KEGG   ENZYME: 1.3.8.17
Entry
EC 1.3.8.17                 Enzyme                                 
Name
dehydro coenzyme F420 reductase;
fbiB (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
oxidized coenzyme F420-0:FMN oxidoreductase
Reaction(IUBMB)
oxidized coenzyme F420-0 + FMN = dehydro coenzyme F420-0 + FMNH2 [RN:R12720]
Reaction(KEGG)
R12720
Substrate
oxidized coenzyme F420-0 [CPD:C19153];
FMN [CPD:C00061]
Product
dehydro coenzyme F420-0 [CPD:C22277];
FMNH2 [CPD:C01847]
Comment
This enzyme is involved in the biosynthesis of coenzyme F420, a redox-active cofactor found in all methanogenic archaea, as well as some eubacteria. In some eubacteria the enzyme is multifunctional, also catalysing the activities of EC 6.3.2.31, coenzyme F420-0:L-glutamate ligase, and EC 6.3.2.34, coenzyme F420-1:gamma-L-glutamate ligase.
History
EC 1.3.8.17 created 2021
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K24998  dehydro coenzyme F420 reductase / coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase
Genes
MTURv3262(fbiB)
MTVRVBD_3262
MTCMT3361
MRAMRA_3303(fbiB)
MTFTBFG_13291
MTBTBMG_03310
MTKTBSG_03333
MTZTBXG_003290
MTIMRGA423_20440
MTECCDC5079_3010
MTURCFBS_3451(fbiB)
MTLCCDC5180_2973
MTOMTCTRI2_3329(fbiB)
MTDUDA_3262(fbiB)
MTNERDMAN_3576(fbiB)
MTJJ112_17525
MTUBMT7199_3304
MTUEJ114_17485
MTXM943_16850
MTULTBHG_03198
MTUTHKBT1_3438(fbiB)
MTUUHKBT2_3445(fbiB)
MTQHKBS1_3448(fbiB)
MBOBQ2027_MB3290(fbiB)
MBBBCG_3291(fbiB)
MBTJTY_3287(fbiB)
MBMBCGMEX_3289(cofE)
MBKK60_033910
MBXBCGT_3129
MAFMAF_32730(fbiB)
MMICRN08_3597
MCEMCAN_32811(fbiB)
MCQBN44_70047(fbiB)
MCVBN43_60272(fbiB)
MCXBN42_41313(fbiB)
MCZBN45_60292(fbiB)
MLEML0758
MLBMLBr00758
MPAMAP_3375
MAOMAP4_0407
MAVIRC58_01945
MAVURE97_01955
MAVMAV_4225
MITOCO_40840
MIAOCU_40750
MIDMIP_06149
MYOOEM_41100
MCHIAN480_21445
MIROCQ_42110
MMALCKJ54_19480
MLPMLM_3384
MMANMMAN_28880(fbiB)
MSAMycsm_01370
MULMUL_2607(fbiB)
MMCMmcs_1323
MKMMkms_1340
MJLMjls_1359
MMIMMAR_1280(fbiB)
MMAEMMARE11_12460(fbiB)
MMMW7S_20390
MLIMULP_01441(fbiB)
MKNMKAN_21195
MYVG155_09330
MYEAB431_07855
MGOAFA91_29765
MHADB586_17495
MDXBTO20_26035
MSHGMSG_01180(fbiB)
MFJMFLOJ_22080(fbiB)
MSTOMSTO_25790(fbiB)
MSIMMSIM_13090(fbiB)
MSAKMSAS_48330(fbiB)
MKUI2456_06470
MGROFZ046_13185
MXEMYXE_37100(fbiB)
MNVMNVI_28170(fbiB)
MPAGC0J29_07130
MNMMNVM_30580(fbiB)
MGORH0P51_06355
MCOOMCOO_44630(fbiB)
MBAIMB901379_01171(fbiB)
MSEOMSEO_51120(fbiB)
MPSEMPSD_14580(fbiB)
MSHOMSHO_60300(fbiB)
MHEKJMUB5695_03655(fbiB)
MGAUMGALJ_57750(fbiB)
MLJMLAC_04490(fbiB)
MBRDMBRA_03620(fbiB)
MSHJMSHI_24910(fbiB)
MKRMKOR_20220(fbiB)
MDFK0O62_07960
MMAMK3U93_05770
MHOLK3U96_19390
MHERK3U94_17040
MSENK3U95_20445
MPAEK0O64_07420
MSPGF6B93_05480
MOTLTS72_18970
MLMMLPF_1194(cofE)
MSMMSMEG_1829
MSGMSMEI_1786(cofE)
MSBLJ00_09120
MSNLI99_09120
MSHLI98_09120
MVAMvan_1732
MGIMflv_4731
MSPMspyr1_40650
MCBMycch_1341
MNED174_08420
MYNMyAD_08275
MFTXA26_18660
MPHLMPHLCCUG_01626(fbiB_3)
MVQMYVA_1476
MRHMycrhN_0423
MTHN4412656_01186
MHASMHAS_00503(fbiB)
MDUMDUV_28080(fbiB)
MCHTMCHIJ_50210(fbiB)
MDRMDOR_09060(fbiB)
MAUUNCTC10437_01439
MMAGMMAD_14820(fbiB)
MMORMMOR_51220(fbiB)
MFXMFAL_19180(fbiB)
MAICMAIC_13030(fbiB)
MIJMINS_15970(fbiB)
MALVMALV_19540(fbiB)
MTYMTOK_35130(fbiB)
MPSCMPSYJ_49690(fbiB)
MARZMARA_24300(fbiB)
MGADMGAD_25260(fbiB)
MHEVMHEL_36230(fbiB)
MSARMSAR_04250(fbiB)
MANYMANY_52680(fbiB)
MAUBMAUB_17100(fbiB)
MPOFMPOR_20170(fbiB)
MPHUMPHO_54230(fbiB)
MMUCC1S78_020465
MMATMMAGJ_47580(fbiB)
MBOKMBOE_56010(fbiB)
MFGK6L26_23200
MSEIMSEDJ_27360(fbiB)
MFLVNCTC10271_03864
MABMAB_3608
MMVMYCMA_1979
MABBMASS_3615
MABLMMASJCM_3605
MCHEBB28_18455
MIZBAB75_20520
MSTEMSTE_03740(fbiB)
MSAOMYCSP_16600
MSALDSM43276_03406(fbiB_2)
MJDJDM601_3011(fbiB)
MTER4434518_02998(fbiB)
MMINMMIN_07420(fbiB)
MHIBMHIB_24550(fbiB)
ASDAS9A_3811
MPAKMIU77_13980
NFANFA_46200
NFRERS450000_05308
NCYNOCYR_4343(cofE)
NBRO3I_035155
NNONONO_c63240(cofE)
NSLBOX37_24635
NSRNS506_02073(cofE)
NTPCRH09_32615
NOZDMB37_13815
NODFOH10_03605
NAHF5544_37070
NADNCTC11293_05924
NWLNWFMUON74_13470(fbiB)
NIEKV110_34190
NTCKHQ06_12820
NHUH0264_12275
NYALTV02_20665
NGPLTT66_19775
RHARHA1_ro06311
RERRER_21520(fbiB)
REYO5Y_10280
REBXU06_10505
RQIC1M55_10945
ROPROP_63730(fbiB)
ROAPd630_LPD02975
REQREQ_33520
RPYY013_07660
RBYCEJ39_18580
RHBNY08_1684
RAVAAT18_17235
RFAA3L23_00048(fbiB_1)
RHSA3Q41_03365(fbiB_1)
RHWBFN03_04460
RRZCS378_06790
RHUA3Q40_02035(fbiB_2)
RHQIM25_21975
RHODAOT96_21125
RRT4535765_03352
RCRNCTC10994_03905
RTMG4H71_17760
RKOJWS14_25820 JWS14_34320
RGOKYT97_07800
GBRGbro_3303
GPOGPOL_c30990(cofE)
GORKTR9_3343
GOQACH46_06010
GTABCM27_16975
GOCCXX93_08500
GITC6V83_14660
GRUGCWB2_17195(fbiB2)
GOMD7316_05386(fbiB_2)
GAVC5O27_11005
GODGKZ92_16075
GAMGII34_16030
GPDGII33_15470
GJIH1R19_16015
GOILK459_17875
SPINKV203_15570
TPRTpau_1182
SRTSrot_2671
DTMBJL86_1019
DITC3V38_10625
DIZCT688_04535
DPCA6048_04610
DLUA6035_04845
TOYFO059_04830
SCOSCO3037(SCE34.18)
SALBXNR_1924
SMASAVERM_5039(cofE)
SGRSGR_4500
SGBWQO_13020
SCBSCAB_55051(cofE)
SSXSACTE_2503
SVLStrvi_8423
SHYSHJG_4504
SHOSHJGH_4267
SRCM271_29475
SMALSMALA_3142
SSOII1A49_19505
SCTSCAT_2044(cofE)
SCYSCATT_20260
SFASfla_3870
SBHSBI_04466
SVESVEN_2779
SDVBN159_5255(cofE)
SALSSLNWT_2577
STRPF750_2862
SFISFUL_2633
SCIB446_15770
SALUDC74_3466
SALLSAZ_18455
SLVSLIV_22510(fbiB)
SGUSGLAU_13805(fbiB)
SVTSVTN_14815
STREGZL_05424
SCWTU94_13265
SLDT261_5067
SLCSL103_04165
SXISXIM_18240
STRMM444_14305
STRCAA958_11405
SAMBSAM23877_3079(fbiB)
SPRISPRI_4520
SCZABE83_22875
SCXAS200_27265
SRWTUE45_04628(fbiB)
STRFASR50_20135
SLEsle_42440(sle_42440)
SRNA4G23_02040(fbiB)
SPAVSpa2297_13150
STRTA8713_12285
SCLFBB341_17710
SGSAVL59_42925
STSIA4E84_15955
SKYD0C37_11385
SALWCP975_13855
SGMGCM10017557_50170(fbiB)
SCADDN051_23465
SLSSLINC_3443
SNRSNOUR_25325
SPLULK06_011885
STRDNI25_23605
SNWBBN63_21600
SAUOBV401_19200
SSIAA7J05_21720
SVUB1H20_12300
SPUNBFF78_25295
SGVB1H19_16745
SLAUSLA_2760
SALFSMD44_03377(cofE)
SALJSMD11_4188(cofE)
SLXSLAV_22855(fbiB2)
STROSTRMOE7_15725
SFKKY5_3202
SNZDC008_13675
SGEDWG14_05053(fbiB)
SRJSRO_4452
SLKSLUN_15505
SDXC4B68_24085
SGDELQ87_23315
SQZFQU76_11445
SCYAEJ357_18280
SASTCD934_20160
SNQCP978_14105
STIRDDW44_10220
SKACP970_26365
SGZC0216_27105
SVNCP980_20515
SNKCP967_21060
SHAWCEB94_16545
SRKFGW37_12640
SFICEIZ62_20205
SGALCP966_14465
SSPODDQ41_08710
SVRCP971_20715
SPADDVK44_11200
SFYGFH48_24385
SAQUEJC51_20735
SGFHEP81_04779
SCAVCVT27_11715
SSEOD0Z67_11260
SBYH7H31_22365
SRIMCP984_24925
SSUBCP968_20295
SPHVF9278_18580
SCINCP977_13490
SFUGCNQ36_13865
SPACB1H29_22320
STSUB7R87_11095
SCHACP983_26045
SGXH4W23_16035
SCOECP976_17680
SBATG4Z16_21465
SSPBCP982_17990
SNFJYK04_03614(fbiB_1)
SPLACP981_15395
SBROGQF42_18835
STUIGCM10017668_27350(fbiB)
SATAC5746_16555
SCHFIPT68_14690
SHUNDWB77_04646(fbiB_2)
SHARHUT13_11500
SCYGS1361_16340(fbiB)
SFEUIM697_05850
SLIAHA039_21540
SDWK7C20_14510
SVDCP969_16340
SCALI6J39_12570
SAUHSU9_012975
SFBCP974_11285
SMOBJ7W19_12340
SPRACP972_14540
SPEUCGZ69_13690
SROIIAG44_24880
SXNIAG42_21210
SGJIAG43_12135
SHKJ2N69_14070
SANUK7396_22165
SDDD9753_21320
SACTDMT42_15905
KSKKSE_29440(fbiB)
KABB7C62_12015
KAUB6264_15380
KITCFP65_2740
STRIC7M71_010640
YIALO772_21665
PSICJ4E96_05755
AARCG127AT_06815(cofE)
SUBTKPL76_08050
AJGKKR91_03250(cofE)
YIMJ5M86_04315
ALXLVQ62_16230(cofE)
GYUFE374_05890(cofE)
NAROCFH99_18255
NPIG7071_09225(cofE)
NAQUENKNEFLB_03315(fbiB)
NROK8W59_12200(cofE)
TFUTfu_2518
THAONI17_015400
NDANdas_3768
NALB005_0946(cofE)
NGVCDO52_24250
STRREKD16_04580(fbiB)
SAIUJ4H86_12280
TCUTcur_4073
ACTWF7P10_11800
AGRAAGRA3207_002959
SROSros_1379
NOABKM31_38775
NOWGBF35_06595
NCXNocox_05950(fbiB1)
NGNLCN96_06640
TBITbis_0748
FRAFrancci3_0741
FREFranean1_5869
FRIFraEuI1c_6072
FALFRAAL1259
FSYFsymDg_1076
ACEAcel_1962
NMLNamu_4176
NAKEH165_10590
SENSACE_6467
SACGFDZ84_07210
SVISvir_06230
SACCEYD13_03495(fbiB1)
AMDAMED_1022
AMNRAM_05200
AMMAMES_1018
AMZB737_1019
AOIAORI_1009(cofE)
AJAAJAP_34535(fbiB)
AMQAMETH_0931
AMYCCU254_03580
AMYBBKN51_39150
AABA4R43_35495
AMYYYIM_42560(fbiB2)
AORISD37_36145
AACDLWP59_04470
PDXPsed_5207
PSEAWY02_11515
PSEEFRP1_02695
PSEHXF36_02100
PSEQAD006_10310
PECQAD017_18140
PHHAFB00_16170
PAUTPdca_56440
PBROHOP40_13555
APRECNX65_31170
AMIAmir_6334
SESPBN6_76250(cofE)
SSYIEKG83_42420
KALKALB_7914
KPHYAOZ06_48155
LEDBBK82_19180
AHMTL08_23385
ACTIUA75_27205
ACADUA74_26615
AHGAHOG_24535(fbiB)
ACTAC1701_14675
ALOCRK59729
PMADBAY61_03990
SACEGIY23_18810
AIHAiant_52200
ASERAsera_25000(fbiB)
DVCDvina_48730
NHYJQS43_20535
CAICaci_7612
AEYCDG81_04205
AQZKSP35_00875(cofE)
IAMHC251_16065(cofE)
LOKILokiarch_23940(cofE_1) Lokiarch_46970(cofE_3)
 » show all
Reference
1  [PMID:30952857]
  Authors
Bashiri G, Antoney J, Jirgis ENM, Shah MV, Ney B, Copp J, Stuteley SM, Sreebhavan S, Palmer B, Middleditch M, Tokuriki N, Greening C, Scott C, Baker EN, Jackson CJ
  Title
A revised biosynthetic pathway for the cofactor F420 in prokaryotes.
  Journal
Nat Commun 10:1558 (2019)
DOI:10.1038/s41467-019-09534-x
  Sequence
[mtu:Rv3262]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.17
IUBMB Enzyme Nomenclature: 1.3.8.17
ExPASy - ENZYME nomenclature database: 1.3.8.17
BRENDA, the Enzyme Database: 1.3.8.17

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