KEGG   ENZYME: 1.3.8.14Help
Entry
EC 1.3.8.14                 Enzyme                                 

Name
L-prolyl-[peptidyl-carrier protein] dehydrogenase;
pigA (gene name);
bmp3 (gene name);
pltE (gene name);
redW (gene name);
(L-prolyl)-[peptidyl-carrier protein]:electron-transfer flavoprotein oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
L-prolyl-[peptidyl-carrier protein]:electron-transfer flavoprotein oxidoreductase
Reaction(IUBMB)
L-prolyl-[peptidyl-carrier protein] + 2 electron-transfer flavoprotein = 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] + 2 reduced electron-transfer flavoprotein [RN:R06747]
Reaction(KEGG)
Substrate
L-prolyl-[peptidyl-carrier protein] [CPD:C12470];
electron-transfer flavoprotein [CPD:C04253]
Product
1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] [CPD:C12483];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains FAD. The enzyme participates in the biosynthesis of several pyrrole-containing compounds, such as undecylprodigiosin, prodigiosin, pyoluteorin, and coumermycin A1. It is believed to catalyse the formation of a Delta2-pyrrolin-2-carbonyl-[peptidyl-carrier protein] intermediate, followed by a two-electron oxidation to 1H-pyrrol-2-carbonyl-[peptidyl-carrier protein].
History
EC 1.3.8.14 created 2017
Pathway
ec00333  Prodigiosin biosynthesis
ec00401  Novobiocin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K12721  L-prolyl-[peptidyl-carrier protein] dehydrogenase
K21782  L-prolyl-PCP dehydrogenase
Genes
SRR: SerAS9_1753
SRS: SerAS12_1753
SRA: SerAS13_1754
SMW: SMWW4_v1c11040(pigA)
SERF: L085_23030
SERA: Ser39006_020695
SERQ: CWC46_20700
SERM: CLM71_22610
VGA: BSQ33_17325
PRR: AT705_06580
HCH: HCH_06021
SCO: SCO5879(redW)
STRD: NI25_09835
 » show all
Taxonomy
Reference
1  [PMID:11880032]
  Authors
Thomas MG, Burkart MD, Walsh CT.
  Title
Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis.
  Journal
Chem Biol 9:171-84 (2002)
DOI:10.1016/S1074-5521(02)00100-X
  Sequence
[pfl:PFL_2791] [sco:SCO5879]
Reference
2  [PMID:15528645]
  Authors
Harris AK, Williamson NR, Slater H, Cox A, Abbasi S, Foulds I, Simonsen HT, Leeper FJ, Salmond GP
  Title
The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation.
  Journal
Microbiology 150:3547-60 (2004)
DOI:10.1099/mic.0.27222-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.14
IUBMB Enzyme Nomenclature: 1.3.8.14
ExPASy - ENZYME nomenclature database: 1.3.8.14
BRENDA, the Enzyme Database: 1.3.8.14

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