KEGG ENZYME: 1.3.7.8

ENZYME: 1.3.7.8

Entry

EC 1.3.7.8                  Enzyme

Name

benzoyl-CoA reductase;
benzoyl-CoA reductase (dearomatizing)

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor

Sysname

cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming)

Reaction(IUBMB)

cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 ADP + 2 phosphate = benzoyl-CoA + reduced ferredoxin + 2 ATP + 2 H2O [RN:R02451]

Reaction(KEGG)

R02451;
(other) R00283

Substrate

cyclohexa-1,5-diene-1-carbonyl-CoA [CPD:C06322];
oxidized ferredoxin [CPD:C00139];
ADP [CPD:C00008];
phosphate [CPD:C00009]

Product

benzoyl-CoA [CPD:C00512];
reduced ferredoxin [CPD:C00138];
ATP [CPD:C00002];
H2O [CPD:C00001]

Comment

An iron-sulfur protein. Requires Mg2+ or Mn2+. Inactive towards aromatic acids that are not CoA esters but will also catalyse the reaction: ammonia + acceptor + 2 ADP + 2 phosphate = hydroxylamine + reduced acceptor + 2 ATP + H2O. In the presence of reduced acceptor, but in the absence of oxidizable substrate, the enzyme catalyses the hydrolysis of ATP to ADP plus phosphate.

History

EC 1.3.7.8 created 1999 as EC 1.3.99.15, transferred 2011 to EC 1.3.7.8, modified 2011

Pathway

ec00362

Benzoate degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K04112

benzoyl-CoA reductase subunit C

K04113

benzoyl-CoA reductase subunit B

K04114

benzoyl-CoA reductase subunit A

K04115

benzoyl-CoA reductase subunit D

Genes

SPOI:

IMCC21906_00682 IMCC21906_00683 IMCC21906_02698 IMCC21906_02701

STAW:

NCG89_10770

BBAY:

A4V04_12765

SHD:	SUTH_01645(bcrC) SUTH_01646(bcrB) SUTH_01647(bcrD) SUTH_01648(bcrA)

EBA:	ebA5282(bcrC) ebA5284(bcrB) ebA5286(bcrD) ebA5287(bcrA) ebA742(bcrA) ebA744(bcrD) ebA746(bcrB) ebA748(bcrC)

ABRE:

pbN1_04340(bcrA1) pbN1_04350(bcrD1) pbN1_04360(bcrB1) pbN1_04370(bcrC1) pbN1_30580(bcrC2) pbN1_30590(bcrB2) pbN1_30600(bcrD2) pbN1_30610(bcrA2)

APET:

ToN1_26840(bcrC1) ToN1_26850(bcrB1) ToN1_49070(bcrA) ToN1_49080(bcrD) ToN1_49090(bcrB2) ToN1_49100(bcrC2)

AZA:	AZKH_2137(bcrC) AZKH_2138(bcrB_bzdO) AZKH_2139(bcrD) AZKH_2140(bcrA_bzdQ) AZKH_p0330 AZKH_p0331

AZI:	AzCIB_1602 AzCIB_1603 AzCIB_1604 AzCIB_1605 AzCIB_4492 AzCIB_4493 AzCIB_4619 AzCIB_4620 AzCIB_4621 AzCIB_4622

AZD:	CDA09_09240 CDA09_09245 CDA09_12145(bzdQ) CDA09_12150 CDA09_12155(bzdO) CDA09_12160(bzdN) CDA09_21825 CDA09_21830 CDA09_22645(bzdQ) CDA09_22650 CDA09_22655(bzdO) CDA09_22660(bzdN)

TMZ:	Tmz1t_2948 Tmz1t_2949 Tmz1t_2950 Tmz1t_2951

TCL:	Tchl_2147 Tchl_2148 Tchl_2149 Tchl_2150 Tchl_3425 Tchl_3426

TAK:	Tharo_1305 Tharo_1306 Tharo_1307 Tharo_1308

DDZ:	DSYM_16280 DSYM_16290 DSYM_16300 DSYM_16310 DSYM_19010 DSYM_19020 DSYM_23700

RPA:	TX73_003405(bcrC) TX73_003410(bcrB) TX73_003415(bcrA) TX73_003420(bcrD)

RPC:	RPC_1026 RPC_1027 RPC_1028 RPC_1029

RPD:	RPD_1535 RPD_1536 RPD_1537 RPD_1538

RPE:	RPE_0605 RPE_0606 RPE_0607 RPE_0608

RPT:	Rpal_0724 Rpal_0725 Rpal_0726 Rpal_0727

RPX:	Rpdx1_4126 Rpdx1_4127 Rpdx1_4128 Rpdx1_4129

RVA:	Rvan_0037 Rvan_0038 Rvan_0039 Rvan_0040

RLAC:

QMO75_01835(bcrC) QMO75_01840(bcrB) QMO75_01845(bcrA) QMO75_01850(bcrD)

BLAG:

BLTE_16480 BLTE_16490 BLTE_16500 BLTE_16510(hadC)

OCD:	FHY55_13740

NPP:	PP1Y_AT13082

NOT:	C7W88_19650

SMAZ:

LH19_27085 LH19_27090

SPHR:

BSY17_1002

BLAS:

BSY18_3534

BFW:	B5J99_08465

MAGX:

XM1_2273(mbdO) XM1_2274 XM1_2893(bcrD) XM1_2894(bcrA) XM1_2895(bcrB) XM1_2896(bcrC) XM1_3815

MAGN:

WV31_08600 WV31_08605 WV31_08610 WV31_08615

MAG:	amb2138 amb2139 amb2140 amb2141

GLO:	Glov_2400 Glov_2401

DOL:

Dole_2770

DOV:	DSCO28_15710(hadC) DSCO28_15720

DWD:	DSCW_52390(hadC_2) DSCW_52400

DEK:	DSLASN_23180

DTI:	Desti_1473 Desti_1474 Desti_1525

DMP:	FAK_34100(hadC) FAK_34110 FAK_34120 FAK_34130

SHYR:

LA303_09490

NCM:	QNK12_19365

NNV:	QNH39_14145

SLP:	Slip_0467 Slip_0468

DHD:

Dhaf_1100

DDL:	Desdi_0719 Desdi_0720

AACX:

DEACI_1765 DEACI_1766 DEACI_1767 DEACI_1769

DGI:	Desgi_0510 Desgi_0511 Desgi_1429 Desgi_1430

EMJ:	V1225_00140

SSID:

SPSIL_023990(hadI_2) SPSIL_024000(hadI_3)

SACV:

SPACI_016630(bcrC)

EYY:	EGYY_24080(HgdB)

ROA:	Pd630_LPD06921 Pd630_LPD06922 Pd630_LPD06958 Pd630_LPD06959

RRZ:	CS378_10705 CS378_10710

RKO:	JWS14_14645 JWS14_14650

ROZ:	CBI38_28250 CBI38_28255

RPSK:

JWS13_30560 JWS13_30565

RHOU:

KZJ41_22620 KZJ41_22625

RHOJ:

JVH1_22925 JVH1_22930 JVH1_22970 JVH1_22975

RHOY:

QNA09_02755 QNA09_02760

GOM:	D7316_03195(bcrC) D7316_03196(hadB_1) D7316_03203(fldC) D7316_03204(hadB_2)

FRP:	AX769_19070 AX769_19075

SUBA:

LQ955_14170

AACD:

LWP59_12880

FPL:	Ferp_1184 Ferp_1185 Ferp_1186 Ferp_1187

GAC:	GACE_0796 GACE_0797 GACE_0798 GACE_0799

BARC:

AOA65_0733 AOA65_0734 AOA65_0735 AOA65_0736

» show all

Reference

1 [PMID:8575453]

Authors

Boll M, Fuchs G

Title

Benzoyl-coenzyme A reductase (dearomatizing), a key enzyme of anaerobic aromatic metabolism. ATP dependence of the reaction, purification and some properties of the enzyme from Thauera aromatica strain K172.

Journal

Eur J Biochem 234:921-33 (1995)
DOI:10.1111/j.1432-1033.1995.921_a.x

Sequence

[ag:CAA12249 CAA12248 CAA12247 CAA12250]

Reference

2 [PMID:20578740]

Authors

Kung JW, Baumann S, von Bergen M, Muller M, Hagedoorn PL, Hagen WR, Boll M

Title

Reversible biological Birch reduction at an extremely low redox potential.

Journal

J Am Chem Soc 132:9850-6 (2010)
DOI:10.1021/ja103448u