KEGG   ENZYME: 1.3.7.12Help
Entry
EC 1.3.7.12                 Enzyme                                 

Name
red chlorophyll catabolite reductase;
RCCR;
RCC reductase;
red Chl catabolite reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
primary fluorescent chlorophyll catabolite:ferredoxin oxidoreductase
Reaction(IUBMB)
primary fluorescent chlorophyll catabolite + 2 oxidized ferredoxin [iron-sulfur] cluster = red chlorophyll catabolite + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ [RN:R09032]
Reaction(KEGG)
Substrate
primary fluorescent chlorophyll catabolite [CPD:C18098];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Product
red chlorophyll catabolite [CPD:C18022];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080]
Comment
The enzyme participates in chlorophyll degradation, which occurs during leaf senescence and fruit ripening in higher plants. The reaction requires reduced ferredoxin, which is generated from NADPH produced either through the pentose-phosphate pathway or by the action of photosystem I [1,2]. This reaction takes place while red chlorophyll catabolite is still bound to EC 1.14.15.17, pheophorbide a oxygenase [3]. Depending on the plant species used as the source of enzyme, one of two possible C-1 epimers of primary fluorescent chlorophyll catabolite (pFCC), pFCC-1 or pFCC-2, is normally formed, with all genera or species within a family producing the same isomer [3,4]. After modification and export, pFCCs are eventually imported into the vacuole, where the acidic environment causes their non-enzymic conversion into colourless breakdown products called non-fluorescent chlorophyll catabolites (NCCs) [2].
History
EC 1.3.7.12 created 2007 as EC 1.3.1.80, transferred 2016 to EC 1.3.7.12
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K13545  red chlorophyll catabolite reductase
Genes
RSS: 109442856
ATH: AT4G37000(ACD2)
ALY: ARALYDRAFT_353127
CRB: 111828541
CSAT: 104716415 104721055 104729460
EUS: EUTSA_v10025731mg EUTSA_v10027845mg EUTSA_v10027846mg
BRP: 103862886(RCCR)
BNA: 106426866 106438613 111202026
BOE: 106325027
THJ: 104807582
CPAP: 110814300
TCC: 18611120
GRA: 105803912
GAB: 108461228
EGR: 104418575
VRA: 106763057
VAR: 108337053
CCAJ: 109806983
CAM: 101488374
LJA: Lj2g3v3246900.1(Lj2g3v3246900.1) Lj2g3v3315570.1(Lj2g3v3315570.1)
ADU: 107496225
AIP: 107608673
LANG: 109356885
FVE: 101301239
PPER: 18769442
PMUM: 103339882
PAVI: 110765868
MDM: 103401375
PXB: 103964494
ZJU: 107424775
CSV: 101202861 101223133(CsRCCR)
RCU: 8262890
JCU: 105639704
HBR: 110646846
MESC: 110629083
VVI: 100252439
SLY: 778267
SPEN: 107014711
SOT: 102591737
CANN: 107868112(RCCR)
NSY: 104239946
NTO: 104108838
INI: 109177802
OEU: 111410341
HAN: 110909121
LSV: 111876719
CCAV: 112518578
DCR: 108192987
BVG: 104883759
SOE: 110777086
NNU: 104608870
OSA: 4348519
DOSA: Os10t0389100-00(Os10g0389100) Os10t0389200-01(Os10g0389200) Os10t0389300-01(Os10g0389300)
OBR: 102703616
BDI: 100843855
ATS: 109745881(LOC109745881) 109767332(LOC109767332)
ZMA: 100272914
SITA: 101780665
PDA: 103701815
MUS: 103999342
DCT: 110101222
PEQ: 110027504
AOF: 109827526
ATR: 18421357
PPP: 112292462
 » show all
Taxonomy
Reference
1  [PMID:12223835]
  Authors
Rodoni S, Muhlecker W, Anderl M, Krautler B, Moser D, Thomas H, Matile P, Hortensteiner S.
  Title
Chlorophyll Breakdown in Senescent Chloroplasts (Cleavage of Pheophorbide a in Two Enzymic Steps).
  Journal
Plant Physiol 115:669-676 (1997)
Reference
2  [PMID:10743659]
  Authors
Wuthrich KL, Bovet L, Hunziker PE, Donnison IS, Hortensteiner S.
  Title
Molecular cloning, functional expression and characterisation of RCC reductase involved in chlorophyll catabolism.
  Journal
Plant J 21:189-98 (2000)
DOI:10.1046/j.1365-313x.2000.00667.x
  Sequence
Reference
3  [PMID:17237353]
  Authors
Pruzinska A, Anders I, Aubry S, Schenk N, Tapernoux-Luthi E, Muller T, Krautler B, Hortensteiner S.
  Title
In vivo participation of red chlorophyll catabolite reductase in chlorophyll breakdown.
  Journal
Plant Cell 19:369-87 (2007)
DOI:10.1105/tpc.106.044404
  Sequence
[ath:AT4G37000]
Reference
4  [PMID:16669755]
  Authors
Hortensteiner S.
  Title
Chlorophyll degradation during senescence.
  Journal
Annu Rev Plant Biol 57:55-77 (2006)
DOI:10.1146/annurev.arplant.57.032905.105212
Reference
5  [PMID:12223836]
  Authors
Rodoni S, Vicentini F, Schellenberg M, Matile P, Hortensteiner S.
  Title
Partial Purification and Characterization of Red Chlorophyll Catabolite Reductase, a Stroma Protein Involved in Chlorophyll Breakdown.
  Journal
Plant Physiol 115:677-682 (1997)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.12
IUBMB Enzyme Nomenclature: 1.3.7.12
ExPASy - ENZYME nomenclature database: 1.3.7.12
BRENDA, the Enzyme Database: 1.3.7.12

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