Entry
Name
2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase;
AF0464 (gene name);
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
2,3-bis-(O-phytanyl)-sn-glycero-phospholipid:ferredoxin oxidoreductase
Reaction(IUBMB)
a 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid + 16 oxidized ferredoxin [iron-sulfur] cluster = a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H+
Reaction(KEGG)
Substrate
2,3-bis-(O-phytanyl)-sn-glycero-phospholipid [CPD:
C22634 ];
oxidized ferredoxin [iron-sulfur] cluster [CPD:
C00139 ]
Product
2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid;
reduced ferredoxin [iron-sulfur] cluster [CPD:
C00138 ];
H+ [CPD:
C00080 ]
Comment
A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipids and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol phospholipids with comparable activity. Unlike EC
1.3.1.101 , 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], this enzyme shows no activity with NADPH, and requires a dedicated ferredoxin [4].
History
EC 1.3.7.11 created 2013 as EC 1.3.99.34, transferred 2015 to EC 1.3.7.11
Pathway
ec00564 Glycerophospholipid metabolism
ec01110 Biosynthesis of secondary metabolites
Orthology
K17830 digeranylgeranylglycerophospholipid reductase
Genes
CLB : Clo1100_3094 Clo1100_3095
CLT : CM240_1758 CM240_1759
RHER : EHE19_004620 EHE19_004625
TEX : Teth514_0218 Teth514_0219
TMT : Tmath_0322 Tmath_0323
FSU : Fisuc_0330 Fisuc_2122
POB : LPB03_12595 LPB03_16045
MFE : Mefer_0023 Mefer_0586
MVU : Metvu_0248 Metvu_0470
MFS : MFS40622_0302 MFS40622_0533
MMG : MTBMA_c02950 MTBMA_c07260 MTBMA_c11210
MWO : MWSIV6_0259 MWSIV6_0692 MWSIV6_1100
MTEE : MTTB_09190 MTTB_14720
METC : MTCT_0239 MTCT_1570
METE : tca_00257(menJ_1) tca_01663(menJ_2)
METZ : METMT2_0572 METMT2_0721 METMT2_1561
METK : FVF72_00920 FVF72_03085
MTHM : FZP57_01175 FZP57_03320 FZP57_05215
METJ : FZP68_06180 FZP68_08325
MST : Msp_0758 Msp_0874 Msp_1062 Msp_1307 Msp_1320
METB : AW729_08940 AW729_09050 AW729_10575 AW729_10930
MEIS : PXD04_00860 PXD04_02310 PXD04_02685
MRU : mru_1341 mru_1441 mru_1471
MEL : Metbo_0471 Metbo_2033 Metbo_2366
MEW : MSWAN_0290 MSWAN_0605 MSWAN_1925
METH : MBMB1_0335 MBMB1_0639 MBMB1_1556 MBMB1_1827
MFC : BRM9_0792 BRM9_1599 BRM9_1933 BRM9_2158
MFI : DSM1535_0120 DSM1535_0754 DSM1535_1097 DSM1535_2293
MCUB : MCBB_0308 MCBB_0619 MCBB_1812
MSUB : BK009_01280 BK009_06770 BK009_11855
METN : BK008_02415 BK008_07495 BK008_09685
METT : CIT01_01350 CIT01_04015 CIT01_04025 CIT01_07320 CIT01_10150
METO : CIT02_03745 CIT02_05170 CIT02_08440 CIT02_10165
MEME : HYG87_07945 HYG87_10880
MFEG : GCM10025860_04480 GCM10025860_12360 GCM10025860_16550
AST : Asulf_00147 Asulf_01626
GAH : GAH_00300 GAH_00353 GAH_01689
MBY : MSBRM_1245 MSBRM_2785
MBAR : MSBR2_1164 MSBR2_2742
MBAK : MSBR3_1297 MSBR3_2679
MAC : MA_1484 MA_2893 MA_3894 MA_4421
MMA : MM_0718 MM_2499 MM_3299
MMAZ : MmTuc01_0739 MmTuc01_2550 MmTuc01_3399
MMJ : MSMAS_0599 MSMAS_1387 MSMAS_2202
MMAC : MSMAC_0600 MSMAC_2252 MSMAC_2749
MVC : MSVAZ_0959 MSVAZ_1325 MSVAZ_1805
MEK : MSKOL_0928 MSKOL_1264 MSKOL_1782
MLS : MSLAZ_1440 MSLAZ_1542 MSLAZ_2928
METM : MSMTP_0646 MSMTP_0954 MSMTP_1509
MEF : MSWH1_1330 MSWH1_1478 MSWH1_1898
MEQ : MSWHS_1414 MSWHS_1853 MSWHS_3173
MSJ : MSSAC_1463 MSSAC_2883 MSSAC_4107
MSZ : MSSIH_1494 MSSIH_2538 MSSIH_3643
MSW : MSSIT_1552 MSSIT_2581 MSSIT_3698
MTHR : MSTHT_0217 MSTHT_0358 MSTHT_1727 MSTHT_2311
MTHE : MSTHC_0364 MSTHC_0514 MSTHC_0969 MSTHC_1561
MHOR : MSHOH_0251 MSHOH_1697 MSHOH_2811
MFZ : AOB57_000445 AOB57_001340 AOB57_003910 AOB57_007820
MBU : Mbur_0303 Mbur_0369 Mbur_0939 Mbur_1077 Mbur_1308
MMET : MCMEM_0833 MCMEM_0997 MCMEM_1441 MCMEM_1598 MCMEM_1755
MELO : J7W08_02385 J7W08_03355 J7W08_05920 J7W08_06945 J7W08_07805
MMH : Mmah_0579 Mmah_0675 Mmah_1258 Mmah_1613
MHAZ : BHR79_00515 BHR79_05660 BHR79_07245 BHR79_10225
MPOT : BKM01_01750 BKM01_07890 BKM01_09925
MEV : Metev_0262 Metev_0801 Metev_1607 Metev_1731
MZH : Mzhil_0235 Mzhil_0513 Mzhil_0683 Mzhil_1608
MPY : Mpsy_0099 Mpsy_1026 Mpsy_1467 Mpsy_2554
MZI : HWN40_01470 HWN40_03330 HWN40_05930 HWN40_09670
MHZ : Metho_0239 Metho_0947 Metho_1579 Metho_1933
MEES : MmiEs2_09160(thi4_2) MmiEs2_09170(thi4_3)
MTP : Mthe_0044 Mthe_0513 Mthe_0671 Mthe_0714
MCJ : MCON_1147 MCON_3250 MCON_3296
MHI : Mhar_0556 Mhar_1078 Mhar_1156 Mhar_2172
MEM : Memar_0506 Memar_1711
MPD : MCP_0504 MCP_1168 MCP_1480
MEZ : Mtc_0895(bchP) Mtc_1643 Mtc_1724
RCI : RCIX2051(bchP) RCIX2708
HALR : EFA46_006370 EFA46_006470
HALJ : G9465_08440 G9465_08805 G9465_20450
HUT : Huta_0881 Huta_1007 Huta_2954
HALA : Hrd1104_04765 Hrd1104_09045
HMU : Hmuk_1955 Hmuk_2206 Hmuk_3091 Hmuk_3127
HALZ : E5139_02700 E5139_02875 E5139_12890 E5139_14170
HALL : LC1Hm_1280 LC1Hm_1619(fixC) LC1Hm_2428(fixC3) LC1Hm_2469(fixC4)
HAZP : GBQ70_02700 GBQ70_12905 GBQ70_14185
HRR : HZS55_18830 HZS55_20705
HPEL : HZS54_21655 HZS54_22270 HZS54_24195
HLT : I7X12_15485 I7X12_16545 I7X12_17600
HAQ : DU484_09565 DU484_17775
HAJ : DU500_00815 DU500_09815
HAER : DU502_06905 DU502_07185 DU502_16565
HRA : EI982_07520 EI982_14380
HDF : AArcSl_1381 AArcSl_1813
HSAL : JMJ58_01855 JMJ58_05545 JMJ58_12995 JMJ58_22355
HAKZ : J0X25_02870 J0X25_13780
NMG : Nmag_0668 Nmag_1523 Nmag_2507 Nmag_2778
HXA : Halxa_3925 Halxa_3960
NPE : Natpe_0646 Natpe_1962 Natpe_3244
NPL : FGF80_01135 FGF80_07435
HALY : HYG82_09140 HYG82_16990
NGE : Natgr_0786 Natgr_1266 Natgr_3103
HRU : Halru_1246 Halru_2474
NOU : Natoc_0699 Natoc_2139 Natoc_4277
HLR : HALLA_08655 HALLA_13160 HALLA_17630
HLC : CHINAEXTREME15935 CHINAEXTREME19570
NAJ : B1756_02305 B1756_04290 B1756_12495
NAG : AArcMg_1023 AArcMg_2971 AArcMg_3119
NAN : AArc1_0731 AArc1_2601 AArc1_3025
NBG : DV706_00945 DV706_09380 DV706_16325 DV706_19090
NAS : GCU68_02695 GCU68_12755
HDA : BB347_05735 BB347_10350 BB347_10530
MELU : MTLP_05820 MTLP_05840 MTLP_09940
TVO : TVG1046096(TVG1046096) TVG1579590(TVG1579590)
CDIV : CPM_0295 CPM_0485 CPM_0894
TAR : TALC_00223 TALC_00435 TALC_00774
MAX : MMALV_02090 MMALV_03590 MMALV_08730
MER : MMINT_02130 MMINT_12590 MMINT_13170 MMINT_17750
MEAR : Mpt1_c01650 Mpt1_c12530
MARC : AR505_0892 AR505_1433 AR505_1618
ACF : AciM339_0374 AciM339_0468
THB : N186_01490 N186_04950
TCB : TCARB_0050 TCARB_1382
THF : MA03_00905 MA03_06135
THEL : IG193_04155 IG193_06980
NIN : NADRNF5_0722 NADRNF5_1519
NOX : C5F49_05755 C5F49_06640
NGA : Ngar_c10460 Ngar_c11500 Ngar_c18750
NVN : NVIE_003360 NVIE_011700
TAA : NMY3_01977 NMY3_02141 NMY3_02989
NFN : NFRAN_0449 NFRAN_2927
CSY : CENSYa_0520 CENSYa_1317
CSU : CSUB_C1349 CSUB_C1610
TAH : SU86_000125 SU86_003010
» show all
Taxonomy
Reference
Authors
Murakami M, Shibuya K, Nakayama T, Nishino T, Yoshimura T, Hemmi H
Title
Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus.
Journal
Sequence
Reference
Authors
Sato S, Murakami M, Yoshimura T, Hemmi H
Title
Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl donor, not a dead-end product.
Journal
Reference
Authors
Sasaki D, Fujihashi M, Iwata Y, Murakami M, Yoshimura T, Hemmi H, Miki K
Title
Structure and mutation analysis of archaeal geranylgeranyl reductase.
Journal
Reference
Authors
Isobe K, Ogawa T, Hirose K, Yokoi T, Yoshimura T, Hemmi H
Title
Geranylgeranyl reductase and ferredoxin from Methanosarcina acetivorans are required for the synthesis of fully reduced archaeal membrane lipid in Escherichia coli cells.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.11
ExPASy - ENZYME nomenclature database: 1.3.7.11