KEGG ENZYME: 1.3.7.4

KEGG

ENZYME: 1.3.7.4

Entry

EC 1.3.7.4                  Enzyme

Name

phytochromobilin:ferredoxin oxidoreductase;
HY2;
PPhi B synthase;
phytochromobilin synthase

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor

Sysname

(3Z)-phytochromobilin:ferredoxin oxidoreductase

Reaction(IUBMB)

(3Z)-phytochromobilin + 2 oxidized ferredoxin = biliverdin IXalpha + 2 reduced ferredoxin [RN:R03678]

Reaction(KEGG)

Substrate

(3Z)-phytochromobilin [CPD:C05913];
oxidized ferredoxin [CPD:C00139]

Product

biliverdin IXalpha;
reduced ferredoxin [CPD:C00138]

Comment

Catalyses the two-electron reduction of biliverdin IXalpha. Can use [2Fe-2S] ferredoxins from a number of sources as acceptor but not the [4Fe-4S] ferredoxin from Clostridium pasteurianum. The isomerization of (3Z)-phytochromobilin to (3E)-phytochromobilin is thought to occur prior to covalent attachment to apophytochrome in the plant cell cytoplasm. Flavodoxins can be used instead of ferredoxin.

History

EC 1.3.7.4 created 2002

Pathway

Porphyrin metabolism

Biosynthesis of secondary metabolites

Orthology

phytochromobilin:ferredoxin oxidoreductase

Genes

ATH:	AT3G09150(HY2)

ALY:

9320783

CRB:

17892864

104745078 104749614 104764610

EUS:	EUTSA_v10011657mg

BRP:	103859309 103870559

BNA:	106352983 106439211 125587929

BOE:	106295900 106331861

RSZ:

108863089

THJ:

104799118

110811856

CIT:

102609362

CIC:	CICLE_v10015899mg

PVY:

116135627

123205883

TCC:

18589938

GRA:

105783974

GHI:	107939449 107945135

GAB:

108450615

DZI:	111302716 111303932

EGR:

104421483

GMX:

100791053

GSJ:	114385397 114403479

PVU:	PHAVU_008G284200g

VRA:

106765267

VAR:

108338713

VUN:

114193684

109795293

113846963

MTR:

11434871

123881987 123919836

CAM:	101503524 101506703 101510774 105851316

127117521

LJA:	Lj0g3v0050649.1(Lj0g3v0050649.1) Lj2g3v3337330.1(Lj2g3v3337330.1)

ADU:

107496238

AIP:

107609834

AHF:	112701760 112766749

109342143

129317400 129318213 129318261

FVE:

101309029

RCN:

112202176

18778367

103326785

110761571

117624673

MDM:

103426911

126615439

PXB:	103929552 103934579

ZJU:

107406401

MNT:

21385429

115721362

CSV:

101217650

CMO:

103492001

BHJ:

120071771

111021651

111485492

111461368

111779700

RCU:

8261167

JCU:

105647226

HBR:

110634414

110610189

POP:	7467396 7478520

PEU:

105131030

118032978 118035177

JRE:

108994596

122292677

132164719 132183158

QSU:

111997816

QLO:

115981670

TWL:

120001734

VVI:

100267105

VRI:

117916930

SLY:	778324(AUREA)

107008239

SOT:

102604691

125863480

107875610

LBB:

132626409

NTA:	107761635 107823317

NSY:

104250102

NTO:

104118127

NAU:

109228690

INI:

109160056

ITR:	116003618 116004293

105170921

EGT:

105958969

121749680 121750085

131006824

127260061

HAN:	110878838 110930825

122599805

LSV:

111883501

112529391

DCR:

108193224

114263854

RVL:

131314522

AEW:

130770127

BVG:

104889193

SOE:

110796859

CQI:	110689478 110704564 110734512

130815023

MOF:

131148975

NNU:

104612006

122091181

TSS:

122671382

113308909 113321152

OSA:

4325761

Os01t0949400-01(Os01g0949400)

OBR:

102708119

OGL:

127756402

BDI:

100829998

ATS:

109784146

TDC:	119270459 119278613

123059393 123066605 123075631

TUA:

125546046

127345746

LRD:

124661795

SBI:

8081332

ZMA:

542164

101767227

SVS:

117857311

120672659 120709242

112893571

PDA:

103705671

EGU:

105047124

MUS:

103976148

ZOF:	122041944 122046470

DCT:

110105041

PEQ:

110018338

AOF:

109850042

116246629

ATR:

18433244

SMO:	SELMODRAFT_151708(HY2-2) SELMODRAFT_83654(HY2-1)

PPP:

112290529

Reference

1 [PMID:11283349]

Authors

Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.

Title

Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.

Journal

Plant Cell 13:965-78 (2001)
DOI:10.1105/tpc.13.4.965

Reference

2 [PMID:11500553]

Authors

McDowell MT, Lagarias JC.

Title

Purification and biochemical properties of phytochromobilin synthase from etiolated oat seedlings.

Journal

Plant Physiol 126:1546-54 (2001)
DOI:10.1104/pp.126.4.1546

Reference

3 [PMID:8215388]

Authors

Terry MJ, Wahleithner JA, Lagarias JC.

Title

Biosynthesis of the plant photoreceptor phytochrome.

Journal

Arch Biochem Biophys 306:1-15 (1993)
DOI:10.1006/abbi.1993.1473

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

CAS:	138263-99-7

DBGET integrated database retrieval system