KEGG   ENZYME: 1.3.8.8
Entry
EC 1.3.8.8                  Enzyme                                 
Name
long-chain acyl-CoA dehydrogenase;
palmitoyl-CoA dehydrogenase;
palmitoyl-coenzyme A dehydrogenase;
long-chain acyl-coenzyme A dehydrogenase;
long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase;
ACADL (gene name).
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
a long-chain acyl-CoA + electron-transfer flavoprotein = a long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein [RN:R00392]
Reaction(KEGG)
R00392 > R01279 R03777 R03857 R03990 R04751 R04754
Substrate
long-chain acyl-CoA [CPD:C02843];
electron-transfer flavoprotein [CPD:C04253]
Product
long-chain trans-2,3-dehydroacyl-CoA;
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains a tightly-bound FAD cofactor. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 6 to at least 16 carbon atoms. The highest activity was found with C12, and the rates with C8 and C16 were 80 and 70%, respectively [2]. The enzyme from rat can accept substrates with C8-C22. It is most active with C14 and C16, and has no activity with C4, C6 or C24 [4]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.
History
EC 1.3.8.8 created 1989 as EC 1.3.99.13, part transferred 2012 to EC 1.3.8.8
Pathway
ec00071  Fatty acid degradation
ec01100  Metabolic pathways
Orthology
K00255  long-chain-acyl-CoA dehydrogenase
Genes
HSA: 33(ACADL)
PTR: 459914(ACADL)
PPS: 100986924(ACADL)
GGO: 101127206(ACADL)
PON: 100440170(ACADL)
NLE: 100595536(ACADL)
HMH: 116810363(ACADL)
MCC: 711485(ACADL)
MCF: 102134056(ACADL)
MTHB: 126932517
MNI: 105481134(ACADL)
CSAB: 103217758(ACADL)
CATY: 105580137(ACADL)
PANU: 101024730(ACADL)
TGE: 112636256(ACADL)
MLEU: 105529404(ACADL)
RRO: 104655498(ACADL)
RBB: 108540361(ACADL)
TFN: 117094580(ACADL)
PTEH: 111545984(ACADL)
CANG: 105504792(ACADL)
CJC: 100414283(ACADL)
SBQ: 101034499(ACADL)
CIMI: 108316699(ACADL)
CSYR: 103269625(ACADL)
MMUR: 105863916(ACADL)
LCAT: 123643779(ACADL)
PCOQ: 105823951(ACADL)
OGA: 100958878(ACADL)
MMU: 11363(Acadl)
MCAL: 110291490(Acadl)
MPAH: 110321743(Acadl)
RNO: 25287(Acadl)
MCOC: 116088527(Acadl)
ANU: 117706257(Acadl)
MUN: 110560007(Acadl)
CGE: 100759026(Acadl)
MAUA: 101833241(Acadl)
PROB: 127226397(Acadl)
PLEU: 114693617(Acadl)
MORG: 121433522(Acadl)
MFOT: 126508805
AAMP: 119820527(Acadl)
NGI: 103744464(Acadl)
HGL: 101698104(Acadl)
CPOC: 100723012(Acadl)
CCAN: 109691994(Acadl)
DORD: 105986229(Acadl)
DSP: 122107366(Acadl)
PLOP: 125350340(Acadl)
NCAR: 124980410
OCU: 100358521
OPI: 101528752(ACADL)
TUP: 102478785(ACADL)
GVR: 103588662(ACADL)
CFA: 478895(ACADL)
CLUD: 112656358(ACADL)
VVP: 112922460(ACADL)
VLG: 121480677(ACADL)
NPO: 129522984(ACADL)
AML: 100467341(ACADL)
UMR: 103659964(ACADL)
UAH: 113250509(ACADL)
UAR: 123798264(ACADL)
ELK: 111143314
LLV: 125095200
MPUF: 101676763(ACADL)
NVS: 122902262(ACADL)
ORO: 101385517(ACADL)
EJU: 114215908(ACADL)
ZCA: 113919326(ACADL)
MLX: 118012086(ACADL)
NSU: 110592142(ACADL)
LWW: 102726087(ACADL)
FCA: 101098884(ACADL)
PYU: 121031008(ACADL)
PCOO: 112872263(ACADL)
PBG: 122481721(ACADL)
LRUF: 124516363
PTG: 102967046(ACADL)
PPAD: 109265125(ACADL)
PUC: 125911236
AJU: 106984776
HHV: 120243742(ACADL)
BTA: 614508(ACADL)
BOM: 102266624(ACADL)
BIU: 109570336(ACADL)
BBUB: 102409588(ACADL)
BBIS: 105003724(ACADL)
CHX: 102176568(ACADL)
OAS: 101123271(ACADL)
BTAX: 128065153(ACADL)
ODA: 120854538(ACADL)
CCAD: 122426438(ACADL)
MBEZ: 129538677(ACADL)
SSC: 396931(ACADL)
CFR: 102511378(ACADL)
CBAI: 105072946(ACADL)
CDK: 105101591(ACADL)
VPC: 102544504(ACADL)
BACU: 103002780(ACADL)
LVE: 103080374(ACADL)
OOR: 101280788(ACADL)
DLE: 111171787(ACADL)
PCAD: 102976178(ACADL)
PSIU: 116756693(ACADL)
NASI: 112411907(ACADL)
ECB: 100066893(ACADL)
EPZ: 103564161(ACADL)
EAI: 106848054(ACADL)
MYB: 102260528(ACADL)
MYD: 102757895(ACADL)
MMYO: 118661430(ACADL)
MLF: 102435683(ACADL)
MNA: 107524805(ACADL)
PKL: 118709024(ACADL)
EFUS: 103289347(ACADL)
HAI: 109390442(ACADL)
DRO: 112307701(ACADL)
SHON: 118984235(ACADL)
AJM: 119064357(ACADL)
PDIC: 114494528(ACADL)
PHAS: 123829433(ACADL)
MMF: 118625400(ACADL)
RFQ: 117025612(ACADL)
PALE: 102878971(ACADL)
PGIG: 120587600(ACADL)
PVP: 105311371(ACADL)
RAY: 107517635(ACADL)
MJV: 108394312(ACADL)
TOD: 119256165(ACADL)
SARA: 101547913(ACADL)
LAV: 100657035(ACADL)
TMU: 101358665
ETF: 101650946(ACADL)
DNM: 101437224(ACADL)
MDO: 100015264(ACADL)
GAS: 123242721(ACADL)
SHR: 100914644(ACADL)
AFZ: 127553154
PCW: 110223331(ACADL)
OAA: 100077024(ACADL)
GGA: 424005(ACADL)
PCOC: 116235917(ACADL)
MGP: 100540388(ACADL)
CJO: 107316458(ACADL)
TPAI: 128076856(ACADL)
LMUT: 125697112(ACADL)
NMEL: 110399290(ACADL)
APLA: 101801335(ACADL)
ACYG: 106034509(ACADL)
CATA: 118257725(ACADL)
AFUL: 116490927(ACADL)
TGU: 100224317(ACADL)
LSR: 110471675(ACADL)
SCAN: 103814572(ACADL)
PMOA: 120511522(ACADL)
OTC: 121339719(ACADL)
PRUF: 121364431(ACADL)
GFR: 102044703(ACADL)
FAB: 101817085(ACADL)
OMA: 130255550(ACADL)
PHI: 102106512(ACADL)
PMAJ: 107207764(ACADL)
CCAE: 111922608(ACADL)
CCW: 104694536(ACADL)
CBRC: 103624331(ACADL)
ETL: 114059418(ACADL)
ZAB: 102064802(ACADL)
ACHL: 103797969(ACADL)
SVG: 106856565(ACADL)
MMEA: 130588879(ACADL)
HRT: 120755314(ACADL)
FPG: 101924862(ACADL)
FCH: 102047187(ACADL)
CLV: 102095816(ACADL)
EGZ: 104124193(ACADL)
NNI: 104010084(ACADL)
PCRI: 104024838(ACADL)
PLET: 104614895(ACADL)
EHS: 104512858(ACADL)
PCAO: 104043513(ACADL)
ACUN: 113482077(ACADL)
TALA: 104355843(ACADL)
PADL: 103921668(ACADL)
AFOR: 103900410(ACADL)
ACHC: 115342988(ACADL)
HALD: 104310955(ACADL)
HLE: 104841527(ACADL)
AGEN: 126043723
GCL: 127018295
CCRI: 104155448(ACADL)
CSTI: 104551065(ACADL)
CMAC: 104473694(ACADL)
MUI: 104539287(ACADL)
BREG: 104629769(ACADL)
FGA: 104077331(ACADL)
GSTE: 104251704(ACADL)
LDI: 104350513(ACADL)
MNB: 103773323(ACADL)
OHA: 104338579(ACADL)
NNT: 104410736(ACADL)
SHAB: 115608236(ACADL)
DPUB: 104298416(ACADL)
PGUU: 104464381(ACADL)
ACAR: 104518361(ACADL)
CPEA: 104388092(ACADL)
CVF: 104288745(ACADL)
CUCA: 104064555(ACADL)
TEO: 104384142(ACADL)
BRHI: 104487905(ACADL)
AAM: 106492331(ACADL)
AROW: 112976587(ACADL)
NPD: 112954273(ACADL)
TGT: 104575235(ACADL)
DNE: 112994329(ACADL)
SCAM: 104153015(ACADL)
ASN: 102387928(ACADL)
AMJ: 102565241(ACADL)
CPOO: 109323024(ACADL)
GGN: 109301990(ACADL)
PSS: 102461956(ACADL)
CMY: 102941001(ACADL)
CCAY: 125644892(ACADL)
DCC: 119863825(ACADL)
CPIC: 101943787(ACADL)
TST: 117884900(ACADL)
CABI: 116816106(ACADL)
MRV: 120374657(ACADL)
ACS: 100562130(acadl)
PVT: 110072389(ACADL)
SUND: 121919027(ACADL)
PBI: 103062999(ACADL)
PMUR: 107301928(ACADL)
CTIG: 120312337(ACADL)
TSR: 106550960(ACADL)
PGUT: 117674289(ACADL)
PTEX: 113440999(ACADL)
NSS: 113415665(ACADL)
VKO: 123024353(ACADL)
PMUA: 114583593(ACADL)
PRAF: 128401575(ACADL)
ZVI: 118096645(ACADL)
HCG: 128340256(ACADL) 128340325
GJA: 107119083(ACADL)
STOW: 125426189
EMC: 129323710(ACADL)
XLA: 446669(acadl.L)
XTR: 734116(acadl)
NPR: 108794423(ACADL)
RTEM: 120943855(ACADL)
BBUF: 121008271(ACADL)
BGAR: 122944876(ACADL)
MUO: 115475100(ACADL)
GSH: 117360471(ACADL)
DRE: 394156(acadl)
SRX: 107747617(acadl)
SANH: 107700586(acadl)
SGH: 107576428
CCAR: 109108344
CAUA: 113061868 113118574
CGIB: 127934185 127977733
PTET: 122362976(acadl)
LROH: 127181183(acadl)
OMC: 131524670(acadl)
PPRM: 120486038(acadl)
MAMB: 125254237 125254660
CIDE: 127500017
MASI: 127417032
TROS: 130550744(acadl)
IPU: 124627118
PHYP: 113534576(acadl)
SMEO: 124396059(acadl)
TFD: 113658614(acadl)
AMEX: 111197552(acadl)
CMAO: 118803981(acadl)
EEE: 113577281(acadl)
CHAR: 116222879
TRU: 101075644(acadl)
TFS: 130523323(acadl)
TNG: GSTEN00015856G001
LCO: 104929358
NCC: 104953624(acadl)
CGOB: 115021000 115021017 115021690(acadl)
ELY: 117254541(acadl)
EFO: 125884732(acadl)
PLEP: 121963024(acadl)
SLUC: 116044465(acadl)
ECRA: 117939622(acadl)
ESP: 116674195(acadl)
PFLV: 114550941(acadl)
GAT: 120828883(acadl)
PPUG: 119223123(acadl)
AFB: 129111563(acadl)
CLUM: 117744519(acadl)
MSAM: 119904627(acadl)
SCHU: 122871847(acadl)
CUD: 121506096(acadl)
ALAT: 119015640(acadl)
MZE: 101469415(acadl)
ONL: 100698696
OAU: 116332244
OLA: 101159651(acadl)
OML: 112156666(acadl)
XMA: 102229820(acadl) 106700234
XHE: 116715758(acadl) 116715759
PFOR: 103139182(acadl)
PLAI: 106940502(acadl)
PMEI: 106914875(acadl) 106923423
GAF: 122827219(acadl)
CVG: 107084233(acadl)
CTUL: 119780761(acadl)
GMU: 124861767(acadl)
NFU: 107377229(acadl)
KMR: 108242184(acadl)
ALIM: 106530711(acadl)
NWH: 119428683(acadl)
AOCE: 111571820(acadl)
MCEP: 125000913(acadl)
POV: 109643952(acadl)
SSEN: 122783223(acadl)
HHIP: 117777854(acadl)
HSP: 118103182(acadl)
LCF: 108873043
SDU: 111234061(acadl)
SLAL: 111665351(acadl)
XGL: 120798316(acadl)
HCQ: 109528476(acadl)
SSCV: 125987682
BPEC: 110170900
MALB: 109968757(acadl)
BSPL: 114870552(acadl)
SASA: 106575817(acadl)
STRU: 115179855(acadl)
OTW: 112214841(acadl)
OMY: 110527282 110528748
OGO: 124018695 124018697
ONE: 115117891(acadl)
OKI: 109882513(acadl)
SALP: 111960779(acadl)
SNH: 120033335 120039490
CCLU: 121575664(acadl)
ELS: 105023135(acadl)
SFM: 108928934(acadl)
PKI: 111852206(acadl)
AANG: 118214162(acadl)
LOC: 102687372(acadl)
PSPA: 121322451(acadl)
ARUT: 117426942(acadl)
PSEX: 120530707(acadl)
LCM: 102362263(ACADL)
CMK: 103182964(acadl)
LERI: 129698856(acadl)
BFO: 118403143 118403144
BBEL: 109461586 109461619
CIN: 100180056
SCLV: 120330792 120330793 120330923 120330926 120331437 120346468
SPU: 115930018 577166
LPIC: 129255524 129256978 129256979
AJC: 117102027 117102051
SKO: 100375371
BCOO: 119084328
IEL: 124155694
DPX: DAPPUDRAFT_110684
DMK: 116923550
DPZ: 124321276 124340281
PVM: 113806064
PJA: 122247998
PCHN: 125047101
PMOO: 119592997
HAME: 121853660
PCLA: 123766734
PTRU: 123503282
ESN: 126980380
HAZT: 108678307 108680106 108680240 108681914
EAF: 111695631 111696514
LSM: 121122406
PPOI: 119112010 119112280
HRO: HELRODRAFT_158178
LGI: LOTGIDRAFT_158547
PCAN: 112557703
BGT: 106051136
GAE: 121385404
HRF: 124136786
HRJ: 124253167
CRG: 105333437 117687133
CVN: 111108184
CANU: 128165128
OED: 125646285
MYI: 110457184
PMAX: 117319963
MCAF: 127729286
MMER: 123559484
DPOL: 127860186
LAK: 106173170
OVI: T265_01445
MBR: MONBRDRAFT_35315
SRE: PTSG_02553
AAF: AURANDRAFT_24725
EHX: EMIHUDRAFT_360281
ACB: A1S_1108 A1S_2279
ACI: ACIAD1723(hcaD) ACIAD2226
APOT: MZO21_04825
ATZ: M5E07_08205 M5E07_10660
THAT: H3N35_08845
TACT: SG35_009115
TVD: SG34_020080
SNAN: I6N98_02130
FCE: JN531_013365
TEI: QS257_04870
RHA: RHA1_ro00550 RHA1_ro02715 RHA1_ro08138
RSA: RSal33209_2142
NBT: KLP28_16550
 » show all
Reference
1  [PMID:13239683]
  Authors
CRANE FL, HAUGE JG, BEINERT H
  Title
Flavoproteins involved in the first oxidative step of the fatty acid cycle.
  Journal
Biochim Biophys Acta 17:292-4 (1955)
DOI:10.1016/0006-3002(55)90374-7
Reference
2  [PMID:13319294]
  Authors
HAUGE JG, CRANE FL, BEINERT H.
  Title
On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A.  III.  Palmityl coA dehydrogenase.
  Journal
J Biol Chem 219:727-33 (1956)
Reference
3  [PMID:1015826]
  Authors
Hall CL, Heijkenskjold L, Bartfai T, Ernster L, Kamin H.
  Title
Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef hart mitochondria.
  Journal
Arch Biochem Biophys 177:402-14 (1976)
DOI:10.1016/0003-9861(76)90453-7
Reference
4  [PMID:3968063]
  Authors
Ikeda Y, Okamura-Ikeda K, Tanaka K
  Title
Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme.
  Journal
J Biol Chem 260:1311-25 (1985)
  Sequence
[rno:25287]
Reference
5  [PMID:8155643]
  Authors
Djordjevic S, Dong Y, Paschke R, Frerman FE, Strauss AW, Kim JJ
  Title
Identification of the catalytic base in long chain acyl-CoA dehydrogenase.
  Journal
Biochemistry 33:4258-64 (1994)
DOI:10.1021/bi00180a021
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.8
IUBMB Enzyme Nomenclature: 1.3.8.8
ExPASy - ENZYME nomenclature database: 1.3.8.8
BRENDA, the Enzyme Database: 1.3.8.8
CAS: 59536-74-2

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Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (18)   
   KEGG COMPOUND (18)   
Chemical reaction (8)   
   KEGG REACTION (7)   
   KEGG RCLASS (1)   
Gene (4896)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (448)   
   KEGG MGENES (192)   
   RefGene (4255)   
Protein sequence (19400)   
   UniProt (11300)   
   SWISS-PROT (12)   
   RefSeq(pep) (8088)   
DNA sequence (103569)   
   RefSeq(nuc) (95342)   
   GenBank (5753)   
   EMBL (2474)   
Protein domain (14)   
   InterPro (14)   
All databases (127910)   

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