KEGG   ENZYME: 1.3.3.13
Entry
EC 1.3.3.13                 Enzyme                                 

Name
albonoursin synthase;
cyclo(dipeptide):oxygen oxidoreductase;
cyclic dipeptide oxidase;
AlbA
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With oxygen as acceptor
Sysname
cyclo(L-leucyl-L-phenylalanyl):oxygen oxidoreductase
Reaction(IUBMB)
cyclo(L-leucyl-L-phenylalanyl) + 2 O2 = albonoursin + 2 H2O2 (overall reaction) [RN:R10329];
(1a) cyclo(L-leucyl-L-phenylalanyl) + O2 = cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2 [RN:R10327];
(1b) cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 = albonoursin + H2O2 [RN:R10328]
Reaction(KEGG)
Substrate
cyclo(L-leucyl-L-phenylalanyl) [CPD:C20519];
O2 [CPD:C00007];
cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] [CPD:C20521]
Product
albonoursin [CPD:C20520];
H2O2 [CPD:C00027];
cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] [CPD:C20521]
Comment
A flavoprotein from the bacterium Streptomyces noursei. The enzyme can also oxidize several other cyclo dipeptides, the best being cyclo(L-tryptophyl-L-tryptophyl) and cyclo(L-phenylalanyl-L-phenylalanyl) [1,2].
History
EC 1.3.3.13 created 2013
Orthology
K21375  albonoursin synthase
Genes
SALU: DC74_8070
SALL: SAZ_41675
STRE: GZL_03261
SNR: SNOUR_14230
Reference
1  [PMID:11248691]
  Authors
Gondry M, Lautru S, Fusai G, Meunier G, Menez A, Genet R
  Title
Cyclic dipeptide oxidase from Streptomyces noursei. Isolation, purification and partial characterization of a novel, amino acyl alpha,beta-dehydrogenase.
  Journal
Eur J Biochem 268:1712-21 (2001)
DOI:10.1046/j.1432-1327.2001.02038.x
Reference
2  [PMID:12498889]
  Authors
Lautru S, Gondry M, Genet R, Pernodet JL
  Title
The albonoursin gene Cluster of S noursei biosynthesis of diketopiperazine metabolites independent of nonribosomal peptide synthetases.
  Journal
Chem Biol 9:1355-64 (2002)
DOI:10.1016/S1074-5521(02)00285-5
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.3.13
IUBMB Enzyme Nomenclature: 1.3.3.13
ExPASy - ENZYME nomenclature database: 1.3.3.13
BRENDA, the Enzyme Database: 1.3.3.13

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