KEGG   ENZYME: 1.3.7.1
Entry
EC 1.3.7.1                  Enzyme                                 
Name
6-hydroxynicotinate reductase;
6-oxotetrahydronicotinate dehydrogenase;
6-hydroxynicotinic reductase;
HNA reductase;
1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
Sysname
6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase
Reaction(IUBMB)
6-oxo-1,4,5,6-tetrahydronicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin [RN:R03164]
Reaction(KEGG)
R03164
Substrate
6-oxo-1,4,5,6-tetrahydronicotinate [CPD:C04226];
oxidized ferredoxin [CPD:C00139]
Product
6-hydroxynicotinate [CPD:C01020];
reduced ferredoxin [CPD:C00138]
History
EC 1.3.7.1 created 1972
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K20449  6-hydroxynicotinate reductase
Genes
GAIIMCC3135_06315(hnr)
BUGBC1001_4289
BGFBC1003_5111
BUQAC233_28025
BXEBxe_B0654
BXBDR64_5985(hnr)
BPXBUPH_00873
BPYBphyt_4323
BUZAYM40_31855
BFNOI25_6341
PSPWBJG93_23380
PARBCJU94_26160
PGPCUJ91_28190
PCJCUJ87_25450
PTSCUJ90_21690
PCAFDSC91_000560
PMEGFNZ07_07660
PUDG9Q38_02620
RHYRD110_24225
POLBpro_4068
ACKC380_01145
ARADKI609_01150
VEIVeis_0853
VAPVapar_0178
VPEVarpa_0207
VPDVAPA_1c02140
VAAAX767_09785
VBOCKY39_01135
VAMC4F17_17935
DRGH9K76_16610
DTIDesti_0418
MLOmll4879
MLNA9174_02935
MCIMesci_0583
MOPMesop_0593
MAMMesau_00495
MAMOA6B35_05610
MESWA9K65_002930
MESMEJ066_08415
MESPC1M53_10265
MHUAMCHK_5949
MJREB229_02990
MERDEB233_03090
MESRFGU64_20370
MESOBSQ44_15105
AAKAA2016_0466
AMIHCO731_00454(hnr)
NIYFQ775_19705
NKIKW403_05175
KMNHW532_02575
ARAArad_8284
RGARGR602_PC02236
RLSHB780_10950
NENNCHU2750_46320(hnr)
BJAblr3822(blr3822)
BJUBJ6T_60350
BJPRN69_29240
BRABRADO2116
BBTBBta_2425
BRSS23_44200
AOLS58_54180
BRCBCCGELA001_15875
BRADBF49_1223
BICLMTR13_29570
BROBRAD285_5145
BRKCWS35_16945
BOTCIT37_34795
BRQCIT40_11910
BGQX265_24200
BGZXH91_21385
BSYMCIT39_11150
BBETF8237_03110
BARHWN72_20530
BVZBRAD3257_5214(Hnr)
BELBE61_72860
BDGLPJ38_21285
BSEPHAP48_0029600
BQBJ4P68_0030870
RPBRPB_1667
BOPAXW83_07780
BOSBSY19_2963
BVVBHK69_21680
BOIBLM15_19770
XAUXaut_4211
XDIEZH22_09200
AZCAZC_2798
LNEFZC33_25885
METM446_1984
MNOMnod_1248
MAQUMaq22A_1p33500
MEEDA075_10915
MTEADK419_06590
MINDmvi_52570
MICOGDR74_16690
CHELAL346_07270
CDQBOQ54_00410
PLEOOHA_2_00062(Hnr)
HDIHDIA_4444(Hnr)
RBMTEF_05290
PHRC6569_02185
PSTGE8M01_20800
LIZLGH83_07395
ACUTMRB58_02490
SILSPO0829
RDERD1_1534
RLIRLO149_c031650
OATOAN307_c22970
OTMOSB_05920
TPROGa0080559_TMP3382
PABYGa0080574_TMP4632
SUAMBOO69_08865
SPOTG6548_15205
SMEDJNX03_20295
SPSESULPSESMR1_04043(hnr)
RIDRIdsm_05002(hnr)
ROMEI983_16075
ROHFIU89_19765(hnr)
THAACFI11_12470
TGLHFZ77_04315
RBLB6K69_01550
DAAAKL17_2935
GFUKM031_10955
SALOEF888_04480
SEDIEBB79_04790
PPRUFDP22_07675
PAEDG5B38_12195
PAMOBAR1_16965
PSHQF3W81_08840
PALWPSAL_014220(hnr)
THASC6Y53_07610
HDHG5B40_11885
CMAGCBW24_09675
MAGamb1482
FERFNB15_14115
HTQFRZ44_34550
HADHFRZ61_33740
DEXHWD60_14030
DVNHQ394_03945
ELIOKO353_13315
CPATCLPA_c02890(hnr)
CPAECPAST_c02890(hnr)
ACOLK5I23_11295
DORDesor_0448
FWADCMF_09585
AACXDEACI_1475
ACAEHYG86_14540
TEPTepRe1_0415
TAETepiRe1_0462(Hnr)
NTHNther_2148
STEDSPTER_39190(hnr)
IPOIlyop_0118
CPORBED41_14045
 » show all
Reference
1  [PMID:5767303]
  Authors
Holcenberg JS, Tsai L
  Title
Nicotinic acid metabolism. IV. Ferredoxin-dependent reduction of 6-hydroxynicotinic acid to 6-oxo-1,4,5,6-tetrahydronicotinic acid.
  Journal
J Biol Chem 244:1204-11 (1969)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.1
IUBMB Enzyme Nomenclature: 1.3.7.1
ExPASy - ENZYME nomenclature database: 1.3.7.1
BRENDA, the Enzyme Database: 1.3.7.1
CAS: 9030-84-6

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