KEGG   ENZYME: 1.3.8.12Help
Entry
EC 1.3.8.12                 Enzyme                                 

Name
(2S)-methylsuccinyl-CoA dehydrogenase;
Mcd
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
(2S)-methylsuccinyl-CoA:electron-transfer flavoprotein oxidoreductase
Reaction(IUBMB)
(2S)-methylsuccinyl-CoA + electron-transfer flavoprotein = 2-methylfumaryl-CoA + reduced electron-transfer flavoprotein [RN:R09293]
Reaction(KEGG)
Substrate
(2S)-methylsuccinyl-CoA [CPD:C18324];
electron-transfer flavoprotein [CPD:C04253]
Product
2-methylfumaryl-CoA [CPD:C06028];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. The enzyme contains FAD.
History
EC 1.3.8.12 created 2015
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K14448  (2S)-methylsuccinyl-CoA dehydrogenase
Genes
PSET: THL1_4233
MARI: ACP86_19405
GAI: IMCC3135_16910(mcd)
KAK: Kalk_01775
OME: OLMES_2174
GBI: PG2T_00815
GPB: HDN1F_16010
ADN: Alide_3214
ADK: Alide2_1233
HYB: Q5W_20085
SCL: sce0587
PLA: Plav_1613
RBS: RHODOSMS8_02653(mcd)
XAU: Xaut_0310
AZC: AZC_4648
MEX: Mext_2228
MEA: Mex_1p2223(ibd2)
MDI: METDI3005(msd)
MCH: Mchl_2504
MPO: Mpop_2186
MET: M446_4575
MNO: Mnod_4511
MOR: MOC_5019
META: Y590_10710
MAQU: Maq22A_c07055(ibd2)
HDN: Hden_0214
HMC: HYPMC_0100(msd)
RVA: Rvan_2966
BVR: BVIR_182
BLAG: BLTE_34660
MSC: BN69_1942
PLEO: OHA_1_02835(ibd2)
MCG: GL4_3336
HDI: HDIA_3966(mmgC_1)
RBM: TEF_03545
CCR: CC_3087
CAK: Caul_1059
CSE: Cseg_3655
PZU: PHZ_c3145
SIL: SPO0693
RSP: RSP_1679
JAN: Jann_0530
RDE: RD1_1372(ibd2)
PDE: Pden_2840
DSH: Dshi_0204(mmgC)
PSF: PSE_0035
PGD: Gal_00245
OTM: OSB_02210(mmgC_1)
CID: P73_0612
MALG: MALG_03387
RSU: NHU_01021
RHC: RGUI_2888
SPSE: SULPSESMR1_02661(mcd)
RMM: ROSMUCSMR3_01322(mcd)
HNE: HNE_3379
HBA: Hbal_0249
NAR: Saro_3795
SAL: Sala_2897
SPHP: LH20_06640
SMAZ: LH19_02450
SGI: SGRAN_3010(ibd2)
SPHD: HY78_18255
SPHT: K426_13845
BLAS: BSY18_3598
ELI: ELI_00035
RRU: Rru_A3064
RRF: F11_15695
MAG: amb0308
MGY: MGMSRv2__2675(mmgC)
MGRY: MSR1_36910(mmgC_5)
MAGX: XM1_1236(mmgC)
MAGN: WV31_14295
TMO: TMO_0120
TXI: TH3_17600
MAGQ: MGMAQ_3099
LIL: LA_0560(caiA)
LIE: LIF_A0461(caiA)
LIC: LIC_13009
LIS: LIL_13118(caiA9)
LBJ: LBJ_2405
LBL: LBL_0703
LBI: LEPBI_I3317(acdA3)
LBF: LBF_3202
LST: LSS_06909
 » show all
Taxonomy
Reference
1  [PMID:19703103]
  Authors
Erb TJ, Fuchs G, Alber BE.
  Title
(2S)-Methylsuccinyl-CoA dehydrogenase closes the ethylmalonyl-CoA pathway for acetyl-CoA assimilation.
  Journal
Mol Microbiol 73:992-1008 (2009)
DOI:10.1111/j.1365-2958.2009.06837.x
  Sequence
[rsp:RSP_1679]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.12
IUBMB Enzyme Nomenclature: 1.3.8.12
ExPASy - ENZYME nomenclature database: 1.3.8.12
BRENDA, the Enzyme Database: 1.3.8.12

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