W60_17930(pqqC)
CCAX : KZ686_11265(pqqC) KZ686_17485
CUK : KB879_10035(pqqC) KB879_14440
BUB : BW23_3519(pqqC) BW23_6194
BGL : bglu_1g16720 bglu_1g23050 bglu_2g05730 bglu_2g11480 bglu_2g22320
BGU : KS03_2569 KS03_3141 KS03_3686(pqqC) KS03_4775 KS03_5341
BUE : BRPE67_BCDS01140(pqqC)
BGP : BGL_2c07550 BGL_2c14220 BGL_2c29020(pqqC)
BPLA : bpln_2g08410 bpln_2g14980 bpln_2g29040
BXE : Bxe_A1825 Bxe_B2468(pqqC)
BXB : DR64_3987 DR64_4795(pqqC)
BFN : OI25_1558 OI25_3474(pqqC)
PSPW : BJG93_19545(pqqC) BJG93_33580(pqqC)
PTRO : G5S35_24695(pqqC) G5S35_37755 G5S35_37800
PDIO : PDMSB3_0597.1(pqqC) PDMSB3_1134.1
PLG : NCTC10937_04971(pqqC)
CABA : SBC2_61720(pqqC_1) SBC2_81670(pqqC_2)
TVL : FAZ95_12170(pqqC) FAZ95_34015(pqqC)
TCAR : U0034_17385(pqqC) U0034_27680
BBH : BN112_1977 BN112_3779
BBM : BN115_1438 BN115_4321
BBX : BBS798_1444 BBS798_4420
AMIM : MIM_c14270(pqqC) MIM_c33510
VPD : VAPA_1c31210(pqqC) VAPA_2c08060
HTN : KI616_05540 KI616_05605 KI616_09225(pqqC)
HCZ : G9Q37_03605(pqqC) G9Q37_15085
ETB : N7L95_03455 N7L95_12155(pqqC)
NLC : EBAPG3_003235 EBAPG3_003250
AAK : AA2016_0319 AA2016_0334
AMIS : Amn_04130 Amn_04260
SMEL : SM2011_b20206(pqqC)
SFH : SFHH103_05875(pqqC) SFHH103_06436(pqqC)
SFD : USDA257_c31230(pqqC)
SIX : BSY16_5728(pqqC) BSY16_6308(pqqC)
SAME : SAMCFNEI73_pC0400(pqqC)
RGA : RGR602_PC01540(pqqC)
NEN : NCHU2750_46870(pqqC)
BRK : CWS35_13765 CWS35_34275
BSEP : HAP48_0003610(pqqC)
BCAN : BcanWSM471_29715(pqqC)
METS : DK389_02250 DK389_20590
MMES : MMSR116_16625(pqqC)
MTUN : MTUNDRAET4_0211.1(pqqC)
HNI : W911_11775 W911_13135
FIL : BN1229_v1_0595(pqqC)
FIY : BN1229_v1_0597(pqqC)
RLI : RLO149_c036940(pqqC)
RMM : ROSMUCSMR3_01475(pqqC)
EBLA : JGUZn3_05290(pqqCD)
SRF : LHU95_06865 LHU95_20545(pqqC)
SKT : IGS68_06430(pqqC) IGS68_31105
TMO : TMO_0015 TMO_3112(pqqC) TMO_3170
CFUS : CYFUS_002596 CYFUS_006417
NCM : QNK12_01480(pqqC) QNK12_17650
ANX : ACH33_11595 ACH33_13320
ATHE : K3F53_05600 K3F53_07360
MMAN : MMAN_21300 MMAN_21540 MMAN_21840
MSM : MSMEG_1458 MSMEG_3723(pqqC)
MSG : MSMEI_1422 MSMEI_3635
MSB : LJ00_07285 LJ00_18500
MSN : LI99_07285 LI99_18505
MSH : LI98_07285 LI98_18510
MGO : AFA91_21335 AFA91_31610
SHO : SHJGH_0454 SHJGH_2196
SSOI : I1A49_00645 I1A49_39100(pqqC)
SGS : AVL59_04170 AVL59_14240
SGM : GCM10017557_13120(pqqC)
SAUO : BV401_00905 BV401_38970
SPUN : BFF78_08685 BFF78_37910 BFF78_41180
SCHA : CP983_07770(pqqC) CP983_17445(pqqC)
SROI : IAG44_01905 IAG44_42420(pqqC)
SGOB : test1122_26280(pqqC)
AGRA : AGRA3207_007106(pqqC)
SACG : FDZ84_00620(pqqC) FDZ84_32310(pqqC)
ARHD : VSH64_08505(pqqC) VSH64_15850(pqqC) VSH64_21115(pqqC)
PSEA : WY02_08075 WY02_28705
PSEE : FRP1_13230 FRP1_13955
PSEQ : AD006_20910 AD006_21620
PECQ : AD017_00490 AD017_01205
PHH : AFB00_23640 AFB00_24045
RMAR : GBA65_05820(pqqC) GBA65_18650
KOV : K9N68_09060 K9N68_33710
LSC : KIK02_06955 KIK02_09270
LSK : J5X98_01565 J5X98_17895
KBS : EPA93_15955(pqqC) EPA93_43915(pqqC)
CCZ : CCALI_00348 CCALI_01929
CSUI : Chls_963(alternative_para-aminobenzoate_biosynthesis_enzyme)
HTH : HTH_1212(pqqC1) HTH_1214(pqqC2)
HTE : Hydth_1204 Hydth_1206
NMV : NITMOv2_0065 NITMOv2_0773(pqqC)
SACD : HS1genome_0419 HS1genome_2203
» show all
Taxonomy
Reference
Authors
Magnusson OT, Toyama H, Saeki M, Schwarzenbacher R, Klinman JP.
Title
The structure of a biosynthetic intermediate of pyrroloquinoline quinone (PQQ) and elucidation of the final step of PQQ biosynthesis.
Journal
Reference
Authors
Magnusson OT, Toyama H, Saeki M, Rojas A, Reed JC, Liddington RC, Klinman JP, Schwarzenbacher R
Title
Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone.
Journal
Sequence
Reference
Authors
Toyama H, Chistoserdova L, Lidstrom ME
Title
Sequence analysis of pqq genes required for biosynthesis of pyrroloquinoline quinone in Methylobacterium extorquens AM1 and the purification of a biosynthetic intermediate.
Journal
Sequence
Reference
Authors
Yasunaga K.
Title
[Concept of thrombocytopathy and problems involved in its diagnosis (author's transl)]
Journal
Nippon Ketsueki Gakkai Zasshi 38:734-40 (1975)
Reference
Authors
Schwarzenbacher R, Stenner-Liewen F, Liewen H, Reed JC, Liddington RC.
Title
Crystal structure of PqqC from Klebsiella pneumoniae at 2.1 A resolution.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.3.3.11
ExPASy - ENZYME nomenclature database: 1.3.3.11