KEGG   ENZYME: 1.3.8.13
Entry
EC 1.3.8.13                 Enzyme                                 
Name
crotonobetainyl-CoA reductase;
caiA (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
gamma-butyrobetainyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
gamma-butyrobetainyl-CoA + electron-transfer flavoprotein = crotonobetainyl-CoA + reduced electron-transfer flavoprotein [RN:R11600]
Reaction(KEGG)
R11600
Substrate
gamma-butyrobetainyl-CoA [CPD:C20749];
electron-transfer flavoprotein [CPD:C04253]
Product
crotonobetainyl-CoA [CPD:C20748];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
The enzyme has been purified from the bacterium Escherichia coli O44 K74, in which it forms a complex with EC 2.8.3.21, L-carnitine CoA-transferase. The electron donor is believed to be an electron-transfer flavoprotein (ETF) encoded by the fixA and fixB genes.
History
EC 1.3.8.13 created 2017
Orthology
K08297  crotonobetainyl-CoA dehydrogenase
Genes
ECOb0039(caiA)
ECJJW0038(caiA)
ECDECDH10B_0040(caiA)
EBWBWG_0037(caiA)
ECOKECMDS42_0032(caiA)
ECOCC3026_00205
ECEZ0045(caiA)
ECSECs_0042(caiA)
ECFECH74115_0043(caiA)
ETWECSP_0042(caiA)
ELXCDCO157_0041
EOIECO111_0040(caiA)
EOJECO26_0040(caiA)
EOHECO103_0041(caiA)
ECOOECRM13514_0040(caiA)
ECOHECRM13516_0042(caiA)
ESLO3K_21350
ESOO3O_04035
ESMO3M_21250
ECKEC55989_0039(caiA)
ECGE2348C_0040(caiA)
EOKG2583_0041(caiA)
ELRECO55CA74_00195
ELHETEC_0039
ECWEcE24377A_0041(caiA)
EUNUMNK88_39
ECPECP_0039
ENAECNA114_0026(caiA)
ECOSEC958_0173(caiA)
ECVAPECO1_1942(caiA)
ECOAAPECO78_03655
ECXEcHS_A0043(caiA)
ECMEcSMS35_0040(caiA)
ECYECSE_0040
ECRECIAI1_0041(caiA)
ECQECED1_0038(caiA)
EUMECUMN_0041(caiA)
ECTECIAI39_0040(caiA)
EOCCE10_0040(caiA)
EBRECB_00043(caiA)
ECOBC3029_03950
EBLECD_00043(caiA)
EBEB21_00042(caiA)
EBDECBD_3576
ECIUTI89_C0045(caiA)
EIHECOK1_0038(caiA)
ECZECS88_0042(caiA)
ECCc0048(caiA)
ELOEC042_0041(caiA)
ELNNRG857_00205
ESEECSF_0044
ECLEcolC_3616
EKOEKO11_3873
EKFKO11_00195(caiA)
EABECABU_c00440(caiA)
EDHEcDH1_3560
EDJECDH1ME8569_0038(caiA)
ELUUM146_22975
ELWECW_m0039(caiA)
ELLWFL_00195(caiA)
ELCi14_0041(caiA)
ELDi02_0041(caiA)
ELPP12B_c0034(caiA)
ELFLF82_0257(caiA)
ECOLLY180_00200
ECOIECOPMV1_00040(caiA_1)
ECOJP423_00195
EFEEFER_0047(caiA)
EALEAKF1_ch1383(caiA)
EMAC1192_12775
ESZFEM44_14690(caiA)
ERUYOSH18_09410(caiA)
STYSTY0083(caiA)
STTt0074(caiA)
SEXSTBHUCCB_840
SENTTY21A_00380
STMSTM0073(caiA)
SEOSTM14_0087(caiA)
SEVSTMMW_00751
SEYSL1344_0074(caiA)
SEMSTMDT12_C00740
SEJSTMUK_0074(caiA)
SEBSTM474_0076(caiA)
SEFUMN798_0081(caiA)
SETUSTU288_00365
SETCCFSAN001921_17055
SENRSTMDT2_00741(caiA)
SENDDT104_00741(caiA)
SENICY43_00360
SEENSE451236_06375
SPTSPA0074(caiA)
SEKSSPA0070
SPQSPAB_00090
SEISPC_0078(caiA)
SECSCH_0067(caiA)
SEHSeHA_C0077(caiA)
SHBSU5_0708
SENHCFSAN002069_08865
SEEHSEEH1578_09395
SEESNSL254_A0077(caiA)
SENNSN31241_10520
SEWSeSA_A0081(caiA)
SEASeAg_B0080(caiA)
SENSQ786_00360
SEDSeD_A0079(caiA)
SEGSG0076(caiA)
SELSPUL_0078(caiA)
SEGASPUCDC_0078(caiA)
SETSEN0074(caiA)
SENAAU38_00360
SENOAU37_00360
SENVAU39_00360
SENQAU40_00395
SENLIY59_00375
SENJCFSAN001992_10660
SEECCFSAN002050_06815
SEEBSEEB0189_019020
SEEPI137_00340
SENBBN855_760(caiA)
SENEIA1_00370
SENCSEET0819_07255
SESSARI_02927
SBGSBG_0058(caiA)
SBZA464_61
SBVN643_00280
SALZEOS98_18875
SFLSF0036(caiA)
SFXS0038(caiA)
SFVSFV_0033(caiA)
SFESFxv_0037(caiA)
SFNSFy_0045
SFSSFyv_0049
SFTNCTC1_00036(caiA)
SSNSSON_0047(caiA)
SDYSDY_0061(caiA)
SDZAsd1617_00066
SHQA0259_04035
CROROD_00411(caiA)
CKOCKO_03344
CFDCFNIH1_09905
CBRAA6J81_13205
CWECO701_18215
CYOCD187_20355
CPOTFOB25_07450(caiA)
CFQC2U38_03525
CSEDJY391_18140(caiA)
CAMAF384_00210
CAFAL524_22255
CIFAL515_05000
CFARCI104_04650
CIRC2U53_04680
CIEAN232_26285
CPARCUC49_00190
CTELGBC03_25645(caiA)
CITZE4Z61_13390(caiA)
CARSE1B03_04740(caiA)
CIXM4I31_19965(caiA)
CIBHF677_019720(caiA)
CENSP2W74_19330(caiA)
EBTEBL_c33140(caiA)
ESCEntcl_2475
KLEAO703_09860
ASUBNLZ15_03200(caiA)
YREHEC60_04865(caiA)
KINAB182_21535
PDZHHA33_24100(caiA)
METYMRY16398_47840(caiA)
PSGCG163CM_28640(caiA)
TOEQMG90_18000(caiA)
EBFD782_3830
EBCC2U52_03230
EBBF652_2816
PMRPMI2655(caiA)
PMIBBB2000_2646(caiA)
PVLAOB99_14510
PVGCRN77_06415
PHAUPH4a_04750
PROTBTA34_14490
PCOLF1325_16705(caiA)
PCIBF9282_17050(caiA)
PPEEI6G31_11900(caiA)
PRGRB151_007300(caiA_2)
PHEINCTC12003_00738(caiA)
PRQCYG50_11995(caiA)
PHAGPZ638_03510(caiA)
EICNT01EI_2959
ETRETAE_2663(caiA)
ETDETAF_2401
ETEETEE_0764
ETCETAC_12795
EDWQY76_07180
EDLAAZ33_14085(caiA)
EHOA9798_03955
HAVAT03_19300
HPARAL518_07295
OPODSM2777_06085
LPVHYN51_05075
PRAGEKN56_12490(caiA)
LRINCTC12151_02504(caiA)
SLOShew_2675
SSESsed_3228
SPLSpea_4037
SHLShal_0221
SWPswp_4937
SALGBS332_05315 BS332_05360
SLJEGC82_18075
SCAATUM17387_35670(caiA_1) TUM17387_35760(caiA_2)
SCHKGII14_20175(caiA) GII14_20235(caiA)
SAEGK0H80_13660(caiA)
SSPAK0I31_13905(caiA)
SHNSK0J45_13750(caiA)
SRHSK0I63_13835(caiA)
CPINCPIN18020_0491(caiA)
CRXCRECT_1851(caiA)
AHSAHALO_2624(caiA)
AMARAMRN_2723(caiA)
PBIZLWC08_01450(caiA)
BACIB1NLA3E_21285
CAPREQM14_13825
DRMDred_0570
RHORHOM_09505
CSHClosa_3931
CALKHUE98_15945
ELEElen_1834
EYYEGYY_17990(CaiA)
EGDGS424_010370(caiA)
CBACJI75_07140
XYLET495_16520(caiA)
CELCK5O09_10670(caiA)
OEKFFI11_010750(caiA)
GYUFE374_07885(caiA)
PFRPFREUD_02420(caiA)
PFRERM25_0219
AHEArch_1363
ARCAHC352_07040(caiA)
TPYCQ11_04205
TPYOX956_03580
TPECHLG82_02695(caiA)
TBERQPC17_02455(caiA)
AMYADJ76_00875
FSLEJO69_02440
WNEPIG85_00160(caiA)
VCBCYK25_001665(caiA)
 » show all
Reference
1  [PMID:8060125]
  Authors
Roth S, Jung K, Jung H, Hommel RK, Kleber HP
  Title
Crotonobetaine reductase from Escherichia coli--a new inducible enzyme of anaerobic metabolization of L(-)-carnitine.
  Journal
Antonie Van Leeuwenhoek 65:63-9 (1994)
DOI:10.1007/BF00878280
Reference
2  [PMID:10209289]
  Authors
Preusser A, Wagner U, Elssner T, Kleber HP
  Title
Crotonobetaine reductase from Escherichia coli consists of two proteins.
  Journal
Biochim Biophys Acta 1431:166-78 (1999)
DOI:10.1016/S0167-4838(99)00032-1
  Sequence
[eco:b0039]
Reference
3  [PMID:10978161]
  Authors
Elssner T, Hennig L, Frauendorf H, Haferburg D, Kleber HP
  Title
Isolation, identification, and synthesis of gamma-butyrobetainyl-CoA and crotonobetainyl-CoA, compounds involved in carnitine metabolism of E. coli.
  Journal
Biochemistry 39:10761-9 (2000)
DOI:10.1021/bi000776c
Reference
4  [PMID:12081978]
  Authors
Walt A, Kahn ML
  Title
The fixA and fixB genes are necessary for anaerobic carnitine reduction in Escherichia coli.
  Journal
J Bacteriol 184:4044-7 (2002)
DOI:10.1128/JB.184.14.4044-4047.2002
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.13
IUBMB Enzyme Nomenclature: 1.3.8.13
ExPASy - ENZYME nomenclature database: 1.3.8.13
BRENDA, the Enzyme Database: 1.3.8.13

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