KEGG   ENZYME: 1.3.7.11
Entry
EC 1.3.7.11                 Enzyme                                 

Name
2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase;
AF0464 (gene name);
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
Sysname
2,3-bis-(O-phytanyl)-sn-glycero-phospholipid:ferredoxin oxidoreductase
Reaction(IUBMB)
a 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid + 16 oxidized ferredoxin [iron-sulfur] cluster = a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H+
Reaction(KEGG)
(other) R10331
Substrate
2,3-bis-(O-phytanyl)-sn-glycero-phospholipid;
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Product
2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid;
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080]
Comment
A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipids and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol phospholipids with comparable activity. Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], this enzyme shows no activity with NADPH, and requires a dedicated ferredoxin [4].
History
EC 1.3.7.11 created 2013 as EC 1.3.99.34, transferred 2015 to EC 1.3.7.11
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K17830  digeranylgeranylglycerophospholipid reductase
Genes
STEM: CLM74_07965
LAB: LA76x_2426
LAQ: GLA29479_2709
LGU: LG3211_2789
LEZ: GLE_2795
LEM: LEN_2236
LMB: C9I47_1426
LYT: DWG18_07380
LYJ: FKV23_07190
THES: FHQ07_02060
TGR: Tgr7_2205
TKM: TK90_0643
TVR: TVD_10595
SVA: SVA_2992
CGD: CR3_0650(fixC)
DOL: Dole_0399
DBR: Deba_3038
HDN: Hden_0684
RVA: Rvan_3542
RHC: RGUI_1289
AFR: AFE_2544
ACU: Atc_2341
HSC: HVS_14075
SALQ: SYNTR_0780
PTH: PTH_0378(FixC)
TPZ: Tph_c09910(bchP)
TOC: Toce_0251
TSH: Tsac_0175
STED: SPTER_30020(kmo)
PMT: PMT_0686
MAR: MAE_31260
MPK: VL20_5387
PNL: PNK_0017
IAL: IALB_0329
TAL: Thal_0865
CABY: Cabys_957
DTU: Dtur_0864
MJA: MJ_0532
MMP: MMP0388
MMD: GYY_02010
MMAD: MMJJ_06490
MAE: Maeo_1307
MVO: Mvol_1689
METE: tca_00257(menJ_1) tca_01663(menJ_2)
MSI: Msm_1701
MMIL: sm9_1381
MEYE: TL18_04135
AFU: AF_0464
TAC: Ta0516
TVO: TVG1046096(TVG1046096) TVG1579590(TVG1579590)
FAI: FAD_1079
ABI: Aboo_0578
PFU: PF0097
PFI: PFC_07720
PHO: PH0181(PH0181)
PAB: PAB0109(bchP)
PYN: PNA2_0702
PYS: Py04_0252
TKO: TK1088
TON: TON_0316
TGA: TGAM_1305
TSI: TSIB_0988
THE: GQS_03690
THA: TAM4_1982
THM: CL1_0388
TLT: OCC_08470
THS: TES1_0613
TNU: BD01_0182
TEU: TEU_06540
PPAC: PAP_07210
MHU: Mhun_1123
MLA: Mlab_0431
MEMA: MMAB1_2023
MBN: Mboo_1945
MPL: Mpal_0962
RCI: RCIX2051(bchP) RCIX2708
HAL: VNG_0468C
HSL: OE_1699R
HHB: Hhub_1531
HALH: HTSR_0966
HHSR: HSR6_0997
HMA: rrnAC0726
HHI: HAH_1373
NPH: NP_4564A
HALL: LC1Hm_1280 LC1Hm_1619(fixC) LC1Hm_2428(fixC3) LC1Hm_2469(fixC4)
HWA: HQ_1534A
HVO: HVO_1799
HME: HFX_1905(fixC)
HLA: Hlac_0926
SMR: Smar_1462
DKA: DKAM_0159
TAG: Tagg_0378
HBU: Hbut_1257
STO: STK_04940
SOL: Ssol_0166
SSOA: SULA_0158
SSOL: SULB_0159
SSOF: SULC_0158
SID: M164_0170
SII: LD85_0155
SIH: SiH_0155
SIR: SiRe_0151
SIC: SiL_0142
MSE: Msed_0681
MCN: Mcup_1399
AHO: Ahos_2154
STEP: IC006_2737
CMA: Cmaq_0840
VDI: Vdis_1715
VMO: VMUT_2242
ACIA: SE86_02030
NMR: Nmar_0631
NCV: NCAV_0324
BARC: AOA65_1634
BARB: AOA66_1225
 » show all
Reference
1  [PMID:17288560]
  Authors
Murakami M, Shibuya K, Nakayama T, Nishino T, Yoshimura T, Hemmi H
  Title
Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus.
  Journal
FEBS J 274:805-14 (2007)
DOI:10.1111/j.1742-4658.2006.05625.x
  Sequence
[afu:AF_0464]
Reference
2  [PMID:18375567]
  Authors
Sato S, Murakami M, Yoshimura T, Hemmi H
  Title
Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl donor, not a dead-end product.
  Journal
J Bacteriol 190:3923-9 (2008)
DOI:10.1128/JB.00082-08
Reference
3  [PMID:21515284]
  Authors
Sasaki D, Fujihashi M, Iwata Y, Murakami M, Yoshimura T, Hemmi H, Miki K
  Title
Structure and mutation analysis of archaeal geranylgeranyl reductase.
  Journal
J Mol Biol 409:543-57 (2011)
DOI:10.1016/j.jmb.2011.04.002
Reference
4  [PMID:24214941]
  Authors
Isobe K, Ogawa T, Hirose K, Yokoi T, Yoshimura T, Hemmi H
  Title
Geranylgeranyl reductase and ferredoxin from Methanosarcina acetivorans are required for the synthesis of fully reduced archaeal membrane lipid in Escherichia coli cells.
  Journal
J Bacteriol 196:417-23 (2014)
DOI:10.1128/JB.00927-13
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.11
IUBMB Enzyme Nomenclature: 1.3.7.11
ExPASy - ENZYME nomenclature database: 1.3.7.11
BRENDA, the Enzyme Database: 1.3.7.11

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