KEGG   ENZYME: 1.3.4.1
Entry
EC 1.3.4.1                  Enzyme                                 
Name
fumarate reductase (CoM/CoB);
thiol:fumarate reductase;
Tfr
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a disulfide as acceptor
Sysname
fumarate CoM:CoB oxidoreductase (succinate-forming)
Reaction(IUBMB)
fumarate + CoM + CoB = succinate + CoM-S-S-CoB [RN:R10660]
Reaction(KEGG)
R10660
Substrate
fumarate [CPD:C00122];
CoM [CPD:C03576];
CoB [CPD:C04628]
Product
succinate [CPD:C00042];
CoM-S-S-CoB [CPD:C04832]
Comment
The enzyme, isolated from the archaeon Methanobacterium thermoautotrophicum, is very oxygen sensitive. It cannot use reduced flavins, reduced coenzyme F420, or NAD(P)H as an electron donor. Distinct from EC 1.3.1.6 [fumarate reductase (NADH)], EC 1.3.5.1 [succinate dehydrogenase (ubiquinone)], and EC 1.3.5.4 [fumarate reductase (quinol)].
History
EC 1.3.4.1 created 2014 as EC 1.3.98.2, transferred 2014 to EC 1.3.4.1
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18209  fumarate reductase (CoM/CoB) subunit A
K18210  fumarate reductase (CoM/CoB) subunit B
Genes
LCJNCTC11976_02789(nadB_2)
EPSL0Y14_11940
BGEBC1002_5768
BFNOI25_7370
PSPWBJG93_06520
PKFRW095_05110 RW095_24620
PPULRO07_01465
PSPUNA29_12930
PNRAT302_16660
TCARU0034_26070
SLACSKTS_06150
XDIEZH22_13185
HMCHYPMC_0241
RHZRHPLAN_26730
RSQRsph17025_1547
CAZTLV780_06990
PFEOE3U26_14950
SPHITS85_13175
SRFLHU95_15895
RAPRHOA_4370
CSPFCSF_1076
CCORCCORG_0898
GEFFO488_11755
DMSE8L03_00165
BACOOXB_3153
FECQNH15_23770
RUEDT065_10055
NCMQNK12_18805
ALKGMOJ78_01935
DOMRRU94_18845
PNPIJ22_25670 IJ22_47240
POWIJ21_10130
PYGAWM70_00700
AACOK1I37_00670
EFFskT53_06110 skT53_13780
ACOLK5I23_15405
PETRQKW49_19270
DSYDSY3532
DHDDhaf_1873
DMTDESME_00810
DKUDesku_0815
FWADCMF_09465 DCMF_09620 DCMF_14880
CCOMI6K69_15150
BLIQINP51_11880
BCOCBLCOC_07600
LACYA4V08_05955
CSCIHDCHBGLK_01871 HDCHBGLK_01882
CSHClosa_1173
CBOLCGC65_07300 CGC65_22960
MDVC5Q96_06350
PBQC3V37_06420
TPZTph_c24010
GEKkuro4_13740 kuro4_28190
TEPTepRe1_0409
TAETepiRe1_0453
HALSD7D81_18240
ATEAthe_2084
COBCOB47_1860
COWCalow_1774
CKNCalkro_0547
CCHAELD05_03760
CDIACaldiYA01_05050
CDANSOJ16_002198
FMAFMG_0304
PIVNCTC13079_01033
STEDSPTER_31650(nadB)
ELEElen_0252
AHATADCFC_08680 ADCFC_08710
NIEKV110_17120
NCANoca_0032
PSUUPsuf_024840
KBSEPA93_42720
BHCJFL75_16050
BHDBHYOB78_11155
BRMBmur_0641 Bmur_2561
BPOBP951000_2187
BPJB2904_orf1096 B2904_orf718
BPIPBPP43_04180
BPWWESB_1607 WESB_1949
BIPBint_2001
FULC4N20_09145
CPORBED41_11845
MJAMJ_0033 MJ_0092
MFEMefer_0390 Mefer_1238
MVUMetvu_1248 Metvu_1286
MFSMFS40622_0414 MFS40622_0946
MIFMetin_0533 Metin_0972
MJHJH146_0495 JH146_1538
MESGMLAUSG7_0989 MLAUSG7_1167
MESAMLASG1_0610 MLASG1_0788
MIGMetig_0017 Metig_0562
MMPMMP1067 MMP1277(frdA)
MMQMmarC5_0315 MmarC5_0522
MMXMmarC6_1397 MmarC6_1592
MMZMmarC7_0320 MmarC7_0522
MMDGYY_06170 GYY_07220(sdhA)
MMAKMMKA1_12460(tfrB) MMKA1_15020(tfrA)
MMAOMMOS7_11760(tfrB) MMOS7_13840(tfrA)
MMADMMJJ_15680(frdA) MMJJ_17830(frdB)
MAEMaeo_0245 Maeo_0717
MVNMevan_0390 Mevan_0588
MVOMvol_0038 Mvol_0098 Mvol_0369
MOKMetok_0260 Metok_1350
METFCFE53_06655 CFE53_06830
MTHMTH_1502 MTH_1850
MMGMTBMA_c00880(tfrA) MTBMA_c04210(tfrB)
MWOMWSIV6_0043(tfrA) MWSIV6_0381(tfrB)
MTEEMTTB_00770 MTTB_12870
METCMTCT_1366 MTCT_1689
METEtca_01449(nadB) tca_01787(frdB)
METZMETMT2_0107 METMT2_1345
METKFVF72_02455 FVF72_04100
MTHMFZP57_00160 FZP57_01780
METJFZP68_01540 FZP68_06805
MSTMsp_0180(tfrA) Msp_1044(tfrB)
METBAW729_06205(sdhA) AW729_10665
MEISPXD04_02390 PXD04_04780
MRUmru_0088(sdhA) mru_0655(sdhB) mru_1212(hdrB2)
MSIMsm_0393 Msm_1258
MEBAbm4_0015(sdhA) Abm4_1340(sdhB)
MMILsm9_0007(sdhA) sm9_0612(sdhB)
MEYETL18_00105(sdhA) TL18_02920
MOLYLM1_0294 YLM1_1577
MAROMarbSA_07560 MarbSA_11160
METVK4897_02485 K4897_05045
MELMetbo_0043 Metbo_0664
MEWMSWAN_0058 MSWAN_1693
METHMBMB1_0037 MBMB1_0259 MBMB1_1319
MFCBRM9_0092(sdhA) BRM9_0542(sdhB)
MFIDSM1535_0523 DSM1535_1410
MCUBMCBB_0053(tfrA) MCBB_1554
MSUBBK009_05580 BK009_09905
METNBK008_01125 BK008_06905
METTCIT01_03165 CIT01_05860 CIT01_08295
METOCIT02_06880 CIT02_11385
MEMEHYG87_06795 HYG87_08750
MFEGGCM10025860_08050 GCM10025860_26970
MFVMfer_0085 Mfer_0228
MKAMK0132(frdB_glpC) MK0498 MK0828(sdhA)
FPLFerp_1387
TGATGAM_1022
TSITSIB_0772
THEGQS_01385
TGYX802_09190
TRLA3L10_02300
PPACPAP_08545
MBYMSBRM_0047
MBARMSBR2_0046
MBAKMSBR3_0027
MMAMM_1290
MMAZMmTuc01_1336
MMJMSMAS_0025
MMACMSMAC_0025
MVCMSVAZ_0061
MEKMSKOL_0057
MLSMSLAZ_0024
METMMSMTP_0027
MEFMSWH1_0026
MEQMSWHS_0027
MTHRMSTHT_1799
MTHEMSTHC_1487
MHORMSHOH_0025
MMETMCMEM_0031 MCMEM_1454
MELOJ7W08_10190
MMHMmah_1949
MHAZBHR79_03890
MEVMetev_0037
MZHMzhil_0031
MPYMpsy_1801
MZIHWN40_01325
MHZMetho_2408
MTPMthe_1652
MCJMCON_3042(hdrD)
MHIMhar_0709
MHUMhun_3052 Mhun_3053
MRTJKHC33_01635 KHC33_01640
MLAMlab_0139 Mlab_0140
MEMMemar_0220 Memar_0221
MBGBN140_0102(sdhB) BN140_0103(sdhA)
MEMAMMAB1_0142 MMAB1_0144
MCHKMchiMG62_03460 MchiMG62_03470
MSUMOH143_07845 OH143_07850
MRCR6Y96_01290(tfrA) R6Y96_01295(tfrB)
MPIMpet_2648 Mpet_2649
MENDL6E24_08655 L6E24_08660
MEFWF1737_00215 F1737_00220
MAQERJ40_08785 RJ40_08790
MOUOU421_05760 OU421_05765
MESBL1S32_09100 L1S32_09105
MANQL1994_00360 L1994_00365
MBNMboo_0085 Mboo_0086
MFOMetfor_0059 Metfor_0060
MPLMpal_0402 Mpal_0403
MPDMCP_0282(hdrD-1) MCP_1107(hdrD-2)
MEZMtc_0078 Mtc_1543 Mtc_2258
RCILRC216 LRC333 RCIX1755 RCIX780
TARTALC_01391
MAXMMALV_14890
MERMMINT_04140
MARCAR505_0168
BARCAOA65_0073 AOA65_0074 AOA65_2161(nadB_2)
LOBNEF87_003194
 » show all
Reference
1  [PMID:2499256]
  Authors
Khandekar SS, Eirich LD
  Title
Purification and characterization of an anabolic fumarate reductase from Methanobacterium thermoautotrophicum.
  Journal
Appl Environ Microbiol 55:856-61 (1989)
DOI:10.1128/AEM.55.4.856-861.1989
Reference
2  [PMID:9578488]
  Authors
Heim S, Kunkel A, Thauer RK, Hedderich R
  Title
Thiol:fumarate reductase (Tfr) from Methanobacterium thermoautotrophicum--identification of the catalytic sites for fumarate reduction and thiol oxidation.
  Journal
Eur J Biochem 253:292-9 (1998)
DOI:10.1046/j.1432-1327.1998.2530292.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.4.1
IUBMB Enzyme Nomenclature: 1.3.4.1
ExPASy - ENZYME nomenclature database: 1.3.4.1
BRENDA, the Enzyme Database: 1.3.4.1

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