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Entry
EC 1.3.7.5                  Enzyme                                 

Name
phycocyanobilin:ferredoxin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
(3Z)-phycocyanobilin:ferredoxin oxidoreductase
Reaction(IUBMB)
(3Z)-phycocyanobilin + 4 oxidized ferredoxin = biliverdin IXalpha + 4 reduced ferredoxin [RN:R05817]
Reaction(KEGG)
Substrate
(3Z)-phycocyanobilin [CPD:C05786];
oxidized ferredoxin [CPD:C00139]
Product
biliverdin IXalpha;
reduced ferredoxin [CPD:C00138]
Comment
Catalyses the four-electron reduction of biliverdin IXalpha (2-electron reduction at both the A and D rings). Reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin. Flavodoxins can be used instead of ferredoxin. The direct conversion of biliverdin IXalpha (BV) to (3Z)-phycocyanolbilin (PCB) in the cyanobacteria Synechocystis sp. PCC 6803, Anabaena sp. PCC7120 and Nostoc punctiforme is in contrast to the proposed pathways of PCB biosynthesis in the red alga Cyanidium caldarium, which involves (3Z)-phycoerythrobilin (PEB) as an intermediate [2] and in the green alga Mesotaenium caldariorum, in which PCB is an isolable intermediate.
History
EC 1.3.7.5 created 2002, modified 2014
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K05371  phycocyanobilin:ferredoxin oxidoreductase
Genes
MPSY: CEK71_07465
CCRO: CMC5_010270
BRA: BRADO1265
SYN: slr0116
SYZ: MYO_127170
SYY: SYNGTS_2691(slr0116)
SYT: SYNGTI_2690(slr0116)
SYS: SYNPCCN_2689(slr0116)
SYQ: SYNPCCP_2689(slr0116)
SYJ: D082_22710(pcyA)
SYW: SYNW1084(PcyA)
SYC: syc0325_d
SYG: sync_1656(pcyA)
SYR: SynRCC307_1284(pcyA)
SYX: SynWH7803_1335(pcyA)
CYA: CYA_2492(pcyA)
CYB: CYB_0698(pcyA)
SYNR: KR49_02860
SYND: KR52_10550
SYH: Syncc8109_1464(pcyA)
SYNW: SynWH8103_01226(pcyA)
TEL: tll2308
THN: NK55_08135(pcyA)
CYI: CBM981_0635(pcyA)
LET: O77CONTIG1_02243(pcyA)
HHG: XM38_011470(pcyA)
PMA: Pro_0819(pcyA)
PMM: PMM0747(pcyA)
PMT: PMT_0590
PMB: A9601_08081(pcyA)
PMC: P9515_08371(pcyA)
PMF: P9303_16581(pcyA)
PMG: P9301_08071(pcyA)
PMH: P9215_08411(pcyA)
PMJ: P9211_10161(pcyA)
PME: NATL1_07831(pcyA)
PRC: EW14_0836
PRM: EW15_0833
AMR: AM1_5311(pcyA)
MAR: MAE_06540(pcyA)
MPK: VL20_1154
CYL: AA637_01130(pcyA)
GEN: GM3709_84
CYT: cce_3569
TER: Tery_4156
ARP: NIES39_C04490(pcyA)
PAGH: NIES204_09690(pcyA)
GVI: gvip359(pcyA)
GLJ: GKIL_0241(pcyA)
ANA: alr3707
AVA: Ava_3585
NAZ: Aazo_0093
CALH: IJ00_12770
CTHE: Chro_2660
 » show all
Taxonomy
Reference
1  [PMID:11283349]
  Authors
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
  Title
Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.
  Journal
Plant Cell 13:965-78 (2001)
  Sequence
[npu:Npun_R5577] [ana:alr3707] [pmm:PMM0747]
Reference
2
  Authors
Beale, S.I.
  Title
Biosynthesis of phycobilins.
  Journal
Chem Rev 93:785-802 (1993)
Reference
3  [PMID:9325294]
  Authors
Wu SH, McDowell MT, Lagarias JC.
  Title
Phycocyanobilin is the natural precursor of the phytochrome chromophore in the green alga Mesotaenium caldariorum.
  Journal
J Biol Chem 272:25700-5 (1997)
DOI:10.1074/jbc.272.41.25700
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.5
IUBMB Enzyme Nomenclature: 1.3.7.5
ExPASy - ENZYME nomenclature database: 1.3.7.5
BRENDA, the Enzyme Database: 1.3.7.5
CAS: 347401-12-1

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