KEGG   ENZYME: 1.3.98.1
Entry
EC 1.3.98.1                 Enzyme                                 
Name
dihydroorotate dehydrogenase (fumarate);
DHOdehase (ambiguous);
dihydroorotate dehydrogenase (ambiguous);
dihydoorotic acid dehydrogenase (ambiguous);
DHOD (ambiguous);
DHODase (ambiguous);
dihydroorotate oxidase;
pyr4 (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other, known, physiological acceptors
Sysname
(S)-dihydroorotate:fumarate oxidoreductase
Reaction(IUBMB)
(S)-dihydroorotate + fumarate = orotate + succinate [RN:R01867]
Reaction(KEGG)
R01867
Substrate
(S)-dihydroorotate [CPD:C00337];
fumarate [CPD:C00122]
Product
orotate [CPD:C00295];
succinate [CPD:C00042]
Comment
Binds FMN. The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. Molecular oxygen can replace fumarate in vitro. Other class 1 dihydroorotate dehydrogenases use either NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
History
EC 1.3.98.1 created 1961 as EC 1.3.3.1, transferred 2011 to EC 1.3.98.1
Pathway
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K00226  dihydroorotate dehydrogenase (fumarate)
Genes
QSU112014477
SCEYKL216W(URA1)
SEUBDI49_3169
SPAOSPAR_K00080
KLAKLLA0_C19360g
KMXKLMA_10832(URA1)
LTHKLTH0F00308g
ZROZYRO0D00396g
NCSNCAS_0D03520(NCAS0D03520)
NDINDAI_0H00120(NDAI0H00120)
TPFTPHA_0K00200(TPHA0K00200)
TBLTBLA_0B10140(TBLA0B10140)
TDLTDEL_0F05620(TDEL0F05620)
TGBHG536_0C00200
KAFKAFR_0L00170(KAFR0L00170)
KNGKNAG_0K02180(KNAG0K02180)
ZMKHG535_0D00200
LELLELG_00532
NCRNCU04318
NTENEUTE1DRAFT15063(NEUTE1DRAFT_15063)
SMPSMAC_05569
PANPODANSg8855
TTTTHITE_2039441
MTMMYCTH_2302739
CTHRCTHT_0063240
MGRMGG_07263
PPEIPpBr36_01903
TMNUCRPA7_6289
SSCKSPSK_01211
FGRFGSG_03777
FPUFPSE_03470
FVRFVEG_12862
FOXFOXG_16831
NHENECHADRAFT_87157
TRETRIREDRAFT_67494
TRRM419DRAFT_133060
MAWMAC_06929
MAJMAA_00067
PLJVFPFJ_09532
VALVDBG_00442
VDAVDAG_00052
CFJCFIO01_08503
CHIGCH63R_09074
ELAUCREL1_10685
PFYPFICI_13125
SSLSS1G_09113
BFUBCIN_16g04110(Bcura1)
PSCOLY89DRAFT_779573
GLZGLAREA_12815
PNOSNOG_06955
PTEPTT_01403
BZECOCCADRAFT_36785
BSCCOCSADRAFT_162941
BORCOCMIDRAFT_102290
AALTCC77DRAFT_1019245
ZTRMYCGRDRAFT_53893
PFJMYCFIDRAFT_100268
FFUCLAFUR5_00821
BCOMBAUCODRAFT_60865
TMLGSTUM_00009301001
TASAA1Q1_07191
TVSTRAVEDRAFT_93176
DSQDICSQDRAFT_36335
PCOPHACADRAFT_110318
SHSSTEHIDRAFT_144014
HIRHETIRDRAFT_306992
PSQPUNSTDRAFT_128891
FMEFOMMEDRAFT_83881
GTRGLOTRDRAFT_69333
LBCLACBIDRAFT_243747
MRRMoror_12976
MOREE1B28_000339
CCICC1G_03745
SCMSCHCO_02645180(SCHCODRAFT_02645180)
ABPAGABI1DRAFT51017(AGABI1DRAFT_51017)
ABVAGABI2DRAFT214748(AGABI2DRAFT_214748)
CPUTCONPUDRAFT_148446
SLASERLADRAFT_374190
SMINv1.2.031230.t1(symbB.v1.2.031230.t1)
PTIPHATRDRAFT_48112
FCYFRACYDRAFT_159735
TPSTHAPSDRAFT_262575
SPARSPRG_07872
EHXEMIHUDRAFT_447879 EMIHUDRAFT_454934
TBRTb927.5.3830
TBGTbgDal_V5320
TCR507091.40 508375.50 511643.20 511923.120
LMALMJF_16_0530(DHODH)
LIFLINJ_16_0540(DHODH)
LDOLDBPK_160540
LMILMXM_16_0530
LBZLBRM_16_0550(DHODH)
LPANLPMP_160530(DHODH)
SLIGGTU79_13620
EAMEAMY_0442
EAYEAM_2979
PLUplu3917
PAKHB0X70_19550
PLUICE143_19590
HSOHS_0799
HSMHSM_1268
MHTD648_7350
MHQD650_20270
MHATB824_7980
MHXMHH_c13360
MHAEF382_11785
MHAMJ450_10470
MHAOJ451_11895
MHALN220_03905
MHAQWC39_09975
MHAYVK67_09975
MVRX781_16500
MVIX808_6700
MVGX874_6790
MVEX875_14030
MANNGM695_09135
MBOSICJ55_09750
BTOWQG_17660
BTREF542_4910
BTRHF543_5590
BTRAF544_17520
AVNAvin_16810
AVLAvCA_16810
AVDAvCA6_16810
ACXAchr_26260
MADHP15_3391
MARIACP86_07480
MSQBKP64_16755
MARAD0851_10945 D0851_18410
SVOSVI_3253(pyrD-2)
SJASJ2017_0984
SPSWSps_04212
SMAIEXU30_18570
SPOLFH971_08915
SBKSHEWBE_3881(pyrDA)
SAESHBH39_14755
SPSHFM037_06995
SEURFM038_018380
HALCEY643_09390
MCAMCA0768
METUGNH96_04320
MMTMetme_2775
MDNJT25_001530
MDHAYM39_15425
MKOMKLM6_3174
METLU737_16125
MPADKEF85_07025
MELLIVG45_04850
MPSYCEK71_06400
MMAIsS8_1223
MMOBF6R98_04715
MOZMoryE10_08030
MISZMishRS11D_17740
MESLKKZ03_21285
ALVAlvin_0263
ATEPAtep_27990
TVIThivi_3812
TMBThimo_1403
MPURMARPU_05485
TSYTHSYN_04345
TTPE6P07_12915
THIPN838_16860
CJAPGWK36_01240
THIMKFB96_04600
TBOGLT988_24185
TTCFOKN1_1242
THICTspCOW1_14190
KAKKalk_02580 Kalk_07040
MGEOCFI10_15325
MSECLN244_02885
NCUF0U83_00185
NIKF5I99_05325
GBIPG2T_06905
TBNTBH_C0805
SEDSAAY24_15345
REVHUE57_13135
EPSL0Y14_13385
NSIA6J88_09380
NMJNM96_03960
NFVFAH67_03720
NSFFAH66_03810
NSCJ7445_05750
NPFLPB400_06780
NMBMON40_06645
KOAH3L93_07410
ECORSAMEA4412678_1339(pyrDA)
EEXEZJ17_01640
MCERMON37_06680
USULVJ78_03140
UTELVJ83_00100
CVICV_3551(pydA)
CVCBKX93_08625
CHRIDK842_02830
CHRBDK843_08315
CRZD1345_16690
CHRMFYK34_12210
CHAECH06BL_34350(pyrDA)
IODEJO50_06000
IFLC1H71_19290
LHKLHK_00854
JEUBJP62_00695
AMAHDLM_0496
AQSDKK66_02525
DEEHQN60_14255
CHIZHQ393_06550
CFONHZU75_00840
JABVN23_05145
TBDTbd_2467
DARDaro_2839
DEYHYN24_06185
DDENKI615_07115
QAUKI612_11625
FLEKI610_14895
ACOMCEW83_02880
THKCCZ27_20915
SKUSulku_1859
SULRB649_05420
GSBGSUB_01640
DESDSOUD_1621
DVEDESUT3_21070
DPSDP0769
DBKDGMP_36840
DMLDmul_38520(pyrD2)
DWDDSCW_05980 DSCW_06290
DALKDSCA_43100
DEKDSLASN_19100
ADEAdeh_0762
ACPA2cp1_0813
AFWAnae109_0808
ANKAnaeK_0809
BOPAXW83_04650
MSLMsil_2988
MTUNMTUNDRAET4_0045.1 MTUNDRAET4_4084
PZUPHZ_p0133
SDOSD1155_02675
RCPRCAP_rcc01727(pyrD1)
NPPPP1Y_AT22953
APTAPA01_14720
APWAPA42C_14720
APFAPA03_14720
APUAPA07_14720
APGAPA12_14720
APQAPA22_14720
APXAPA26_14720
APZAPA32_14720
APKAPA386B_337
ASZASN_2514
ASVWG31_07745
APERA0U91_00355
APOMCPF11_12800
ATOCIW82_01015
AASCA4S02_05460
ACETDS739_07630
AOYEOV40_006810
SWFE3E12_02125
SKTIGS68_25625
SMUCJL100_028115
SROEJL101_026530
MAGamb2359
MAGXXM1_3143
MAGNWV31_07695
DEXHWD60_06700
DVNHQ394_06335
MAESGa0123461_1564
MFNGa0123462_0818
SAUSA2375
SAVSAV2589
SAWSAHV_2573
SAHSaurJH1_2665
SAJSaurJH9_2611
SAMMW2509
SASSAS2475
SARSAR2669
SACSACOL2606(pyrD)
SAXUSA300HOU_2583(pyrD)
SAASAUSA300_2526(pyrD)
SAOSAOUHSC_02909
SAENWMN_2488(pyrD)
SADSAAV_2655(pyrD)
SUUM013TW_2563
SUVSAVC_11825
SUESAOV_2634
SUJSAA6159_02486
SUKSAA6008_02648(pyrD)
SUCECTR2_2443(pyrD)
SUTSAT0131_02823
SUQHMPREF0772_10602(pyrD)
SUZMS7_2595(pyrD)
SUDST398NM01_2639
SUXSAEMRSA15_24920
SUWSATW20_27300
SUGSAPIG2639(pyrD)
SUFSARLGA251_23630
SAUASAAG_00409
SAUERSAU_002430(pyrD)
SAUNSAKOR_02583
SAUSSA40_2343
SAUUSA957_2427
SAUGSA268_2505
SAUZSAZ172_2709
SAUTSAI1T1_2019270
SAUJSAI2T2_1019280
SAUKSAI3T3_1019270
SAUQSAI4T8_1019280
SAUVSAI7S6_1019270
SAUWSAI5S5_1019210
SAUXSAI6T6_1019220
SAUYSAI8T7_1019250
SAUFX998_2573
SABSAB2464
SUYSA2981_2527
SAUBC248_2650
SAUMBN843_26270
SAUCCA347_2666(pyrD)
SAURSABB_02002
SAUIAZ30_13560
SAUDCH52_06060
SAMSNI36_12960
SUHSAMSHR1132_24040
SERSERP2144(pyrD)
SEPSE_2132
SEPPSEB_02136
SEPSDP17_1072(pyrD)
SHASH0471
SHHShL2_00375(pyrD)
SSPSSP0278
SLGSLGD_00405
SLNSLUG_04010
SWAA284_01580
SPASSTP1_1082
SXYBE24_10565
SXLSXYLSMQ121_0306
SXOSXYL_00310(pyrD)
SCAPAYP1020_1752(pyrD)
SEQOSE1039_22680
SPETCEP67_06915
SCOHBZ166_06040
SNLBJD96_01840
SKLC7J89_03360
SHOMEGX58_05985
SCARDWB96_01845
SARLSAP2_04040
SSHNCTC13712_02544(pyrD)
SSIMSAMEA4384339_2389(pyrD)
SLLOISP08_02110
SAULI6G39_10075
SSACI6I31_02655
SPSDJMB28_02050
STASHYI43_02165
GOTAXE85_02950
GMONCTC11323_00512(pyrDA)
GEQCG018_05105
GSAFOC50_01420
GHANCTC10459_00606(pyrDA)
LLAL192589(pydA)
LLKLLKF_1674(pydA)
LLTCVCAS_1457(pydA)
LLSlilo_1474(pydA)
LLDP620_08460
LLXNCDO2118_1571(pyrDA)
LLJLG36_1498(pydA)
LLMllmg_0952(pyrDA)
LLCLACR_1644
LLRllh_4795
LLNLLNZ_04890
LLIuc509_1504(pyrDA)
LLWkw2_1506
LGRLCGT_1508
LGVLCGL_1530
LPKLACPI_0826
LRNCMV25_01670
LTIJW886_07030
LCARBHS00_06855
LPAABHS01_07430
SPYSPy_1432(pyrD)
SPZM5005_Spy1165(pyrD)
SPYMM1GAS476_1227(pyrD)
SPYAA20_1200(pyrD)
SPMspyM18_1441
SPGSpyM3_1091(pyrD)
SPSSPs0774
SPHMGAS10270_Spy1236(pyrD)
SPIMGAS10750_Spy1273(pyrD)
SPJMGAS2096_Spy1237(pyrD)
SPKMGAS9429_Spy1214(pyrD)
SPFSpyM50695(pyrD)
SPAM6_Spy1191
SPBM28_Spy1159(pyrD)
STGMGAS15252_1104(pyrD)
STXMGAS1882_1099(pyrD)
SOZSpy49_1144(pyrD)
STZSPYALAB49_001164(pyrD)
SPYHL897_05790
SPYOSTAB901_06095
SPNSP_0764(pyrDA)
SPDSPD_0665(pyrDa)
SPRspr0672(pyrDA)
SPWSPCG_0713
SJJSPJ_0701
SNVSPNINV200_06750(pyrD)
SPXSPG_0695
SNTSPT_0777
SNDMYY_0796
SPNNT308_03565
SNESPN23F06860(pyrD)
SPVSPH_0863
SNCHMPREF0837_11046
SNMSP70585_0807
SPPSPP_0773
SNIINV104_06350(pyrD)
SPNGHMPREF1038_00774(pyrDA)
SNBSP670_1562
SNPSPAP_0737
SNXSPNOXC06910(pyrD)
SNUSPNA45_01088(pyrD)
SPNESPN034156_17400(pyrD)
SPNUSPN034183_06920(pyrD)
SPNMSPN994038_06810(pyrD)
SPNOSPN994039_06820(pyrD)
SAGSAG0507(pyrDA)
SANgbs0553
SAKSAK_0657(pyrD)
SGCA964_0538(pyrD)
SAGSSaSA20_0492(pyrD)
SAGLGBS222_0484(pyrD)
SAGMBSA_5950
SAGIMSA_6100
SAGRSAIL_6240
SAGPV193_02825
SAGCDN94_02825
SAGTGBSCOH1_0490
SAGEEN72_02920
SAGGEN73_02995
SAGNW903_0684
SMUSMU_595(pyrD)
SMCSmuNN2025_1383(pyrD)
SMUTSMUGS5_02615
SMJSMULJ23_1390(pyrD)
SMUASMUFR_0516(pyrD)
STCstr1207(pyrDa)
STLstu1207(pyrDa)
STESTER_1173
STNSTND_1143
STUSTH8232_1412(pyrD2)
STWY1U_C1109
STHET303_06890
STHSAVT04_08805
SSASSA_0373(pyrDA)
SSBSSUBM407_0226(pyrD)
SSUSSU05_0253
SSVSSU98_0249
SSISSU0235(pyrD)
SSSSSUSC84_0224(pyrD)
SSFSSUA7_0233
SSWSSGZ1_0229
SUPYYK_01095
SSUSNJAUSS_0246
SSTSSUST3_0256
SSUYYB51_1255
SSKSSUD12_0231
SSQSSUD9_0275
SUISSUJS14_0240
SUOSSU12_0237
SRPSSUST1_0248
SSUTTL13_0279(pyrD)
SSUIT15_0241(pyrD)
SGOSGO_0277(pyrA)
SEZSez_0633
SEQSZO_13640
SEZOSeseC_00765(pyrD)
SEQUQ426_06160
SEUSEQ_0655
SUBSUB1264(pyrD)
SDSSDEG_1471(pyrD)
SDGSDE12394_07655
SDAGGS_1341(pyrD)
SDCSDSE_1579(pyrD)
SDQSDSE167_1579(pyrD)
SGAGALLO_0639(pyrD)
SGGSGGBAA2069_c05820(pyrD)
SGTSGGB_0614(pyrD1)
SMBsmi_0815(pyrD2)
SORSOR_0779(pyrD)
STKSTP_1098
STBSGPB_0508(pyrD.1)
SCPHMPREF0833_11208
SCFSpaf_1800(pyrD3)
SSRSALIVB_1200(pyrD)
STFSsal_01281(pyrD)
STJSALIVA_0882(pyrD)
STRSSSAL8618_04675
SSAHHSISS4_00782(pyrDa)
STDSPPN_03865
SMNSMA_0601(pyrD)
SIFSinf_0520(pyrD)
SIESCIM_0207(pyrD)
SIBSIR_0264(pyrDa)
SIUSII_0247(pyrDa)
SANGSAIN_1602(pyrDa)
SANCSANR_1834(pyrDa)
SANSDK43_01485
SCGSCI_0264(pyrDa)
SCONSCRE_0244(pyrDa)
SCOSSCR2_0244(pyrDa)
SOII872_07830
SIKK710_0597
SIQDQ08_02880
SIODW64_02870
SIZSI82_03100
SLUKE3_0599
SIGN596_05700
SIPN597_07540
STVV470_03580
SPATA0O21_06580
STRAATM98_05310
STRNSNAG_0804(pyrDA)
SSOBDK181_07280
SRQSR187_1325
SEQIA6J79_07300
SKID7D50_04920
SPEIEHW89_07920
SRATFY406_00795
SGWD7D53_05105
SPLRC0J00_07435
STRGSRT_15260(pyrD)
SVBNCTC12167_01130(pyrDa)
SMENSAMEA4412692_1637(pyrDA)
SFERNCTC12278_00551(pyrD)
SCAINCTC12191_01271(pyrD)
SCHJDDV21_003720
SPABKQ224_08155
SLATJ4854_09040
SAUPNCTC3168_01081(pyrA)
SURNNCTC13766_00581(pyrDa)
SACOSAME_01789(pyrDa)
SVFNCTC3166_01667(pyrA)
SOSINT76_08735
LJOLJ_1281
LJFFI9785_918(pyrD)
LJHLJP_0899
LJNT285_04430
LACLBA1384(pyrD)
LADLA14_1382
LAFSD55_1367(pyrD)
LDBLdb1530(pyrD2) Ldb2114(pyrD1)
LBULBUL_1421 LBUL_1955
LDELDBND_1465(pyrD2)
LDLLBU_1312 LBU_1730
LGALGAS_1092
LHElhv_2937
LHLLBHH_0706
LHRR0052_04255
LHVlhe_1366
LHHLBH_1217
LHDHUO_04845
LCRLCRIS_01374(pyrD)
LAMLA2_07985
LAILAC30SC_07710
LAYLAB52_07030
LKEWANG_0334
LAWLACWKB8_1177
LAELBAT_0593
LGLAO203_10565
LAMYB1745_02515
LPWLpgJCM5343_08490(pyrD)
LKLDKL58_05950
LAPIDKL56_04930
LHSDLD54_05560
LTAH1A07_04175
LUUH4B44_04115
LPAIGYM71_06600
LIDGYK47_03885
LIQKBW87_03095
LCALSEI_1732
LCZLCAZH_1724
LCSLCBD_1929
LCELC2W_1908
LCWBN194_19150(pyrDA)
LCLLOCK919_1905
LPQAF91_05220
LPILBPG_01010
LPAPLBPC_1652
LCBLCABL_19520(pyrDA)
LCXLCA12A_0064
LRHLGG_01789(pyrD)
LRGLRHM_1725
LRLLC705_01772(pyrD)
LRALRHK_1764(ura1)
LROLOCK900_1732
LRCLOCK908_1825
LCHIKG086_07665
LZEKG087_08315
LFELAF_1201
LFRLC40_0780
LFFLBFF_1312
LORAYI71_12915
LVALV515_05160
LFNLF145_04870
LGASLG045_03135
LSNLSA_05870(pyrDA)
LLEAYR59_06700
LFVLF543_00405
FIXM8332_02270
LBHLbuc_0385
LBNLBUCD034_0423(pyrD)
LPARFAM21731_00580
LCUPL11_003320
LHILG8J22_00338(pyrDA)
LSLLSL_0194(pyrD)
LSIHN6_00184(pyrD)
LSJLSJ_0237(pyrD)
LRMLRC_09270
LAGLBEN83_03670
LACALAC1533_1249
LSWGTO87_04595
LBTAYR52_09035
LKUAPS55_01755
LPDAYR62_08915
LSALCA_0446
LCVFBA2_02465
LGMLG542_07010
LHBD1010_09270
OOEOEOE_0264
OENDSM07_06855
OSIDLJ48_04450
LMELEUM_1279
LMMMI1_05585
LMKLMES_1061
LKILKI_09935
LECLGMK_02480
LCNC270_04425
LGSLEGAS_1084(pyrDA)
LGEC269_05380
LLFBCR17_00420
LGCA9176_06245
LSUA6B45_05980
LPSEFGL85_06620
WCEWS08_0824
WCTWS74_0890
WCIWS105_0888
WCFC6P13_07115
WSOWSWS_00901(pyrD)
WDIH9L19_08060
WVRIE337_05655
WEIEQG49_10180
FRUM3M36_05880
LBEMOO44_07200
EFAEF0285(pyrD-1)
EFLEF62_0674(pyrD-1)
EFIOG1RF_10228(pyrDA)
EFDEFD32_0224
EFSEFS1_0226(pyrD-1)
EFNDENG_00270(pyrD)
EFQDR75_2333(ura1)
EFCEFAU004_00893(pyrDA)
EFAUEFAU085_01453(pyrDA)
EFUHMPREF0351_11431(pyrD2)
EFMM7W_1926
EFTM395_08605
EHREHR_11760
ECASECBG_02253
EMUEMQU_1428(pyrDA)
EDULIU_08370
EGAAL523_12545
ETHCK496_06715
ESGEsVE80_11910(pyrDA)
ELACI4Q40_07110
EIEENLAB_32560(pyrD_2)
THLTEH_14370(pyrD)
TEYGLW17_01140
TOOC7K38_09730
TKRC7K43_03450
AUNAWM73_03900
ASANAWM72_08265
ACGAWM71_06430
ADCFOC79_04410
IRUM0R79_01675
CDFCD630_20770(pyrD1)
PDCCDIF630_02300(preA1)
CDCCD196_1941(pyrD)
CDLCDR20291_1984(pyrD)
PDFCD630DERM_20770(pyrD1)
EACEAL2_c20820
AACXDEACI_1684
ATEAthe_2085
COBCOB47_1861
COWCalow_1775
CKNCalkro_0546
CCHAELD05_03755
CDIACaldiYA01_05040
MASMahau_0412
MHAPJFY71_02310
MMCMmcs_4864
MKMMkms_4953
MJLMjls_5232
MMIMMAR_3409
MMAEMMARE11_33160
MLIMULP_03673
MKNMKAN_03625
MCOOMCOO_35610
MSEOMSEO_01210
MPSEMPSD_34850
MSHOMSHO_48180
MMAMK3U93_06375
MVAMvan_4110
MRHMycrhN_0031
MFXMFAL_33820
MPSCMPSYJ_00340
MHEVMHEL_40650
RAVAAT18_23505
RRZCS378_13285
SBHSBI_02815
SMAOCAG99_07290
ICAIntca_3069
PEIH9L10_02520
AUSIPK37_15620 IPK37_16900
PACPPA0161
PAKHMPREF0675_3201
PAVTIA2EST22_00810
PAXTIA2EST36_00820
PAZTIA2EST2_00800
PAWPAZ_c01720(pyrD1)
PADTIIST44_05455
PCNTIB1ST10_00810
PACCPAC1_00855
PACHPAGK_0189
PACNTIA1EST1_00815
CACNRN83_01250
PRAPALO_09840
PRLBCB70_05810
CGRN4412665_00536(pyrD)
PFRPFREUD_01850 PFREUD_07080
PFRERM25_0187 RM25_0674
PACDEGX94_05835 EGX94_10695
PAUSNCTC13651_00002(preA_1) NCTC13651_01709(preA_2)
PPCHMPREF9154_0752
PBOPACID_05160
AACIASQ49_02240
ACIJJS278_02796(preA)
AJIC0Z10_11770
TFLRPIT_11090
TFABW733_11395
TESBW730_11575
TEZBKM78_05110
TDFH9L22_11270
TLATLA_TLA_01037(preA)
RAINRai3103_06870
PRVG7070_10075
BRTJ4N02_02810
MGGMPLG2_2719
FRAFrancci3_1185
FREFranean1_5282
FRIFraEuI1c_1941
FALFRAAL1902
FSYFsymDg_0518
BLOBL1213
BNMBALAC2494_01378
GSWK9E37_04665
ATQGH723_11475
IAMHC251_22430
EUZDVS28_a1305
SYNsll0744
SYZMYO_128340
SYYSYNGTS_2808(sll0744)
SYTSYNGTI_2807(sll0744)
SYSSYNPCCN_2806(sll0744)
SYQSYNPCCP_2806(sll0744)
SYJD082_16990
SYOC7I86_14670
SYCsyc1720_c
SYUM744_04335
SYFSynpcc7942_2385
SYPSYNPCC7002_A1442
SYVAWQ23_07395
SYLAWQ21_07330
SYNCCB0101_04305
SYNYBM449_12055
CGCCyagr_3414
CYICBM981_1673
AMRAM1_D0141(pyrD)
LSCKIK02_12015
LSKJ5X98_13180
GLPGlo7428_4040
MARMAE_38150
MPKVL20_5511
MIQB5D77_24730
MVZmyaer102_12990
HAOPCC7418_0565
CYTcce_3252
CWACwatDRAFT_4407
CYPPCC8801_0190
CYHCyan8802_0185
CYCPCC7424_1262
CYJCyan7822_3034
CYNCyan7425_4370
ARPNIES39_L04100(pyrD)
PAGHNIES204_36800(pyrD_2)
PPSUNO713_01710(pyrD)
OXYHCG48_06495
LFSHFV01_05540
MICMic7113_3075
GEIGEI7407_1922
OACOscil6304_5924
ONIOsc7112_1448
PHORJWS08_08745
PYHNEA10_02705
ANAalr1912
NOPNos7524_1841
NONNOS3756_28200
NOECLI64_07475
AVAAva_3045
ANBANA_C11950(pyrD)
ACYAnacy_4208
AWAAA650_01570
ANNEH233_27265
RSINB6N60_01082
CALNNIES2098_53340
FISFIS3754_27360
DOUBMF77_00528(preA)
DFSHGD76_13390
CCURIAR63_06285
CRKL3I90_15325
AFLOHEQ12_11585
NCNBZZ01_04220
CTHEChro_4406
PLPPle7327_2009
SCSSta7437_4659
STANSTA3757_05380(pyrD_1)
RRSRoseRS_1785
RCARcas_2064
CAUCaur_2081
CHLChy400_2244
CAGCagg_2635
ATMANT_28310
ABATCFX1CAM_0325
PSUBPelsub_P0691
LEKhrd7_11400
CAPCLDAP_36880
PBFCFX0092_A0455 CFX0092_A0485
THUGKNN16_09620
TSCTSC_c13100
THCTCCBUS3UF1_11810
TOSTheos_1517
TBCA0O31_00009(pyrD)
TANTKNN15_11295
OTEOter_0606
OBGVerru16b_00598(preA_1) Verru16b_01854(preA_2)
VBHCMV30_18235
CAACaka_1151
RUFIK0V07_00720
MINMinf_1387(pyrD) Minf_2385(pyrD)
MKCkam1_1406 kam1_2089
MEAPMTHMO_0210
VBAIMCC26134_01735
RBARB4738 RB4752(pyrD)
RULUC8_16580(pyrDB) UC8_27550
RMLFF011L_27520(pyrDB_1) FF011L_29420(pyrDB_2) FF011L_48580
MFFMFFC18_02890
AHELQ31a_47690(pyrDB_1) Q31a_48380(pyrDB_2)
LCREPla8534_67880
RLCK227x_04690(pyrDB) K227x_04760(pyrD_1)
TTFTHTE_4057
AMUCPan181_30330(pyrD_1)
PNDPla175_23340(pyrD)
AMOBHG15A2_35930(pyrD_2)
PLHVT85_05270(preA)
FMRFuma_01332(preA)
MRIMal4_54110(preA)
ULIETAA1_62400(preA)
AGVOJF2_24280(preA)
PCORKS4_01440(pyrDB_1)
VBLL21SP4_00337(pyrD_1)
TAERGT409_09410
SSMSpirs_2131
STASTHERM_c17710
STQSpith_1841
SFCSpiaf_0536 Spiaf_0539
SLRL21SP2_1672 L21SP2_2986
OCKEXM22_04520
SBUSpiBuddy_1639
SGPSpiGrapes_0130
SASSMUG09_09205
SCDSpica_1957
ABAAcid345_0729
ABASACPOL_5878
SUSAcid_6995
PFERIRI77_26680
ABACLuPra_04112(preA_2)
LBALebu_2234
LEOAMK43_11050
LOTAXF11_03470
LEQBCB68_05100
LHFJCM16775_2172
LSZJCM16776_0398
LHGJMUB5056_0280
LTEJMUB4039_0312
LWDJCM16777_0381
LGOJCM16774_0141
ACOAmico_0095
BTHBT_1333
BTHOBtheta7330_01888(preA)
BFRBF2950
BFSBF9343_2739
BFGBF638R_2834
BFBVU15_12665
BHLBache_1898
BXYBXY_43000
BOABovatus_01352(preA)
BCELBcellWH2_05077(preA)
BCACCGC64_14885
BCAEA4V03_10890
BZGC4H11_13375
BHFC3V43_12950
BISDXK01_014385
BUNBun01g_31230
BEGINE88_00153(preA)
BSTEK6V31_04520
BFEK6V30_19800
BNOK8P02_06300
BHUMJXR92_014825
BVUBVU_3869
BSABacsa_0937
BDOEL88_12980
BDHGV66_20615
PCOPI6J50_03520
PGIPG_2055
PGNPGN_1999
PGTPGTDC60_0330
PAHPoras_0063
PCRENCTC12858_00853(pyrD_1)
PCAGNCTC12856_00153(preA)
PENDLA319_08760
PSOECE91St14_03870
PBTING2E5B_1970 ING2E5B_2366
PMUCING2E5A_0046(URA1) ING2E5A_0807(pyrD1) ING2E5A_2689(pyrD5)
PETPEIBARAKI_4230 PEIBARAKI_6575
PSACPSM36_0452 PSM36_3125
PROJKDN43_02330
PDIBDI_0543
PARCCI960_12285
PMERINE87_01608(preA)
PGOLK6V26_03975
PJOLK449_10485
TFOBFO_0242
TOHBCB71_09795
COPRCop2CBH44_28640
OSPOdosp_0627
BUYD8S85_03235
BVIRI6J59_10440
AFDAlfi_1991
AOKA3BBH6_07330
ACOUA5CBH24_07220
ADAA5CPEGH6_08340
AITAI2BBH_23820
APUTL6V35_04610
RBCBN938_0026
TTZFHG85_06125 FHG85_08615 FHG85_09540
BLQL21SP5_00505(pyrD_2) L21SP5_00918(preA) L21SP5_01040(pyrDA_1) L21SP5_02712(pyrDA_2)
BACCBRDCF_p2298
DORIFH5T_12270 FH5T_15380
DRCG0Q07_05720 G0Q07_13085
MCOSGM418_18080 GM418_18895 GM418_19895
ASXCDL62_00045 CDL62_02800 CDL62_03795 CDL62_17350
ALKQM9189_03830 M9189_05245 M9189_06755 M9189_09210
MBASALGA_0168 ALGA_1617 ALGA_2539
RBARAWN76_001055
FLSGLV81_15450
FLPLK994_03885
SGNSGRA_p0002(pyrD)
FBUUJ101_01334(pyrDI)
ORHOrnrh_0688
ORIQ785_03965
EAOBD94_0307
EMNM876_00490
EENBBD30_05140
ELBVO54_02286(pyrDA)
EMGBBD33_01820
EGOBBD34_10895
EGMAYC65_15670
ELZFCS00_09180
APIBG8C43_01380
BBLBLBBGE_513
BPIBPLAN_127(pyrD)
BMMMADAR_234(pyrD)
BCPBLBCPU_481(pyrD)
BBGBGIGA_124(pyrD)
BBQBLBBOR_510
BLPBPAA_124(pyrD)
BLUK645_2431
BLCKDM815_02555
BPUNDM780_02440
SHYRLA303_01790 LA303_02695 LA303_05480 LA303_05520 LA303_06845
CPBCphamn1_2471
CLIClim_2445
PVICvib_1724
PLTPlut_2084
PAAPaes_2219
PROCPtc2401_02228(pyrD_2)
PRSB9H02_10925
PROSCHL67_11440
CTSCtha_0742
IALIALB_2950(pyrD)
MROMROS_2662
TLETlet_1878
PHYAJ81_02475
TMETmel_0121
DDFDEFDS_0411
DAPDacet_2754 Dacet_2941
GTLEP073_02415
CNICalni_0761
FSIFlexsi_2303
CABYCabys_261
DTHDICTH_0323
DTUDtur_0444
NDENIDE1091(pyrD)
NMVNITMOv2_0967(pyrD)
NIONITINOP_2763(pyrD)
NJANSJP_2098(pyrDA)
NKFNkreftii_000175 Nkreftii_002103
NIFW02_33580(pyrD)
ALAMRT761_00819(pyrDB)
NFTFBF37_00655(pyrD)
MVLKOY49_00795
STOSTK_14770(pyrD)
SOHD1869_08300
SSOSSO0610(pyrD)
SOLSsol_1674
SSOASULA_1702
SSOLSULB_1703
SSOFSULC_1701
SSHIJ5U23_02791
SCASSACC_03670
SAISaci_1592(pyrD)
SACNSacN8_07725
SACRSacRon12I_07735
SACSSUSAZ_07530
SISLS215_1630
SIAM1425_1522
SIMM1627_1637
SIDM164_1519
SIYYG5714_1526
SINYN1551_1310
SIILD85_1729
SIHSiH_1488
SIRSiRe_1397
SICSiL_1400
SULABFU36_02970
SULEGFS03_08675
SULOGFS33_00450
SULLEWF20_09470
MSEMsed_1960
MEMJMJ1HA_2228
MCNMcup_0324
MHKDFR87_08705
MPRUDFR88_08375
MTENGWK48_03320
MJNMjAS7_0261
AHOAhos_1133
AMANB6F84_09750
ABRIDFR85_09375
ASULDFR86_08435
AAMBD1866_00545
ACIHHS5_25290
SACDHS1genome_0356
SAZOD1868_05340
CSTYKN1_26740
STEPIC006_1331
SAHSHS7_09430
PAIPAE3263
PISPisl_0507
PCLPcal_1778
PASPars_1692
PYRP186_1337
POGPogu_0443
TNETneu_1590
PYWPYWP30_01693
TTNTTX_0796(pyrD)
TUZTUZN_0505
VDIVdis_1107
VMOVMUT_1972
CLGCalag_0598
 » show all
Reference
1  [PMID:9405053]
  Authors
Bjornberg O, Rowland P, Larsen S, Jensen KF
  Title
Active site of dihydroorotate dehydrogenase A from Lactococcus lactis investigated by chemical modification and mutagenesis.
  Journal
Biochemistry 36:16197-205 (1997)
DOI:10.1021/bi971628y
  Sequence
[llm:llmg_0952]
Reference
2  [PMID:9655329]
  Authors
Rowland P, Bjornberg O, Nielsen FS, Jensen KF, Larsen S
  Title
The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function.
  Journal
Protein Sci 7:1269-79 (1998)
DOI:10.1002/pro.5560070601
  Sequence
[llm:llmg_0952]
Reference
3  [PMID:12732650]
  Authors
Norager S, Arent S, Bjornberg O, Ottosen M, Lo Leggio L, Jensen KF, Larsen S
  Title
Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function.
  Journal
J Biol Chem 278:28812-22 (2003)
DOI:10.1074/jbc.M303767200
  Sequence
[llm:llmg_0952]
Reference
4  [PMID:17617217]
  Authors
Zameitat E, Pierik AJ, Zocher K, Loffler M
  Title
Dihydroorotate dehydrogenase from Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues.
  Journal
FEMS Yeast Res 7:897-904 (2007)
DOI:10.1111/j.1567-1364.2007.00275.x
  Sequence
[sce:YKL216W]
Reference
5  [PMID:18808149]
  Authors
Inaoka DK, Sakamoto K, Shimizu H, Shiba T, Kurisu G, Nara T, Aoki T, Kita K, Harada S
  Title
Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction.
  Journal
Biochemistry 47:10881-91 (2008)
DOI:10.1021/bi800413r
  Sequence
[tcr:508375.50]
Reference
6  [PMID:19932077]
  Authors
Cheleski J, Wiggers HJ, Citadini AP, da Costa Filho AJ, Nonato MC, Montanari CA
  Title
Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry.
  Journal
Anal Biochem 399:13-22 (2010)
DOI:10.1016/j.ab.2009.11.018
Other DBs
ExplorEnz - The Enzyme Database: 1.3.98.1
IUBMB Enzyme Nomenclature: 1.3.98.1
ExPASy - ENZYME nomenclature database: 1.3.98.1
BRENDA, the Enzyme Database: 1.3.98.1
CAS: 9029-03-2

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