KEGG   ENZYME: 1.3.7.11Help
Entry
EC 1.3.7.11                 Enzyme                                 

Name
2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase;
AF0464 (gene name);
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
2,3-bis-(O-phytanyl)-sn-glycero-phospholipid:ferredoxin oxidoreductase
Reaction(IUBMB)
a 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid + 16 oxidized ferredoxin [iron-sulfur] cluster = a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H+
Reaction(KEGG)
(other) R10331
Show
Substrate
2,3-bis-(O-phytanyl)-sn-glycero-phospholipid;
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Product
2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid;
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080]
Comment
A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipids and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol phospholipids with comparable activity. Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], this enzyme shows no activity with NADPH, and requires a dedicated ferredoxin [4].
History
EC 1.3.7.11 created 2013 as EC 1.3.99.34, transferred 2015 to EC 1.3.7.11
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K17830  digeranylgeranylglycerophospholipid reductase
Genes
CMAR: IMCC12053_1371
TPZ: Tph_c09910(bchP)
KBS: EPA93_17655
POM: MED152_04120
POB: LPB03_16045
PRN: BW723_10930
IAL: IALB_0329
CABY: Cabys_957
MJA: MJ_0532
MFE: Mefer_0023
MMP: MMP0388
MMD: GYY_02010
MAE: Maeo_1307
MVO: Mvol_1689
METE: tca_00257(menJ_1) tca_01663(menJ_2)
MSI: Msm_1701
MRU: mru_1471
MMIL: sm9_1381
MEYE: TL18_04135
MFV: Mfer_1222
AFU: AF_0464
FPL: Ferp_0366
GAC: GACE_0072
GAH: GAH_00300
TAC: Ta0516
TVO: TVG1046096(TVG1046096)
PTO: PTO0896
FAI: FAD_1079
CDIV: CPM_0894
MARC: AR505_1433
ABI: Aboo_0578
PHO: PH0181(PH0181)
PAB: PAB0109(bchP)
PFU: PF0097
PFI: PFC_07720
PYN: PNA2_0702
PYS: Py04_0252
TKO: TK1088
TON: TON_0316
TGA: TGAM_1305
TSI: TSIB_0988
THE: GQS_03690
THA: TAM4_1982
THM: CL1_0388
TLT: OCC_08470
THS: TES1_0613
TNU: BD01_0182
TEU: TEU_06540
PPAC: PAP_07210
MAC: MA_1484
MMA: MM_2499
MMH: Mmah_1613
MPY: Mpsy_2554
MTP: Mthe_0044
MHU: Mhun_1123
MLA: Mlab_0431
MEMA: MMAB1_2023
MPI: Mpet_1752
MBN: Mboo_1945
MPL: Mpal_0962
MEZ: Mtc_0895(bchP) Mtc_1724
RCI: RCIX2051(bchP)
HAL: VNG_0468C
HSL: OE_1699R
HHB: Hhub_1531
HMA: rrnAC0726
HHI: HAH_1373
HUT: Huta_1007
HMU: Hmuk_3091
HVO: HVO_1799
HME: HFX_1905(fixC)
HLA: Hlac_0926
HTU: Htur_3081
NMG: Nmag_2507
NAT: NJ7G_2427
SALI: L593_01650
VDI: Vdis_1715
VMO: VMUT_2242
TPE: Tpen_0718
NMR: Nmar_0631
NCT: NMSP_1055
NEV: NTE_02579
NBV: T478_0975
NDV: NDEV_0107
BARC: AOA65_0632
 » show all
Taxonomy
Reference
1  [PMID:17288560]
  Authors
Murakami M, Shibuya K, Nakayama T, Nishino T, Yoshimura T, Hemmi H
  Title
Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus.
  Journal
FEBS J 274:805-14 (2007)
DOI:10.1111/j.1742-4658.2006.05625.x
  Sequence
[afu:AF_0464]
Reference
2  [PMID:18375567]
  Authors
Sato S, Murakami M, Yoshimura T, Hemmi H
  Title
Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl donor, not a dead-end product.
  Journal
J Bacteriol 190:3923-9 (2008)
DOI:10.1128/JB.00082-08
Reference
3  [PMID:21515284]
  Authors
Sasaki D, Fujihashi M, Iwata Y, Murakami M, Yoshimura T, Hemmi H, Miki K
  Title
Structure and mutation analysis of archaeal geranylgeranyl reductase.
  Journal
J Mol Biol 409:543-57 (2011)
DOI:10.1016/j.jmb.2011.04.002
Reference
4  [PMID:24214941]
  Authors
Isobe K, Ogawa T, Hirose K, Yokoi T, Yoshimura T, Hemmi H
  Title
Geranylgeranyl reductase and ferredoxin from Methanosarcina acetivorans are required for the synthesis of fully reduced archaeal membrane lipid in Escherichia coli cells.
  Journal
J Bacteriol 196:417-23 (2014)
DOI:10.1128/JB.00927-13
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.11
IUBMB Enzyme Nomenclature: 1.3.7.11
ExPASy - ENZYME nomenclature database: 1.3.7.11
BRENDA, the Enzyme Database: 1.3.7.11

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