KEGG   ENZYME: 1.3.8.15
Entry
EC 1.3.8.15                 Enzyme                                 

Name
3-(aryl)acrylate reductase;
acdA (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
3-(phenyl)propanoate:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
(1) phloretate + electron-transfer flavoprotein = 4-coumarate + reduced electron-transfer flavoprotein [RN:R12534];
(2) 3-phenylpropanoate + electron-transfer flavoprotein = trans-cinnamate + reduced electron-transfer flavoprotein [RN:R12535];
(3) 3-(1H-indol-3-yl)propanoate + electron-transfer flavoprotein = 3-(indol-3-yl)acrylate + reduced electron-transfer flavoprotein [RN:R12536]
Reaction(KEGG)
Substrate
phloretate [CPD:C01744];
electron-transfer flavoprotein [CPD:C04253];
3-phenylpropanoate [CPD:C05629];
3-(1H-indol-3-yl)propanoate [CPD:C22236]
Product
4-coumarate [CPD:C00811];
reduced electron-transfer flavoprotein [CPD:C04570];
trans-cinnamate [CPD:C00423];
3-(indol-3-yl)acrylate [CPD:C21283]
Comment
The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. Unlike EC 1.3.1.31, 2-enoate reductase, this enzyme has minimal activity with crotonate.
History
EC 1.3.8.15 created 2019
Orthology
K24016  3-(aryl)acrylate reductase
Genes
CBO: CBO3288(acdA)
CBA: CLB_3344
CBH: CLC_3230
CBY: CLM_3721
CBL: CLK_2704
CBB: CLD_1235
CBI: CLJ_B3568
CBF: CLI_3458
CBJ: H04402_03373
CLD: CLSPO_c34080(mmgC)
Reference
1  [PMID:29168502]
  Authors
Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL
  Title
A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites.
  Journal
Nature 551:648-652 (2017)
DOI:10.1038/nature24661
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.15
IUBMB Enzyme Nomenclature: 1.3.8.15
ExPASy - ENZYME nomenclature database: 1.3.8.15
BRENDA, the Enzyme Database: 1.3.8.15

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