KEGG   ENZYME: 1.3.8.12
Entry
EC 1.3.8.12                 Enzyme                                 
Name
(2S)-methylsuccinyl-CoA dehydrogenase;
Mcd
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
(2S)-methylsuccinyl-CoA:electron-transfer flavoprotein oxidoreductase
Reaction(IUBMB)
(2S)-methylsuccinyl-CoA + electron-transfer flavoprotein = 2-methylfumaryl-CoA + reduced electron-transfer flavoprotein [RN:R09293]
Reaction(KEGG)
R09293
Substrate
(2S)-methylsuccinyl-CoA [CPD:C18324];
electron-transfer flavoprotein [CPD:C04253]
Product
2-methylfumaryl-CoA [CPD:C06028];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. The enzyme contains FAD.
History
EC 1.3.8.12 created 2015
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14448  (2S)-methylsuccinyl-CoA dehydrogenase
Genes
PSETTHL1_4233
MARIACP86_19405
GAIIMCC3135_16910(mcd)
KAKKalk_01775
OMEOLMES_2174
GBIPG2T_00815
GPBHDN1F_16010
ADNAlide_3214
ADKAlide2_1233
HYBQ5W_20085
XYKGT347_20760
APPCAP2UW1_2497
SCLsce0587
SCUSCE1572_04065
MESWA9K65_031175
PLAPlav_1613
PMOBHG718_00340
KMNHW532_17100
RBSRHODOSMS8_02653(mcd)
EMXFKV68_30905
RFVRFYW14_04019
BOPAXW83_03455
BOSBSY19_2144
BVVBHK69_16360
BOIBLM15_14085
BOFFQV39_08880
XAUXaut_0310
XDIEZH22_06665
AZCAZC_4648
MEAMex_1p2223(ibd2)
MDIMETDI3005(msd)
MEXMext_2228
MCHMchl_2504
MPOMpop_2186
MZAB2G69_18750
MRDMrad2831_4351
METM446_4575
MNOMnod_4511
MORMOC_5019
METAY590_10710
MAQUMaq22A_c07055(ibd2)
MPHYMCBMB27_03874
MEEDA075_26015
METDC0214_12585
METXA3862_09600
METSDK389_01585
METIDK427_01745
MMESMMSR116_04950
MTEADK419_07360
MINDmvi_48210
MOGMMB17_24190
RHJHZY79_04285
CDQBOQ54_02770
HDNHden_0214
HDTHYPDE_23628
HMCHYPMC_0100(msd)
HNIW911_17390
RVARvan_2966
FILBN1229_v1_1376
FIYBN1229_v1_1375
RHZRHPLAN_11820
MCGGL4_3336
METGHT051_03010
BVRBVIR_182
BLAGBLTE_34660
MSCBN69_1942
MBRYB1812_14845
MROSEHO51_15530
MHEYH2LOC_017850
MPARF7D14_06305
MTWCQW49_16350
CMETK6K41_15570
PLEOOHA_1_02835(ibd2)
HDIHDIA_3966(mmgC_1)
BRND1F64_21120
PSINCAK95_11900
NOHG5V57_10340
RBMTEF_03545
PSFPSE_0035
PPHRAPZ00_08230
LAPACP90_03340
LABRCHH27_17300
LABPFJ695_06860
LABTFIU93_08975(mmgC1)
LAGGB0E33_14815
SIWGH266_11160
PHRC6569_20730
PSTGE8M01_09815
ACUTMRB58_00795
CCRCC_3087
CCSCCNA_03184
CAKCaul_1059
CSECseg_3655
CHQAQ619_02845
CMBCSW64_19025
CFHC1707_03575
CAUFCSW63_19600
PZUPHZ_c3145
PHBHYN04_01310
TSVDSM104635_01226(mmgC_3)
SILSPO0693
SITTM1040_2444
RUAD1823_10490
RUTFIU92_02785(mmgC1)
JANJann_0530
RDERD1_1372(ibd2)
RLIRLO149_c034140
RPONG3256_02665
DSHDshi_0204(mmgC)
PGAPGA1_c01110
PGLPGA2_c29780
PGDGal_00245
PHPPhaeoP97_00338
PPICPhaeoP14_02942
PHQD1820_10540
OATOAN307_c03080
OAROA238_c02240
OTMOSB_02210(mmgC_1)
OCTFTO60_01335
LMDMETH_00815
LEJETW24_00805
LAQUR2C4_16280
REDroselon_01508
CIDP73_0612
CMARIMCC12053_1518
CEHCEW89_14850
MALGMALG_03387
CONTQ29_01745
YPACCEW88_03080
YANAYJ57_10165
TPROGa0080559_TMP1223
PABYGa0080574_TMP1791
SUAMBOO69_01730
SULZC1J03_02875
SULIC1J05_02105
SULDB5M07_15630
SPOTG6548_14190
SMEDJNX03_10970
SINLDSM14862_03067(mcd)
SPSESULPSESMR1_02661(mcd)
TOMBWR18_13585
RMMROSMUCSMR3_01322(mcd)
ROKRAK1035_0274
RIDRIdsm_00183(mmgC_3)
ROMEI983_14390
ROHFIU89_16755(mmgC5)
AHTANTHELSMS3_01950
SAGUCDO87_13230
THAACFI11_02130
OCDFHY55_18290
MARUFIU81_13010(mmgC4)
ROTFIV09_15425(mmgC3)
MALUKU6B_08810
TGLHFZ77_13930
TMDKUV46_07595
HATRC74_04475
RSPRSP_1679
RSHRsph17029_0312
RSQRsph17025_2567
RSKRSKD131_3079
CAZTLV780_11785
RCPRCAP_rcc03306
RHPLPB142_14090
RBLB6K69_12755
PDEPden_2840
PAMIJCM7686_0656
PYEA6J80_04750
PCONB0A89_08760
PZHCX676_16780
PAROCUV01_04620
PAMNJCM7685_1082
PARREOJ32_04100
PKDF8A10_17805
PPANESD82_07180
PLIAE4191_01960
PSANHGN31_12625
PMAUCP157_02762(mcd)
PTPRCA23_c05210
RSUNHU_01021
RHMB5V46_13600
RHCRGUI_2888
RMBK529_011675
DAAAKL17_0387
DONBSK21_01045
TECAKL02_018800
LVSLOKVESSMR4R_00199(mcd)
RBGBG454_04115
GEHHYN69_01605
GFUKM031_11680
TAWEI545_08280
SALOEF888_00405
SEDIEBB79_01115
BOOE2K80_17425
PSEBEOK75_15210
PPRUFDP22_10630
PAEDG5B38_16425
MONG8E03_13660
PAMOBAR1_16245
PSHQF3W81_12655
POZI0K15_01150
PALWPSAL_022590(mcd)
PGVSL003B_0448
CACTHZ995_08795
RBZB9057_00825
THASC6Y53_12405
HDHG5B40_02075
CMAGCBW24_14615
GCEKYE46_00120
FAQG5B39_04545
HNEHNE_3379
HBAHbal_0249
CBOTATE48_04215
HBCAEM38_11365
NARSaro_3795
NPPPP1Y_AT31373 PP1Y_AT31999
NPNJI59_17585
NOTC7W88_21090
NORFA702_12980
NGFFRF71_05160
NOGGKE62_14150
SALSala_2897
SPHKSKP52_19810
SPHPLH20_06640
SMAGAN936_15840
SMAZLH19_02450
STERAOA14_14405
SGISGRAN_3010(ibd2)
SPHQBWQ93_00925
SPHOC3E99_10420
SPHXE5675_00380
SPHUSPPYR_1404 SPPYR_3581
SPHDHY78_18255
SPHAD3Y57_03955
SLANGV829_02840
SPAPH3Z74_06280
SCHSphch_1000
SYBTZ53_15780
SPHBEP837_00036
SPHTK426_13845
SYAA6768_05870
SCLOSCLO_1006500
SUFLFIL70_02615 FIL70_14440
SBARH5V43_02925
CIJWG74_11805
BLASBSY18_3598
TFVIDJ81_09110
ELIELI_00035
ELQGa0102493_112805
EMVHQR01_02800
PNSA9D12_00115
PORLBG023_111657
PHZCHX26_12895
POTE2E27_09260
SHUMSTHU_50800
SVCSTVA_50710
STELSTAQ_45970
ABSAZOBR_p410033
ABQABAZ39_30385
ABFAMK58_26085
ATIAL072_22095
AZTTSH58p_19350
AZMDM194_21400
SKTIGS68_10650
SMUCJL100_016580
SROEJL101_015005
RRURru_A3064
RRFF11_15695
RPMRSPPHO_00637
MAGamb0308
MGYMGMSRv2__2675(mmgC)
MGRYMSR1_36910(mmgC_5)
MAGXXM1_1236(mmgC)
MAGNWV31_14295
TMOTMO_0120
FERFNB15_00570
HTQFRZ44_46300
HADHFRZ61_44230
DEXHWD60_01575
DVNHQ394_15005
TXITH3_17600
THACCSC3H3_16690
TIIDY252_04205
MAGQMGMAQ_3099
ECOGFIV45_15330
NOWGBF35_13605
ABAIIMCC26256_11419
AFOAfer_1770
AYMYM304_14140
ATQGH723_12935
AQZKSP35_23260
IAMHC251_17070
ERZER308_13570
EUZDVS28_a4047
LILLA_0560(caiA)
LIELIF_A0461(caiA)
LICLIC_13009
LISLIL_13118(caiA9)
LBJLBJ_2405
LBLLBL_0703
LBILEPBI_I3317(acdA3)
LBFLBF_3202
LSTLSS_06909
LAJA0128_02880
LMAYDPV73_01935
LKMEFP84_13705
LWLFHG68_15305
LKBLPTSP3_g34580(caiA_8)
TPXTurpa_3980
 » show all
Reference
1  [PMID:19703103]
  Authors
Erb TJ, Fuchs G, Alber BE.
  Title
(2S)-Methylsuccinyl-CoA dehydrogenase closes the ethylmalonyl-CoA pathway for acetyl-CoA assimilation.
  Journal
Mol Microbiol 73:992-1008 (2009)
DOI:10.1111/j.1365-2958.2009.06837.x
  Sequence
[rsp:RSP_1679]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.12
IUBMB Enzyme Nomenclature: 1.3.8.12
ExPASy - ENZYME nomenclature database: 1.3.8.12
BRENDA, the Enzyme Database: 1.3.8.12

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