cyclic dipeptide oxidase;
Acting on the CH-CH group of donors;
With oxygen as acceptor
cyclo(L-leucyl-L-phenylalanyl) + 2 O2 = albonoursin + 2 H2O2 (overall reaction) [RN:
(1a) cyclo(L-leucyl-L-phenylalanyl) + O2 = cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2 [RN:
(1b) cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 = albonoursin + H2O2 [RN:
A flavoprotein from the bacterium Streptomyces noursei. The enzyme can also oxidize several other cyclo dipeptides, the best being cyclo(L-tryptophyl-L-tryptophyl) and cyclo(L-phenylalanyl-L-phenylalanyl) [1,2].
EC 126.96.36.199 created 2013
Gondry M, Lautru S, Fusai G, Meunier G, Menez A, Genet R
Cyclic dipeptide oxidase from Streptomyces noursei. Isolation, purification and partial characterization of a novel, amino acyl alpha,beta-dehydrogenase.
Lautru S, Gondry M, Genet R, Pernodet JL
The albonoursin gene Cluster of S noursei biosynthesis of diketopiperazine metabolites independent of nonribosomal peptide synthetases.
ExplorEnz - The Enzyme Database: 188.8.131.52
ExPASy - ENZYME nomenclature database: 184.108.40.206