KEGG   ENZYME: 1.3.7.8
Entry
EC 1.3.7.8                  Enzyme                                 
Name
benzoyl-CoA reductase;
benzoyl-CoA reductase (dearomatizing)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
Sysname
cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming)
Reaction(IUBMB)
cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 ADP + 2 phosphate = benzoyl-CoA + reduced ferredoxin + 2 ATP + 2 H2O [RN:R02451]
Reaction(KEGG)
R02451;
(other) R00283
Substrate
cyclohexa-1,5-diene-1-carbonyl-CoA [CPD:C06322];
oxidized ferredoxin [CPD:C00139];
ADP [CPD:C00008];
phosphate [CPD:C00009]
Product
benzoyl-CoA [CPD:C00512];
reduced ferredoxin [CPD:C00138];
ATP [CPD:C00002];
H2O [CPD:C00001]
Comment
An iron-sulfur protein. Requires Mg2+ or Mn2+. Inactive towards aromatic acids that are not CoA esters but will also catalyse the reaction: ammonia + acceptor + 2 ADP + 2 phosphate = hydroxylamine + reduced acceptor + 2 ATP + H2O. In the presence of reduced acceptor, but in the absence of oxidizable substrate, the enzyme catalyses the hydrolysis of ATP to ADP plus phosphate.
History
EC 1.3.7.8 created 1999 as EC 1.3.99.15, transferred 2011 to EC 1.3.7.8, modified 2011
Pathway
ec00362  Benzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04112  benzoyl-CoA reductase subunit C
K04113  benzoyl-CoA reductase subunit B
K04114  benzoyl-CoA reductase subunit A
K04115  benzoyl-CoA reductase subunit D
Genes
SPOIIMCC21906_00682 IMCC21906_00683 IMCC21906_02698 IMCC21906_02701
BBAYA4V04_12765
SHDSUTH_01645(bcrC) SUTH_01646(bcrB) SUTH_01647(bcrD) SUTH_01648(bcrA)
EBAebA5282(bcrC) ebA5284(bcrB) ebA5286(bcrD) ebA5287(bcrA) ebA742(bcrA) ebA744(bcrD) ebA746(bcrB) ebA748(bcrC)
ABREpbN1_04340(bcrA1) pbN1_04350(bcrD1) pbN1_04360(bcrB1) pbN1_04370(bcrC1) pbN1_30580(bcrC2) pbN1_30590(bcrB2) pbN1_30600(bcrD2) pbN1_30610(bcrA2)
APETToN1_26840(bcrC1) ToN1_26850(bcrB1) ToN1_49070(bcrA) ToN1_49080(bcrD) ToN1_49090(bcrB2) ToN1_49100(bcrC2)
AZAAZKH_2137(bcrC) AZKH_2138(bcrB_bzdO) AZKH_2139(bcrD) AZKH_2140(bcrA_bzdQ) AZKH_p0330 AZKH_p0331
AZIAzCIB_1602 AzCIB_1603 AzCIB_1604 AzCIB_1605 AzCIB_4492 AzCIB_4493 AzCIB_4619 AzCIB_4620 AzCIB_4621 AzCIB_4622
AZDCDA09_09240 CDA09_09245 CDA09_12145(bzdQ) CDA09_12150 CDA09_12155(bzdO) CDA09_12160(bzdN) CDA09_21825 CDA09_21830 CDA09_22645(bzdQ) CDA09_22650 CDA09_22655(bzdO) CDA09_22660(bzdN)
TMZTmz1t_2948 Tmz1t_2949 Tmz1t_2950 Tmz1t_2951
TCLTchl_2147 Tchl_2148 Tchl_2149 Tchl_2150 Tchl_3425 Tchl_3426
TAKTharo_1305 Tharo_1306 Tharo_1307 Tharo_1308
DDZDSYM_16280 DSYM_16290 DSYM_16300 DSYM_16310 DSYM_19010 DSYM_19020 DSYM_23700
GLOGlov_2400 Glov_2401
DOLDole_2770
DALDalk_3049 Dalk_3838
DOVDSCO28_15710(hadC) DSCO28_15720
DWDDSCW_52390(hadC_2) DSCW_52400
DEKDSLASN_23180
DTIDesti_1473 Desti_1474 Desti_1525
RPARPA0657(badD) RPA0658(badE) RPA0659(badF) RPA0660(badG)
RPCRPC_1026 RPC_1027 RPC_1028 RPC_1029
RPDRPD_1535 RPD_1536 RPD_1537 RPD_1538
RPERPE_0605 RPE_0606 RPE_0607 RPE_0608
RPTRpal_0724 Rpal_0725 Rpal_0726 Rpal_0727
RPXRpdx1_4126 Rpdx1_4127 Rpdx1_4128 Rpdx1_4129
RVARvan_0037 Rvan_0038 Rvan_0039 Rvan_0040
BLAGBLTE_16480 BLTE_16490 BLTE_16500 BLTE_16510(hadC)
OCDFHY55_13740
NPPPP1Y_AT13082
NOTC7W88_19650
SMAZLH19_27085 LH19_27090
SPHRBSY17_1002
BLASBSY18_3534
BFWB5J99_08465
MAGamb2138 amb2139 amb2140 amb2141
MAGXXM1_2273(mbdO) XM1_2274 XM1_2893(bcrD) XM1_2894(bcrA) XM1_2895(bcrB) XM1_2896(bcrC) XM1_3815
MAGNWV31_08600 WV31_08605 WV31_08610 WV31_08615
SLPSlip_0467 Slip_0468
DHDDhaf_1100
DDLDesdi_0719 Desdi_0720 Desdi_0724
AACXDEACI_1765 DEACI_1766 DEACI_1767 DEACI_1769
DGIDesgi_0510 Desgi_0511 Desgi_1429 Desgi_1430
ETMCE91St48_35420
ROAPd630_LPD06921 Pd630_LPD06922 Pd630_LPD06958 Pd630_LPD06959
RRZCS378_10705 CS378_10710
RKOJWS14_14645 JWS14_14650
GOMD7316_03195(bcrC) D7316_03196(hadB_1) D7316_03203(fldC) D7316_03204(hadB_2)
FRPAX769_19070 AX769_19075
AACDLWP59_12880
EYYEGYY_24080(HgdB)
SHYRLA303_09490
FPLFerp_1184 Ferp_1185 Ferp_1186 Ferp_1187
GACGACE_0796 GACE_0797 GACE_0798 GACE_0799
BARCAOA65_0733 AOA65_0734 AOA65_0735 AOA65_0736
 » show all
Reference
1  [PMID:8575453]
  Authors
Boll M, Fuchs G
  Title
Benzoyl-coenzyme A reductase (dearomatizing), a key enzyme of anaerobic aromatic metabolism. ATP dependence of the reaction, purification and some properties of the enzyme from Thauera aromatica strain K172.
  Journal
Eur J Biochem 234:921-33 (1995)
DOI:10.1111/j.1432-1033.1995.921_a.x
  Sequence
Reference
2  [PMID:20578740]
  Authors
Kung JW, Baumann S, von Bergen M, Muller M, Hagedoorn PL, Hagen WR, Boll M
  Title
Reversible biological Birch reduction at an extremely low redox potential.
  Journal
J Am Chem Soc 132:9850-6 (2010)
DOI:10.1021/ja103448u
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.8
IUBMB Enzyme Nomenclature: 1.3.7.8
ExPASy - ENZYME nomenclature database: 1.3.7.8
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.7.8
BRENDA, the Enzyme Database: 1.3.7.8
CAS: 176591-18-7

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