Entry Name [mycofactocin precursor peptide]-tyrosine decarboxylase;
Class Oxidoreductases;BRITE hierarchy
Sysname C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-L-tyrosine L-tyrosine-carboxylyase
Reaction(IUBMB) C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + CO2 + 5'-deoxyadenosine + L-methionine [RN:
R12724 ]
Reaction(KEGG) Substrate C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-L-tyrosine [CPD:
C22344 ];
S-adenosyl-L-methionine [CPD:
C00019 ]
Product C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol [CPD:
C22345 ];
CO2 [CPD:
C00011 ];
5'-deoxyadenosine [CPD:
C05198 ];
L-methionine [CPD:
C00073 ]
Comment This is a bifunctional radical AdoMet (radical SAM) enzyme that catalyses the first two steps in the biosynthesis of the enzyme cofactor mycofactocin. Activity requires the presence of the MftB chaperone. The other activity of the enzyme is EC
4.1.99.26 , 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase.
History EC 1.3.98.7 created 2021
Orthology K24696 [mycofactocin precursor peptide]-tyrosine decarboxylase / 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase
Genes URU : DSM104443_01508(mftC)
UPL : DSM104440_02432(moaA_2) DSM104440_02434(mftC)
ECEC : NCTC12421_02257(moaA)
MMAE : MMARE11_09740(pqqE)
MBAI : MB901379_00882(albA)
MPAA : MKK62_01650(mftC) MKK62_20125(mftC)
MMEH : M5I08_04070(mftC) M5I08_21200(mftC)
MKY : IWGMT90018_10150(pqqE)
MPHL : MPHLCCUG_01293(albA)
MTHN : 4412656_00903(moaA_1)
MAUU : NCTC10437_01079(moaA_1)
MMAT : MMAGJ_31370 MMAGJ_42610
MFLV : NCTC10271_04120(moaA_2)
MSAL : DSM43276_03628(albA_1)
MTER : 4434518_03335(pqqE)
NFR : ERS450000_00607(moaA_1) ERS450000_01864(moaA_2)
NAD : NCTC11293_06440(moaA_2)
NIE : KV110_01685 KV110_37300(mftC)
NGP : LTT66_16810(mftC) LTT66_27865
RRT : 4535765_03565(moaA_2)
RCR : NCTC10994_03687(moaA_1)
RANT : RHODO2019_14325(mftC)
NARO : CFH99_21865(mftC) CFH99_24470(mftC)
NAQU : ENKNEFLB_00509(mftC)
SACG : FDZ84_29565(mftC) FDZ84_34715(mftC)
SBAE : DSM104329_01719(mftC)
» show all Taxonomy Reference Authors Haft DH.
Title Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners.
Journal Sequence Reference Authors Bruender NA, Bandarian V
Title The Radical S-Adenosyl-l-methionine Enzyme MftC Catalyzes an Oxidative Decarboxylation of the C-Terminus of the MftA Peptide.
Journal Reference Authors Khaliullin B, Ayikpoe R, Tuttle M, Latham JA
Title Mechanistic elucidation of the mycofactocin-biosynthetic radical S-adenosylmethionine protein, MftC.
Journal Sequence Reference Authors Ayikpoe R, Ngendahimana T, Langton M, Bonitatibus S, Walker LM, Eaton SS, Eaton GR, Pandelia ME, Elliott SJ, Latham JA.
Title Spectroscopic and Electrochemical Characterization of the Mycofactocin Biosynthetic Protein, MftC, Provides Insight into Its Redox Flipping Mechanism.
Journal Sequence Other DBs ExplorEnz - The Enzyme Database: 1.3.98.7
ExPASy - ENZYME nomenclature database: 1.3.98.7
