Entry
Name
isovaleryl-CoA dehydrogenase;
isovaleryl-coenzyme A dehydrogenase;
isovaleroyl-coenzyme A dehydrogenase;
3-methylbutanoyl-CoA:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
3-methylbutanoyl-CoA:electron-transfer flavoprotein oxidoreductase
Reaction(IUBMB)
isovaleryl-CoA + electron-transfer flavoprotein = 3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein [RN:
R04096 ]
Reaction(KEGG)
Substrate
isovaleryl-CoA [CPD:
C02939 ];
electron-transfer flavoprotein [CPD:
C04253 ]
Product
3-methylcrotonyl-CoA [CPD:
C03069 ];
reduced electron-transfer flavoprotein [CPD:
C04570 ]
Comment
Contains a tightly-bound FAD cofactor. Pentanoate can act as donor.
History
EC 1.3.8.4 created 1978 as EC 1.3.99.10, modified 1986, transferred 2012 to EC 1.3.8.4
Pathway
ec00280 Valine, leucine and isoleucine degradation
Orthology
K00253 isovaleryl-CoA dehydrogenase
Genes
ETF : 101648269 101659554(IVD)
DNM : 101410782 101431990 101437374(IVD)
CTIG : 120299236(IVD) 120313636
SANH : 107674040 107697747(ivd)
SGH : 107563384(ivd) 107594842
CAUA : 113060602 113076260 113082605 113117361
CGIB : 127933541 127975908
MASI : 127410896 127455153
MSAM : 119910014 119910399(ivd)
CCLU : 121539041 121545167
PSPA : 121324611 121330271
SCLV : 120325855 120337237
SPU : 589735 589757 591888
LPIC : 129281313 129282026 129282273 129282302
DSI : Dsimw501_GD12977(Dsim_GD12977)
AALB : 109401025 109420869
BCOO : 119073547 119073548
LBD : 127286973 127289017 127289018 127289019
CFEL : 113382793 113382876
HAZT : 108671477 108676151
EAF : 111695170 111705703 111716314
PPOI : 119089995 119090874 119104535
CEL : CELE_C02B10.1(ivd-1)
CBR : CBG_19978(Cbr-ivd-1)
TAD : TRIADDRAFT_27663 TRIADDRAFT_58314
CSAT : 104710993 104790784
HSYR : 120144174 120168016 120203245
AHF : 112736538 112786421 114927473
LANG : 109325612 109351640
SPEN : 107003059 107022575
SOT : 102589539(2MBCD) 102601763(IVD)
SSTN : 125843689 125873179
SDUL : 129901607 129903154
CANN : 107847843 107873866 107874670
NTA : 107784199 107785489 107826001 107826219
HAN : 110868522 110868523 110904320
LSV : 111899862 111899864 111899865 111899866
CCAV : 112509388 112511118 112515228
DCR : 108205043 108209336 108209337
PSOM : 113309767 113322749
TAES : 123108145 123180232 123189255
MFLO : 136511430 136519127
PVIR : 120664126 120697321
NCOL : 116254096 116254789
SMO : SELMODRAFT_428295 SELMODRAFT_448534
CVR : CHLNCDRAFT_24676 CHLNCDRAFT_56353
YLI : 2912840(YALI2_E01505g)
NTE : NEUTE1DRAFT125284(NEUTE1DRAFT_125284)
SMP : 10810565(SMAC4_05027)
TATV : 25781755(TrAtP1_008935)
TASP : 36610052(TrAFT101_002508)
MAW : 19245143(J3458_009429)
PLJ : 28882425(PLICBS_001543)
CDET : 87944615(CDEST_08112)
CPW : 9695471(D8B26_006057)
PNO : SNOG_03241(SNOG_03239 SNOG_03240)
PTRR : 6338823(PtrM4_028380)
ADAC : 96088052(ACET3X_007730)
CDEP : 91087915(L203_103705)
KMG : 30161207(I203_105581)
KNE : 92183814(IAR55_006556)
CCAC : CcaHIS019_0402640(CcaverHIS019_0402640)
LBC : LACBIDRAFT_182156(IVD)
ABP : AGABI1DRAFT111184(AGABI1DRAFT_111184)
ABV : AGABI2DRAFT190404(AGABI2DRAFT_190404)
SCM : SCHCO_02608235(SCHCODRAFT_02608235)
PTM : GSPATT00014131001 GSPATT00025475001 GSPATT00028063001
FCY : FRACYDRAFT_291593(ACD3)
AAF : AURANDRAFT_58729 AURANDRAFT_60346
BLAC : 94344270(CCR75_000492)
TCR : 506629.220 509829.20
LMAT : 92513492(LSCM1_03438)
LOI : 92360089(LSCM4_04166)
LEIS : 94179993(GH5_04564)
LENR : 94170799(CUR178_03557)
LEIN : 94187722(JIQ42_04055)
PHET : 94294019(JKF63_08016)
XFU : XFF4834R_chr02380(caiA)
XPH : XppCFBP6546_10560(XppCFBP6546P_10560)
XHD : LMG31886_02870(acdA_1)
LHX : LYSHEL_00780(acdA_1)
LCAS : LYSCAS_00780(acdA_1)
LLZ : LYB30171_01092(acdA_1)
DYG : DYGSA30_39470(acdA_2)
VPB : VPBB_A0564 VPBB_A1028
VPK : M636_02305 M636_05010
VPF : M634_20925 M634_23455
VPH : VPUCM_20553 VPUCM_21024
VEX : VEA_000377 VEA_001543
VDB : AL552_00100 AL552_05985
VNA : PN96_19040 PN96_21475
VEJ : VEJY3_18541 VEJY3_20626
VNL : D3H41_17150 D3H41_19520
VJP : NP165_14480 NP165_19170
VIB : VspSTUT11_39980 VspSTUT11_44710
VIS : VspSTUT16_34000 VspSTUT16_45840
PAEB : NCGM1900_4472(gnyD)
PCQ : PcP3B5_35090(mmgC_11)
PPRC : PFLCHA0_c39950(mmgC8)
PMUD : NCTC8068_03120(ivd)
PFW : PF1751_v1c33230(liuA)
PTAE : NCTC10697_03138(ivd)
PSZ : PSTAB_0206 PSTAB_3251
PSR : PSTAA_0208 PSTAA_3370
PSC : A458_04610 A458_20575
PSH : Psest_1084 Psest_4140
PSTT : CH92_00840 CH92_10665
PSTU : UIB01_16560 UIB01_21080
PSED : DM292_02645 DM292_18140
PCHL : LLJ08_04595 LLJ08_19770
PBM : CL52_00325 CL52_04940
PKG : LW136_05210 LW136_21585
PZD : KQ248_03020 KQ248_14940
HPEG : EAO82_08965 EAO82_13380
PALC : A0T30_12640 A0T30_19315
PCAM : HNE05_00825 HNE05_07920
MSHE : MAALD49_12510(liuA)
SCAA : TUM17387_13420(liuA)
SNAN : I6N98_01530 I6N98_12775
ZAL : AZF00_01765 AZF00_12140
MICC : AUP74_01235(acdA_1)
MSPN : M8T91_14270 M8T91_17055
ASIP : AQUSIP_26350(acdA_3)
GAI : IMCC3135_11190(acdA_1) IMCC3135_21990(mmgC_3)
HAAH : HALA3H3_920017(IVD)
ALCA : ASALC70_04376(mmgC_9)
SOK : D0B54_07665 D0B54_16565
FCE : JN531_007050 JN531_010755
RPJ : N234_00625 N234_12350
REH : H16_A0167(ivd1) H16_A1972(ivd2)
CNC : CNE_1c01580(ivd) CNE_1c19420(bcd2)
REU : Reut_A0135 Reut_A1466
CTI : RALTA_A0110 RALTA_A2851
CBW : RR42_m0173 RR42_s1263
CPAU : EHF44_04895 EHF44_27575
COX : E0W60_10245 E0W60_11435
CUK : KB879_00720 KB879_22115
BCEP : APZ15_22670 APZ15_32790
BGL : bglu_2g11300 bglu_2g19980
PMEG : FNZ07_01195 FNZ07_29010
BTRM : SAMEA390648701150(ivd_1)
AXY : AXYL_00115(ivd) AXYL_06717
AVH : WHX56_00650 WHX56_05365
PVAC : HC248_03117(mmgC_2)
LIM : L103DPR2_00033(acdA_1)
LIH : L63ED372_03167(acdA_6)
HYR : BSY239_2780 BSY239_3634
HPSE : HPF_13295(mmgC14) HPF_21145(mmgC16)
SMIO : CATMQ487_28270(acd_1)
MASY : DPH57_08050 DPH57_20810
MASZ : C9I28_01035 C9I28_13615
MPLI : E1742_01165 E1742_16720
TMJ : P0M04_09705 P0M04_30580
SHD : SUTH_00046 SUTH_00533
URU : DSM104443_01928(mmgC_2)
UPL : DSM104440_01784(mmgC_2)
AZA : AZKH_2504 AZKH_3285(acd)
THAG : CKCBHOJB_03196(bcd)
NTU : NTH_03461(mmgC_3) NTH_04468(acdA_2) NTH_04469(mmgC_6)
AMIH : CO731_04371(mmgC_2)
RBS : RHODOSMS8_01374(acdA)
SMEL : SM2011_b21121(ivdH)
SFD : USDA257_c31600(acdA2)
SAME : SAMCFNEI73_pC0753(acdA)
BRAD : BF49_3679 BF49_7097
BIC : LMTR13_05655 LMTR13_20990
BRK : CWS35_23645 CWS35_29055
BROS : QUH67_07085 QUH67_18570
VGO : GJW-30_1_03385(mmgC_9)
BVES : QO058_03350 QO058_26540
XDI : EZH22_02640 EZH22_20300
AQI : J5J86_01175 J5J86_17610
MAQU : Maq22A_c01570(caiA)
MTUN : MTUNDRAET4_0317.1(mmgC)
PSTG : E8M01_11505 E8M01_34730
PAQT : E8L99_19245 E8L99_19530
CAUF : CSW63_00585 CSW63_15710
PZU : PHZ_c1284(ivd) PHZ_c2406
TSV : DSM104635_00284(acdA_1)
PHAE : N1037_09310 N1037_20150 N1037_20155
MALG : MALG_02376 MALG_03736 MALG_03737
SUAM : BOO69_06525 BOO69_20825 BOO69_21745 BOO69_21750
SINL : DSM14862_01155(bcd)
SPSE : SULPSESMR1_01881(mmgC) SULPSESMR1_04181(acdA) SULPSESMR1_04182(mmgC)
RMM : ROSMUCSMR3_00249(mmgC)
RID : RIdsm_02331(acdA_7) RIdsm_05460(acdA_11) RIdsm_05461(mmgC_18)
SAGU : CDO87_18765 CDO87_24080 CDO87_24085
PMAU : CP157_01587(mmgC_2)
DAA : AKL17_2333 AKL17_4466 AKL17_4467
LVS : LOKVESSMR4R_01815(mmgC)
MON : G8E03_01185 G8E03_02320 G8E03_02325
NOV : TQ38_011025 TQ38_019895
SMAZ : LH19_08665 LH19_27165
SGI : SGRAN_0505(ivd) SGRAN_1041(ivd2) SGRAN_2312(ivd3)
SPHM : G432_00755 G432_06270
SPKC : KC8_01915 KC8_09475
SBD : ATN00_15515 ATN00_15670
SPPH : KFK14_02895 KFK14_05660
SPAG : sphantq_03763(acdA_3)
SFLA : SPHFLASMR4Y_03218(fadE)
SPHJ : BSL82_08890 BSL82_10545
PALG : HFP57_05805 HFP57_16410
TFV : IDJ81_06380 IDJ81_06905
EFV : CHH26_00035 CHH26_15585
NTD : EGO55_05235 EGO55_06330
SNEA : NBZ79_05770 NBZ79_13650
GSO : PH603_09065 PH603_16420
DAX : FDQ92_06590 FDQ92_12495
MRM : A7982_03734 A7982_11301
MBAI : MB901379_02621(mmgC_10)
RHW : BFN03_08185 BFN03_08190
PARN : NBH00_04170 NBH00_08130 NBH00_21795
PARQ : DSM112329_04540(mmgC_13)
LEPV : J4558_21285 J4558_21345
TVO : TVG1333406(TVG1333406)
» show all
Taxonomy
Reference
Authors
BACHHAWAT BK, ROBINSON WG, COON MJ.
Title
Enzymatic carboxylation of beta-hydroxyisovaleryl coenzyme A.
Journal
J Biol Chem 219:539-50 (1956)
Reference
Authors
Ikeda Y, Tanaka K.
Title
Purification and characterization of isovaleryl coenzyme A dehydrogenase from rat liver mitochondria.
Journal
J Biol Chem 258:1077-85 (1983)
Reference
Authors
Tanaka K, Budd MA, Efron ML, Isselbacher KJ.
Title
Isovaleric acidemia: a new genetic defect of leucine metabolism.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.4
ExPASy - ENZYME nomenclature database: 1.3.8.4
BRENDA, the Enzyme Database: 1.3.8.4