KEGG   ENZYME: 1.3.8.11
Entry
EC 1.3.8.11                 Enzyme                                 

Name
cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein);
aliB (gene name);
cyclohexane-1-carbonyl-CoA dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
cyclohexane-1-carbonyl-CoA:electron transfer flavoprotein oxidoreductase
Reaction(IUBMB)
cyclohexane-1-carbonyl-CoA + electron-transfer flavoprotein = cyclohex-1-ene-1-carbonyl-CoA + reduced electron-transfer flavoprotein [RN:R10601]
Reaction(KEGG)
R10601
Substrate
cyclohexane-1-carbonyl-CoA [CPD:C09823];
electron-transfer flavoprotein [CPD:C04253]
Product
cyclohex-1-ene-1-carbonyl-CoA [CPD:C09811];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains FAD. The enzyme, characterized from the strict anaerobic bacterium Syntrophus aciditrophicus, is involved in production of cyclohexane-1-carboxylate, a byproduct produced by that organism during fermentation of benzoate and crotonate to acetate.
History
EC 1.3.8.11 created 2013, modified 2020
Pathway
ec00362  Benzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K19067  cyclohexane-1-carbonyl-CoA dehydrogenase
Genes
GME: Gmet_3307
GBM: Gbem_3576
GEO: Geob_2190
SAT: SYN_02586
Reference
1  [PMID:10781543]
  Authors
Pelletier DA, Harwood CS.
  Title
2-Hydroxycyclohexanecarboxyl coenzyme A dehydrogenase, an enzyme characteristic of the anaerobic benzoate degradation pathway used by Rhodopseudomonas palustris.
  Journal
J Bacteriol 182:2753-60 (2000)
DOI:10.1128/JB.182.10.2753-2760.2000
Reference
2  [PMID:23667239]
  Authors
Kung JW, Seifert J, von Bergen M, Boll M
  Title
Cyclohexanecarboxyl-coenzyme A (CoA) and cyclohex-1-ene-1-carboxyl-CoA dehydrogenases, two enzymes involved in the fermentation of benzoate and crotonate in Syntrophus aciditrophicus.
  Journal
J Bacteriol 195:3193-200 (2013)
DOI:10.1128/JB.00322-13
  Sequence
[sat:SYN_02586]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.11
IUBMB Enzyme Nomenclature: 1.3.8.11
ExPASy - ENZYME nomenclature database: 1.3.8.11
BRENDA, the Enzyme Database: 1.3.8.11

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