KEGG   ENZYME: 1.3.8.14
Entry
EC 1.3.8.14                 Enzyme                                 
Name
L-prolyl-[peptidyl-carrier protein] dehydrogenase;
pigA (gene name);
bmp3 (gene name);
pltE (gene name);
redW (gene name);
(L-prolyl)-[peptidyl-carrier protein]:electron-transfer flavoprotein oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
L-prolyl-[peptidyl-carrier protein]:electron-transfer flavoprotein oxidoreductase
Reaction(IUBMB)
L-prolyl-[peptidyl-carrier protein] + 2 electron-transfer flavoprotein = 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] + 2 reduced electron-transfer flavoprotein [RN:R06747]
Reaction(KEGG)
R06747
Substrate
L-prolyl-[peptidyl-carrier protein] [CPD:C12470];
electron-transfer flavoprotein [CPD:C04253]
Product
1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] [CPD:C12483];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains FAD. The enzyme participates in the biosynthesis of several pyrrole-containing compounds, such as undecylprodigiosin, prodigiosin, pyoluteorin, and coumermycin A1. It is believed to catalyse the formation of a Delta2-pyrrolin-2-carbonyl-[peptidyl-carrier protein] intermediate, followed by a two-electron oxidation to 1H-pyrrol-2-carbonyl-[peptidyl-carrier protein].
History
EC 1.3.8.14 created 2017
Pathway
ec00333  Prodigiosin biosynthesis
ec00401  Novobiocin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12721  L-prolyl-[peptidyl-carrier protein] dehydrogenase
K21782  L-prolyl-PCP dehydrogenase
Genes
SMWSMWW4_v1c11040(pigA)
SRRSerAS9_1753
SRSSerAS12_1753
SRASerAS13_1754
SERFL085_23030
SERMCLM71_22610
SSURATE40_002235
SNEMNLX84_05505
PRODPCO85_04850
SERASer39006_020695
SERQCWC46_20700
VGABSQ33_17325
VSRVspart_03968(pigA)
VRURND59_20195
PRRAT705_06580
PXIJ5O05_20760
PVBJ5X90_18210
PSAZPA25_35580
MMOTQZJ86_10575
HAHHO5O45_30065
KIAG8A07_12225
PAQAK9V56_011385
RUGQC826_00990
MIWASS37A_37750
NTPCRH09_26870
SCOSCO5879(redW)
SLVSLIV_09210
SGMGCM10017557_78270
STRDNI25_09835
SSIAA7J05_21380
SALFSMD44_07473
SRKFGW37_26865
SPADDVK44_31035
SSPBCP982_34510
SFEUIM697_30995
SLFJEQ17_02480
SAOVG3H79_04160
STUBMMF93_27610
SFPQUY26_05280
ARUBJ5A65_13315
AMAZLUW76_14360
ACIROG979_36035
KBBccbrp13_70320
 » show all
Reference
1  [PMID:11880032]
  Authors
Thomas MG, Burkart MD, Walsh CT.
  Title
Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis.
  Journal
Chem Biol 9:171-84 (2002)
DOI:10.1016/S1074-5521(02)00100-X
  Sequence
[pfl:PFL_2791] [sco:SCO5879]
Reference
2  [PMID:15528645]
  Authors
Harris AK, Williamson NR, Slater H, Cox A, Abbasi S, Foulds I, Simonsen HT, Leeper FJ, Salmond GP
  Title
The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation.
  Journal
Microbiology 150:3547-60 (2004)
DOI:10.1099/mic.0.27222-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.14
IUBMB Enzyme Nomenclature: 1.3.8.14
ExPASy - ENZYME nomenclature database: 1.3.8.14
BRENDA, the Enzyme Database: 1.3.8.14

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