KEGG   ENZYME: 1.3.7.11
Entry
EC 1.3.7.11                 Enzyme                                 
Name
2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase;
AF0464 (gene name);
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
Sysname
2,3-bis-(O-phytanyl)-sn-glycero-phospholipid:ferredoxin oxidoreductase
Reaction(IUBMB)
a 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid + 16 oxidized ferredoxin [iron-sulfur] cluster = a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H+
Reaction(KEGG)
(other) R10331
Substrate
2,3-bis-(O-phytanyl)-sn-glycero-phospholipid;
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Product
2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid;
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080]
Comment
A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipids and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol phospholipids with comparable activity. Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], this enzyme shows no activity with NADPH, and requires a dedicated ferredoxin [4].
History
EC 1.3.7.11 created 2013 as EC 1.3.99.34, transferred 2015 to EC 1.3.7.11
Pathway
ec00564  Glycerophospholipid metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K17830  digeranylgeranylglycerophospholipid reductase
Genes
STEMCLM74_07965
PMEXH4W19_05940
LABLA76x_2426
LAQGLA29479_2709
LGULG3211_2789
LEZGLE_2795
LEMLEN_2236
LMBC9I47_1426
LYTDWG18_07380
LYJFKV23_07190
LSXH8B22_00975
LHXLYSHEL_30720
LCASLYSCAS_30690
THESFHQ07_02060
TBVH9L17_15740
HHCM911_11185
EBSECTOBSL9_0276
TGRTgr7_2205
TKMTK90_0643
TVRTVD_10595
APRSBI364_13760
SVASVA_2992
ACIIC4901_12925
ATYA9R16_004045
CNCCNE_1c03080
CGDCR3_0650(fixC)
VPEVarpa_3679
VBOCKY39_19940
VAMC4F17_03155
SDRSCD_n00804
SULFCAP31_01895
SPLBSFPGR_29360
SNIVSFSGTM_27200
URUDSM104443_00527
BEBABWI17_02380
DOLDole_0399
MRMA7982_08128
DTIDesti_0238
DBRDeba_3038
HDNHden_0684
RVARvan_3542
FILBN1229_v1_0189
FIYBN1229_v1_0193
CMARIMCC12053_1371
RHCRGUI_1289
AFRAFE_2544
AFELferr_2172
ACUAtc_2341
ACZAcaty_c2184
AFIAcife_2465
AFJAFERRID_05040
AFPK1Y48_09080
CBKCLL_A1369 CLL_A1370
CLBClo1100_3094 Clo1100_3095
CLTCM240_1758 CM240_1759
HSCHVS_14075
CCECcel_1057 Ccel_1058
RHEREHE19_004620 EHE19_004625
SALQSYNTR_0780
CALKHUE98_00670
DORDesor_4339
PTHPTH_0378(FixC)
DKUDesku_2287
FWADCMF_14630
DGIDesgi_1545
TEXTeth514_0218 Teth514_0219
THXThet_0258 Thet_0259
TPDTeth39_1995
TITThit_0239 Thit_0240
TMTTmath_0322 Tmath_0323
TBOThebr_2044
TWIThewi_0279
TKITKV_c02330
TPZTph_c09910(bchP)
TXYThexy_2059
TSHTsac_0175
TEPTepRe1_0379
TAETepiRe1_0421
TOCToce_0251
NTHNther_1774
KMEH0A61_01699
STEDSPTER_30020(kmo)
PMTPMT_0686
PMFP9303_15361
PMJP9211_08531
MARMAE_31260
MPKVL20_5387
MIQB5D77_03105
MVZmyaer102_06730
CSNCyast_1222
CYCPCC7424_4688
CYJCyan7822_4141
PAGHNIES204_25480
OXYHCG48_06915
MICMic7113_1946
GEIGEI7407_1050
OACOscil6304_0659
ONIOsc7112_3504
PLPPle7327_4278
ABATCFX1CAM_1448
KBSEPA93_17655
PNLPNK_0017
PNDPla175_09780
FSUFisuc_0330 Fisuc_2122
FSCFSU_0745 FSU_2657
POMMED152_04120
POBLPB03_12595 LPB03_16045
PRNBW723_10930
POLABXQ17_11625
POACW731_11625
PLITK8354_10745
IALIALB_0329
HYAHY04AAS1_0807
HHOHydHO_0802
HYSHydSN_0819
TALThal_0865
TRDTHERU_04165
KPFIX53_05590
CPOCOPRO5265_1158
CABYCabys_957
DTHDICTH_0710
DTUDtur_0864
BANABARAN1_0630
BIHBIP78_0559
MJAMJ_0532
MFEMefer_0023 Mefer_0586
MVUMetvu_0248 Metvu_0470
MFSMFS40622_0302 MFS40622_0533
MIFMetin_0313
MJHJH146_0202
MESGMLAUSG7_0668
MESAMLASG1_0156
MIGMetig_0018
MMPMMP0388
MMQMmarC5_1250
MMXMmarC6_0522
MMZMmarC7_1386
MMDGYY_02010
MMAKMMKA1_04070
MMAOMMOS7_04030
MMADMMJJ_06490
MAEMaeo_1307
MVNMevan_1375
MVOMvol_1689
MOKMetok_0574
METFCFE53_00320
MTHMTH_1718 MTH_277
MMGMTBMA_c02950 MTBMA_c07260 MTBMA_c11210
METCMTCT_0239 MTCT_1570
MWOMWSIV6_0259 MWSIV6_0692 MWSIV6_1100
METEtca_00257(menJ_1) tca_01663(menJ_2)
METZMETMT2_0572 METMT2_0721 METMT2_1561
METKFVF72_00920 FVF72_03085
MTHMFZP57_01175 FZP57_03320 FZP57_05215
METJFZP68_06180 FZP68_08325
MSTMsp_0758 Msp_0874 Msp_1062 Msp_1307 Msp_1320
METBAW729_08940 AW729_09050 AW729_10575 AW729_10930
MRUmru_1341 mru_1441 mru_1471
MSIMsm_1701
MEBAbm4_0728 Abm4_1169
MMILsm9_1381
MEYETL18_04135
MOLYLM1_0823 YLM1_0971
MAROMarbSA_00110
MELMetbo_0471 Metbo_2033 Metbo_2366
MEWMSWAN_0290 MSWAN_0605 MSWAN_1925
METHMBMB1_0335 MBMB1_0639 MBMB1_1556 MBMB1_1827
MFCBRM9_0792 BRM9_1599 BRM9_1933 BRM9_2158
MFIDSM1535_0120 DSM1535_0754 DSM1535_1097 DSM1535_2293
MCUBMCBB_0308 MCBB_0619 MCBB_1812
MSUBBK009_01280 BK009_06770 BK009_11855
METNBK008_02415 BK008_07495 BK008_09685
METTCIT01_01350 CIT01_04015 CIT01_04025 CIT01_07320 CIT01_10150
METOCIT02_03745 CIT02_05170 CIT02_08440 CIT02_10165
MEMEHYG87_07945 HYG87_10880
MFVMfer_0516 Mfer_1222
MKAMK1443 MK1645
AFUAF_0464
AFGAFULGI_00004710
APOArcpr_0713
AVEArcve_2050
ASTAsulf_00147 Asulf_01626
FPLFerp_0366 Ferp_1444
GACGACE_0072 GACE_0595
GAHGAH_00300 GAH_00353 GAH_01689
PFUPF0097
PFIPFC_07720
PHOPH0181(PH0181)
PABPAB0109(bchP)
PYNPNA2_0702
PYAPYCH_16330
PYSPy04_0252
PYCTQ32_00315
TKOTK1088
TONTON_0316
TGATGAM_1305
TSITSIB_0988
TBATERMP_00654
THEGQS_03690
THATAM4_1982
THMCL1_0388
TLTOCC_08470
THSTES1_0613
TNUBD01_0182
TEUTEU_06540
TGYX802_10265
THVADU37_CDS08620
TCHCHITON_0316
TPEPA0127_09785
TPIEA7C91_07555
TGGA3K92_03945
TCEA3L02_00260
TBSA3L01_02245
THHCDI07_02200
TSLA3L11_06065
TTDA3L14_03705
TPRFA3L09_05905
TRLA3L10_04285
TPAFA3L08_04750
THYA3L12_01970
TICFH039_04700
TCQTIRI35C_0673
THEMFPV09_04700
PPACPAP_07210
MBAMbar_A3422
MBYMSBRM_1245 MSBRM_2785
MBWMSBRW_1312
MBARMSBR2_1164 MSBR2_2742
MBAKMSBR3_1297 MSBR3_2679
MACMA_1484 MA_2893 MA_3894 MA_4421
MMAMM_0718 MM_2499 MM_3299
MMAZMmTuc01_0739 MmTuc01_2550 MmTuc01_3399
MMJMSMAS_0599 MSMAS_1387 MSMAS_2202
MMACMSMAC_0600 MSMAC_2252 MSMAC_2749
MVCMSVAZ_0959 MSVAZ_1325 MSVAZ_1805
MEKMSKOL_0928 MSKOL_1264 MSKOL_1782
MLSMSLAZ_1440 MSLAZ_1542 MSLAZ_2928
METMMSMTP_0646 MSMTP_0954 MSMTP_1509
MEFMSWH1_1330 MSWH1_1478 MSWH1_1898
MEQMSWHS_1414 MSWHS_1853 MSWHS_3173
MSJMSSAC_1463 MSSAC_2883 MSSAC_4107
MSZMSSIH_1494 MSSIH_2538 MSSIH_3643
MSWMSSIT_1552 MSSIT_2581 MSSIT_3698
MTHRMSTHT_0217 MSTHT_0358 MSTHT_1727 MSTHT_2311
MTHEMSTHC_0364 MSTHC_0514 MSTHC_0969 MSTHC_1561
MHORMSHOH_0251 MSHOH_1697 MSHOH_2811
MFZAOB57_000445 AOB57_001340 AOB57_003910 AOB57_007820
MBUMbur_0303 Mbur_0369 Mbur_0939 Mbur_1077 Mbur_1308
MMETMCMEM_0833 MCMEM_0997 MCMEM_1441 MCMEM_1598 MCMEM_1755
MELOJ7W08_02385 J7W08_03355 J7W08_05920 J7W08_06945 J7W08_07805
MMHMmah_0579 Mmah_0675 Mmah_1258 Mmah_1613
MHAZBHR79_00515 BHR79_05660 BHR79_07245 BHR79_10225
MEVMetev_0262 Metev_0801 Metev_1607 Metev_1731
MZHMzhil_0235 Mzhil_0513 Mzhil_0683 Mzhil_1608
MPYMpsy_0099 Mpsy_1026 Mpsy_1467 Mpsy_2554
MZIHWN40_01470 HWN40_03330 HWN40_05930 HWN40_09670
MHZMetho_0239 Metho_0947 Metho_1579 Metho_1933
MTPMthe_0044 Mthe_0513 Mthe_0671 Mthe_0714
MCJMCON_1147 MCON_3250 MCON_3296
MHIMhar_0556 Mhar_1078 Mhar_1156 Mhar_2172
MHUMhun_1123
MRTJKHC33_08510
MLAMlab_0431
MEMMemar_0506 Memar_1711
MBGBN140_1582
MEMAMMAB1_2023
MCHKMchiMG62_06300
MPIMpet_1752
MBNMboo_1945
MFOMetfor_1011
MPLMpal_0962
MPDMCP_0504 MCP_1168 MCP_1480
MEZMtc_0895(bchP) Mtc_1643 Mtc_1724
RCIRCIX2051(bchP) RCIX2708
HALVNG_0468C
HSLOE_1699R
HDLHALDL1_06480
HHBHhub_1531
HAGSJT689_03235
HABOJRZ79_01735
HNOLT974_03030
HLULT972_10470
HANRLJ422_01955
HJEHacjB3_14420
HALHHTSR_0966
HHSRHSR6_0997
HSUHLASF_0746
HSFHLASA_0743
SALRFQU85_11230
HALREFA46_006370 EFA46_006470
HARAAArcS_1790(fixC3)
HALXM0R89_10965
HMArrnAC0726
HHIHAH_1373
HHNHISP_07025
HABSG26_14865
HTABVU17_06685
HALJG9465_08440 G9465_08805 G9465_20450
HSINKDQ40_06605
NPHNP_4564A
NMONmlp_2334 Nmlp_3608
NHOHWV23_05715
NSALHWV07_05475
HUTHuta_0881 Huta_1007 Huta_2954
HTIHTIA_0743 HTIA_2555
HALAHrd1104_04765 Hrd1104_09045
HMUHmuk_1955 Hmuk_2206 Hmuk_3091 Hmuk_3127
HALZE5139_02700 E5139_02875 E5139_12890 E5139_14170
HALLLC1Hm_1280 LC1Hm_1619(fixC) LC1Hm_2428(fixC3) LC1Hm_2469(fixC4)
HAZPGBQ70_02700 GBQ70_12905 GBQ70_14185
HALIBV210_03410
HSNDV733_10365
HDSHSR122_0270(fixC)
HRRHZS55_18830 HZS55_20705
HPELHZS54_21655 HZS54_22270 HZS54_24195
HLTI7X12_15485 I7X12_16545 I7X12_17600
HARCHARCEL1_04790
HDOMUK72_09380
HWAHQ_1534A
HWCHqrw_1635 Hqrw_3314
HVOHVO_1799
HMEHFX_1905(fixC)
HGIABY42_08860
HALEG3A49_12170
HBOHbor_11300
HAQDU484_09565 DU484_17775
HAJDU500_00815 DU500_09815
HAERDU502_06905 DU502_07185 DU502_16565
HRAEI982_07520 EI982_14380
HLMDV707_07230
HALMFCF25_11425
HLAHlac_0926
HALPDOS48_03545
HALBEKH57_07685
HEZZEO776_04760
HALQHrr1229_002660
HSSJ7656_12430
HSAIHPS36_02425
HAZZKI388_02310
SRUBC2R22_05450
HAEhalTADL_1048
HALNB4589_000260
HALGHUG10_08475
HALUHUG12_17860
HDFAArcSl_1381 AArcSl_1813
HAHHalar_0855
HTUHtur_1377 Htur_3081
HDABB347_05735 BB347_10350 BB347_10530
HJTDVR14_12450
HALYHYG82_09140 HYG82_16990
HSALJMJ58_01855 JMJ58_05545 JMJ58_12995 JMJ58_22355
HLOJ0X27_13130
HAKZJ0X25_02870 J0X25_13780
NMGNmag_0668 Nmag_1523 Nmag_2507 Nmag_2778
HXAHalxa_3925 Halxa_3960
NATNJ7G_0898 NJ7G_2427
NPENatpe_0646 Natpe_1962 Natpe_3244
NVRFEJ81_03545
NPLFGF80_01135 FGF80_07435
NAYHYG81_07440
NGENatgr_0786 Natgr_1266 Natgr_3103
HRUHalru_1246 Halru_2474
NOUNatoc_0699 Natoc_2139 Natoc_4277
SALIL593_01650
SAIMK0C01_10790
HLRHALLA_08655 HALLA_13160 HALLA_17630
HLCCHINAEXTREME15935 CHINAEXTREME19570
NAJB1756_02305 B1756_04290 B1756_12495
NAGAArcMg_1023 AArcMg_2971 AArcMg_3119
NANAArc1_0731 AArc1_2601 AArc1_3025
NBGDV706_00945 DV706_09380 DV706_16325 DV706_19090
NASGCU68_02695 GCU68_12755
NACAQV86_03970
MELUMTLP_05820 MTLP_05840 MTLP_09940
MEAMMU439_04990
TACTa0516
TVOTVG1046096(TVG1046096) TVG1579590(TVG1579590)
PTOPTO0568 PTO0896
FACFACI_IFERC01G0166
FAIFAD_1079
CDIVCPM_0295 CPM_0485 CPM_0894
TARTALC_00223 TALC_00435 TALC_00774
MAXMMALV_02090 MMALV_03590 MMALV_08730
MERMMINT_02130 MMINT_12590 MMINT_13170 MMINT_17750
MEARMpt1_c01650 Mpt1_c12530
MARCAR505_0892 AR505_1433 AR505_1618
ABIAboo_0578
ACFAciM339_0374 AciM339_0468
SMRSmar_1462
DKADKAM_0159
DFDDesfe_0234
DMUDesmu_0290
TAGTagg_0378
THGTCELL_1246
HBUHbut_1257
STOSTK_04940
SOHD1869_02295
SOLSsol_0166
SSOASULA_0158
SSOLSULB_0159
SSOFSULC_0158
SSHIJ5U23_01149
SCASSACC_19360
SISLS215_0182
SIAM1425_0151
SIMM1627_0151
SIDM164_0170
SIYYG5714_0155
SINYN1551_2754
SIILD85_0155
SIHSiH_0155
SIRSiRe_0151
SICSiL_0142
SULABFU36_10465
SULEGFS03_02305
SULOGFS33_08920
MSEMsed_0681
MCNMcup_1399
MHKDFR87_03150
MPRUDFR88_03175
MTENGWK48_08960
MJNMjAS7_1447
AHOAhos_2154
AMANB6F84_03335
ABRIDFR85_06060
ASULDFR86_03340
AAMBD1866_05750
ACIHHS5_09650
SACDHS1genome_0804
SAZOD1868_10400
STEPIC006_2737
CMACmaq_0840
VDIVdis_1715
VMOVMUT_2242
TPETpen_0114 Tpen_0718
THBN186_01490 N186_04950
TCBTCARB_0050 TCARB_1382
THFMA03_00905 MA03_06135
THELIG193_04155 IG193_06980
ACIASE86_02030
FFOFFONT_1180
NMRNmar_0631
NIRNSED_03245
NKRNKOR_03230
NIDNPIRD3C_1636
NINNADRNF5_0722 NADRNF5_1519
NIWNisw_01750
NCLC5F47_05915
NOXC5F49_05755 C5F49_06640
NUEC5F50_04660
NIPNsoK4_05210
NCTNMSP_0453 NMSP_1055
NICDSQ20_03360
CSYCENSYa_0520 CENSYa_1317
NGANgar_c10460 Ngar_c11500 Ngar_c18750
NVNNVIE_003360 NVIE_011700
NEVNTE_01655 NTE_02579
TAANMY3_01977 NMY3_02141 NMY3_02989
NFNNFRAN_0449 NFRAN_2927
NCVNCAV_0324
CSUCSUB_C1349 CSUB_C1610
NBVT478_0510 T478_0975
TAHSU86_000125 SU86_003010
NIUDSQ19_03605
NDVNDEV_0107 NDEV_1206
KCRKcr_0058 Kcr_1359
BARCAOA65_1634
BARBAOA66_1225
FLTSv326_0975
LOKILokiarch_51240
PSYTDSAG12_02297
AGWQT03_C0001G0827
 » show all
Reference
1  [PMID:17288560]
  Authors
Murakami M, Shibuya K, Nakayama T, Nishino T, Yoshimura T, Hemmi H
  Title
Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus.
  Journal
FEBS J 274:805-14 (2007)
DOI:10.1111/j.1742-4658.2006.05625.x
  Sequence
[afu:AF_0464]
Reference
2  [PMID:18375567]
  Authors
Sato S, Murakami M, Yoshimura T, Hemmi H
  Title
Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl donor, not a dead-end product.
  Journal
J Bacteriol 190:3923-9 (2008)
DOI:10.1128/JB.00082-08
Reference
3  [PMID:21515284]
  Authors
Sasaki D, Fujihashi M, Iwata Y, Murakami M, Yoshimura T, Hemmi H, Miki K
  Title
Structure and mutation analysis of archaeal geranylgeranyl reductase.
  Journal
J Mol Biol 409:543-57 (2011)
DOI:10.1016/j.jmb.2011.04.002
Reference
4  [PMID:24214941]
  Authors
Isobe K, Ogawa T, Hirose K, Yokoi T, Yoshimura T, Hemmi H
  Title
Geranylgeranyl reductase and ferredoxin from Methanosarcina acetivorans are required for the synthesis of fully reduced archaeal membrane lipid in Escherichia coli cells.
  Journal
J Bacteriol 196:417-23 (2014)
DOI:10.1128/JB.00927-13
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.11
IUBMB Enzyme Nomenclature: 1.3.7.11
ExPASy - ENZYME nomenclature database: 1.3.7.11
BRENDA, the Enzyme Database: 1.3.7.11

DBGET integrated database retrieval system